Novel Pyrrolo[2,3-d]pyrimidines and Pyrrolo[2,3-b]pyridines: Design, Synthesis, and In
Vivo TNF-α Inhibitory Activity.
Khaled M. H. Hilmy1*, Hanan G. Abdul-Wahab2, Dalia H. Soliman2, Maha M. A. Khalifa2,
Amany M. Hegab3
1*Department
of Chemistry, Faculty of Science, Monufyia University, Shebin El-Kom,
Egypt
2Pharmaceutical
Chemistry Department,
University, Cairo, Egypt
Faculty
of
Pharmacy
3Developmental
(Girls),
Al-Azhar
Pharmacology Department, National Organization for Drug Control and
Research,
Agouza,
Egypt
*Corresponding author, Tel.: +2024701516, +2022470355
E-mail:hilmykhaled@yahoo.com
P.O.Box 73, Shoubra Misr, Cairo, Egypt.
Figure capture
Figure 1: IR spectrum of compound 1e
Figure 2: 1H NMR spectrum of compound 1e in CDCl3
Figure 3: 1H NMR spectrum of compound 1e in CDCl3+ D2O
Figure 4:13C NMR spectrum of compound 1e in DMSO
Figure 5: Mass spectrum of compound 1e
Figure 6: IR spectrum of compound 2b
Figure 7: 1H NMR spectrum of compound 2b in DMSO
Figure 8: 1H NMR spectrum of compound 2b in DMSO+ D2O
Figure 9: 13C NMR spectrum of compound 2b in DMSO
Figure 10: Mass spectrum of compound 2b
Figure 11: IR spectrum of compound 5f
Figure 12: 1H NMR spectrum of compound 5f in DMSO
Figure 13: 1H NMR spectrum of compound 5f in DMSO+ D2O
Figure 14: 13C NMR spectrum of compound 5f in DMSO
Figure 15: Mass spectrum of compound 5f
Figure 16: IR spectrum of compound 6f
Figure 17: 1H NMR spectrum of compound 6f in DMSO
Figure 18: 1H NMR spectrum of compound 6f in DMSO+ D2O
Figure 20: IR spectrum of compound 7e
Figure 21: 1H NMR spectrum of compound 7e in DMSO
Figure 22: 1H NMR spectrum of compound 7e in DMSO+ D2O
Figure 23: 13C NMR spectrum of compound 7e in DMSO
Figure 24: Mass spectrum of compound 7e
Figure 25: Elemental analysis data for compounds 5b, 1f, 2b, 5f, 6b, 7a respectively as in
the above table
Figure 26: Elemental analysis data for compounds 6f and7e respectively as in the above
table
*13CNMR data of compounds 1e, 2b, 5f, 6f and 7e
Figure 1: IR spectrum of compound 1e
Figure 2: 1H NMR spectrum of compound 1e in CDCl3
Figure 3: 1H NMR spectrum of compound 1e in CDCl3+ D2O
Figure 4:13C NMR spectrum of compound 1e in DMSO
Figure 5: Mass spectrum of compound 1e
Figure 6: IR spectrum of compound 2b
Figure 7: 1H NMR spectrum of compound 2b in DMSO
Figure 8: 1H NMR spectrum of compound 2b in DMSO+ D2O
Figure 9: 13C NMR spectrum of compound 2b in DMSO
Figure 10: Mass spectrum of compound 2b
Figure 11: IR spectrum of compound 5f
Figure 12: 1H NMR spectrum of compound 5f in DMSO
Figure 13: 1H NMR spectrum of compound 5f in DMSO+ D2O
Figure 14: 13C NMR spectrum of compound 5f in DMSO
Figure 15: Mass spectrum of compound 5f
Figure 16: IR spectrum of compound 6f
Figure 17: 1H NMR spectrum of compound 6f in DMSO
Figure 18: 1H NMR spectrum of compound 6f in DMSO+ D2O
Figure 19: 13C NMR spectrum of compound 6f in DMSO
Figure 20: IR spectrum of compound 7e
Figure 21: 1H NMR spectrum of compound 7e in DMSO
Figure 22: 1H NMR spectrum of compound 7e in DMSO+ D2O
Figure 23: 13C NMR spectrum of compound 7e in DMSO
Figure 24: Mass spectrum of compound 7e
Figure 25: Elemental analysis data for compounds 5b, 1f, 2b, 5f, 6b, 7a respectively as in
the above table
Figure 26: Elemental analysis for compounds 6f and7e respectively as in the above table