Supplemental Digital Content (SDC) 1: Composition of Treatment Supplement Primary Ingredients Amount / 4 Softgels Omega-3 Fatty Acidsa 18:3 ALA (alpha-linolenic acid) 196.0 mg 20:5 EPA (eicosapentaenoic acid) 126.0 mg 22:5 DPA (docosapentaenoic acid) 39.0 mg 22:6 DHA (docosahexaenoic acid) 99.0 mg Omega-6 Fatty Acidsa 18:2 LA (linoleic acid) 710.0 mg 18:3 GLA (gamma-linolenic acid) 240.0 mg 20:4 ARA (arachidonic acid) < 3.0 mg Vitaminsb Vitamin A (retinyl palmitate) 2180.0 IU Vitamin B6 (pyridoxal 5’-phosphate) 12.8 Vitamin C (ascorbic acid) 262.0 mg Vitamin E (d tocopherol) 13.7 mg mg Mineral Magnesium (sulfate) 40.8 mg SDC 1: Composition of treatment supplement (Cont.) a Fatty acids derived from a combination of black currant seed oil (Ribes nigrum) and USP-verified fish oil b Vitamins A and E expressed in International Units (IU)