Online Resource 1: Serum chemistry values for the chronic PediVAS

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Online Resource
Table S1: Serum chemistry values for the chronic PediVAS implant animals (S003-10, S010-10 and S011-10).
Data are presented as the average + standard deviation over the 30 day study with baseline values in
parenthesis. Reference values for sheep are provided in the last column (Merck veterinary manual 1998).
*denotes values for which there are no reference ranges available and are based on target anticoagulation
parameters. †denotes values for which there are no reference ranges and are based on two standard
deviations from the average baseline value.
Parameters
WBC 103/L
RBC 106/L
Hgb g/dl
HCT %
Platelets 103/L
Neutrophils %
Lymphocytes %
PT sec
PTR
aPTT sec
Fibrinogen mg/dl
Pla Hgb mg/dl
BUN mg/dl
Glucose mg/dl
Creatinine mg/dl
Ca mg/dl
Mg mEq/L
Cl mmol/L
K mmol/L
Na mmol/L
SGPT (ALT) IU/L
Albumin g/dl
SGOT (AST) IU/L
Tot. Bilirubin mg/dl
GGTP IU/L
LDH IU/L
Phos mg/dl
Cholesterol mg/dl
Amylase U/L
Lipase U/L
ALK IU/L
CK IU/L
Tot. Protein g/dl
S003-10
7.03 + 1.93 (6. 7)
7.1 + 0.39 (11.3)
8.2 + 0.9 (12.7)
23.6 + 2.8 (30.0)
596 + 331 (205)
41.1 +19.2 (17.7)
54 + 19.1 (70.8)
19.7 + 3.49
2.13 + 0.44
64.05 + 19.85
292 + 151 (150)
8.6 + 2.4 (14.4)
12.8 + 3.19 (9)
73.2 + 14.57 (77)
0.57 + 0.07 (0.8)
9.39 +1.24 (11.5)
1.64 + 0.19
114.43 + 5.59
5.92 + 1.36
140.19 + 2.41
31.4 + 24.66 (31)
2.2 + 0.74 (3)
162.11 + 132.23
0.12 + 0.08 (0.4)
56.7 + 13.95 (88)
382.6 + 110.4
6.25 + 1.58 (5.3)
51.7 + 35.74 (65)
15.75 + 4.35
20 + 9.27
91 + 15.96 (146)
262 + 487
5.7 + 0.6 (6.3)
S010-10
9.06 + 2.44 (9.9)
8.2 + 1.26 (11.45)
9.1 + 1.4 (10.8)
27.0 + 4.0 (31)
946 + 373 (852)
36.6 + 11.21 (42)
59.5 + 10.3 (48)
16.6 + 3.09 (14.8)
1.12 + 0.21 (1)
45.7 + 17.4 (35.9)
194 + 116 (100)
7.1 + 2.6 (5.6)
14.63 + 1.6 (13)
76.2 + 10.19 (84)
0.59 + 0.08 (0.8)
8.79 + 1.1 (8.9)
1.83 + 0.2 (2)
110.5 + 6.12 (106)
5.48 + 0.93 (3.8)
140.6 + 4.05 (143)
15.25 + 10.69 (16)
2.35 + 0.5 (2.6)
99 + 76.91 (120)
0.08 + 0.07 (0.1)
40.8 + 3.45 (48)
466 + 228 (520)
6.51 + 0.83 (6.1)
47 + 24.72 (64)
15 + 4.63 (19)
8.5 + 3.3 (12)
145.2 + 20.5 (137)
1295 + 2902 (345)
5.3 + 0.5 (5.7)
S011-10
11.0 + 2.06 (13.2)
8.28 + 0.71 (11.1)
9.3 + 1.0 (11.1)
27.6 + 2.9 (31.5)
752 + 270 (896)
34 + 11.2 (34)
63 + 11.2 (64)
19.5 + 8.4 (18.6)
1.13 + 0.48 (1)
49.2 + 18.11 (32)
319 + 173 (150)
8.2 + 2.3 (13.6)
16.78 + 2.54 (18)
72.3 + 12.14 (72)
0.57 + 0.07 (0.8)
8.93 + 0.87 (9.9)
1.91 + 0.19 (2.4)
110.3 + 5.7 (107)
4.84 + 1.06 (4.4)
145 + 5.81 (150)
13 + 7.65 (13)
2.5 + 0.33 (2.9)
107.8 + 72.8 (99)
0.64 + 1.75 (0.1)
42 + 10.5 (48)
503 + 189.8 (474)
6.39 + 0.82 (7.2)
53 + 15.14 (72)
9.11 + 2.76 (7)
13.22 + 2.22 (16)
144.9 + 31.4 (149)
694 + 1235 (165)
5.8 + 0.4 (6.1)
Reference
Value
4-12
9-15
8-15
27-45
250-750
10-50
40-75
N/A
2-3*
46-70*
100-500
0-15
10-26
44-88
0.9-2
9.3-11.7
2-2.7
101-113
4.3-6.3
142-160
15-44
2.7-3.7
49-123
0-0.05
20-44
83-476
4-7.3
44-90
140-270
4.3-17.3†
27-156
7.7-101
5.5-7.5
WBC=whole blood count; RBC=red blood cell count; Hgb= hemoglobin; HCT=hematocrit; PT=prothrombin
time; PTR=relative prothrombin time; aPTT=activated partial thromboplastin time; BUN=Blood urea
nitrogen; Pla Hgb=Plasma free hemoglobin; Ca=calcium; Mg=magnesium; Cl=chloride; K=Potassium;
Na=Sodium; SGPT= Serum glutamic pyruvic transaminase; ALT= Alanine transaminase; SGOT= Serum
glutamic oxaloacetic transaminase; AST= Aspartate aminotransferase; GGTP= Gamma-glutamyl
transpeptidase; LDH=Lactate dehydrogenase; Phos=Phosphorous; ALK= Anaplastic lymphoma receptor
tyrosine kinase; CK=Creatine kinase;
1. Merck veterinary manual (1998). 8th edn. MERCK and Co. Inc., Whitehouse Station
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