Acta Neuropathologica. Olabarria M, Putilina M, Riemer EC, Goldman JE. Department of Pathology and Cell Biology,
Columbia University (jeg5@columbia.edu).
Table S1: Total list of GOs considered as immune related and itemized by sub-categories.
Immune Subcategory
Generic
immune and
inflammation
GO ID
Description
GO:0002758
innate immune responseactivating signal
transduction
activation of innate immune
response
somatic recombination of
immune receptors built from
immunoglobulin superfamily
domains
GO:0050671
positive regulation of
lymphocyte proliferation
GO:0030217
T cell differentiation
GO:0045580
regulation of T cell
differentiation
GO:0045087
innate immune response
GO:0002706
GO:0045088
regulation of innate immune
response
positive regulation of
adaptive immune response
immune response-activating
signal transduction
positive regulation of
adaptive immune response
based on somatic
recombination of immune
receptors built from
immunoglobulin superfamily
domains
GO:0046649
regulation of lymphocyte
mediated immunity
lymphocyte activation
positive regulation of innate
immune response
immune response-regulating
signaling pathway
regulation of adaptive
immune response
GO:0046637
positive regulation of
immune effector process
adaptive immune response
GO:0001914
GO:0002822
regulation of adaptive
immune response based on
somatic recombination of
immune receptors built from
immunoglobulin superfamily
domains
GO:0043372
positive regulation of CD4positive, alpha-beta T cell
differentiation
GO:0002253
activation of immune
response
positive regulation of
immune response
immune response
GO:2000514
cell activation involved in
immune response
immune response-activating
cell surface receptor
signaling pathway
GO:0030889
regulation of CD4-positive,
alpha-beta T cell activation
positive regulation of T cell
proliferation
negative regulation of
lymphocyte proliferation
negative regulation of B
cell proliferation
positive regulation of T cell
mediated immunity
GO:0002218
GO:0002460
GO:0002821
GO:0002757
GO:0002824
GO:0045089
GO:0002764
GO:0002819
GO:0002699
GO:0002250
GO:0050778
GO:0006955
GO:0002263
GO:0002429
Immune Subcategory
GO ID
GO:0045619
GO:0051249
GO:0030098
GO:0002709
GO:2000516
GO:0019724
GO:0042102
GO:0050672
GO:0002711
Description
regulation of lymphocyte
differentiation
regulation of lymphocyte
activation
lymphocyte differentiation
regulation of alpha-beta T
cell differentiation
regulation of T cell
mediated immunity
positive regulation of CD4positive, alpha-beta T cell
activation
regulation of T cell
mediated cytotoxicity
B cell mediated immunity
Acta Neuropathologica. Olabarria M, Putilina M, Riemer EC, Goldman JE. Department of Pathology and Cell Biology,
Columbia University (jeg5@columbia.edu).
GO:0050776
GO:0050729
GO:0002252
GO:0050777
GO:0002768
GO:0002684
GO:0002697
GO:0002683
regulation of immune
response
positive regulation of
inflammatory response
immune effector process
GO:0050869
negative regulation of
immune response
immune response-regulating
cell surface receptor
signaling pathway
GO:0043029
GO:0002708
positive regulation of
lymphocyte mediated
immunity
positive regulation of
immune system process
regulation of immune
effector process
negative regulation of
immune system process
GO:0002260
lymphocyte homeostasis
GO:0045625
regulation of T-helper 1 cell
differentiation
regulation of CD4-positive,
alpha-beta T cell
differentiation
GO:0050871
GO:0002285
GO:0043370
GO:0006954
inflammatory response
GO:0002376
immune system process
GO:0061041
regulation of wound healing
GO:0007159
GO:0009611
response to wounding
GO:0002274
GO:0002682
regulation of immune system
process
regulation of inflammatory
response
immunoglobulin mediated
immune response
myeloid cell activation
involved in immune
response
negative regulation of
immune effector process
regulation of production of
molecular mediator of
immune response
GO:0070661
negative regulation of innate
immune response
GO:1902107
GO:0050727
GO:0016064
GO:0002275
GO:0002698
GO:0002700
GO:0045824
Leukocytes
GO:0002886
GO:0001910
GO:0097529
GO:0002687
GO:0002685
GO:0002366
GO:0002443
Denfese
response
GO:0031347
GO:0006952
regulation of defense
response
defense response
GO:0002703
GO:2000106
GO:0002695
Cytokine,
chemokines
and
chemotaxis
GO:0035456
response to interferon-beta
GO:0070663
GO:0035458
cellular response to
interferon-beta
GO:0002696
negative regulation of B
cell activation
positive regulation of B cell
activation
lymphocyte activation
involved in immune
response
T cell homeostasis
regulation of myeloid
leukocyte mediated
immunity
leukocyte cell-cell
adhesion
myeloid leukocyte
activation
leukocyte proliferation
regulation of leukocyte
mediated cytotoxicity
myeloid leukocyte
migration
positive regulation of
leukocyte migration
regulation of leukocyte
migration
leukocyte activation
involved in immune
response
positive regulation of
leukocyte differentiation
leukocyte mediated
immunity
regulation of leukocyte
mediated immunity
regulation of leukocyte
apoptotic process
negative regulation of
leukocyte activation
regulation of leukocyte
proliferation
positive regulation of
leukocyte activation
Acta Neuropathologica. Olabarria M, Putilina M, Riemer EC, Goldman JE. Department of Pathology and Cell Biology,
Columbia University (jeg5@columbia.edu).
GO:0071346
GO:0045321
leukocyte activation
GO:0050900
leukocyte migration
GO:0070665
positive regulation of
leukocyte proliferation
regulation of leukocyte
activation
leukocyte differentiation
GO:0030593
cellular response to
interferon-gamma
positive regulation of
chemokine production
response to interferongamma
positive regulation of tumor
necrosis factor production
regulation of interleukin-1
production
neutrophil chemotaxis
GO:0071621
granulocyte chemotaxis
GO:0002705
GO:0060759
regulation of response to
cytokine stimulus
regulation of cytokinemediated signaling pathway
regulation of tumor necrosis
factor production
positive regulation of
leukocyte chemotaxis
GO:0001776
GO:1990266
GO:0030595
regulation of chemokine
production
leukocyte chemotaxis
GO:0019955
cytokine binding
GO:0032944
GO:0042108
positive regulation of
cytokine biosynthetic
process
regulation of leukocyte
chemotaxis
regulation of cytokine
biosynthetic process
GO:0032946
positive regulation of
chemotaxis
cell chemotaxis
GO:0042119
negative regulation of
mononuclear cell
proliferation
neutrophil activation
GO:0042116
macrophage activation
GO:0001774
microglial cell activation
GO:0050764
regulation of phagocytosis
GO:0050766
positive regulation of
phagocytosis
GO:0002224
toll-like receptor signaling
pathway
pattern recognition
receptor signaling pathway
GO:0032722
GO:0034341
GO:0032760
GO:0032652
GO:0001959
GO:0032680
GO:0002690
GO:0032642
GO:0002688
GO:0042035
GO:0050921
GO:0060326
GO:0032675
GO:0019221
GO:0001819
GO:0050707
GO:0034097
GO:0071345
GO:0001817
GO:0050920
regulation of interleukin-6
production
cytokine-mediated signaling
pathway
positive regulation of
cytokine production
regulation of cytokine
secretion
response to cytokine
cellular response to cytokine
stimulus
regulation of cytokine
production
regulation of chemotaxis
GO:0002694
GO:0002521
GO:1902105
GO:0070664
GO:0043300
GO:2000108
GO:0032943
GO:0097530
GO:0032945
Macrophages
and microglia
Phagocytosis
Toll-like
receptors
GO:0002221
regulation of leukocyte
differentiation
positive regulation of
leukocyte mediated
immunity
leukocyte homeostasis
negative regulation of
leukocyte proliferation
regulation of leukocyte
degranulation
positive regulation of
leukocyte apoptotic
process
neutrophil migration
mononuclear cell
proliferation
regulation of mononuclear
cell proliferation
positive regulation of
mononuclear cell
proliferation
granulocyte migration
Acta Neuropathologica. Olabarria M, Putilina M, Riemer EC, Goldman JE. Department of Pathology and Cell Biology,
Columbia University (jeg5@columbia.edu).
GO:0005126
cytokine receptor binding
GO:0006935
chemotaxis
GO:0032732
positive regulation of
interleukin-1 production
GO:0002718
regulation of cytokine
production involved in
immune response
GO:0019886
GO:0001818
negative regulation of
cytokine production
GO:0019884
GO:0032651
regulation of interleukin-1
beta production
GO:0002474
GO:0050715
positive regulation of
cytokine secretion
GO:0048002
GO:0032731
positive regulation of
interleukin-1 beta production
GO:0002495
GO:0032479
regulation of type I interferon
production
GO:0002504
GO:0010759
positive regulation of
macrophage chemotaxis
chemokine receptor binding
GO:0042611
GO:0050851
GO:0008009
regulation of interferon-beta
production
chemokine activity
GO:0004896
cytokine receptor activity
GO:0042613
GO:0034612
response to tumor necrosis
factor
positive regulation of
interleukin-1 secretion
positive regulation of
interleukin-1 beta secretion
regulation of interleukin-1
secretion
GO:0042379
GO:0032648
GO:0050716
GO:0050718
GO:0050704
MHC and
antigen
GO:0034142
toll-like receptor 4 signaling
pathway
GO:0002478
antigen processing and
presentation of exogenous
peptide antigen
antigen processing and
presentation of exogenous
peptide antigen via MHC
class II
antigen processing and
presentation of exogenous
antigen
antigen processing and
presentation of peptide
antigen via MHC class I
antigen processing and
presentation of peptide
antigen
antigen processing and
presentation of peptide
antigen via MHC class II
antigen processing and
presentation of peptide or
polysaccharide antigen via
MHC class II
MHC protein complex
GO:0019882
GO:0002483
Cell killing
GO:0031341
regulation of cell killing
External biotic
GO:0042832
defense response to
protozoan
negative regulation of viral
genome replication
response to protozoan
GO:0045071
Lymphocytes
GO:0050853
GO:0042098
GO:0046638
GO:2000401
GO:0046635
antigen processing and
presentation
antigen receptor-mediated
signaling pathway
antigen processing and
presentation of
endogenous peptide
antigen
MHC class II protein
complex
B cell receptor signaling
pathway
T cell proliferation
GO:0001562
positive regulation of alphabeta T cell differentiation
regulation of lymphocyte
migration
positive regulation of alphabeta T cell activation
GO:0050830
GO:0048525
GO:0051607
negative regulation of viral
process
defense response to
Gram-positive bacterium
defense response to virus
GO:0009615
response to virus
Acta Neuropathologica. Olabarria M, Putilina M, Riemer EC, Goldman JE. Department of Pathology and Cell Biology,
Columbia University (jeg5@columbia.edu).
GO:0002449
GO:0046634
GO:0030888
GO:0046651
GO:0045621
GO:0045582
GO:0050868
GO:0042110
GO:0050870
GO:0050864
GO:0051250
GO:0050670
GO:0042129
GO:0051251
GO:0050863
lymphocyte mediated
immunity
regulation of alpha-beta T
cell activation
regulation of B cell
proliferation
lymphocyte proliferation
GO:0002831
positive regulation of
lymphocyte differentiation
positive regulation of T cell
differentiation
negative regulation of T cell
activation
T cell activation
GO:0043207
positive regulation of T cell
activation
regulation of B cell activation
GO:0071216
negative regulation of
lymphocyte activation
regulation of lymphocyte
proliferation
regulation of T cell
proliferation
positive regulation of
lymphocyte activation
regulation of T cell activation
GO:0051704
response to other
organism
cellular response to biotic
stimulus
cellular response to
molecule of bacterial origin
multi-organism process
GO:0009617
response to bacterium
GO:0042742
defense response to
bacterium
regulation of viral process
GO:0002237
GO:0043900
GO:0043901
GO:0098542
GO:0009607
GO:0051707
GO:0071219
GO:0050792
GO:0045069
regulation of response to
biotic stimulus
response to molecule of
bacterial origin
regulation of multiorganism process
negative regulation of
multi-organism process
response to external biotic
stimulus
defense response to other
organism
response to biotic stimulus
regulation of viral genome
replication