Supplementary Table 1. Genomic islands of M. avium subsp. paratuberculosis K-10. Location in genome Gene content summary 99000..117073 Hypotheticals 292974.. 314208 Hypotheticals; osmoprotection proteins Hypotheticals, Fadproteins 865425.. 899160 1285436.. 1321324 Best BLASTn hit to genomic islands in other species Mycobacterium avium 104 M. avium 104 Possible donor organism* M. avium 104 Pseudonocardia, Geodermatophilus, Frankia, Beutenbergia Pseudonocardia Hypotheticals; Mycobacterium esterase; GDP-Dcanettii mannose dehydratase; nucleotide-sugar epimerase; drug resistance 1781905.. 1803222 Hypotheticals; Alicycliphilus alpha1,3denitrificans glucosyltransferase; isocitrate lyase 1881405.. 1904640 Hypotheticals; M. avium 104 hydrolases; membrane proteins 2373873.. 2399346 Hypotheticals; ISM. avium 104 element; heatinducible transcription repressor; phosphohydrolase 4147431.. 4173538 Hypotheticals M. avium 104 4163490..4199728 Hypotheticals; ISM. avium 104 element; membrane proteins 4254011.. 4277488 Hypotheticals; Mycobacterium deoxycytidine marinum triphosphate deaminase 4446083.. 4467623 Hypotheticals; Mycobacterium pyrroline and liflandii glutamyl reductase; phosphoserine phosphatase; dehydratase *Donor organisms are given as predicted in Pre_GI database. Pseudonocardia Pseudonocardia Pseudonocardia Pseudonocardia Pseudonocardia Pseudonocardia Pseudonocardia Blastococcus Pseudonocardia