Table S2. Differentially expressed genes in the kidneys of 12 week
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Table S2. Differentially expressed genes in the kidneys of 12 week old BPH/2J females, relative to BPN/3J females, using Bonferroni corrected p <0.05 Gene 0610010B08Rik 1110017F19Rik 1700049E17Rik1 1810037I17Rik 2310001H12Rik 4930466F19Rik 4930503E14Rik 4933409K07Rik 5330426P16Rik 5730407I07Rik Aadac Abhd1 Abhd14a Abhd14b Acp5 Adra2b Aga Ahcyl2 Ak084462 Alad Angptl7 Ankrd33b Ap3m1 Arfgef2 Arhgef2 Armcx1 Armcx3 Atg4a Atp10d Atp4a Atp6v1c1 Atp6v1f Bc040756 Bc067074 Bc126957 Bid Bik Description RIKEN cDNA 0610010B08 gene RIKEN cDNA 1110017F19 gene RIKEN cDNA 1700049E17 gene, gene 1 RIKEN cDNA 1810037I17 gene RIKEN cDNA 2310001H12 gene RIKEN cDNA 4930466F19 gene RIKEN cDNA 4930503E14 gene RIKEN cDNA 4933409K07 gene RIKEN cDNA 5330426P16 gene RIKEN cDNA 5730407I07 gene arylacetamide deacetylase (esterase) abhydrolase domain containing 1 abhydrolase domain containing 14A abhydrolase domain containing 14b acid phosphatase 5, tartrate resistant adrenergic receptor, alpha 2b aspartylglucosaminidase S-adenosylhomocysteine hydrolase-like 2 Mus musculus 13 days embryo heart cDNA, RIKEN full-length enriched library, clone aminolevulinate, delta-, dehydratase angiopoietin-like 7 ankyrin repeat domain 33B adaptor-related protein complex 3, mu 1 subunit ADP-ribosylation factor guanine nucleotideexchange factor 2 rho/rac guanine nucleotide exchange factor (GEF) 2 armadillo repeat containing, X-linked 1 armadillo repeat containing, X-linked 3 autophagy-related 4A (yeast) ATPase, class V, type 10D ATPase, H+/K+ exchanging, gastric, alpha polypeptide ATPase, H+ transporting, lysosomal V1 subunit C1 ATPase, H+ transporting, lysosomal V1 subunit F cDNA sequence BC040756 cDNA sequence BC067074 Mus musculus cDNA clone IMAGE BH3 interacting domain death agonist BCL2-interacting killer Fold Change 1.10 -1.18 -1.26 -1.32 -1.06 1.27 -1.15 1.12 1.13 1.47 -1.07 -1.02 -1.14 -1.08 1.06 -1.07 -1.07 1.04 -1.23 p value 0.003 0.032 <0.001 0.027 0.024 <0.001 <0.001 0.047 <0.001 <0.001 <0.001 0.017 0.002 0.001 0.007 0.001 0.022 0.047 0.001 1.06 1.68 1.18 -1.01 <0.001 <0.001 <0.001 0.032 1.04 0.002 1.04 0.003 1.09 1.05 -1.43 1.25 1.31 0.001 0.034 <0.001 <0.001 <0.001 -1.04 0.046 1.01 -1.05 1.07 1.18 -1.05 -1.18 0.018 0.038 0.004 0.046 0.027 0.003 C10orf11 C14orf138 C14orf149 C16orf62 C1orf192 C1orf91 C20orf118 C3orf25 C5orf28 C5orf34 C6orf162 C6orf35 C7orf10 Cast Cbr2 Ccbl2 Ccdc163 Ccdc56 Cd97 Cda Cdh20 Cdh4 Cep97 Chrm3 Cited1 Cldn12 Clip4 Cmtm6 Cmtm7 Cndp1 Cndp2 Commd2 Cox6b2 Cox7a1 Crym Ctsl2 Cwh43 Cyp4b1 Cysltr2 D14ertd449e RIKEN cDNA 1700112E06 gene predicted gene 71 RIKEN cDNA 2810055F11 gene RIKEN cDNA 9030624J02 gene RIKEN cDNA 1700009P17 gene RIKEN cDNA 2510006D16 gene predicted gene 1332 cDNA sequence BC060267 predicted gene 7120 RIKEN cDNA 4833420G17 gene RIKEN cDNA 1810030N24 gene RIKEN cDNA 5730437N04 gene RIKEN cDNA 5033411D12 gene calpastatin carbonyl reductase 2 cysteine conjugate-beta lyase 2 coiled-coil domain containing 163 coiled-coil domain containing 56 CD97 antigen cytidine deaminase cadherin 20 cadherin 4 centrosomal protein 97 cholinergic receptor, muscarinic 3, cardiac Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 claudin 12 CAP-GLY domain containing linker protein family, member 4 CKLF-like MARVEL transmembrane domain containing 6 CKLF-like MARVEL transmembrane domain containing 7 carnosine dipeptidase 1 (metallopeptidase M20 family) CNDP dipeptidase 2 (metallopeptidase M20 family) COMM domain containing 2 cytochrome c oxidase subunit VIb polypeptide 2 cytochrome c oxidase, subunit VIIa 1 crystallin, mu cathepsin L cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) cytochrome P450, family 4, subfamily b, polypeptide 1 cysteinyl leukotriene receptor 2 DNA segment, Chr 14, ERATO Doi 449, -1.32 1.05 -1.07 1.05 -1.29 -1.02 1.13 1.08 -1.31 -1.18 -1.03 -1.06 1.06 1.03 1.28 -1.05 -1.16 -1.04 -1.28 -1.03 1.24 -1.09 -1.05 1.07 1.21 <0.001 0.018 <0.001 0.004 0.001 0.032 0.041 0.024 <0.001 <0.001 0.040 <0.001 <0.001 0.014 0.007 0.002 0.002 <0.001 0.001 0.023 0.010 <0.001 0.018 0.004 0.005 -1.05 1.16 0.006 0.001 -1.04 0.031 1.11 0.046 1.14 0.005 1.08 0.002 -1.13 1.09 1.05 -1.17 -1.03 -1.08 0.005 0.047 0.019 <0.001 0.050 0.023 1.39 <0.001 1.36 1.08 0.006 <0.001 expressed Dao Dap Dcbld2 Ddc Ddhd1 Defb1 D-amino acid oxidase death-associated protein discoidin, CUB and LCCL domain containing 2 dopa decarboxylase DDHD domain containing 1 defensin beta 1 dehydrogenase E1 and transketolase domain Dhtkd1 containing 1 Dio1 deiodinase, iodothyronine, type I Dnajc28 DnaJ (Hsp40) homolog, subfamily C, member 28 Dna2 DNA-replication helicase 2 homolog (yeast) Dynlt1a dynein light chain Tctex-type 1A Dynlt1c dynein light chain Tctex-type 1C E330013p04rik RIKEN cDNA E330013P04 gene Edn3 endothelin 3 epidermal growth factor-containing fibulin-like Efemp2 extracellular matrix protein 2 Eif4a3 eukaryotic translation initiation factor 4A3 Ensmusg00000068790 predicted gene, ENSMUSG00000068790 Ensmust00000082886 ncrna Ensmust00000082910 ncrna Ensmust00000124790 cdna Ensmust00000137619 cdna Ensmust00000147499 cdna ectonucleoside triphosphate Entpd4 diphosphohydrolase 4 Esrp1 epithelial splicing regulatory protein 1 Fam132a family with sequence similarity 132, member A Fam173a family with sequence similarity 173, member A Fbxo44 F-box protein 44 fasciculation and elongation protein zeta 2 Fez2 (zygin II) Fgf1 fibroblast growth factor 1 Fggy FGGY carbohydrate kinase domain containing Fuca1 fucosidase, alpha-L- 1, tissue gamma-aminobutyric acid (GABA) A receptor, Gabra3 subunit alpha 3 growth arrest and DNA-damage-inducible, Gadd45gip1 gamma interacting protein 1 Gart phosphoribosylglycinamide formyltransferase Gas2 growth arrest specific 2 Gas5 growth arrest specific 5 Gas6 growth arrest specific 6 Gba glucosidase, beta, acid glycerophosphodiester phosphodiesterase Gdpd3 domain containing 3 -1.05 -1.08 1.07 -1.07 1.05 1.09 1.09 0.002 0.004 0.017 0.003 0.008 <0.001 <0.001 -1.12 -1.18 1.08 1.03 1.03 1.26 1.16 1.06 0.047 0.043 0.043 <0.001 <0.001 0.007 0.028 0.043 -1.27 -1.19 -1.52 1.07 -1.03 -1.07 1.10 -1.03 <0.001 <0.001 0.025 0.011 <0.001 <0.001 0.006 0.020 -1.11 -1.03 1.09 -1.07 1.10 0.004 0.016 0.001 0.028 <0.001 -1.07 -1.04 -1.05 1.56 <0.001 0.047 0.011 0.006 -1.08 <0.001 1.03 -1.03 -1.13 1.17 -1.07 1.18 0.035 0.049 <0.001 0.002 0.003 <0.001 Gfra2 Gjb4 Glt25d2 Gm10406 Gm10524 Gm10732 Gm10845 Gm11428 Gm13238 Gm13306 Gm14305 Gm14326 Gm14403 Gm14430 Gm15772 Gm1943 Gm1973 Gm2897 Gm3002 Gm3696 Gm3893 Gm5458 Gm5622 Gm773 Gpr125 Gprc5a Gprc5b Grm7 Gsto1 H60b Hdc Hdhd3 Hgd Hmgcs1 Hoxa10 Hps5 Hrsp12 Hsd17b14 Iah1 Ifi35 glial cell line derived neurotrophic factor family receptor alpha 2 gap junction protein, beta 4 glycosyltransferase 25 domain containing 2 predicted gene 10406 predicted gene 10524 predicted gene 10732 predicted gene 10845 predicted gene 11428 predicted gene 13238 predicted gene 13306 predicted gene, 100043387 predicted gene 14326 predicted gene 14403 predicted gene 14430 ribosomal protein L26 pseudogene WD repeat domain 70 pseudogene predicted gene 1973 predicted gene 2897 alpha-takusan pseudogene predicted gene 3696 predicted gene 3893 predicted gene 5458 predicted gene 5622 predicted gene 773 G protein-coupled receptor 125 G protein-coupled receptor, family C, group 5, member A G protein-coupled receptor, family C, group 5, member B glutamate receptor, metabotropic 7 glutathione S-transferase omega 1 histocompatibility 60b histidine decarboxylase haloacid dehalogenase-like hydrolase domain containing 3 homogentisate 1, 2-dioxygenase 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 homeobox A10 Hermansky-Pudlak syndrome 5 homolog (human) heat-responsive protein 12 hydroxysteroid (17-beta) dehydrogenase 14 isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) interferon-induced protein 35 -1.17 0.017 -1.20 1.10 -1.21 1.19 1.29 -1.16 -1.41 -1.03 -1.07 1.10 -1.02 -1.24 1.10 -1.05 -1.08 -1.21 -1.27 -1.22 -1.20 1.13 -1.16 -1.12 1.25 1.04 1.06 0.046 0.029 <0.001 0.003 0.016 0.034 0.010 0.003 0.004 0.003 0.039 <0.001 0.003 0.007 <0.001 0.009 <0.001 <0.001 0.002 0.012 0.028 0.018 0.026 <0.001 0.016 1.09 0.023 1.22 1.05 1.21 1.10 1.13 0.034 0.005 <0.001 0.046 0.007 -1.02 -1.07 0.044 0.001 1.04 1.11 0.041 0.002 -1.02 1.19 1.09 0.012 0.049 <0.001 1.10 0.010 Il10rb Inpp5b Itga1 Ivd Kcnk1 Kctd2 Kidins220 Klhdc1 Klk1 Laptm4b Ldha Leprot Leprotl1 Lig3 Loc100043371 Loc280487 Loc388630 Loxl2 Lyrm7 Lzts2 Mcfd2 Mcm6 Mogat1 Mogat2 Mpp7 Mro Mrpl12 Mrpl15 Mto1 Naaladl1 Ndufs2 Nell2 Nipal2 Nkiras1 Nnt Nucb2 Nudt19 Olfml2b Osbpl10 interleukin 10 receptor, beta inositol polyphosphate-5-phosphatase B integrin alpha 1 isovaleryl coenzyme A dehydrogenase potassium channel, subfamily K, member 1 potassium channel tetramerisation domain containing 2 kinase D-interacting substrate 220 kelch domain containing 1 kallikrein 1 lysosomal-associated protein transmembrane 4B lactate dehydrogenase A leptin receptor overlapping transcript leptin receptor overlapping transcript-like 1 ligase III, DNA, ATP-dependent similar to development and differentiation enhancing factor 2 pol polyprotein predicted gene 12824 lysyl oxidase-like 2 LYR motif containing 7 leucine zipper, putative tumor suppressor 2 multiple coagulation factor deficiency 2 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) monoacylglycerol O-acyltransferase 1 monoacylglycerol O-acyltransferase 2 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) maestro mitochondrial ribosomal protein L12 mitochondrial ribosomal protein L15 mitochondrial translation optimization 1 homolog (S. cerevisiae) N-acetylated alpha-linked acidic dipeptidaselike 1 NADH dehydrogenase (ubiquinone) Fe-S protein 2 NEL-like 2 (chicken) NIPA-like domain containing 2 NFKB inhibitor interacting Ras-like protein 1 nicotinamide nucleotide transhydrogenase nucleobindin 2 nudix (nucleoside diphosphate linked moiety X)type motif 19 olfactomedin-like 2B oxysterol binding protein-like 10 -1.06 -1.06 1.03 -1.04 -1.18 -1.05 0.006 0.029 0.011 0.019 <0.001 0.011 1.03 1.09 1.02 1.04 0.040 0.027 0.002 0.001 1.04 -1.07 1.06 1.05 1.04 <0.001 0.030 0.001 <0.001 0.006 -1.34 -1.07 1.11 -1.14 1.05 -1.07 -1.30 <0.001 <0.001 0.003 0.004 0.010 0.002 0.007 1.17 1.15 -1.07 <0.001 0.001 0.028 -1.17 -1.07 1.05 -1.03 0.013 <0.001 0.010 0.003 1.16 0.004 1.03 0.016 1.31 1.22 -1.07 -1.03 -1.06 1.07 <0.001 <0.001 0.036 0.030 0.010 0.026 -1.13 -1.13 0.002 0.010 Oxgr1 P2rx4 Pak1 Pak6 Pde3a Pde6d Pfas Phf20 Pigx Pik3c2g Pla2g5 Plac9 Plat Pld1 Plekhb1 Plxdc1 Polr1b Ppm1l Prkcq Procr Prom2 Psmb3 Pter Pxk Rbfa Rbp7 Rgs5 Rhbg Rhobtb2 Rnf13 Rnf187 Rpap2 Rpgrip1l Rpl15 Rpl26l1 Rpl35a Rps13 Rsph3a Rtf1 Scn2b oxoglutarate (alpha-ketoglutarate) receptor 1 purinergic receptor P2X, ligand-gated ion channel 4 p21 protein (Cdc42/Rac)-activated kinase 1 p21 protein (Cdc42/Rac)-activated kinase 6 phosphodiesterase 3A, cGMP inhibited phosphodiesterase 6D, cGMP-specific, rod, delta phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) PHD finger protein 20 phosphatidylinositol glycan anchor biosynthesis, class X phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide phospholipase A2, group V placenta specific 9 plasminogen activator, tissue phospholipase D1 pleckstrin homology domain containing, family B (evectins) member 1 plexin domain containing 1 polymerase (RNA) I polypeptide B protein phosphatase 1 (formerly 2C)-like protein kinase C, theta protein C receptor, endothelial prominin 2 proteasome (prosome, macropain) subunit, beta type 3 phosphotriesterase related PX domain containing serine/threonine kinase RIKEN cDNA 1110032A13 gene retinol binding protein 7, cellular regulator of G-protein signaling 5 Rhesus blood group-associated B glycoprotein Rho-related BTB domain containing 2 ring finger protein 13 ring finger protein 187 RNA polymerase II associated protein 2 Rpgrip1-like ribosomal protein L15 predicted pseudogene 10136 ribosomal protein L35A ribosomal protein S13 radial spoke 3A homolog (Chlamydomonas) Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) sodium channel, voltage-gated, type II, beta 1.07 1.03 0.013 0.003 1.13 -1.11 1.07 -1.05 0.028 0.004 0.034 0.001 1.07 0.003 1.05 -1.05 0.032 <0.001 -1.07 0.029 1.11 1.18 1.05 -1.11 1.28 <0.001 <0.001 0.044 0.005 <0.001 -1.14 -1.07 -1.05 1.03 1.09 -1.07 -1.03 0.003 0.050 0.025 0.041 0.014 0.024 0.017 -1.03 1.03 1.04 1.25 1.06 1.08 1.06 1.06 -1.05 1.05 -1.05 -1.02 -1.05 -1.03 1.03 1.06 1.05 0.008 0.002 0.003 0.044 0.025 0.003 0.029 <0.001 0.002 0.020 0.019 0.020 0.003 0.037 0.023 0.015 <0.001 1.12 0.007 Scnn1b Scrg1 Sectm1 Sectm1b Sema5a Serinc3 Serpina1f Serpinb8 Serpinh1 Sfxn1 Shisa7 Slc12a7 Slc15a2 Slc16a5 Slc25a10 Slc26a1 Slc35e1 Slc5a6 Slc6a13 Slco1a6 Slit2 Slitrk6 Snord53 Snx31 Sorbs3 Spink6 Spns2 Sppl2a Sptlc3 Sqrdl St7 Stard10 Stx18 Stxbp5l Sympk sodium channel, nonvoltage-gated 1 beta scrapie responsive gene 1 secreted and transmembrane 1A secreted and transmembrane 1B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A serine incorporator 3 serine (or cysteine) peptidase inhibitor, clade A, member 1F serine (or cysteine) peptidase inhibitor, clade B, member 8 serine (or cysteine) peptidase inhibitor, clade H, member 1 sideroflexin 1 shisa homolog 7 (Xenopus laevis) solute carrier family 12, member 7 solute carrier family 15 (H+/peptide transporter), member 2 solute carrier family 16 (monocarboxylic acid transporters), member 5 solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 solute carrier family 26 (sulfate transporter), member 1 solute carrier family 35, member E1 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 solute carrier family 6 (neurotransmitter transporter, GABA), member 13 solute carrier organic anion transporter family, member 1a6 slit homolog 2 (Drosophila) SLIT and NTRK-like family, member 6 small nucleolar RNA, C/D box 53 sorting nexin 31 sorbin and SH3 domain containing 3 serine peptidase inhibitor, Kazal type 6 spinster homolog 2 (Drosophila) RIKEN cDNA 2010106G01 gene serine palmitoyltransferase, long chain base subunit 3 sulfide quinone reductase-like (yeast) suppression of tumorigenicity 7 START domain containing 10 syntaxin 18 syntaxin binding protein 5-like symplekin 1.05 1.63 -1.41 -1.16 1.05 0.009 0.001 <0.001 0.002 0.005 1.03 1.07 <0.001 <0.001 -1.22 <0.001 -1.08 0.038 -1.02 -1.05 -1.05 1.06 0.008 0.028 0.011 <0.001 -1.26 <0.001 -1.06 0.005 -1.08 0.003 -1.04 -1.10 0.025 0.018 -1.05 0.045 1.08 <0.001 1.06 1.32 1.31 1.11 1.05 -1.88 -1.04 1.03 1.10 0.023 0.028 0.001 0.047 0.007 <0.001 0.023 0.030 0.004 -1.06 -1.08 -1.02 -1.03 -1.07 -1.03 <0.001 0.001 0.003 0.031 0.016 0.028 Tc2n Tex15 Tfpi Thbs1 Thsd7a Tmc4 Tmco1 Tmed5 Tmem20 Tmem39b Tmem8a Tomm34 Tox Trappc2l Trim13 Tspan15 Ube2c Ubiad1 Ugt3a1 Usp53 Vmn2r37 Vmn2r43 Vwa1 Vwa5a Zcchc14 Zfp106 Zfp125 Zfp738 Znf426 Znf605 Znf830 Zpld1 tandem C2 domains, nuclear testis expressed gene 15 tissue factor pathway inhibitor thrombospondin 1 thrombospondin, type I, domain containing 7A transmembrane channel-like gene family 4 transmembrane and coiled-coil domains 1 transmembrane emp24 protein transport domain containing 5 transmembrane protein 20 transmembrane protein 39b transmembrane protein 8 (five membranespanning domains) translocase of outer mitochondrial membrane 34 thymocyte selection-associated high mobility group box trafficking protein particle complex 2-like tripartite motif-containing 13 tetraspanin 15 ubiquitin-conjugating enzyme E2C UbiA prenyltransferase domain containing 1 UDP glycosyltransferases 3 family, polypeptide A1 ubiquitin specific peptidase 53 vomeronasal 2, receptor 37 vomeronasal 2, receptor 43 von Willebrand factor A domain containing 1 von Willebrand factor A domain containing 5A zinc finger, CCHC domain containing 14 zinc finger protein 106 zinc finger protein 125 zinc finger protein 738 zinc finger protein 426 zinc finger protein 605 zinc finger protein 830 zona pellucida like domain containing 1 1.15 1.41 1.05 1.04 1.07 1.04 1.04 1.06 0.006 <0.001 0.018 0.026 0.027 0.004 <0.001 0.031 1.04 1.08 -1.05 0.050 <0.001 <0.001 -1.04 0.020 1.15 0.023 -1.08 -1.07 1.10 -1.24 1.06 -1.02 0.001 <0.001 0.004 0.019 0.016 0.013 1.07 -1.11 -1.14 -1.14 -1.03 -1.05 1.05 -1.67 1.09 -1.06 1.37 1.17 1.30 <0.001 0.012 0.012 <0.001 0.010 0.005 0.012 0.006 0.003 <0.001 <0.001 0.016 <0.001
