Table S4. The brain regions enriched by the genes mined by present study
relevant to “Neurological disease”, “Nervous system development and
function”, “Inflammatory response” and “Cell death”
Brain region
Entrez ID
Gene
Symbol
Log
Ratio
Olfactory bulb
16504
114142
KCNC3
FOXP2
0.97
0.96
12801
CNR1
0.88
213262
140919
18213
11550
16522
14680
20508
63993
12310
16504
110893
FSTL5
SLC17A6
NTRK3
ADRA1D
KCNJ6
GNAL
SLC18A3
SLC5A7
CALCB
KCNC3
SLC8A3
0.83
0.83
0.8
0.54
0.41
0.36
1.2
0.84
1.33
0.97
0.98
Neurological Disease; Nervous system
development and functions; Inflammatory
response, cell death
MvD
MvD, PD
AD, MvD, PD; SyT, Ngs (GoN, DCNS, DoN);
ImRes
AD, MvD, PD
MvD, PD
AD, MvD, PD; Ngs (Ntg, GoN, FPMP, DoN); Apop
AD, MvD, PD
MvD, PD
MvD
MvD
AD; SyT
ImRes
MvD
MvD, PD; SyT
140919
SLC17A6
0.83
MvD, PD
18125
18753
21834
18610
14680
226922
14407
NOS1
PRKCD
THRB
PDYN
GNAL
KCNQ5
GABRG3
0.54
0.31
0.71
0.67
0.36
0.69
0.46
AD, MvD, PD; Ngs (Ntg, FPMP, DoN)
AD; Ngs (GoN); Apop, ImRes
MvD, PD; Ngs (DCNS)
MvD
MvD
MvD, PD
AD, MvD, PD
226922
KCNQ5
0.69
MvD, PD
18753
PRKCD
0.31
AD; Ngs (GoN); Apop, ImRes
16521
KCNJ5
1.45
AD
Oculomotor nucleus
Somatosensory areas
Retrosplenial area
Amygdala
(including cortical, central
and medial)
Dentate gyrus
Isocortex
Nucleus accumbens
Hippocampus (including
CA1, CA2 and CA3, all
pyramidal regions)
Thalamus (including
ventral posterior complex,
paraventricular nucleus,
reticular nucleus)
Subthalamic nucleus
Zona incerta
Colliculus (superior and
inferior)
Midbrian trigeminal
nucleus
Cerebellar cortex (purkinje
and granular layer)
Cerebellar nuclei
Entorhinal area
Triangular nucleus of
septum
16504
11550
17536
14680
20660
16504
17536
KCNC3
ADRA1D
MEIS2
GNAL
SORL1
KCNC3
MEIS2
0.97
0.54
-0.5
0.36
1.32
0.97
-0.5
MvD
AD, MvD, PD
MvD
MvD
AD, MvD
MvD
MvD
14680
GNAL
0.36
MvD
213783
PLEKHG1
0.64
AD
18053
NGFR
1.15
AD; Ngs (Ntg, FPMP, GoN, DCNS, DoN); Apop
110893
SLC8A3
0.98
MvD, PD
16504
319924
14804
13653
140919
58178
17536
110893
65254
22422
KCNC3
APBA1
GRID2
EGR1
SLC17A6
SORCS1
MEIS2
SLC8A3
DPYSL5
WNT7B
0.97
0.51
0.32
-0.61
0.83
0.45
-0.5
0.98
1.02
0.7
MvD
AD; SyT
AD, MvD; SyT
MvD; ImRes, Apop
MvD, PD
AD
MvD
SyT
Ngs (GoN)
Ngs (Ntg, FPMP)
20562
SLIT1
0.74
Ngs (Ntg, GoN, FPMP, DCNS)