Centre for Population Health Sciences University of Edinburgh A systematic review of the effectiveness of policies and interventions to reduce socio-economic inequalities in smoking among youth. Report March 2013 Amanda Amos Tamara Brown Stephen Platt SILNE - Tackling socio-economic inequalities in smoking: learning from natural experiments by time trend analyses and cross-national comparisons 1 Project team Amanda Amos, Professor of Health Promotion Tamara Brown, Research Fellow Stephen Platt, Professor of Health Policy Research Centre for Population Health Sciences School of Molecular, Genetic and Population Health Sciences The University of Edinburgh Medical School Teviot Place Edinburgh Scotland EH8 9AG Phone: (+44)-(0)131-650-3237 Fax: (+44)-(0)131-650-6909 Acknowledgements The project team would like to thank members of the SILNE project and members of the European Network for Smoking and Tobacco Prevention (ENSP) who helped in the search for grey literature. 2 Table of Contents EXECUTIVE SUMMARY................................................................................................................ 4 1 INTRODUCTION ....................................................................................................................... 6 1.1 Background ........................................................................................................................................... 6 1.2 Aims and objectives .............................................................................................................................. 8 2 METHODS ................................................................................................................................ 10 2.1 Search strategy ................................................................................................................................... 10 2.2 Study selection.................................................................................................................................... 11 2.2.1 Study selection process ................................................................................................................... 11 2.2.2 Inclusion criteria .............................................................................................................................. 11 2.2.3 Data extraction ................................................................................................................................ 13 2.2.4 Quality assessment .......................................................................................................................... 13 2.2.5 Data synthesis .................................................................................................................................. 14 3 RESULTS .................................................................................................................................. 16 3.1 Introduction ........................................................................................................................................ 16 3.2 Impact of population-level policies and interventions on smoking inequalities in youth .................... 21 3.2.1 Smoking restrictions in cars, schools, workplaces and other public places .......................................... 21 3.2.1 Controls on advertising, promotion and marketing of tobacco....................................................... 29 3.2.2 Mass media campaigns .................................................................................................................... 32 3.2.3 Increases in price/tax of tobacco products ...................................................................................... 33 3.2.4 Controls on access to tobacco products .......................................................................................... 37 3.2.5 School-based prevention ................................................................................................................. 43 3.2.6 Multiple policy interventions ........................................................................................................... 48 3.3 Impact of individual level cessation services and support on smoking inequalities in youth ............... 51 4 DISCUSSION ............................................................................................................................ 55 5 CONCLUSIONS ........................................................................................................................ 60 6 REFERENCES .......................................................................................................................... 61 7 APPENDICES ........................................................................................................................... 65 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 7.9 Appendix A Search strategies: electronic searches, handsearching and searching for grey literature . 65 Appendix B WHO European countries and other stage 4 countries ..................................................... 77 Appendix C Inclusion/exclusion form .................................................................................................. 78 Appendix D Included studies-Youth .................................................................................................... 80 Appendix E Excluded studies-Youth .................................................................................................... 83 Appendix F Data extraction - Youth .................................................................................................... 86 Appendix G Quality assessment ........................................................................................................ 152 Appendix H Summary of equity impact of youth polices/interventions ............................................ 154 Appendix I Equity impact model of youth policies/interventions by SES measure ............................ 161 3 EXECUTIVE SUMMARY Smoking is the single most important preventable cause of premature mortality in Europe and a major cause of inequalities in health. While there is good evidence on what types of tobacco control policies are effective in reducing smoking uptake in young people, little is known about what is effective in reducing inequalities in smoking in young people. The aim of this report was to undertake a systematic review of the effectiveness of policies and interventions in reducing socioeconomic inequalities in smoking among youth. The systematic review included primary studies involving young people (aged 1125), published between January 1995 and January 2013, which assessed the impact of smoking prevention policies and interventions, and smoking cessation support, by socioeconomic status. Any type of tobacco control intervention, of any length of follow-up, with any type of smoking-related outcome was included. A broad range of smoking related outcomes and socioeconomic variables was included. The equity impact(s) of each intervention/policy on smoking-related outcomes was assessed as either being positive (reduced inequality), neutral (no difference by socioeconomic status) or negative (increased inequality). Very few studies were found to have assessed the equity impact of the policy/intervention and all were from tobacco control. Thirty-three studies were included in the review, of which 31 were population level tobacco control policies/interventions and two were individual level cessation support interventions. The types of policies/intervention included were: smoking restrictions in cars, schools, workplaces and other public places (9); controls on the advertising, promotion and marketing of tobacco (3); mass media campaigns (1); increases in price/tax of tobacco products (6); controls on access to tobacco products (5); schoolbased prevention programmes (5); multiple policy interventions (3) and individual cessation support (2). (One study was included in two types of policies/intervention category). Assessing the overall equity impact of different types of interventions/policies was complicated by studies having different outcome measures and length of follow-up. However, overall there was no consistent equity effect for each type of tobacco 4 control policy/intervention. Most interventions had, on balance, either a negative (11) or neutral (15) equity impact. One had a mixed impact. Only six of the 31 population level prevention studies showed the potential to produce a positive equity impact. These included three US studies of increasing the price/tax of tobacco products, two US studies on age-of-sales laws and one UK study of a smoking prevention programme (ASSIST). The two smoking cessation studies both used text-messaging interventions. The New Zealand study had a short-term neutral equity impact and the US study had a short-term positive equity impact. Very few studies have assessed the equity impact of policies and interventions on smoking prevention or cessation in youth. There is therefore little available evidence to inform tobacco control policy and interventions that are aimed at reducing socioeconomic inequalities in youth smoking. There is a need to strengthen the evidence base for the equity impact of tobacco control interventions which target young people. 5 1 INTRODUCTION 1.1 Background Smoking prevalence rates differ substantially within European countries according to people’s educational level, occupational class and income level; and smoking is the largest single contributor to socioeconomic inequalities in mortality in Northern Europe. The patterning of smoking by socioeconomic status (SES) within a country reflects the stage of the tobacco epidemic in that country. In general smoking is initially taken up by higher SES groups, followed by lower SES groups. Higher SES groups are then the first to show declines in smoking, followed by lower SES groups.1 The tobacco epidemic is also gendered in that men first take up smoking, followed by women.2 Most countries in the European Union (EU) are characterised as being in the fourth (last) stage of the epidemic. In these countries lower SES groups have higher rates of smoking prevalence, higher levels of cigarette consumption and lower rates of quitting.3;4 Some EU countries are at a slightly earlier stage. This is reflected in the differential patterning of smoking by SES and gender, where the clear relationship between low SES and smoking found in men is only starting to emerge in women. SES is an important determinant of smoking uptake in young people. Parental smoking status, which is related to SES, is a predictor of smoking uptake in young people.5;6 However, the relationship between SES and smoking uptake is generally less clear than that for adult smoking, reflecting the difficulty of assessing SES among adolescents. Commonly used adult measures of SES such as educational attainment, occupation and income are not relevant for adolescents. However, some surveys have developed measures of youth SES, including the Health Behaviour in School-aged Children survey (HBSC). The HBSC, which is carried out in 39 countries, mostly in Europe, uses a measure of ‘family affluence’ (FAS) to assess participants’ SES. The 2005/6 survey found that, as with adult smoking, the relationship between youth smoking and SES varied between countries depending on their stage of the tobacco epidemic and gender.7 Low family affluence was significantly associated with weekly smoking among girls in nearly half the countries, but in only a few countries among boys. This pattern was strongest for girls in countries in stage four of the tobacco epidemic (North and Western Europe, Canada, USA). In Eastern and Southern Europe (mostly Stage 3 countries such as Ukraine, Estonia, Russia), family affluence was generally not associated with smoking. Fifteen year old girls from low affluent families in North Europe were also more likely to have started smoking earlier i.e. at age 13 or younger. 6 Since the 1990s, many European countries have implemented new and stronger tobacco control policies including smokefree legislation covering smoking in public places, bans on tobacco advertising and promotion, and tax increases. There is good evidence on what is effective in reducing adult smoking amongst the general population. A review of the international evidence by the World Bank in 20038 identified six cost-effective policies which they concluded should be prioritised in comprehensive tobacco control programmes: price increases through higher taxes on cigarettes and other tobacco products including measures to combat smuggling comprehensive smokefree public and work places better consumer information including mass media campaigns comprehensive bans on the advertising and promotion of all tobacco products, logos and brand names large, direct health warnings on cigarette packs and other tobacco products treatment to help dependent smokers stop, including increased access to medications These priorities have been endorsed by World Health Organisation (WHO)9 and form the basis of the Framework Convention on Tobacco Control (FCTC), the first international public health treaty.10 Reviews on smoking prevention in young people have endorsed the importance of these measures for preventing smoking uptake, though the evidence on effective youth cessation support is less strong than that for adults.5 The recent US Surgeon General’s report on Preventing Tobacco Use Among Youth and Young Adults6 stated that the evidence is sufficient to conclude that mass media campaigns, comprehensive community programmes, comprehensive statewide tobacco control programmes and increases in cigarette prices reduce smoking initiation and prevalence in youth (and taxes also reduce prevalence among young adults). They also concluded that certain types of school programmes can produce at least short-term effects in reducing youth smoking prevalence. What is much less certain is how ‘real world’ policies and interventions that reduce overall smoking prevalence within the general population impact on socioeconomic inequalities in smoking. Tackling these socioeconomic inequalities in smoking is central to reducing the health inequalities gap and is the fundamental underpinning aim of the “SILNE” project,11 “Tackling socioeconomic inequalities in smoking: learning from natural experiments by time trend analyses and cross-national comparisons”. SILNE is a three-year European project, coordinated by the University of Amsterdam, Department of Public Health, Academic Medical Centre, the Netherlands, with financial support from the European Commission Seventh 7 Framework Programme; ‘Developing methodologies to reduce inequities in the determinants of health’ programme (grant agreement no. 278273). The SILNE project involves twelve European partners who will deliver the seven work packages which make up the project. This systematic review is part of Work Package 6 of the SILNE project. There have been two previous reviews on the equity impact of tobacco control interventions.12;13 In 2008 the Centre for Reviews and Dissemination (CRD) at the University of York published a systematic review of the equity impact of tobacco control on young people and adults,12 focussing on population level interventionsa (not individual-level smoking cessation interventions) published up to January 2006. In 2010 the Department of Health’s Policy Research Programme, through the Public Health Research Consortium (PHRC), funded a study of tobacco control and inequalities in health in England.13 This study included a review of the evidence on the effectiveness of interventions to reduce adult smoking amongst socioeconomically deprived populations, which built on the CRD review and included evidence published from January 2006 until September 2010. It included both population-level interventions and individual-level cessation support interventions. The PHRC review concluded that there was limited evidence to inform tobacco control policy and interventions that are aimed at reducing socioeconomic inequalities in smoking behaviour. While considerable progress has been made in tobacco control in many countries in the EU in recent years, there is considerable variation in the strength and comprehensiveness of tobacco control policies and their implementation.14 However, while overall smoking prevalence is reducing; the social gradient is not. Addressing inequalities in smoking is a key public health priority, starting with improving our understanding of the equity impact of existing policies and interventions. 1.2 Aims and objectives The overarching aims of Work Package 6 are to undertake a systematic review of the effectiveness of policies and interventions to reduce socioeconomic inequalities in smoking among youth and adults, and to assess the implications of this evidence for understanding the effects of such policies and interventions in countries within the EU. Population level control interventions have been defined as ‘those applied to populations, groups, areas, jurisdictions or institutions with the aim of changing the social, physical, economic or legislative environments to make them less conducive to smoking.’ a 8 This report focuses on the findings of the systematic review of the effectiveness of policies and interventions to reduce socio-economic inequalities in smoking among youth. It has two objectives: 1. To identify and review the strengths and limitations of the published evidence on the effectiveness of policies (at the population level) to prevent and/or reduce smoking amongst socioeconomically deprived populations as compared to higher socioeconomic groups, and implications for European and other countries at stage 4 b of the tobacco epidemic. 2. To identify and review the strengths and limitations of the published evidence on the effectiveness of tobacco control interventions (at the individual level) to prevent and/or reduce smoking amongst socioeconomically deprived populations as compared to higher socioeconomic groups, and implications for European and other countries at stage 4 of the tobacco epidemic. b The 4 stages of the tobacco epidemic are described: Stage 1, characterised by low uptake of smoking and low cessation rates; Stage 2, characterised by increases in smoking rates among women and an increase to 50% or more among men; Stage 3, typified by a marked downturn in smoking prevalence among men, and a plateau and then gradual decline in women; and Stage 4, marked by further declines in smoking prevalence among men and women, with numbers of new smokers starting to decrease. Richmond, R. Addiction 2003;98 (5). 9 2 METHODS 2.1 Search strategy A comprehensive search strategy was developed to encompass studies published from January 1995 to May 2012. The search included published papers identified through searches of relevant electronic databases, and papers pending publication identified through handsearching of key journals, and contacting key tobacco control experts. A database of relevant references was produced using Reference Manager 12 software package. Details of the search strategies, including hand searching and searching for grey literature, can be found in Appendix A. The following databases were searched: BIOSIS CINAHL Plus Cochrane Library (Cochrane Database of Systematic Reviews; Database of Abstracts of Reviews of Effects; Cochrane Central Register of Controlled Trials; Health Technology Assessment Database) EMBASE ERIC Conference Proceedings Citation Index MEDLINE PsycINFO Science Citation Index Expanded Social Science Citation Index. This search was supplemented by handsearching of four key journals from January 2012 to the end of July 2012 to identify articles ‘in press’ published on the journals’ websites: Addiction Nicotine and Tobacco Research Social Science and Medicine Tobacco Control 10 Three key reviews were also searched for relevant primary studies: the York review,12 the PHRC review,13 and a report by the US Surgeon General on Preventing Tobacco Use Among Youth and Young Adults6 which was published during the production of this review. Bibliographies of included studies were also searched for further relevant studies. Members of SILNE and members of the ENSP were asked to identify any relevant studies not identified by the extensive searching of the electronic databases and the handsearching. Update search The electronic search strategy was rerun in the three databases which yielded the majority of the included studies from the initial search (EMBASE, MEDLINE and PsycINFO) to identify studies published between May 2012 and end of January 2013. In February 2013, the same four key journals were handsearched to identify articles published on the journals’ websites (but not yet listed in electronic databases) for publication in journal issues up to April 2013. See appendix A for details. 2.2 Study selection 2.2.1 Study selection process Articles retrieved from the searches were screened by title and abstract, to identify potentially relevant studies. An initial screen of the first 200 references imported into Reference Manager from MEDLINE were screened by title and abstract by two reviewers (AAc and TBd) to clarify inclusion and exclusion criteria and establish consistency. The remaining references were screened by title and abstract by one reviewer (TB) and checked by a second reviewer (AA). A second screen of full text articles was then carried out by one reviewer (TB) and checked by a second reviewer (AA). Any disagreements between reviewers were resolved by discussion at each stage and, if necessary, a third reviewer (SPe) was consulted. 2.2.2 Inclusion criteria All primary study designs based in a WHO European country or non-European country at stage 4 of the tobacco epidemic were eligible for inclusion (see Appendix B for list of included countries). The inclusion ages for the youth review were 11-25 years and, for the adult review, 18+ years. Smoking uptake continues until around the age of 25 years, which is why this cut-off c AA=Amanda Amos TB=Tamara Brown e SP=Stephen Platt d 11 was chosen for the youth review; it also enables comparisons to be made across studies set within different countries where age of leaving secondary education can vary considerably. However, many adult focused interventions target smokers aged 18 years and older. Thus 18 years and older was used to categorise adult interventions. In the rare cases where studies straddled both age categories they were included in both the youth and adult reviews. When the inclusion ages for the youth review were defined this was with a focus on studies relating to smoking initiation. This inclusion criterion was later modified for studies evaluating smokefree legislation in light of studies that included all ages of children. In order to assess the equity impact of tobacco control measures in the general population, we included both population-level policies and interventions, and individual-level interventions which aimed to reduce adult smoking or to prevent youth starting to smoke. Studies of population-level policies and interventions cover secondhand smoke (SHS) exposure by SES, the strength or reach of policy coverage by SES, and the impact by SES of the 'voluntary' adoption/spread/strength of smokefree policies, i.e., where countries do not have comprehensive legislation. In order to be included in the reviews an article must have assessed the equity impact of a tobacco control intervention or policy, and have presented results with a differentiation between high and low socioeconomic groups. In other words, the review only included studies which reported differential smoking-related outcomes for at least two socioeconomic groups. Any type of tobacco control intervention, of any length of follow-up, with any type of smoking-related outcome was included. A broad range of smoking related outcomes, either self-reported or observed/validated, was included: initiation and cessation rates, quit attempts, intentions to smoke/quit, prevalence, exposure to SHS, policy reach, social norms/attitudes, use of quitting services and sources of smoking (i.e. vending machines). Socioeconomic variables included income, education, and occupational social class, arealevel socio-economic deprivation (including neighbourhood and school-level SES), housing tenure, subjective social status and health insurance. Proxy measures for youth SES were also included, such as free school meals, parental educational, occupation and income. 12 A measure of SES had to be reported in the abstract of the electronic references in order to be included. Evidence identified through handsearching, searching of key reviews, or contacting experts, could be included if a measure of SES was reported in the main body of the text even if the abstract did not report that SES was assessed. If grey literature, such as reports not published as journal articles, was identified by experts as assessing equity impact then this evidence could be included even if the abstract did not report that SES was assessed. In addition, such reports that were written in non-English were included if an English synopsis was provided (and otherwise met the inclusion criteria). Only studies published since 1995 in full-text and in English language were included. No settings were excluded. See Appendix C for inclusion/exclusion form. The SILNE review excluded interventions targeted exclusively at one socioeconomic group and also excluded studies which reported socio-demographic data only (without any socioeconomic data). For example, ethnicity alone was not considered to be an appropriate indicator of SES for this review as the smoking patterns associated with ethnicity differ from one country to another. Interventions that focused solely on tobacco products other than cigarettes (e.g. cigars, smokeless tobacco, waterpipes) or tobacco replacement products were excluded, unless used as part of a smoking cessation programme. Interventions that focused solely on outcomes for providers of a smoking cessation intervention were excluded unless results were also reported for high versus low socioeconomic participant groups. Papers reporting study protocol and design only without reporting the impact of the intervention or policy were excluded. 2.2.3 Data extraction Data from the included studies were extracted by one reviewer (TB) and independently checked by another reviewer (AA). Data relating to population characteristics, study design and outcomes were extracted into data extraction forms. Data from studies presented in multiple publications were extracted and reported as a single study with all other relevant publications listed in the report. Data extraction from non-English reports (grey literature) was limited because it was derived from an English synopsis provided by an expert; therefore the synopsis is reported directly in the text (not in data extraction tables). 2.2.4 Quality assessment All included studies were assessed for methodological quality by one reviewer (TB) and independently checked by another reviewer (SP). The exception to this was non-English 13 language reports (grey literature); where any reference to quality was derived from an English synopsis and reported directly in the text. Methodological quality was assessed by adapting the method used in the York review.12 Each study was assessed on a scale of quality of execution using the six item checklist of quality of execution adapted from the criteria developed for the Effective Public Health Practice Project in Hamilton, Ontario.15 Certain items of quality are not applicable to all study designs, for example, randomisation and comparability are not applicable to cross-sectional study designs. We added a new criterion of ‘generalisability’ (external validity) and assessed whether the findings of each study were generalisable at a national, regional, or local level. 2.2.5 Data synthesis Given the variations in study methodologies, intervention types and outcome measures, the results are presented in the form of a narrative synthesis and according to intervention type (population level policies/interventions and individual level cessation support interventions). In order to provide a simple basis for comparing the methodology of each study a typology of study designs was devised (Table 1). Table 1 Typology of study designs Code Study design 1.0 Population-based observational 1.1 Cross-sectional 1.2 Repeat cross-sectional 1.3 Cohort longitudinal 1.4 Econometric analyses (cross-sectional data) 2.0 Intervention-based observational 2.1 Single intervention (before and after, same participants) 2.2 Single intervention with internal comparison 2.3 Comparison between different types of intervention 3.0 Intervention-based experimental 3.1 Randomised controlled trial (individual or cluster) 3.2 Non-randomised controlled trial 3.3 Quasi-experimental trial 4.0 Qualitative 4.1 Cross-sectional 4.2 Repeat cross-sectional 4.3 Longitudinal 14 The equity impact of each intervention/policy is summarised by adapting a model used in the York review16: The null hypothesis that for any given socio-economic characteristic related to education, occupation or income, there is no social gradient in the effectiveness of the intervention i.e. a neutral equity impact. The hypothesis of a positive equity impact defined as evidence that groups such as lower occupational groups, those with a lower level of educational attainment, the less affluent, those living in more deprived areas, are more responsive to the intervention. The hypothesis of a negative equity impact defined as evidence that groups such as higher occupational groups, those with a higher level of educational attainment, the more affluent, or those who live in more affluent areas are more responsive to the intervention. The main strengths and limitations of each study, particularly internal and external validity, are considered when discussing the equity impact of each intervention. Particular attention is given to the issue of generalisability: to what extent are results from interventions and policies carried out in various countries transferable across Europe despite differences in tobacco control policies, stage of the tobacco epidemic, socioeconomic conditions, and other factors? We draw conclusions about the strengths and weaknesses of the current evidence of the impact of tobacco control and other policy interventions on reducing socioeconomic inequalities in smoking in youths and adults (equity impact) and identify the most effective and promising interventions. 15 3 RESULTS 3.1 Introduction The initial electronic search produced 12,605 references after duplicates were removed. Two hundred and eighty-seven references were identified as potentially relevant to the reviews and 286 references were successfully obtained as full-text journal articles. Of these 286 fulltext articles, 171 were excluded. Sixteen of the remaining 115 studies focused on young people and were included in the youth review. In addition to these 16 studies, a further 10 studies (11 papers) were identified through handsearching, searching of key reviews and contacting experts. Three of these 10 studies17-19 were identified in one paper by Mercken et al20 which included secondary analyses of these three primary studies, and these four papers are classed as three studies. An update of the searches was carried out in January 2013 which included both electronic searching, handsearching and contact with experts, which identified a further seven relevant studies . In summary, a total of 33 studies were included in the youth review; of which 31 studies were population level polices/interventions and two studies were individual level cessation support interventions. Appendix D contains bibliographic details for all the included youth studies including details of source. The details of studies that were excluded at the stage of screening the full-text articles, for the initial electronic search (n=13) and for the updated electronic search (n=7) are listed in Appendix E with reasons for exclusion. The findings of these 33 included studies are presented by intervention type. A summary of studies by design and type of intervention are summarised in Table 2. Population-level interventions (which aimed to change social norms, smoking behaviour and/or access to tobacco) included: smoking restrictions in cars, schools, workplaces and other public places; controls on advertising, promotion and marketing of tobacco; anti-tobacco mass media campaigns; increases in price/tax of tobacco products; controls on access to tobacco products, school-based prevention programmes, and multiple policy interventions. Individual-level cessation support interventions included two interventions using mobile phone text messaging. Data extraction tables and quality assessment, grouped by intervention type, can be found in Appendices F and G, respectively. Textual and visual summaries of the data can be found in Appendices H and I, respectively. It should be noted that whilst the equity impact graph 16 (Appendix I) is meant to provide a visual representation of the equity impact of the various population-level policies/interventions; it should be interpreted in conjunction with the narrative descriptions of the results. 17 Figure 1 Study selection flow chart Electronic search May 2012 Titles and abstracts screened n = 12,605 excluded from title and abstract Full papers ordered n = 287 n = 12,318 screened n = 286 EXCLUDED (full text) n = 171 INCLUDED N = 115 (13 youth + 34 adult policy + 133 adult cessation)* update electronic search January 2013 titles and abstracts n = 1149 youth included n = 16 update full papers screened n = 42 update included n = 16 youth handsearching, reviews, experts update excluded n = 26 n = 11 (7 youth + 13 adult policy + 8)*** update youth n=2 update youth handsearch, experts n=5 total number youth studies n = 33** population-level studies n = 31 individual-level cessation studies n=2 *9 papers assessed in more than 1 review; **1 paper = secondary analyses of 3 papers, so 4 papers classed as 3 studies;***2 papers assessed in more than 1 review 18 Table 2 Summary of studies by design and intervention type* Design code Intervention type Smoking restrictions in cars, schools, workplaces, and other public places 1.2 Akhtar 2010 1.1 Galan 2012 1.2 MacKay 2010 1.2 Millett 2013 1.2 Moore 2011 1.2 Moore 2012 1.1 Nabi-Burza 2012 1.1 Noach 2012 2.1 Woodruff 2000 Controls on advertising, promotion and marketing of tobacco 1.1 Gilpin & Pierce 1997 3.1 Hammond 2011 1.1 Pucci 1998 Mass media campaigns 1.2 Vallone 2009 Increases in price/tax of tobacco products 1.1 Biener 1998 1.1 Gilpin & Pierce 1997 1.3 Glied 2002 1.4 Gruber 2000 1.4 Madden 2007 1.1 Perretti-Watel 2010 Controls on access to tobacco products 1.3 Kim 2006 1.1 Lipperman-Kreda 2012 1.2 Millett 2011 1.2 Schneider 2011 1.1 Widome 2012 School-based prevention programmes 3.1 Bacon 2001 3.1 Crone 2003** 3.1 De Vries 2006** 3.1 Campbell 2008** 3.3 Menrath 2012 Multiple policy interventions*** 1.2 Helakorpi 2008 1.3 Pabayo 2012 19 1.2 White 2008 Individual cessation support 3.1 Rodgers 2005 3.3 Ybarra 2013 * Studies can be categorised in more than one intervention type; **Study identified in Mercken 2012; ***Interventions that have several elements and/or papers that try to assess the relative impact of several policy interventions over a period of time 20 3.2 Impact of population-level policies and interventions on smoking inequalities in youth 3.2.1 Smoking restrictions in cars, schools, workplaces and other public places A total of nine studies assessed the socio-economic impact of smoking restrictions in public places; one intervention study21 five repeat cross-sectional studies22-26 and three single crosssectional studies.27-29 Three studies explored the impact of national comprehensive smokefree legislation on primary school children’s exposure to secondhand smoke (SHS), one of which was set in Scotland22 one in Wales25and one study pooled data from Scotland, Wales and Northern Ireland.26 Two studies examined whether smokefree legislation was associated with change in hospital admissions for childhood asthma in Scotland23 and England.24 One study examined smoking behaviour in cars with children present, amongst smoking parents in the US.27 A further two studies explored the impact of voluntary compliance with smoking restrictions on smoking behaviour in secondary school children, one of which was set in Spain29 and one in Israel.28 An intervention study assessed the impact of an organisational (workplace) smokefree ban in 19 year old female US Navy recruits, using a before and after experimental study design.30 Only the two school-based studies of comprehensive smokefree legislation22;25 scored the maximum according to study design. All the study samples except two27;28 were representative of the study population. All cross-sectional studies used credible data collection methods, and all repeat cross-sectional studies had a sufficient number of participants included in analysis in each wave. The US intervention study30 had partially validated data collection instruments and an acceptable level of attrition for post-intervention data but not at the 3-month follow-up. It is reasonably likely that the observed effects of smokefree legislation in Scotland, Wales and Northern Ireland; and the smokefree workplace ban30 were attributable to the interventions under investigation. The comprehensive smokefree legislation studies including two studies of hospital admissions for asthma are all generalisable on a national level (all UK based). The Spanish study29 results of voluntary compliance are likely to be generalisable at the regional level. The study population in the Israeli study28 of voluntary compliance, was heterogeneous; with a broad range of ethnic, religious and socioeconomic subpopulations and is not generalisable to other WHO European or stage 4 countries. It was unclear how generalisable the results 21 were from the study of smoking in cars amongst US parents.27 The workplace study population was specific to female young US Navy recruits only30. National smokefree policies Three studies from the changes in child exposure to environmental tobacco smoke (CHETS) study were included: CHETS Scotland,22 CHETS Wales25 and a CHETS UK study.26 Individual data from the Scottish22 and Welsh25 studies are described separately and are also included in the pooled analyses of UK data along with data from Northern Ireland.26 The Scottish, Welsh and Northern Irish studies applied repeat cross-sectional class-based surveys, in order to explore the impact of smokefree legislation on 11 year old children’s exposure to SHS; using biochemical measures (salivary cotinine levels). The smokefree legislation in Scotland22 was associated with a decline in cotinine levels across all socio-economic groups. The greatest absolute decline in cotinine levels was among the lowest self-reported family socioeconomic classification (SEC) and family affluence scale (FAS) groups, even after adjusting for parental smokers (e.g. 0.10ng/ml in SEC1 vs 0.28ng/ml in SEC4). However, a linear regression model suggests that relative inequality between socio-economic groups had widened; the decline in SHS exposure among children from lower SES households was greater in absolute terms but smaller in relative terms, compared with changes in SHS exposure among children from higher SES households. Cotinine levels remained the highest in children from the lowest SEC/FAS groups. The likelihood of providing a sample containing an undetectable level of cotinine increased significantly after smokefree legislation in Wales25 among children from high SES households [relative risk ratio (RRR) = 1.44, 95% CI = 1.04–2.00, p=0.03] and medium SES households (RRR = 1.66, 95% CI = 1.20–2.30, p<0.01), while exposure among children from lower SES households remained unchanged (RRR=0.93, 95% CI=0.62-1.40, p=0.72). Parental smoking in the home, car-based SHS exposure, and perceived smoking prevalence were highest among children from low SES households. Parental smoking in the home and children’s estimates of adult smoking prevalence declined only among children from higher SES households. Children’s estimates of people smoking in the streets outside buildings declined greatest and approached statistical significance amongst children from high-SES households only.25 In summary, in Wales25 post-legislation reductions in SHS exposure were limited to children from higher SES households whose exposure was already significantly lower prior to 22 smokefree legislation. Children from lower SES households continued to have high levels of exposure (though these had not increased), particularly in homes and cars, and to perceive that smoking is the norm among adults. Therefore the smokefree legislation was potentially associated with increased socioeconomic disparity in terms of SHS exposure amongst children. Average cotinine concentrations among children in the Scottish study were substantially higher than in the Welsh study, and children’s SHS exposure outside of the home was perhaps greater in Scotland, with impacts of the smokefree legislation therefore greater overall in Scotland than in Wales, and distributed among all socio-economic groups. One UK study26 pooled data from the Scottish, Welsh and Northern Irish CHETS studies. The pooled data were used to examine socioeconomic patterning (using the FAS) in children’s SHS exposure, and parental restrictions on smoking in private spaces (cars, home). Participants were non-smokers (self-reported non-smokers providing saliva samples containing <15ng/ml cotinine) in their final year at 304 primary schools in Scotland (n = 111), Wales (n = 71) and Northern Ireland (n = 122). Multinomial regressions were used to assess change in SHS exposure as measured by cotinine levels; and change in home-smoking restrictions. Binary logistic regression models examined car-based smoking. The pooled data was adjusted for country and age, and clustering was accounted for. The data set comprised 10, 867 children (5347 baseline/5520 follow-up), average age was 11.2 years. SES varied significantly between survey years, with affluence being higher at follow-up survey. Percentages of children with undetectable concentrations of cotinine increased from 31.0% (n = 1715) to 41.0% (n = 2251) following legislation overall, and from 20.1% to 34.2%, 44.9% to 51.0% and 38.6% to 42.9% in Scotland, Wales and Northern Ireland, respectively. 26 Regression analysis indicated that the relative risk of children’s samples containing no detectable cotinine increased significantly following legislation. However this was accounted for by decreases in samples containing low levels of cotinine rather than decreases in samples containing higher levels of cotinine; and this was the case in all three countries and after adjusting for parental smoking and smoking restriction levels in homes and cars. 26 Children of high SES were significantly more likely to have no detectable cotinine and significantly less likely to have high levels of cotinine following the smokefree legislation compared to lower SES children, and this remained significant following adjustment for country, parental smoking and private smoking restrictions. The study26 author’s report that the gap between low and high SES children appears to have widened following the 23 legislation, in terms of children with no detectable cotinine levels. A trend towards widening inequality was also seen within each individual country for no detectable cotinine levels. Gradients for higher cotinine levels remain unchanged. Two studies evaluated the impact of national smokefree legislation on emergency hospital admissions for asthma in children aged less than fifteen years: one set in Scotland23 and one set in England.24 Both study samples were representative of the general population and generalisable on a national scale. Both studies used SES quintiles based on the Index for Multiple Deprivation and both studies applied binomial regression models to assess hospital admissions. The English study24 also produced admission rate ratios, which is the ratio of the actual admission rate in relation to the rate projected by the underlying trend. A Scottish study23 assessed the impact of national smokefree legislation on hospital admissions for childhood asthma by linking data from the Scottish Morbidity Record and death-certificate data to identify all hospital admissions and deaths before arrival at the hospital that occurred from January 2000 through October 2009. Before the legislation was implemented, admissions for asthma were increasing at a mean rate of 5.2% per year (95% confidence interval [CI], 3.9 to 6.6). After implementation of the legislation, there was a reduction of 18.2% (95% CI, 14.7 to 21.8; P<0.001) in the annual rate of asthma admissions, resulting in a net reduction in asthma admissions of 13.0% per year (95% CI, 10.4 to 15.6). The study accounted for asthma deaths and showed that the decrease in admissions was not due to an increase in the incidence of deaths before arrival at the hospital. There were no significant interactions between hospital admissions for asthma and quintile of SES. All SES subgroups were associated with significant reduction in admissions. An English study24 assessed the impact of national smokefree legislation on hospital admissions for childhood asthma, using Hospital Episode Statistics over 8.5 years (April 2002 to November 2010). Before the implementation of the legislation, there was a mean increase in the admission rate for asthma of 2.2% per year (adjusted rate ratio 1.02; 95% CI: 1.02–1.03). After implementation of the legislation, there was a significant immediate reduction in the admission rate of 8.9% (adjusted rate ratio 0.91; 95% CI: 0.89–0.93) and a reduction in time trend of 3.4% per year (adjusted rate ratio 0.97; 95% CI: 0.96–0.98). Overall, the legislation was associated with a net 12.3% reduction of hospital admissions for childhood asthma in the first year. This change was equivalent to 6802 fewer hospital admissions in the first 3 years after implementation. The results were very similar when 24 based on admissions data alone, as there were few recorded deaths prior to admission. Reductions in asthma admissions did not differ by SES. Both studies23;24 were sufficiently similar to enable comparison and show that both the English and Scottish smokefree legislation were associated with significant reductions in admissions for asthma across all SES subgroups i.e. a neutral equity impact. The relative rate of admissions before the legislation was higher in Scotland compared to England, and relative reductions in hospital admissions after the legislation were higher in Scotland compared with England, however the net overall reduction in hospital admissions was similar in both studies (12-13%). Neither study determined the extent to which the observed reduction in asthma was due to reduced exposure to SHS by setting (public places, home, car) or reduction in smoking among children. The impact on results of changes in the treatment of asthma and diagnostic coding of asthma cannot be ruled out. However both studies assessed asthma which required hospitalisation (i.e. severe asthma). Smokefree car policies Pooled data from the CHETS26 study showed that in the UK as a whole and also within England, Northern Ireland and Wales, as SES increased, the likelihood of partial or no home smoking restrictions (rather than full smoking restrictions) decreased significantly, whilst the odds of smoking being allowed inside the family car also decreased significantly. These trends remained after adjustment for parental smoking and there was no change in inequality following legislation i.e. a neutral equity impact. A US study27 determined the prevalence of parents smoking in their cars with children present and how often paediatric health care providers advised parents to have smoke-free cars. The study used baseline data from 10 control sites (in 8 US states) from a cluster RCT ‘Clinical Efforts Against Secondhand Smoke Exposure’ which was an intervention to address parental tobacco use within the paediatric clinic setting. The study sample were parents or legal guardians who accompanied a child to the visit; were at least 18 years old; spoke English; had smoked at least a puff of a cigarette in the past 7 days and completed a baseline enrolment survey for which they received $5 cash. 25 Parents who smoked were asked about smoking behaviours in their car and receipt of smokefree car advice at the visit. Parents were considered to have a “strictly enforced smoke-free car policy” if they reported having a smoke-free car policy and nobody had smoked in their car within the past 3 months. The measure of SES used was level of education (high school or less versus some college or college graduates). Analyses were limited to parents who smoked and who reported having a car that they owned or travelled in frequently, it was unclear how representative this study sample was of the SES of the general population. Twenty-nine percent of 795 parents reported a smokefree car policy and 48% reported that smoking occurred with children present in the car. Fourteen percent of smoking parents reported being asked if they had a smoke-free car, and 12% reported being advised to have a smoke-free car policy by a paediatric health care provider. Of those who smoked with children present in the car, only 5% were counselled about having a smoke-free car. No significant association was found between parents education level and having a strictly enforced smokefree car policy. However, parents of children aged less than one year were more likely to have strict smoke-free car policies if they were college educated (OR:2.42; 95% CI: 1.21 to 4.83, p = 0.013). Strict smoke-free car policies were more common when parents were both light smokers (smoked 10 cigarettes or less per day) and college educated (OR: 2.88; 95% CI: 1.24 to 6.66, p = 0.013). Voluntary compliance with smoking restrictions in schools Two cross-sectional studies explored the impact of voluntary compliance with smoking restrictions on smoking behaviour in secondary school children, one of which was set in Spain29 and one in Israel.28 The smoking outcomes were not biochemically validated and were based on self-report. In Madrid smoking has been banned in schools since August 2002 however at the time of this survey29 among smokers aged 15 to 16 years, 50.6% had smoked on school premises during the last thirty days with significant variability (0% to 100%) between schools. A lower probability of smoking on school premises was found among adolescents whose fathers had a university education (OR 0.43; 95% CI: 0.19 to 0.96) or among those who did not know the level of studies of their father (OR 0.39; 95% CI: 0.16 to 0.94) compared with those with fathers who had a very low level of educational attainment. A lower probability of smoking on school premises was found for state subsidized private schools (OR 0.20; 95% 26 CI: 0.11 to 0.35) and non-subsidized private schools (OR 0.30; 95% CI: 0.14 to 0.62) when compared with that for public schools. Employment status of either parent, educational level of the mother, SES of the school census tract, written reference to a smoking control policy and educational activities about smoking prevention were not significantly associated with smoking on school premises among student smokers. In Israel28 there was no comprehensive smokefree ban at the time of the survey and most Israeli adolescents (average age 15 years) were exposed to SHS (total: 85.6%; home: 40%; school: 31.4%; entertainment: 73.3%; other: 16.3%). Parental education was not a significant determinant of smoking in school but correlates of exposure at school differed from those at home. Adolescents whose fathers had less than 12 years of education were more exposed to SHS at home, than were teenagers whose fathers had a degree from a university or college (OR = 1.48; CI: 1.09 to 1.99, p = 0.0111). Adolescents with less-educated mothers were more exposed to SHS at home than teenagers with mothers with degrees from a university or college (OR = 1.39; CI: 1.02 to 1.90, p = 0.0366). The high levels of SHS exposure among Israeli adolescents were characterized by different patterns of exposure among different population subgroups. Israel is a heterogeneous country; with a broad range of ethnic, religious and socioeconomic populations and the results are not generalisable to other WHO European or stage 4 countries. Workplace smokefree policies One intervention study assessed the impact of an organisational (workplace) smokefree ban (24-hours, 8-weeks) in 19 year old female US Navy recruits, using a before and after experimental study design.30 Among the 4393 recruits who provided entry (before) and graduation (after) survey data, 41.4% (n = 1819) reported any smoking in the 30 days before entering compared with 25% that reported being a smoker at graduation (after), which was a significant reduction. Slightly over two-thirds (n = 724) of “smokers” who responded to the follow-up survey had resumed smoking three months after graduation, and 32% (n = 340) reported not smoking. Among past month smokers at entry (before), the relapse rate at the three month follow-up after graduation was 81%. Daily smokers at entry (before) had the highest relapse rate (89%) at the three month follow-up after graduation. The study did not aim to assess differential impact by SES but reported that education did not significantly predict smoking relapse. It was not reported whether there was a difference by SES in change over time. 27 A response bias is present in this study; there was a low response rate (39%) at the 3-month follow-up, and non-respondents had a slightly higher past 30 day smoking rate at baseline than did respondents. In addition, the definition of ‘smoker’ differed at graduation (post 8 weeks) from baseline and 3-month follow-up. The group of smokers assessed for relapse was broadly defined and included daily smokers, occasional smokers, experimenters, or former smokers. As well as these quality-related issues, the study only included female recruits and results may not be generalisable to a civilian population or setting. Summary The evidence relating to smokefree restrictions is limited to eight cross-sectional studies and an intervention study of a workplace 24-hour 8-week smoking ban. National comprehensive smokefree restrictions are associated with declines in SHS exposure in primary school children but the equity effect may vary according to how exposure is measured (absolute levels or relative levels), on the pre-ban level of exposure and the balance between sources of exposure i.e. public places versus home. Prior to the CHETS studies, scant attention has been paid to whether adoption of private smoking restrictions following smokefree legislation has been patterned by SES. Pooled data from Scotland, Wales and Northern Ireland following national smokefree legislation showed that declines in exposure occurred predominantly among children with low exposure before legislation, and from more affluent families, leading to increased socioeconomic disparity (negative equity impact). Substantial socioeconomic gradients in proportions of children with higher SHS exposure levels remained unchanged. Children from lower SES households continued to perceive that smoking is the norm among adults whereas smoking as a perceived norm declined amongst high-SES children. Pooled data from Scotland, Wales and Northern Ireland following national smokefree legislation showed that there was no change in inequality following legislation. As SES increased, the likelihood of partial or no home smoking restrictions (rather than full smoking restrictions) decreased significantly, whilst the odds of smoking being allowed inside the family car also decreased significantly. Only one US study was included, of parental smoking behaviour in cars it was found that parent’s education level interacted with a child’s age and the number of cigarettes smoked per day, both of which were significant predictors of car smoking policy. Parents with higher SES that were light smokers were more likely to 28 have a strict no smoking car policy and higher SES parents with children less than one year were also more likely to have a smokefree car policy. English and Scottish national smokefree legislation was associated with a significant reduction in childhood asthma admissions which did not differ by SES (neutral equity impact). When reviewing whether students comply with smoking restrictions in secondary schools where there is no enforced and comprehensive smokefree ban, it is apparent that parental education may influence smoking behaviour of adolescents and smoking behaviour amongst adolescents is also influenced by the setting (home/school). Two school-based studies in two very different countries showed conflicting results. A study in Israel where there was no comprehensive smokefree ban showed high levels of SHS exposure among Israeli adolescents which were characterized by different patterns of exposure among different religious groups; however parental education was not a significant determinant of smoking in schools. Second-hand smoke exposure from outside the home and school settings was sizeable and overall SHS exposure and SHS exposure at home was greater among lower SES adolescents. In a study in Spain where there were school smoking bans but variable enforcement; adolescents whose fathers had a lower level of educational attainment were more likely to smoke on school premises. A 24-hour 8-week workplace ban in the US Navy did reduce the proportion of women smoking immediately post-ban but most had relapsed by 3-month follow-up. Education did not significantly predict smoking relapse however the response rate to the follow-up was low and non-respondents were more likely to be smoking. 3.2.1 Controls on advertising, promotion and marketing of tobacco Three very different US studies assessed the equity impact of controls on the advertising, promotion and marketing of tobacco products including; a retrospective survey31 of the impact on smoking initiation of cigarette prices and tobacco industry marketing budgets conducted in the US in 1993 of nearly 141,00 respondents aged 17 to 38 years that would have been aged between 14 and 21 years old between 1979 and 1989, an RCT32 of a short online survey of brand appeal of cigarette packaging, and an observational field study of advertising density with school ‘buffer zones’.33 The RCT consisted of a convenience internet sample and it was not clear if it was representative of the study population. In addition there were some significant differences among the women at baseline between 29 treatment groups which may have affected the results: education varied by condition, with the highest level of education in the standard pack condition, and number of cigarettes smoked per day was significantly higher in the plain pack condition compared with the standard pack condition among current smokers. All three studies used credible data collection methods. It is reasonably likely that the observed effects of cigarette packaging were attributable to the intervention under investigation and that these results are likely to be generalisable at a national level. The observational field study of advertising density with school buffer zones may only be generalisable at the local level as the study population were limited to neighbourhoods in Boston, Massachusetts, US and no details of the 6 Boston neighbourhoods were provided. One retrospective survey31 conducted in the US in 1993 of nearly 141,00 respondents aged 17 to 38 years that would have been aged between 14 and 21 years old between 1979 and 1989 examined trends in smoking initiation by cigarette prices and tobacco industry marketing budget. Adolescent initiation rates decreased from 1979 to 1984 but increased thereafter. Initiation rates were highest among high school dropouts and lowest amongst those who eventually attended college. In 1988 the initiation rate was 9.9% for those who did not graduate from high school, 6.9% for high-school graduates reporting no college and 3.7% for those reporting at least some college education. The equity results from the study can only be tentative because the study does not directly assess the effect of changes in the tobacco marketing budget or cigarette prices on smoking initiation rates by education level. The study simply highlights that cigarette prices and tobacco marketing budget increased during this decade as did smoking initiation rates amongst adolescents, and that marketing expenditure may be associated with an increase in smoking initiation especially in young people with lower levels of education. A recent RCT of a short online survey intervention32 examined brand appeal of cigarette packaging amongst women aged 18 to 19 years in the US. The convenience sample was randomised to four experimental conditions which viewed eight cigarette packages one at a time displayed in random order and according to the four experimental conditions: (1) female-oriented packages (standard condition); (2) female-oriented packages with brand imagery, including colours and graphics, but with descriptors (e.g. slims) removed; (3) female-oriented packages without brand imagery and descriptors (i.e., plain packages); and (4) popular U.S. brands of “ regular ” or non – female- oriented packages. 30 Women in the high income and high education categories endorsed a greater number of positive smoker traits (female/male, glamorous/not glamorous, cool/not cool, popular/not popular, attractive/unattractive, slim/overweight, and sophisticated/not sophisticated) than those in the low income and low education categories. High income respondents were more likely to endorse smoking and weight control beliefs compared with respondents reporting low (OR = 1.70, 95% CI = 1.12 – 2.60) and medium income (OR = 1.73, 95% CI = 1.09 – 2.73) and those who did not state their income (OR = 2.17, 95% CI = 1.29 – 3.65). The reactions to and perceptions of the different types of packs was the same by SES for nearly all the measures. No significant differences in pack selection were observed for smoking status, age, income, education, ethnicity, or weight concerns. An observation field study33 assessed youth exposure to stationary outdoor tobacco advertising density within FDA 1,000 foot buffer zones around schools in 6 Boston neighbourhoods in the US. The overall advertising density for schools in all neighbourhoods combined was higher for middle (10.1) and high schools (9.9) than for elementary schools (6.3). The majority of outdoor tobacco advertising was in the neighbourhoods with the lowest median household incomes. The study probably underestimated advertising density because it does not include point-of-purchase advertising, advertising inside stores that is seen from the street, or advertising on taxis and buses. Summary Three very different US-based studies assessed the equity impact of controls on the advertising, promotion and marketing of tobacco products. One study showed that initiation rates of smoking amongst adolescents varied by level of education; initiation rates were highest amongst high-school dropouts and lowest amongst those who eventually attended college. Marketing expenditure may be associated with an increase in smoking initiation especially in young people with lower levels of education. Very tentatively, controlling the promotion of cigarettes through plain packaging might have a positive effect on all young women and have a neutral equity effect for young women because reactions to/perceptions of different types of packs were the same regardless of SES for nearly all the measures. 31 Despite the FDA buffer zone policy, one study showed that tobacco advertising is targeted at adolescents of low SES inside school buffer zones, particularly middle and high school adolescents, and this has the potential to increase inequality in smoking behaviour amongst youth. Banning all outdoor tobacco advertising would reduce exposure particularly in children of lower SES. 3.2.2 Mass media campaigns One telephone survey34 evaluated the impact of the US truth® campaign on awareness and receptivity among youth aged 12 to 17 years. The truth® campaign is a branded counter tobacco marketing campaign designed to prevent smoking among at-risk youth, primarily through edgy television advertisements with an anti-tobacco industry theme. Seven waves of Legacy Media Tracking Survey data were collected from September 2000 through to January 2004. It was unclear how representative the study sample was of the study population because response rates declined over the seven waves of data collection, from 60% to 30%. Youth who lived in zip codes in which the median household income was less than or equal to US$ 35,000 had a lower level of confirmed awareness of the campaign than respondents in each of the other income categories (p< 0.05). There were no statistically significant differences in confirmed awareness by median level of education, though there was a pattern in which the proportion of confirmed awareness increased with education. There were no differences in receptivity by median household income or median household education, though there was a pattern of increasing receptivity with greater income and education. During the campaign there was a gradual shift towards cable TV ownership and education is positively associated with cable TV ownership. However the authors report that SES differences were concentrated in the early years of the campaign when it was aired mainly through network TV. The study controlled for year of survey administration and the effect of the intervention over the seven waves of survey data. It is not reported whether the effect of the intervention differed by SES over time. Summary This one study of a relatively large, lengthy and well-funded anti-tobacco mass media campaign, using repeat cross-sectional data over four years, showed that youth who lived in zip codes in which the median household income was less than or equal to US$ 35,000 had a lower level of confirmed awareness than respondents in each of the other income categories. 32 Zip code level median household education was not associated with confirmed awareness and there were no differences in receptivity by zip code level income or education. The equity impact of the mass media campaign is unclear as the effect on campaign awareness varied according to the SES variable that was measured (income/education) and the equity impact in terms of receptivity appeared neutral. 3.2.3 Increases in price/tax of tobacco products Six studies evaluated the equity impact of increases in the price or tax of cigarettes, the majority of which were US-based studies using retrospective survey data. Two studies35;36 were econometric studies (report price elasticities), one of which used both longitudinal and cross-sectional data.35 One study used retrospective cohort data37 and the remaining three studies were single cross-sectional studies.31;38;39 Four of the study samples were representative of the study populations and for two studies it was unclear if the samples were representative.35;37 For three studies it was unclear if credible methods of data collection had been used, due to lack of reported information in one case38 and unpublished data in the other two studies.37;39 Two studies38;39 were likely to be generalisable at the regional level and two studies31;35;36 at a national level. A retrospective survey38 examined smokers aged 12 to 17 years perceptions of the impact of statewide tobacco taxes in Massachusetts, USA. Teenage smokers from low income households were much more likely than more affluent teenagers to report cutting the costs of their smoking (by cutting down the amount smoked or, less often, by switching to cheaper brands) in response to the price increase, rather than do nothing (OR 7.57; 95%CI: 1.55 to 36.98) or cutting costs rather than consider quitting (OR 14.72; 95%CI: 2.55 to 84.95). Household income was unrelated to the choice between considering quitting and doing nothing (OR 0.51; 95% CI: 0.13 to 2.77). Young low income smokers were not more likely than wealthier teenagers to consider quitting. There appeared to be a positive equity impact on smoking less and a neutral equity impact on quitting behaviour of statewide tobacco tax increases. It should be noted that 53% of the teenagers who continued to smoke denied having had any of the 3 potential reactions to price increase and so it is possible that the study failed to measure an important variable. 33 One US retrospective survey31 examined trends in smoking initiation by cigarette prices and tobacco industry marketing budget; results are reported in section 3.2.1. Initiation rates were highest among high school dropouts and lowest amongst those who eventually attended college. The study highlights that cigarette prices and tobacco marketing budget increased during this decade as did smoking initiation rates amongst adolescents, and that price increases did not reduce smoking initiation. One US econometric study35 tested the assumption that policies targeting youth to reduce smoking initiation will reduce lifetime smoking propensities. Estimates of the effect of current taxes (taxes in the year of interview) on current adult smoking measured in 1984 (aged 19 to 28), 1992 (aged 27 to 35), and 1994 (aged 29 to 37) revealed that the age coefficients were positive (measured in 1979) showing that there was a positive secular trend in youth smoking. Youth from higher income families were less likely to smoke, whereas the results were inconsistent for level of education between different types of analyses (probit marginal effects and linear regression fixed effects). Participation elasticities for the three tax current tax variables (1984, 1992, and 1994) using probit marginal effects or linear regression fixed effects were −0.1 and−0.09, respectively. The study estimated the effect of cigarette taxes at age 14 years (in 1979) on future overall smoking behaviour, quitting and initiation using prospective longitudinal cohort data with cross-sectional analyses. Cigarette tax at age 14 had the most effect on low income people at ages 19-28 for current smoking but not late initiation or quitting according to longitudinal data. The effect of cigarette tax at age 14 on subsequent smoking (at follow-up in 1992 and 1994) was not significant. Elasticities declined over time for low income people indicating that by age 39 the effect of taxes at age 14 had largely disappeared. Low income (< $12,000 median in 1979) elasticity was -0.65, p<0.10 (at age 14), -0.33 (at age 24), -0.01 (at age 34), and 0.15 (at age 39). Cigarette tax increases at age 14 reduced smoking and had a positive equity effect on young people in their 20’s. It should be noted that in some models (i.e. effect of cigarette tax at age 14 on current smoking), results presented for the low income subgroup include a control for ‘current’ tax (taxes in the year of interview), whereas other models (i.e. effect of cigarette tax at age 14 on late initiation, quitting) did not control for current tax in low-income subgroup. It is difficult to see how an effect of tax at age 14 could be determined if there is no adjustment for tax at other subsequent time points. 34 A US econometric analysis36 using repeated cross-sectional data, evaluated the impact of prices, clean air regulations and youth access restrictions on youth (13 to 18 years) smoking in the 1990’s. Price was the only significant determinant of smoking. Price was the most important determinant of smoking by 16-18 year olds but not for younger teenagers. Sensitivity to price suggested cross-elasticity between price and income: for 16 to 18 year olds: sensitivity to prices increased for teenagers with less educated parents, however sensitivity to smoking intensity increased for those with more educated parents. For 16 to 18 year olds, the elasticity of participation was -4.39 (p<0.05) for those whose parents were high school dropouts or graduates and -0.24 for parents with some college education. For smoking intensity this trend was reversed with elasticities of -0.40 for high school and -2.39 (p<0.05) for college education. There was no pattern for younger teenagers (<16 years), although participation elasticity was positive and statistically significant for high school educated parents (2.72, p<0.05). A survey39 conducted between 2005 and 2006 on a random sample of 2455 university students in South-Eastern France, investigated young smokers’ (mean age 19.5 years) retrospective reactions to an increase in cigarette prices. Daily smokers with low educated parents were less likely to report reacting to the price increase, daily smokers who had at least one parent that completed high school were more prone to report reacting to higher cigarette price (OR 2.5; 95% CI: 1.6 to 4.0 for cheaper smoking versus no reaction; and OR 2.1; 95% CI: 1.4 to 3.3 for smoking less versus no reaction; in multivariate analysis, p < 0.001 and p< 0.01, respectively). Students who reported difficulties in financing their studies were significantly more likely to purchase cheaper cigarettes (OR 1.9; 95% CI: 1.0 to 3.7; p< 0.1). It should be noted that overall, 32% said that they did not react to price increase, the survey was regional rather than national and the reactions to price increase are only relevant to daily smokers who did not quit, all of which may which may limit study generalisability. We can’t tell whether these reactions to a price increase impacted on quitting but there appeared to be a negative equity impact on smoking less. An Irish study37 used retrospective cohort data to investigate the role of tobacco taxes from 1960 to 1998, in starting and quitting smoking and how this differed by level of education. The data was derived from a single cross-sectional survey on women’s knowledge, understanding and awareness of lifetime health needs, but mainly focussed on hormone replacement therapy as part of an unpublished MA thesis at the University College Dublin. The sample consisted of just over 700 women, mean age was 35 years and mean age started 35 smoking was 19 years. The SES measure used was education level (‘primary cert’/’junior cert’/’leaving cert’/’third level’). Higher cigarette tax levels were associated with later initiation of smoking which differed by education level. Taxes had the greatest positive effect in terms of delaying smoking initiation for women with intermediate level education and weakest effect among women with the lowest education. The results were tentative because of the potential for recall bias (going back 40 years in some cases) and the results are specific to a sample of Irish women aged 48 years or younger. The measure of education level used in this study may not be generalisable across time and to other countries. The SES subgroups were relatively small, and during the study period cigarette tax was relatively low and there was increasing awareness of the harms of smoking. Therefore study findings cannot be directly attributed to the effects of increasing cigarette tax. It should be noted that whilst data has been extracted for this review on smoking initiation (because this is the outcome of relevance for youth), the study also reported smoking cessation and showed inconsistent equity impact results for how tax effect differed by education level, depending on the outcome measure (initiation and cessation). Cigarette taxes had the greatest positive effect in terms of delaying smoking initiation for women with intermediate level education and the weakest effect among women with the lowest education. However cigarette taxes had the strongest effect on cessation among women with the lowest education, and an equal impact on those with other levels of education. Summary The majority of evidence is from the US, and suggests there is variation in the evidence of the equity impact of increases in cigarette tax or price on youth smoking behaviour and variation in smoking behaviour amongst youth of different ages and different SES groups. Two retrospective surveys showed contrasting results; one survey showed that low income teenagers were more likely than more affluent teens to cut costs by cutting down smoking or (less often) by switching to cheaper brands but were not more likely than more affluent teenagers to consider quitting. However, only 53% of the teenagers who continued to smoke denied having had any of the 3 potential reactions to the price increase. A regional survey of French university student smokers showed that students with a lower SES were less likely to 36 have reacted to the cigarette price increase which included smoking less, however 32% of students reported that they did not react to the price increase. An Irish study showed that cigarette taxes were associated with later smoking initiation in women with intermediate education but not for women with only a primary education.37 Two econometric studies showed contrasting results; one study showed that cigarette tax at age 14 had a statistically significant negative effect on current smoking for low income people but by age 39 years, the effect of taxes at age 14 had largely disappeared. In the other study, the equity impact varied according to the age of the teenagers and there was no pattern for younger teenagers. For older teenagers: sensitivity to prices increased for teenagers with less educated parents, and sensitivity to smoking intensity increased for those teenagers with more educated parents. It does not appear that low income youth are consistently more responsive to tax/price increases than high income youth groups: youth of lower SES are not more likely to stop smoking when cigarette prices/taxes increase. 3.2.4 Controls on access to tobacco products A total of five studies assessed the socio-economic impact of controls on access to tobacco products. Three studies assessed the impact of legislation on age of sale of cigarettes. Two single cross-sectional studies40;41 examined the impact of age-of-sale laws in the US on retailer compliance and whether the impact differed by SES. One repeat cross-sectional study examined the impact of UK legislation which increased the minimum age for the legal purchase of cigarettes, and was set in secondary schools in England.42 A German study used observational field data of new electronic locking devices on cigarette vending machines to prevent underage purchasing of cigarettes in Cologne43. A prospective cohort study based in the US, examined whether young, especially low SES females, are influenced by tobacco control policies in terms of smoking initiation and transition.44 An English study examined whether there was any differential impact of UK legislation which increased the minimum age for the legal purchase of cigarettes from 16 years to 18 years and which came into force in October 2007.42 The SES variable employed was eligibility for free school meals (FSM) which is assessed on the basis of parental employment status and income levels. Annual survey data was collected before and after the 37 legislation; from 2003 to 2008. There were baseline differences in age, gender and ethnicity but these differences were controlled for in analyses. Increasing the minimum age for purchase was associated with a significant reduction in regular smoking among youth aged between 11 and 15 years (adjusted OR 0.67; 95% CI 0.55 to 0.81, p=0.0005). This effect was not significantly different in pupils eligible for FSM compared with those who were not eligible (adjusted OR 1.29; 95% CI 0.95 to 1.76, p=0.10 for interaction term). Regular smoking was not significantly different in pupils eligible for FSM compared with those that were not (adjusted OR 1.29; 95% CI 0.95 to 1.76, p=0.10). The percentage of regular smokers who usually bought cigarettes from a vending machine decreased significantly in the non-FSM but not in the FSM group. The percentage of regular smokers who usually bought cigarettes from friends and relatives or from other people increased significantly in the non-FSM but not the FSM group after the introduction of age restriction. Regular smokers eligible for FSM were significantly more likely to be given cigarettes by their parents in 2006 (p<0.001) but this was no longer the case in 2008 (p=0.42). The percentage of pupils who stated that they found it difficult to buy cigarettes from a shop did not increase in those eligible for FSM (25.2% to 33.3%; p=0.21) but did increase significantly in others (21.2% to 36.9%; p<0.01) between 2006 and 2008. The percentage of regular smokers who were successful in buying cigarettes from a shop during their latest attempt decreased significantly in the non-FSM but not the FSM group between 2006 and 2008. No differences in ease of purchase were found between pupils eligible for FSM and those not before or after the legislation (2006: p=0.34, 2008: p=0.55). It should be noted that although the response rate for schools was only 58% in 2008, the sampling frame ensured that schools participating in the survey closely reflect the composition of schools in England generally. However, the national smokefree legislation and alcohol restrictions were also introduced during this time which may confound these results. The German Sources of Tobacco for Pupils (STOP) study43 compared the number of vending machines and other commercial sources before and after new legislation which involved electronic locking devices on vending machines to prevent underage (<16 years) purchasing of cigarettes in Germany. Three geocoders made an inventory of commercial cigarette sources in 2005, 2007 and 2009 and mapped using Geographic Information System to produce a density of sources before and after the legislation. Cologne was selected as the 38 area of study because it had existing sociogeographical data, however the authors report data to show that Cologne data appears comparable with Germany as a whole. The number of commercial sources declined by 12% from 2005 to 2009, resulting mainly from the removal of 44% of outdoor cigarette vending machines (indoor machines decreased by 5%). The lower the income level in a district, the higher the availability of cigarettes (Pearson’s r = .595; p = .009). Convenience cigarette sources reduced by only 0.9%, and supermarket and drug stores increased by only 2.6%. The study did not report whether the decline in commercial source by retail category (outdoor and indoor vending machines, convenience stores, supermarkets and drug stores) varied by the income level of districts. The same occurred for the alternative indicators such as youth unemployment (Pearson’s r = .548; p = .019), the percentage of people receiving social welfare (Pearson’s r = .485; p = .041), and the percentage of pupils attending low-qualifying schools (Pearson’s r = .473; p = .048). In 2005 as well as in 2009, there were significantly fewer commercial cigarette sources in districts with above average SES than in districts with below average SES. This can be seen in terms of absolute as well as relative numbers. The density of commercial cigarette sources in 2005 in districts with above average SES was 3.20 per 1,000 inhabitants and 4.84 per 1,000 inhabitants in the districts with below average SES. In 2009, the numbers were 2.63 per 1,000 inhabitants and 4.44 per 1,000 inhabitants, respectively. The differences between socially advantaged and disadvantaged districts appeared to be significant in both years (2005: t(15) = 9.017, p < .001 and 2009: t(17) = 6.915, p < .001). This study showed that electronic locking devices on vending machines to prevent underage (<16 years) purchasing of cigarettes in Germany was not associated with a decrease in inequalities of access to cigarettes, for youth. A US study41 evaluated the relationship of point-of-sale tobacco advertising and neighbourhood characteristics (including 150% below the poverty level) to underage sales of tobacco. Study authors used three data sources: observations of the advertising environment in stores; records of age-of-sale tobacco checks where an undercover minor working with law enforcement attempted to purchase tobacco; and demographic data from the Year 2000 U.S. census. Analyses were conducted on 467 of 655 licensed tobacco vendors in Minnesota, USA. Compliance failure was defined as the sale of tobacco to a youth, regardless of whether the store clerk examined the minor’s ID. 39 The study did not find a significant association between store advertising characteristics or neighbourhood poverty level and stores’ compliance check failure. Of a total of 467 stores, 48 failed the compliance check. Tobacco shops were most likely to fail compliance checks (44%) and supermarkets were least likely to fail (3%). The poverty level of stores ‘block group’ was not associated with compliance failure. Stores in ‘block groups’ with a greater percentage of people living in poverty were not more likely to fail the compliance check. The study sample was representative and the results are generalisable at a regional level. Only vendors with a current license can sell tobacco in state of Minnesota but this is not the case across all US states. Also stores who repeatedly violate youth access laws have their license rescinded. The study authors report that compliance checks may not be a very valid measure of commercial tobacco accessibility for minors. Another US study40 examined contextual, community and retail characteristics associated with youth access to tobacco through commercial sources. Data sources were access surveys carried out by four buyers who were over 18 years of age (mean age 19 years) but who were judged to appear younger by an independent panel. Purchase attempts were made at 997 tobacco outlets in 50 mid-sized California cities by a team of two buyers. At each outlet a single buyer attempted to purchase a pack of Marlboro or Newport cigarettes (the most popular cigarette brands among high school-aged students). If asked about their age they stated that they were over 18 years old, and if asked for an age ID they indicated they had none. If a sale was refused, the buyers left without attempting to pressure the clerk. The main outcome measure was retailer compliance with underage tobacco sales laws. Overall, the rate of retailer non-compliance with underage tobacco sales laws in the 997 selected outlets was 14.3%. Buyer’s actual age, being a male clerk and asking young buyers about their age were each positively associated with successful cigarette purchases. Buyer’s actual age and minimum age signs increased the likelihood that clerks requested identification (ID). A greater percentage of residents (within each city) with at least a college degree was associated with increased likelihood of non-compliance with underage tobacco sales laws. A lower percentage of residents with at least a college degree was associated with retailers asking for an ID. Higher cigarette prices of Marlboro but not Newport were associated with higher median household income. 40 Although the study authors state that there were no significant differences between the sampled and the un-sampled cities in relation to population size, ethnic diversity, household size and median household incomes, there was no data reported to clarify the representativeness of the study sample and therefore the generalisability of the study results. A US national longitudinal study of adolescent health (Add Health) was a school based survey of the health related behaviours of adolescents using follow-up in-home surveys.44 ‘Add Health’ used state level tobacco policy on age of sale scores developed by the US National Cancer Institute, evaluating 9 items for each state each year (statewide enforcement, random inspections, graduated penalties, photo identification, free distribution, minimum age, packaging, vending machines, and clerk intervention). The analyses were restricted to female adolescents, and showed that stronger state level tobacco policies were associated with lower likelihood of smoking initiation and adverse transition among low SES women, although the effect sizes were small. The positive policy effects for initiation were strongest for low SES females, whose odds ratio was 0.95 (0.98 for middle SES, 1.00 for high SES). For initiation, school level smoking rates did not vary substantially across low, middle, and high SES groups (OR=1.01, 0.99 and 1.00, respectively. For statewide enforcement, the odds ratios of initiation were significantly lower for the low (0.89) and middle (0.91) SES female groups; on the other hand, the policy had no effect on the high SES female group (OR=1.00). For random inspections the odds ratios of initiation were significantly lower for low (0.88) and middle (0.90) SES female groups. Photo identification had a significant positive effect on the low SES female group (OR=0.85), but not on the middle SES female group (OR=0.95, NS) and on high SES females (OR=1.10, NS). Other policies had a pattern similar to the significant ones. It should be noted that this US cohort uses longitudinal data with a seven year gap in the data used to assess transition from adolescence to young adulthood, and this gap may have missed other important mediators. Summary Five studies of controls on access to tobacco products showed mixed results for equity impact. Although four of the five studies focussed on age of sale legislation, the German study of vending machines was unique, and in addition, the range of outcomes reported with the studies varied. 41 Increasing the minimum age for the purchase of tobacco in England was associated with a significant reduction in overall youth smoking and regular smoking was not significantly different in pupils eligible for FSM compared with those that were not and so the legislation was neutral with regard to equity. However smokefree legislation also came into force during the time of this study and could have contributed to the reduction in overall youth smoking. In addition there were significant differences in the percentages of adolescents eligible for FSM compared to those not eligible for FSM in terms of higher rates of accessing cigarettes from a variety of sources, which showed negative equity impact differences. New legislation which involved electronic locking devices on vending machines to prevent underage purchasing of cigarettes in Germany has not been associated with a decrease in inequalities of access to cigarettes, for youth. The supply density of cigarette vending machines in Germany was greater in socially disadvantaged areas, both before and after new legislation to prevent underage access; there were also greater decreases in the number of vending machine sources in socially advantaged areas. Two US studies reporting retailer compliance with age-of-sale laws showed inconsistent results for SES. A US study41 evaluating the relationship of point-of-sale tobacco advertising and neighbourhood characteristics to underage sales of tobacco did not find a significant association between store advertising characteristics or poverty and stores’ compliance check failure. A study of compliance with underage tobacco sales laws in California40 showed that higher education was a significant predictor of underage tobacco sales and youth in communities with higher educational levels may have easier access to cigarettes from commercial sources. A US national longitudinal study of adolescent health showed that stronger state level tobacco policies on age of sale were associated with lower likelihood of smoking initiation and adverse transition among low SES adolescent girls, although the effect sizes were small. It is difficult to ascertain how access to tobacco translates into smoking prevalence and how stricter enforcement of access laws would help to reduce the gap between low and high SES in terms of smoking prevalence. Increasing age of sale and restricting youth access do not appear to be widening the gap between high and low SES but the evidence is limited and only two studies report smoking outcomes rather than supply outcomes. 42 3.2.5 School-based prevention Five RCTs assessed the socio-economic impact of school-based smoking prevention programmes. Two interventions were drug prevention programmes which included elements of smoking prevention.45;46 One RCT examined the effects of a school-based drug prevention programme which included smoking prevention in school children aged 11 years in Florida, US.45 One quasi-randomised trial46 in 53 public secondary schools in northern Germany evaluated the effects of two validated life skills programmes: ‘Fit and Strong for Life’ and ‘Lions Quest’. Three intervention studies focused on smoking prevention. One RCT investigated whether a peer group pressure and social influence intervention reduced the percentage of adolescents who start to smoke, in the Netherlands.17 The European Smoking Prevention Framework (ESFA) study assessed the impact of a social influence school-based intervention with parental and community involvement on smoking uptake amongst adolescents in six European countries.19 The ‘A Stop Smoking in Schools Trial’ (ASSIST) assessed the effectiveness of a peer-led intervention that aimed to prevent smoking uptake in secondary schools in England and Wales.18 Two of the studies did not report socioeconomic impact on initial analyses; however a paper by Mercken et al.20 was identified which performed secondary analyses of the socioeconomic impact of these three intervention studies17-19 using the SES variables reported within the original primary studies. The secondary analysis included a review to identify ‘high-quality European intervention studies with clear overall effects that could be selected for secondary analyses'. Included intervention studies had to be published in the international scientific literature in English language, since 1995 and conducted in Europe since 1990. This procedure resulted in the inclusion of three school-based intervention studies. The three studies were reanalysed using the definitions of variables as defined in the original studies. Multilevel modelling techniques were used; models were estimated using the restricted iterative generalized least squares (RIGLS) estimation procedure combined with first-order penalized quasi-likelihood within MLWin 2.10 beta. The multilevel model was tested separately for adolescents in each of the categories of the included SES indicators. It is unclear how representative all five study samples were of the respective study populations. The groups in three of the studies17-19 had comparable characteristics at baseline. Attrition rates were acceptable for three studies18;45;46 but relatively high for the 43 other two studies17;19. The ASSIST study was the only study to biochemically validate measures of self-reported smoking, and scored highest for quality.18 It is likely that the observed effects of each of the five interventions were attributable to the interventions. Two studies evaluated school-based programmes which included elements of smoking prevention: one based in the US and one in Germany.46 One RCT examined the effects of a school-based drug prevention programme which included smoking prevention in school children.45 The study was published as a paper presented at the Annual Conference of the American Educational Research Association and assesses the impact of a school-based drug prevention programme ‘Too Good for Drugs II’ (TGFD II) on student’s behaviours and risk and protective factors. Students in six middle schools in Florida, US were randomised to 9 lesson units (40 minutes each) taught by a trained classroom teacher or TGFD II instructor; including social and emotional competencies, reducing risk factors and building protective factors; emphasising cooperative learning activities, role-play and skills building methods. Students were followed-up 20 weeks after the 9 week intervention. The school-based curriculum also involved community partners and parents; and the theoretical basis included Social Learning Theory, Problem Behaviour Theory and Social Development Theory. At the end of the intervention, 8% (48/588) of students in the intervention group indicated greater likelihood of actual tobacco use compared with 12% (45/375) of students in the control group, and this difference was statistically significant. There was no statistically significant difference between the groups at 20 weeks follow-up. The overall findings of the comparison of change scores for treatment students indicated the programme was similarly effective in impacting on students risk and protective factors regardless of economic status (perception of peer resistance skills; positive attitudes toward non-drug use, perceptions of peer normative substance use, perceptions of peer disapproval of substance use, association with prosocial peers, perceptions of locus of control self-efficacy). A significant interaction effect for treatment students was seen between level of risk and protective factor scores and SES (measured by free/reduced lunch status) at the end of intervention and 20-week follow-up. Significant trends appeared between low and high SES in the areas of ‘perceived peer norms’ and ‘perceived peer approval of substance use’ at the end of the intervention and in addition with ‘association with prosocial peers’ at 20-week follow-up. The direction of the effect by SES is not reported. 44 One RCT investigated whether a peer group pressure and social influence intervention reduced the percentage of adolescents who start to smoke, in 26 junior secondary education schools in the Netherlands.17 The intervention consisted of three lessons on knowledge, attitudes, and social influence, followed by a class agreement not to start or to stop smoking for five months and a class based competition. At five months 9.6% of the non-smokers at baseline had started to smoke in the intervention group, whereas 14.2% started to smoke in the control group (N = 1388, OR = 0.61, 95% CI = 0.41–0.90). After 1-year follow-up, the effect was no longer significant. At 5 months, smoking behaviour was significantly lower in adolescents who indicated that their parents had mid to high completed education (OR = 0.35, 95% CI = 0.13–0.95). The intervention did not result in smoking fewer cigarettes among adolescents who indicated that their parents had lower education (OR = 0.80, 95% CI = 0.37–1.72). The additional analyses stratified by gender and SES showed that the intervention was only effective at 5 months follow-up among boys with higher parental educational levels (OR = 0.24, 95% CI = 0.07–0.79). All significant intervention effects disappeared at 12 months follow-up.17 The ESFA study assessed the impact of a social influence school-based intervention with parental and community involvement on smoking uptake amongst adolescents in six European countries.19 In Finland, Denmark, UK and Portugal schools or regions were randomly assigned whereas in Spain and The Netherlands the study design was quasirandomised. Since the strongest and significant long-term effects after 24 and 30 months were found in the Portuguese sample, only data of the ESFA study in Portugal were reanalysed on the impact by SES and so only results for Portugal are discussed within this review. The Portuguese intervention consisted of lessons on the effects of tobacco, reasons for (not) smoking, social influence processes, refusal skills and decision making and a smoke-free competition. Due to the fact that peer-led programmes were uncommon in the ESFA countries, programmes were teacher-led. Teachers received 48 hours of training, a manual and smoking cessation material. Schools received the ESFA no-smoking policy manual and non-smoking posters. For the parents, information was offered on how to discuss nonsmoking with their adolescents. Pharmacists furthermore offered cessation courses for 150 parents. At the community level, the Portuguese Health Minister and mayor of the community introduced the ESFA study on the national no smoking day.19 45 At 30 months, 41.8% of the never smokers at baseline had started to smoke in the intervention group, compared to 53.8% of the never smokers at baseline in the control group (N = 1304, OR = 0.62, 95% CI = 0.48–0.80). The results were mixed depending on the SES indicator used (mother/father and full-time/not full-time jobs were not included as a measure of SES in our review). The intervention was significant in reducing smoking uptake among adolescents who indicated having no to only a low amount of spending money (OR = 0.62, 95% CI = 0.46–0.84). This statistically significant effect was not seen among adolescents reporting receiving mid to high amounts of spending money (OR = 0.57, 95% CI = 0.32– 1.03). Although the actual odds ratio is smaller for the ‘mid to high’ spending money subgroup compared with the ‘none to low’ spending money subgroup, the lack of significance here is due to the wider confidence intervals, which are explained by the relatively small numbers in the subgroup with ‘mid to high’ spending money (n=182). Additional analyses stratified by gender and SES showed that the intervention was mostly effective among girls.19 Pocket money was used as a proxy measure and there may not be a strong association between adolescents’ pocket money and household income. As Mercken et al.20 state; those adolescents with less pocket money may well have parents with higher levels of education or income. The ASSIST study assessed the effectiveness of a peer-led intervention that aimed to prevent smoking uptake in secondary schools in S.W. England and Wales.18 Influential students were trained by external professionals to act as peer supporters during informal interactions outside the classroom to encourage peers not to smoke. During the 10-week intervention period, peer supporters undertook informal conversations about smoking with their peers when travelling to and from school, in breaks, at lunchtime and after school in their free time. At 1-year follow-up, the OR of being a smoker in intervention compared with control group was 0·77 (95% CI 0·59–0·99). At 2-year follow-up, the corresponding OR of 0·85 (0·72– 1·01) was not significant (p=0·067). For the high-risk group (occasional, experimental, or ex-smokers at baseline), the OR at 1-year follow-up was 0·75 (0·56–0·99) and at 2-year follow-up was 0·85 (0·70–1·02). In a three-tier multi-level model using data from all three follow-ups the odds of being a smoker in the intervention group compared with the control group was 0.78 (95% CI = 0.64–0.96).18 The original primary study paper found no evidence of a differential effect by FSM entitlement (0.99 (95% CI =0.65-1.51)). 46 The secondary data analysis20 combined data from the three follow-up periods and conducted a multi-level analysis using three measures of SES: FAS, FSM and school located in the Valleys (which are areas of deprivation). No significant main effect of the intervention was found for FAS or FSM entitlement, though a trend was visible for FSM. The intervention was significant among schools located in the valleys but not in schools in other locations. Additional analyses showed that in Valley schools the intervention was also effective among those with low FAS score, and a gender analysis showed that the intervention was mostly effective among lower SES girls. Summary The overall findings from the five school-based studies are mixed in terms of the impact by SES, the results also varied by the type of SES used to measure effect, and over time (shorter-term benefit appeared to attenuate over time). The findings from a substance abuse prevention programme set in schools were equally effective for students regardless of SES, however the study did not ask about current smoking behaviour and the outcome was intention to smoke in the next 12 months rather than actual smoking behaviour.45 The results of this prevention programme relate to scores for substance use which includes (but is not limited to) tobacco use and so this limits study findings. A German study46 of two life skills programmes had a positive effect on smoking prevention regardless of SES; with socially disadvantaged children benefitting equally (neutral equity impact). The Netherlands study had a significant effect among higher SES adolescents only and in the short-term only, and appeared to widen inequalities (negative equity impact).17 The ESFA study showed mixed results depending on the specific SES indicator used; when using spending money as a SES indicator, the intervention did appear to decrease inequalities in smoking.19 However, the amount of spending money which an adolescent has may not be strongly associated with household income. For example, in Scotland low SES adolescents have higher levels of disposable income than higher SES adolescents.47 ESFA interventions differed between countries and Portugal received the most intensive teacher training; so results may only be generalisable to that type of intervention in that country. Process evaluation of ESFA included self-report of exposure to each element of the intervention and showed it was reasonably likely that the observed effects were attributable to the schoolbased elements of the intervention rather than outside school elements. 47 The most promising findings in terms of equity impact were for ASSIST which used a social network approach in which adolescents delivered the intervention. While this intervention also showed mixed results depending on the specific SES indicator used, it was effective at one year and most effective for adolescents in deprived areas, particularly among low SES girls (positive equity impact). However, the beneficial effects of the intervention seemed to attenuate over time.18 3.2.6 Multiple policy interventions Three studies assessed the socio-economic impact of multiple policy interventions: two repeat cross-sectional studies48;49 and a prospective cohort study.50 One repeat crosssectional study49 was set in Australia and examined the impact of tobacco control policy on smoking prevalence. The other repeat cross-sectional study48 assessed the impact of the 1976 Tobacco Control Act (TCA) on smoking initiation across socioeconomic groups of Finnish youth. A prospective cohort study described the association between smoking intolerance in schools, restaurants and corner shops near secondary schools, and the initiation of smoking in a convenience sample of adolescents (mean age 13 years) in Montreal, Canada.50 The cohort study50 used a convenience sample and it was unclear whether the study sample was representative of the study population or whether the study results are generalisable. The Australian study49 reported changing retention rates which meant that the characteristics of the student sample in school years 11 and 12 were likely to differ systematically across the survey years, which could have affected the prevalence rates (instead of, or as well as, tobacco control policy). Both the Australian and Finnish studies were large population surveys with results that are likely to be generalisable at the national level. An Australian national survey49 examined whether SES was associated with changes in smoking prevalence among adolescents during three phases of tobacco control activity: low tobacco-control funding (1992-1996) and high tobacco-control activity (1984-1991 and 1997-2005) which included smoking restrictions and increased tax. Random samples of students aged 12 to 17 years from each Australian state and territory and three main education sectors, completed anonymous surveys of cigarette use as part of a larger survey assessing the use of alcohol and illicit drugs between 1987 and 2005. There was a significant and substantial reduction in the likelihood of smoking among all SES groups for older (1617 years) and younger students (12-15 years) between 1987 and 2005. Overall, for younger 48 students (12-15) the reductions differed by SES (interactions p <0.01), with reductions in all smoking behaviours, greater for students from higher SES groups. Among older students (16-17), only the reductions in committed smoking (cigarette use on at least three of the previous seven days) differed across SES groups (interaction p < 0.01), and again reductions were greater among students from higher SES groups. Between 1990 and 1996 the proportion of younger and older students involved with smoking increased significantly. Among younger students, the increase in monthly and weekly smoking was greater among lower SES students. Between 1996 and 2005 the prevalence of monthly and weekly smoking decreased significantly among both younger and older students, and these decreases were consistent across SES groups. The magnitude of the decreases in smoking prevalence between 1996 and 2005 did not differ significantly between SES groups for most indicators of smoking behaviour. For committed smoking, the interaction between year and SES was of borderline significance for students from both age groups, suggesting that the decrease may not be consistent across SES groups. It should be noted that co-operation rates of the schools declined over time from 85% in 1987 to 63% in 2005 and the changing prevalence estimates might be the result of different survey samples. A Finnish study48 assessed the impact of the 1976 TCA on smoking initiation across socioeconomic groups. The TCA prohibited smoking in most public places, including public transport; and the sale of tobacco products to those below 16 years of age; and required obligatory health warnings on packages. The study used annual cross-sectional postal survey data from 1978 to 2002 to assess the impact of the TCA on smoking prevalence (defined as ever smoked daily for at least a year). The study authors defined the critical age range for smoking initiation as 13 to 20 years. Most of the analyses were focussed on the three largest socioeconomic groups (upper white collar workers, lower white collar workers, blue collar workers manual workers). Amongst men the secular cohort trend showed a decline in smoking only in upper white collar workers before the TCA (stable for lower white collar and blue collar) and this trend remained unchanged after the TCA, with no difference for the interaction between SES and trend. Among women the secular cohort trend was increasing in each SES group before the TCA and was reversed after the TCA, evenly across SES groups. For women, the general cohort trend after the TCA differed from the secular cohort trend before the TCA, and this differed by SES. In cohorts reaching the smoking initiation age after the TCA, the 49 prevalence of ever smoking remained relatively stable among white collar female workers but tended to decline among blue collar female workers (OR 0.88; 95% CI: 0.72 to 1.02), in contrast to the sharply increasing trend in older cohorts. In terms of study validity, the average response rate during 1978 to 2002 was 70% among men and 79% among women and the response rate declined during this period, in both genders and all age groups. The decline was faster among men than women, and in younger than older age groups, which may have biased the study results. Other tobacco control policies came into force during the study period which could have influenced the study results and explain some of the variability in smoking initiation by SES: the 1976 TCA was supplemented by a total tobacco advertising ban in 1978, and the environmental tobacco smoke amendment (of the TCA) in 1995. In addition, tobacco prices rose substantially (real price increase 27%) in 1975–1976. A Canadian study described the association between smoking intolerance (the extent to which smoking is socially unacceptable) in schools, restaurants and corner stores near schools and the initiation of smoking in adolescents. ‘The Natural History of Nicotine Dependence in Teens Study’50 involved completion of questionnaires administered in the classroom, every 3 months from 1999 to 2005 by students average age 13 years, in seven English and three French language secondary public schools in Canada. The study used a convenience sample which produced a 55% student response rate. Students in smoking-intolerant schools (access and restrictions) were less likely to initiate smoking than students in smoking-tolerant schools (Hazard ratio [HR] = 0.83; 95% CI: 0.68, 1.01). Students attending schools located in neighbourhoods with smoking-intolerant restaurants were less likely to initiate smoking (HR 0.85; 95% CI: 0.68 to 1.07). There was no association between corner store smoking intolerance and smoking initiation. The HR’s for cigarette use initiation for low SES schools were not significant. However, there was a 25% loss to follow-up of students over the five years and these students were more likely to attend a low SES school, which may have impacted on the results. Summary The Australian survey49 showed that the magnitude of the decreases in smoking prevalence between 1996 and 2005 did not differ significantly between SES groups for most indicators of smoking behaviour, but there may be differences between younger and older youth. 50 However, there appeared to be an association between level of tobacco control funding and smoking prevalence. There was also some evidence that low tobacco control funding had a negative equity effect on smoking prevalence among 12-15 year olds but not older students. The Finnish TCA48 was associated with a reduction in smoking initiation across all SES groups. Among men, the 1976 TCA appears to have had the greatest impact on male white collar employees. Among women, the apparent effect was very pronounced in all socioeconomic groups and among blue collar female workers the cohort trend tended to decline. A convenience sample of pupils in Canada50 showed that cigarette use initiation was associated with levels of smoking intolerance in schools and communities but that this did not differ by SES. But there was evidence of response bias by SES which may have impacted on the results. 3.3 Impact of individual level cessation services and support on smoking inequalities in youth There were only two individual cessation support interventions identified for youth which assessed smoking outcomes by SES, one set in New Zealand and one in USA: both of which used text-messaging as the mode of intervention. The New Zealand study51 aimed to determine the effectiveness of a mobile phone text messaging smoking cessation programme which provided advice, support and distraction for smokers who owned a mobile phone and who wanted to quit smoking. Participants were aged 16 years and over, with a mean age of 25 years. The intervention included five free personalised text messages per day for one week prior to a negotiated quit date and for four weeks after the quit date. The control participants received one free month of text messaging if they participated until 26 weeks. A total of 1,705 smokers were recruited from adverts on websites, media, email and text messaging mailing lists; and posters at tertiary education institutions. The RR of not smoking in the past week was 2.20 (95% CI 1.79 to 2.70) at 6 weeks, 1.55 (95% CI 1.30 to 1.84) at 12 weeks and 1.07 (95% CI 0.91 to 1.26) at 26 weeks (when all participants with missing status were assumed to be smoking). The RR of not smoking (in the past week) at six weeks by income level was presented as a forest plot and showed no 51 difference in effect by income level; all income levels showed significant positive effects of the intervention. Biochemically verified abstinence was only performed on a random selection of participants and showed over-reporting of quit rates but this over reporting was not different between the intervention and control group. The quit rate at 6 weeks was 28.1% in the intervention group compared with 12.8% in the control group. Assuming the rate of true quitters was the same as in the sample assessed for cotinine levels, then the quit rate at 6 weeks was 13.9% in the intervention group compared with 6.2% in the control group and the absolute difference in quit rates at 6 weeks is reduced to 7.7% from 15.3%. Only 74% (n=1265) of participants were followed-up at 26 weeks and the attrition rate differed significantly between the groups at 12 weeks and at 26 weeks (69% in intervention group vs 79% in control group at 26 weeks). This meant there was some uncertainty about between group differences at 26 weeks. In addition reported quit rates increased amongst the control group from 13% at 6 weeks to 24% at 26 weeks, however this would have led to an underestimation of treatment effects and all methods of data analyses showed a significant difference in quit rates in favour of the intervention. The US study52 targeted a diverse sample of motivated daily smokers aged 18 to 25 years, owning their own mobile phone and ‘seriously thinking about quitting in the next 30 days’. Two hundred and eleven young adults were randomised from 585 eligible participants and the final sample included 164 participants: 101 in the intervention group and 63 in the control group; mean age 22 years, 56% male, with 43% reporting an annual household income of less than $15,000. The 6-week text-messaging intervention was tailored to each young adult smoker based on their quitting stage. Intervention participants also had access to a ‘Text Buddy’ similar to that used in the New Zealand study51 and ‘Text Crave’ (immediate, on-demand messages aimed at helping the participant through a craving); and a project website (StopMySmoking.com). The control group received a similar number of text messages, but message content was aimed at improving sleep and exercise habits within the context of how it would help the participant quit smoking. Control group messages were not tailored nor were Text Buddy and Text Crave components available. 52 Intervention participants were significantly more likely to have quit at 4 weeks post quit (39%) than those in the control group (21%; adjusted odds ratio [aOR] = 3.33, 95% CI: 1.48, 7.45); and this was also the case for 7-day point prevalence (44% vs. 27%; aOR = 2.55, 95% CI: 1.22, 5.30). However the impact was not sustained, and 40% of the intervention participants had a quit status verified by a ‘significant other’ compared with 30% in the control arm at 3 months post-quit, which was not statistically significant (OR = 1.62, 95% CI:0.82, 3.21). Cessation rates among intervention participants were stable between 4 weeks and 12 weeks, but increased among control participants The intervention appeared to be more effective in young adults not currently enrolled in higher education settings (45% intervention vs. 26% control had quit at 3 months, p = .07; aOR of verified quit at 3 months = 2.7, 95% CI: 1.0 to 7.4). The US study52 was a feasibility study with a relatively small sample size so it was not sufficiently powered particularly to detect differences in subgroup results. Eight participants were manually assigned to treatment groups (rather than randomly) due to an imbalance within study subgroups. Summary Two studies of text messaging smoking cessation interventions were included, one set in the USA and one in New Zealand. Participants in both studies were mobile phone owners in their late teens to early twenties, who were motivated to quit smoking. The New Zealand study control participants received a passive control (one month free text messaging) and US control participants received a text-messaging service that was not tailored (intervention participants received a tailored text-messaging service). The New Zealand study showed personalised mobile phone text messaging support could double quit rates at 6 weeks amongst young adult smokers who wanted to quit, irrespective of income level. The effect was still significant at 12 weeks but not at 26 weeks, in addition there was an increase in quit rates amongst the control group and significantly more intervention participants were lost to follow-up at 26 weeks. The US study of a tailored text-messaging intervention compared to a non-tailored textmessaging intervention, showed a significant increase in quit rates in intervention group participants compared with control group participants at 6 weeks that were not sustained at 12 weeks. Quit rates increased in control group participants. However youth not enrolled in higher education (i.e. lower SES) appeared to benefit from the tailored text messaging 53 intervention with significantly positive quit rates at 12 weeks compared to youth enrolled in higher education. The New Zealand study showed a short-term neutral equity effect and the US study showed a short-term positive equity effect. Quit rates increased in the control groups in both studies. It is unclear how representative either study samples were of each study population, however both studies cut across all settings and all locations. 54 4 DISCUSSION Only one review, the CRD review, has previously assessed the equity impact of tobacco control policies on youth smoking. No intervention, including restrictions on smoking in schools and restrictions on sales to minors, provided any evidence about possible differential effects by parental income, occupation or educational level for the youth population. The review presented in this report has systematically assessed the available evidence on the impact of population- and individual-level tobacco control interventions on socioeconomic inequalities in youth smoking. It identified 31 studies which have evaluated the impact of population level prevention policies/interventions and two individual level cessation support interventions, on smoking in young people by SES, measured by income, occupation or education. Before presenting the main review findings it is important to consider the strengths and limitations of both the review and the available evidence. 4.1 Strengths and limitations of the review Considerable attempts were made to include published and ‘in press’ studies. However, it is possible that some relevant studies might have been missed which had not been published in the peer reviewed literature and/or which were not published in English. It is also possible that papers which undertook analyses by SES were not included because these analyses were not mentioned in their abstract. However, this review goes beyond the previous CRD review in including all types of youth interventions (prevention and cessation, population and individual levels) and also searching for non-tobacco control interventions and polices (eg education, social policy) which assessed any smoking-related equity impacts. It also included ‘in press’ articles from four key journals and asked European tobacco control experts to provide any other relevant peer reviewed articles (non-English language) or grey literature. We also developed a modified quality assessment tool which was designed to enable us to assess the quality of the diverse range of types of interventions and study designs encompassed in the included studies. 4.2 Strengths and limitations of the available evidence There are major limitations in the available evidence, most importantly the very small number of studies which have considered the equity impact of tobacco control interventions aimed at young people. In addition, there was a lack of consistency on the reported outcome measures and length of follow-up. There was also considerable variation in the quality of the studies (Section 7.6 Appendix G). Several of the studies were pilot or feasibility studies 55 and/or involved small numbers of participants. Thus, their findings may not be replicable. For several important areas of youth tobacco control eg social marketing, multifaceted community programmes, mass media approaches using social media, combating smuggling/reducing the black market, smokefree homes interventions and most forms of cessation support, we found no evidence on equity impact. Nearly half the studies were from North America (US and Canada) and a third from the UK, which raises concerns about their generalisability and potential transferability to, or relevance for, countries in Europe which have different social and cultural contexts and/or different levels of tobacco control. Finally, a range of indicators of SES was used in papers (e.g. education level, income, area deprivation, and other indicators) which made comparisons between studies difficult. Most studies used education income level as a measure of SES but levels of educational attainment and income vary between countries and generations. 4.3 Main findings and conclusions Relatively few intervention studies have assessed their impact on socioeconomic inequalities in youth smoking or other smoking-related outcomes (eg exposure to second-hand smoke). Out of the original 12, 605 identified papers (which also included papers focusing on adults) only 33 studies met the inclusion criteria and were included in the review and none were from outwith tobacco control (Figure 1 and Table 2). The literature was international, with nearly half of the studies being carried out in North America. Studies also included the UK, the Netherlands, France, Spain, Finland, Israel, New Zealand and Australia. Of the 33 studies included in the review 31 were population level tobacco control policies/interventions and 2 were individual level cessation support interventions. The types of policies/intervention included were: smoking restrictions in cars, schools, workplaces and other public places (9); controls on the advertising, promotion and marketing of tobacco (3); mass media campaigns (1); increases in price/tax of tobacco products (6); controls on access to tobacco products (5); school-based prevention programmes (5); multiple policy interventions (3) and individual cessation support (2). (One study was included in two types of policies/intervention category). 4.3.1 Positive equity impact Only six of the 31 population-level studies showed the potential to produce a positive equity impact i.e. to reduce inequalities in youth smoking. These ‘positive’ studies included three US studies of increasing the price/tax of tobacco products,35;36;38 two US studies on age-of56 sales laws,40;44 and UK one school-based smoking prevention programme.18 Three US studies of cigarette price/tax increases35;36;38 demonstrated a positive effect on low SES youth of increasing price/tax to reduce smoking. A US prospective cohort study44 showed that stronger state level tobacco policies on age of sale were associated with a lower likelihood of smoking initiation and adverse transition among low SES adolescent girls, although the effect sizes were small. A study of compliance with underage tobacco sales laws in California40 showed that higher education was a significant predictor of underage tobacco sales and youth in communities with higher educational levels may have easier access to cigarettes from commercial sources. One school-based smoking prevention study (ASSIST), using a peer-delivered intervention through social networks, appeared to reduce smoking inequalities in school-children in England and Wales. However, results were mixed depending on the specific SES indicator used. 4.3.2 Equity impact by type of tobacco control policy/intervention Assessing the overall equity impact of different types of interventions/policies was complicated by studies having different outcome measures and length of follow-up. In some studies different outcomes varied in equity impact or the same SES measure and outcome varied by gender or by setting. For example, one school-based prevention programme showed a positive effect only in high SES girls and had the potential to widen inequalities. Which specific measures of SES were used appeared to influence the results across all types of policy interventions. The equity impact could also vary depending on the timing of the outcome measurement. For example, two of the school-based prevention programmes found that the effect varied across time points; with beneficial intervention effects attenuating over time. Similarly both cessation interventions using text-messaging showed a significant beneficial effect that was not sustained in the longer-term. Thus, the summary of the equity impact of policies/interventions was derived ‘on balance’ (Appendices H and I). Overall there was no consistent equity effect for each type of tobacco control policy/intervention. Most interventions had, on balance, either a negative (11) or neutral (15) equity impact. One had a mixed impact. However, it should be borne in mind that studies of policies associated with a neutral equity effect indicate that these policies have benefits for youth across SES groups. For example, both the English and Scottish national smokefree legislation were associated with significant reductions in admissions for asthma across all SES subgroups. 57 Smoking restrictions in cars, schools, workplaces and other public places- None of the nine studies showed a positive equity impact. Four had a negative equity impact, four had a neutral impact, and one had both negative and neutral impacts. The studies indicate that the equity impact of comprehensive smoking legislation in public places may differ depending on the pre-ban level of exposure and the balance between sources of exposure i.e. public places versus the home. While comprehensive smoking restrictions can reduce overall SHS exposure across all SES groups of children. Changes in smoking restrictions in homes and cars following UK smokefree legislation did not appear to be patterned by SES in pooled analyses, however smoking in homes and cars remains more prevalent amongst children from low SES families. Evidence shows that there is significant variation by SES in levels of exposure prior to smokefree legislation with higher levels of exposure in lower SES. Whether exposure is measured in relative or absolute terms appears to influence the equity impact results. However, there is some evidence that smokefree legislation can also have a neutral equity impact in terms of increasing voluntary smoking restrictions in cars. The evidence also suggests that where there are no comprehensive smoking restrictions in schools or where there is variable compliance with voluntary bans; inequity in smoking will continue. Controls on the advertising, promotion and marketing of tobacco- Two of the studies had a negative equity impact and one had a neutral impact. The three studies were very different with one indicating that tobacco companies marketing expenditure may be associated with an increase in smoking initiation especially in young people with lower levels of education. Another study found that despite an FDA buffer zone policy to protect children from tobacco advertising, tobacco advertising was specifically targeted at adolescents of low SES inside school buffer zones and that this has the potential to increase inequality in smoking amongst youth. This would indicate that banning all tobacco advertising would be particularly beneficial for low SES children. There was also some tentative support from one study that introducing plain packaging would have a similar impact across all SES groups. Mass media campaigns- only one study assessed the equity impact of a mass media campaign, the Truth campaign. The overall equity impact was difficult to assess but there was a neutral equity impact in terms of receptivity. Increases in price/tax of tobacco products - the majority of evidence on price/tax is from the US, and suggests that there is variation in the equity impact of increases in 58 cigarette tax or price on youth smoking behaviour and variation in smoking behaviour amongst youth of different ages and different SES groups. Low income youth were not consistently more responsive to tax/price increases compared with high income youth: youth of lower SES were not more likely to stop smoking when cigarette prices/taxes increased. The inconsistency within the evidence could reflect a true effect or measurement errors such as failure to capture youth behavioural reactions in retrospective recall studies. Controls on access to tobacco products- Reducing access to cigarettes through increasing the minimum age of sale, including vending machines sales, may impact on youth sales but the inconsistent evidence from the UK and US studies make it difficult to draw conclusions about whether they also reduce youth smoking inequalities. School-based prevention programmes-only one study (ASSIST) had promising findings in terms of a positive equity impact. The other studies findings were inconsistent, varied by type of SES measure used and attenuated over time. Multiple policy interventions- these were three very different studies (two national and one at community level) in three different countries looking at different types of policies which makes it difficult to draw any conclusions about the equity impact of multiple policy interventions. Individual cessation support- only two studies were included which evaluated individual level smoking cessation support for youth. Both of these interventions used text messaging. The US study showed a short-term (12 weeks) neutral equity impact and the New Zealand study showed a short-term (12 weeks) positive equity impact but this was not significant at 26 weeks. Their equity impacts should be viewed with caution given that the representativeness of both study samples were unclear: both sample participants were motivated young adults who owned a mobile phone. However text messaging interventions have the potential to reach large numbers of young smokers. 59 5 CONCLUSIONS Thirty-three studies were included which evaluated the effect of policies and interventions to prevent or stop youth smoking by SES. Only six of the 31 population level studies showed the potential to reduce inequalities in youth smoking; including three on increasing the price/tax of cigarettes, enforcing strong policies on age-of-sale, and one school-based prevention study (ASSIST). There were only two individual level cessation support interventions identified for youth which assessed smoking outcomes by SES. Both cessation studies used text messaging. One showed a neutral equity impact and the other showed a positive equity impact. There was variation in the equity impact of each type of tobacco control policy/intervention. The limited nature and extent of the evidence base considerably constrains what conclusions can be drawn about which types of tobacco control polices/interventions are likely to reduce inequalities in youth smoking. Very few studies have assessed the equity impact of policies and interventions on smoking prevention or cessation in youth. There is therefore little available evidence to inform tobacco control policy and interventions that are aimed at reducing socioeconomic inequalities in youth smoking. There is a need to strengthen the evidence base for the equity impact of tobacco control interventions aimed at young people. 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Nicotine & Tobacco Research Advance Access. 2013. 64 7 APPENDICES 7.1 Appendix A Search strategies: electronic searches, handsearching and searching for grey literature Electronic searches Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) 1946 to May 04 2012, search date 09/05/2012; also Ovid MEDLINE(R) 1946 to January week 3, 2013, search date 23/01/2013 1. smoking/ 2. smoking cessation/ 3. tobacco/ 4. "Tobacco Use Disorder"/ 5. nicotine/ 6. tobacco, smokeless/ 7. tobacco use, cessation/ 8. (smokers or smoker).ti,ab. 9. cigar$.mp. 10. smoking.ti,ab. 11. or/1-10 12. smoking cessation/ 13. tobacco use, cessation/ 14. tobacco use, cessation products/ 15. smoking/pc 16. smoking/dt 17. smoking/th 18. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (ban or bans or prohibit$ or restrict$ or discourage$)).ti,ab. 19. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (workplace or work place or work site or worksite)).ti,ab. 20. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (public place$ or public space$ or public area$ or office$ or school$ or institution$)).ti,ab. 21. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (legislat$ or government$ or authorit$ or law or laws or bylaw$ or byelaw$ or bye law$ or regulation$)).ti,ab. 22. ((tobacco free or smoke free) adj3 (hospital or inpatient or outpatient or institution$)).ti,ab. 23. ((tobacco-free or smoke-free) adj3 (facilit$ or zone$ or area$ or site$ or place$ or environment$ or air)).ti,ab. 24. ((tobacco or smok$ or cigarette$) adj3 (campaign$ or advertis$ or advertiz$)).ti,ab. 25. ((billboard$ or advertis$ or advertiz$ or sale or sales or sponsor$) adj3 (restrict$ or limit$ or ban or bans or prohibit$)).ti,ab. 26. (tobacco control adj3 (program$ or initiative$ or policy or policies or intervention$ or activity or activities or framework)).ti,ab. 27. ((smok$ or tobacco) adj (policy or policies or program$)).ti,ab. 28. ((retailer$ or vendor$) adj3 (educat$ or surveillance$ or prosecut$ or legislat$)).ti,ab. 29. test purchas$.ti,ab. 30. voluntary agreement$.ti,ab. 31. health warning$.ti,ab. 32. ((tobacco or cigarette$) adj3 (tax or taxes or taxation or excise or duty free or duty paid or customs)).ti,ab. 33. ((cigarette$ or tobacco) adj3 (packaging or packet$)).ti,ab. 34. ((cigarette$ or tobacco) adj3 (marketing or marketed)).ti,ab. 35. ((cigarette$ or tobacco) adj3 (price$ or pricing)).ti,ab. 36. point of sale.ti,ab. 37. vending machine$.ti,ab. 65 38. (trade adj (restrict$ or agreement$)).ti,ab. 39. (contraband$ or smuggl$ or bootleg$ or cross border shopping).ti,ab. 40. (tobacco control act or clean air or clean indoor air).ti,ab. 41. ((reduce$ or prevent$) adj3 (environmental tobacco smoke or passive smok$ or secondhand smok$ or second hand smok$ or SHS)).ti,ab. 42. ((population level or population based or population orientated or population oriented) adj3 (intervention$ or prevention or policy or policies or program$ or project$)).ti,ab. 43. (community adj3 (intervention$ or prevention or policy or policies or program$ or project$)).ti,ab. 44. ((sale or sales or retail$ or purchas$) adj3 (minors or teenage$ or underage$ or under-age$ or child$)).ti,ab. 45. (youth access adj3 restrict$).ti,ab. 46. (smoking cessation or cessation support).ti,ab. 47. (smokefree or smoke-free or smoke free).ti,ab. 48. ((stop$ or quit$ or reduc$ or give up or giving up) adj3 (cigarette$ or tobacco or smoking)).ti,ab. 49. quit attempt$.ti,ab. 50. tobacco quit.ti,ab. 51. quit rate$.ti,ab. 52. (quitline$ or quit line$ or quit-line$).ti,ab. 53. ((smok$ or tobacco or nicotine or cigarette$) adj2 (abstinence or cessation)).ti,ab. 54. or/12-53 55. (socioeconomic or socio economic or socio-economic).ti,ab. 56. inequalit$.ti,ab. 57. depriv$.ti,ab. 58. disadvantage$.ti,ab. 59. educat$.ti,ab. 60. (social adj (class$ or group$ or grade$ or context$ or status)).ti,ab. 61. (employ$ or unemploy$).ti,ab. 62. income.ti,ab. 63. poverty.ti,ab. 64. SES.ti,ab. 65. demographic$.ti,ab. 66. (uninsur$ or insur$).ti,ab. 67. minorit$.ti,ab. 68. poor.ti,ab. 69. affluen$.ti,ab. 70. equity.ti,ab. 71. (underserved or under served or under-served).ti,ab. 72. occupation$.ti,ab. 73. (work site or worksite or work-site).ti,ab. 74. (work place or workplace or work-place).ti,ab. 75. (work force or workforce or work-force).ti,ab. 76. (high risk or high-risk or at risk).ti,ab. 77. (marginalised or marginalized).ti,ab. 78. (social$ adj (disadvant$ or exclusion or excluded or depriv$)).ti,ab. 79. exp socioeconomic factors/ 80. exp public assistance/ 81. exp social welfare/ 82. vulnerable populations/ 83. or/55-82 84. 11 and 54 85. 83 and 84 86. limit 85 to (abstracts and english language and yr="1990 -Current") 66 Embase; Excerpta Medica Database Guide, 1980 to 2012 Week 18, search date 09/05/2012; also 1980 to 2013 week 3, search date 23/01/2013 1. smoking/ 2. smoking cessation/ 3. tobacco/ 4. nicotine/ 5. tobacco, smokeless/ 6. "smoking and smoking related phenomena"/ 7. cigarette smoking/ 8. cigarette smoke/ 9. tobacco smoke/ 10. (smokers or smoker).ti,ab. 11. cigar$.mp. 12. smoking.ti,ab. 13. or/1-12 14. smoking cessation program/ 15. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (ban or bans or prohibit$ or restrict$ or discourage$)).ti,ab. 16. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (workplace or work place or work site or worksite)).ti,ab. 17. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (public place$ or public space$ or public area$ or office$ or school$ or institution$)).ti,ab. 18. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (legislat$ or government$ or authorit$ or law or laws or bylaw$ or byelaw$ or bye law$ or regulation$)).ti,ab. 19. ((tobacco free or smoke free) adj3 (hospital or inpatient or outpatient or institution$)).ti,ab. 20. ((tobacco-free or smoke-free) adj3 (facilit$ or zone$ or area$ or site$ or place$ or environment$ or air)).ti,ab. 21. ((tobacco or smok$ or cigarette$) adj3 (campaign$ or advertis$ or advertiz$)).ti,ab. 22. ((billboard$ or advertis$ or advertiz$ or sale or sales or sponsor$) adj3 (restrict$ or limit$ or ban or bans or prohibit$)).ti,ab. 23. (tobacco control adj3 (program$ or initiative$ or policy or policies or intervention$ or activity or activities or framework)).ti,ab. 24. ((smok$ or tobacco) adj (policy or policies or program$)).ti,ab. 25. ((retailer$ or vendor$) adj3 (educat$ or surveillance$ or prosecut$ or legislat$)).ti,ab. 26. test purchas$.ti,ab. 27. voluntary agreement$.ti,ab. 28. health warning$.ti,ab. 29. ((tobacco or cigarette$) adj3 (tax or taxes or taxation or excise or duty free or duty paid or customs)).ti,ab. 30. ((cigarette$ or tobacco) adj3 (packaging or packet$)).ti,ab. 31. ((cigarette$ or tobacco) adj3 (marketing or marketed)).ti,ab. 32. ((cigarette$ or tobacco) adj3 (price$ or pricing)).ti,ab. 33. point of sale.ti,ab. 34. vending machine$.ti,ab. 35. (trade adj (restrict$ or agreement$)).ti,ab. 36. (contraband$ or smuggl$ or bootleg$ or cross border shopping).ti,ab. 37. (tobacco control act or clean air or clean indoor air).ti,ab. 38. ((reduce$ or prevent$) adj3 (environmental tobacco smoke or passive smok$ or secondhand smok$ or second hand smok$ or SHS)).ti,ab. 39. ((population level or population based or population orientated or population oriented) adj3 (intervention$ or prevention or policy or policies or program$ or project$)).ti,ab. 40. (community adj3 (intervention$ or prevention or policy or policies or program$ or project$)).ti,ab. 67 41. ((sale or sales or retail$ or purchas$) adj3 (minors or teenage$ or underage$ or under-age$ or child$)).ti,ab. 42. (youth access adj3 restrict$).ti,ab. 43. (smoking cessation or cessation support).ti,ab. 44. (smokefree or smoke-free or smoke free).ti,ab. 45. ((stop$ or quit$ or reduc$ or give up or giving up) adj2 (cigarette$ or tobacco or smoking)).ti,ab. 46. tobacco quit.ti,ab. 47. quit attempt$.ti,ab. 48. quit rate$.ti,ab. 49. (quit line$ or quitline$ or quit-line$).ti,ab. 50. ((smok$ or tobacco or nicotine or cigarette$) adj2 (abstinence or cessation)).ti,ab. 51. or/14-50 52. (socioeconomic or socio economic or socio-economic).ti,ab. 53. inequalit$.ti,ab. 54. depriv$.ti,ab. 55. disadvantage$.ti,ab. 56. educat$.ti,ab. 57. (social adj (class$ or group$ or grade$ or context$ or status)).ti,ab. 58. (employ$ or unemploy$).ti,ab. 59. income.ti,ab. 60. poverty.ti,ab. 61. SES.ti,ab. 62. demographic$.ti,ab. 63. (uninsur$ or insur$).ti,ab. 64. minorit$.ti,ab. 65. poor.ti,ab. 66. affluen$.ti,ab. 67. equity.ti,ab. 68. (underserved or under served or under-served).ti,ab. 69. occupation$.ti,ab. 70. (work site or worksite or work-site).ti,ab. 71. (work place or workplace or work-place).ti,ab. 72. (work force or workforce or work-force).ti,ab. 73. (high risk or high-risk or at risk).ti,ab. 74. (marginalised or marginalized).ti,ab. 75. (social$ adj (disadvant$ or exclusion or excluded or depriv$)).ti,ab. 76. exp socioeconomics/ 77. public assistance/ 78. welfare, social/ 79. exp social status/ 80. social security/ 81. vulnerable population/ 82. or/52-81 83. 13 and 51 84. 82 and 83 85. limit 84 to (abstracts and english language and yr="1990 -Current") 68 PsycInfo (OVID) 1987 to May Week 1 2012, search date 10/05/2012; also 1987 to January week 3 2013, search date 23/01/2013 1. exp tobacco smoking/ 2. exp smoking cessation/ 3. nicotine/ 4. tobacco, smokeless/ 5. (smokers or smoker).ti,ab. 6. tobacco.ti,ab. 7. nicotine.ti,ab. 8. cigar$.mp. 9. smoking.ti,ab. 10. or/1-9 11. exp smoking cessation/ 12. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (ban or bans or prohibit$ or restrict$ or discourage$)).ti,ab. 13. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (workplace or work place or work site or worksite)).ti,ab. 14. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (public place$ or public space$ or public area$ or office$ or school$ or institution$)).ti,ab. 15. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (legislat$ or government$ or authorit$ or law or laws or bylaw$ or byelaw$ or bye law$ or regulation$)).ti,ab. 16. ((tobacco free or smoke free) adj3 (hospital or inpatient or outpatient or institution$)).ti,ab. 17. ((tobacco-free or smoke-free) adj3 (facilit$ or zone$ or area$ or site$ or place$ or environment$ or air)).ti,ab. 18. ((tobacco or smok$ or cigarette$) adj3 (campaign$ or advertis$ or advertiz$)).ti,ab. 19. ((billboard$ or advertis$ or advertiz$ or sale or sales or sponsor$) adj3 (restrict$ or limit$ or ban or bans or prohibit$)).ti,ab. 20. (tobacco control adj3 (program$ or initiative$ or policy or policies or intervention$ or activity or activities or framework)).ti,ab. 21. ((smok$ or tobacco) adj (policy or policies or program$)).ti,ab. 22. ((retailer$ or vendor$) adj3 (educat$ or surveillance$ or prosecut$ or legislat$)).ti,ab. 23. test purchas$.ti,ab. 24. voluntary agreement$.ti,ab. 25. health warning$.ti,ab. 26. ((tobacco or cigarette$) adj3 (tax or taxes or taxation or excise or duty free or duty paid or customs)).ti,ab. 27. ((cigarette$ or tobacco) adj3 (packaging or packet$)).ti,ab. 28. ((cigarette$ or tobacco) adj3 (marketing or marketed)).ti,ab. 29. ((cigarette$ or tobacco) adj3 (price$ or pricing)).ti,ab. 30. point of sale.ti,ab. 31. vending machine$.ti,ab. 32. (trade adj (restrict$ or agreement$)).ti,ab. 33. (contraband$ or smuggl$ or bootleg$ or cross border shopping).ti,ab. 34. (tobacco control act or clean air or clean indoor air).ti,ab. 35. ((reduce$ or prevent$) adj3 (environmental tobacco smoke or passive smok$ or secondhand smok$ or second hand smok$ or SHS)).ti,ab. 36. ((population level or population based or population orientated or population oriented) adj3 (intervention$ or prevention or policy or policies or program$ or project$)).ti,ab. 37. (community adj3 (intervention$ or prevention or policy or policies or program$ or project$)).ti,ab. 38. ((sale or sales or retail$ or purchas$) adj3 (minors or teenage$ or underage$ or under-age$ or child$)).ti,ab. 39. (youth access adj3 restrict$).ti,ab. 40. (smoking cessation or cessation support).ti,ab. 69 41. (smokefree or smoke-free or smoke free).ti,ab. 42. ((stop$ or quit$ or reduc$ or give up or giving up) adj3 (cigarette$ or tobacco or smoking)).ti,ab. 43. quit attempt$.ti,ab. 44. tobacco quit.ti,ab. 45. quit rate$.ti,ab. 46. (quitline$ or quit line$ or quit-line$).ti,ab. 47. ((smok$ or tobacco or nicotine or cigarette$) adj2 (abstinence or cessation)).ti,ab. 48. or/11-47 49. (socioeconomic or socio economic or socio-economic).ti,ab. 50. inequalit$.ti,ab. 51. depriv$.ti,ab. 52. disadvantage$.ti,ab. 53. educat$.ti,ab. 54. (social adj (class$ or group$ or grade$ or context$ or status)).ti,ab. 55. (employ$ or unemploy$).ti,ab. 56. income.ti,ab. 57. poverty.ti,ab. 58. SES.ti,ab. 59. demographic$.ti,ab. 60. (uninsur$ or insur$).ti,ab. 61. minorit$.ti,ab. 62. poor.ti,ab. 63. affluen$.ti,ab. 64. equity.ti,ab. 65. (underserved or under served or under-served).ti,ab. 66. occupation$.ti,ab. 67. (work site or worksite or work-site).ti,ab. 68. (work place or workplace or work-place).ti,ab. 69. (work force or workforce or work-force).ti,ab. 70. (high risk or high-risk or at risk).ti,ab. 71. (marginalised or marginalized).ti,ab. 72. (social$ adj (disadvant$ or exclusion or excluded or depriv$)).ti,ab. 73. exp socioeconomic status/ 74. poverty/ 75. disadvantaged/ 76. or/49-75 77. 10 and 48 78. 76 and 77 79. limit 78 to (english language and abstracts and yr="1990 - 2012") 70 Cochrane Library 2012 (Cochrane Database of Systematic Reviews; Database of Abstracts of Reviews of Effects; Cochrane Central Register of Controlled Trials; Health Technology Assessment Database), search date 10/05/12 #1 MeSH descriptor Smoking, this term only #2 MeSH descriptor Tobacco Use Cessation explode all trees #3 MeSH descriptor Tobacco explode all trees #4 MeSH descriptor Tobacco Use Disorder, this term only #5 MeSH descriptor Nicotine, this term only #6 (smoking or smokers or smoker or tobacco or cigar* or nicotine) #7 (#1 OR #2 OR #3 OR #4 OR #5 OR #6) #8 (smok* or anti-smok* or tobacco or cigarette*) near3 (ban or bans or prohibit* or restrict* or discourage*) #9 (smok* or anti-smok* or tobacco or cigarette*) near3 (workplace or work place or worksite) #10 (smok* or anti-smok* or tobacco or cigarette*) near3 (public next place*) #11 (smok* or anti-smok* or tobacco or cigarette*) near3 (public next space) #12 (smok* or anti-smok* or tobacco or cigarette*) near3 (public next area*) #13 (smok* or anti-smok* or tobacco or cigarette*) near3 (office* or school* or institution*) #14 (smok* or anti-smok* or tobacco or cigarette*) near3 (legislat* or government* or authorit* or law or laws or bylaw* or byelaw* or bye-law* or regulation*) #15 (tobacco-free or smoke-free) near3 (hospital* or inpatient* or outpatient* or institution*) #16 (tobacco-free or smoke-free) near3 (facility* or zone* or area* or site* or place* or environment* or air) #17 (tobacco or smok* or cigarette*) near3 (campaign* or advertis* or advertiz*) #18 (billboard* or advertis* or advertiz* or sale or sales or sponsor*) near3 (restrict* or limit* or ban or bans or prohibit*) #19 (tobacco next control) near3 (program* or initiative* or policy or policies or intervention* or activity or activities or framework) #20 (smok* or tobacco) next (policy or policies or program*) #21 (retailer* or vendor*) near3 (educat* or surveillance or prosecut* or legslat*) #22 test next purchas* in All Fields or (voluntary next agreement*) #23 (sale or sales or retail* or purchas*) near3 (minors or teenage* or underage* or under-age* or child*) #24 (youth near3 access) near3 restrict* #25 health next warning* #26 (tobacco or cigarette*) near3 (tax or taxes or taxation or excise or duty-free or duty-paid or customs) #27 (cigarette* or tobacco) near3 (packaging or packet*) #28 (cigarette* or tobacco) near3 (marketing or marketed) #29 (cigarette* or tobacco) near3 (price* or pricing) #30 "point of sale" #31 vending next machine* #32 trade near3 (restrict* or agreement*) #33 contraband* or smuggl* or bootleg* or (cross-border next shopping) #34 "tobacco control act" or "clean air" or "clean indoor air" #35 reduce* near3 "environmental tobacco smoke" or (passive next smok*) or (secondhand next smok*) or (second next hand next smok*) or SHS #36 prevent* near3 "environmental tobacco smoke" or (passive next smok*) or (secondhand next smok*) or (second next hand next smok*) or SHS #37 (population next level) near3 (intervention* or prevention or policy or policies or program* or project*) #38 (population next based) near3 (intervention* or prevention or policy or policies or program* or project*) #39 (population next orientated) near3 (intervention* or prevention or policy or policies or program* or project*) 71 #40 (community next level) near3 (intervention* or prevention or policy or policies or program* or project*) #41 (community next based) near3 (intervention* or prevention or policy or policies or program* or project*) #42 (community next orientated) near3 (intervention* or prevention or policy or policies or program* or project*) #43 (community next oriented) near3 (intervention* or prevention or policy or policies or program* or project*) #44 smoking next cessation or cessation next support #45 smokefree or smoke-free or smoke next free #46 (stop* or quit* or reduc* or give next up or giving next up) near3 (cigarette* or tobacco or smoking) #47 quit next attempt* #48 tobacco next quit #49 quit next rate* #50 quitline* or quit-line* or quit next line* #51 (smok* or tobacco or nicotine or cigarette*) near2 (abstinence or cessation) #52 (#8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25 OR #26 OR #27 OR #28 OR #29 OR #30 OR #31 OR #32 OR #33 OR #34 OR #35 OR #36 OR #37 OR #38 OR #39 OR #40 OR #41 OR #42 OR #43 OR #44 OR #45 OR #46 OR #47 OR #48 OR #49 OR #50 OR #51) #53 socioeconomic or socio next economic or socio-economic #54 inequalit* #55 depriv* #56 disadvantage* #57 educat* #58 social next (class* or group* or grade* or context* or status) #59 employ* or unemploy* #60 income #61 poverty #62 SES #63 demographic* #64 insur* or uninsur* #65 minorit* #66 poor #67 affluen* #68 equity #69 underserved or under next served or under-served #70 occupation* #71 work next site or worksite or work-site #72 work next place or workplace or work-place #73 work next force or workforce or work-force #74 high next risk or high-risk or at next risk #75 marginalised or marginalized #76 social* next (disadvant* or exclusion or excluded or depriv*) #77 MeSH descriptor Socioeconomic Factors explode all trees #78 MeSH descriptor Public Assistance, this term only #79 MeSH descriptor Social Welfare, this term only #80 MeSH descriptor Vulnerable Populations, this term only #81 (#53 OR #54 OR #55 OR #56 OR #57 OR #58 OR #59 OR #60 OR #61 OR #62 OR #63 OR #64 OR #65 OR #66 OR #67 OR #68 OR #69 OR #70 OR #71 OR #72 OR #73 OR #74 OR #75 OR #76 OR #77 OR #78 OR #79 OR #80) #82 (#7 AND #52) #83 (#81 and #82), from 1990 to 2012 72 Science Citation Index Expanded, Social Sciences Citation Index, Conference Proceedings Citation Index (Science, and Social Science & Humanities), in Web of Science hosted on ISI Web of Knowledge, search date 10/05/12 (TS=(smoking or smokers or smoker or tobacco or cigar* or nicotine) AND TS=(abstinence or cessation or quit*) AND TS=(socioeconomic or socio economic or socio-economic)) AND Language=(English), Timespan=1990-2012 BIOSIS Previews hosted on ISI Web of Knowledge, search date 10/05/12 (TS=(smoking or smokers or smoker or tobacco or cigar* or nicotine) AND TS=(abstinence or cessation or quit*) AND TS=(socioeconomic or socio economic or socio-economic)) AND Language=(English), Timespan=1990-2012 CINAHL Plus (EBSCO host) search date 10/05/12 S8 S5 AND S9, Limiters - Published Date from: 19900101-20121231 S9 S6 OR S7 OR S8 S8 TX social* W1 (disadvantage* or exclusion or excluded or depriv*) S7 TX social W1 (class* or group* or grade* or context* or status) S6 (MH "Socioeconomic Factors") OR "SOCIOECONOMIC" OR (MH "Poverty") OR "POVERTY" OR "EQUITY" S5 S1 OR S2 OR S3 OR S4 S4 TX (stop* or quit* or reduc* or give up or giving up) W3 (cigarette* or tobacco or smoking) S3 TX Smoking W1 cessation S2 (MH "Tobacco, Smokeless") OR (MH "Tobacco Abuse Control (Saba CCC)") OR (MH "Risk Control: Tobacco Use (Iowa NOC)") OR (MH "Passive Smoking") S1 (MH "Smoking Cessation Programs") OR (MH "Smoking Cessation") OR (MH "Smoking Cessation Assistance (Iowa NIC)") ERIC (EBSCO Host) search date 11/05/12 S10 S8 and S9 S9 S4 or S5 or S6 or S7 S8 S1 or S2 or S3 S7 AB Socioeconomic OR AB Poverty OR AB equity S6 ((DE "Socioeconomic Background" OR DE "Socioeconomic Influences" OR DE "Socioeconomic Status") OR (DE "Poverty")) AND (DE "Disadvantaged Environment" OR DE "Economically Disadvantaged" OR DE "Socioeconomic Influences") S5 TX social* W1 (disadvantage* or exclusion or excluded or depriv*) S4 TX social W1 (class* or group* or grade* or context* or status) S3 TX (stop* or quit* or reduc* or give up or giving up) W3 (cigarette* or tobacco or smoking) S2 TX Smoking W1 cessation S1 DE SMOKING 73 Handsearching: 1. Addiction 2012 volume 107 issues 1 to 8 (August 2012) and Early View, search date 31/7/12; also ‘Accepted Articles’, ‘Early View’, search date 14/2/13 and 2012 volume 107 issues 12 and S2, volume 108 issues 1 to 2 search date 18/2/13. 2. Nicotine and Tobacco Research 2012, volume 14, issues 1 to 6, search date 30/7/12; also 2013 volume 15 issues 1 to 3 and ‘Advance Access’ search date 18/2/13. 3. Social Science and Medicine 2012, volume 74 issues 1 to 12, volume 75 issues 1 to 7, articles ‘in press’ search date 31/7/12; also 2013 volumes 74 to 82 ‘in progress’, and ‘articles in press’, search date 18/2/13. 4. Tobacco Control 2012, volume 21, issues 1 to 4, ‘online first’ search date 31/7/12; also volume 21 issue 6, volume 22 issues 1 to 2 and ‘online first’, search date 18/2/13. 74 Searching for grey literature 23/11/12 Dear All, As you know, ENSP is an Associated Partner in the SILNE project (http://www.ensp.org/node/738). In order to support the implementation of Work Package 6: Review & Synthesis by Amanda Amos and Tamara Brown, our colleagues from the University of Edinburgh, and help them to identify any grey literature, we would be grateful if you could inform them of any such literature that they may be able to include in their review, particularly government reports that they may not have identified through their searching. They are now at the stage where they have a complete list of included studies both for the review of youth policies and the review of adult policies. Please see the attached inclusion/exclusion criteria. Attached are also the reference lists of these studies. Amanda and Tamara are specifically interested in any reports of the socio-economic impact of policies which are written in non-English and which an English synopsis could be provided. Please do not hesitate to contact them should you need any further clarification: Tamara Brown Research Fellow Centre for Population Health Sciences University of Edinburgh Teviot Place Edinburgh EH8 9AG Scotland, UK Tel: 0131 650 3237 Fax: 0131 650 6909 Email: tbrown23@staffmail.ed.ac.uk It would be great if you could not remain simply silent. So, even if you have no available information, a simple negative reply would be appreciated. The deadline is 31/12/12. Thanking you in advance, Best regards Francis Francis Grogna Secretary General ENSP - European Network for Smoking and Tobacco Prevention 75 10/12/12 To all members of SILNE, I am pleased to tell you that the youth report for Work Package 6: Review & Synthesis is nearly complete and the adult policy review is well under way. Amanda and I look forward to presenting the initial results of these reviews when we all meet in Brussels in January. Do you know of any grey literature that we may be able to include in our review, particularly government reports that we may not have identified through our searching? We are specifically interested in any reports of the socio-economic impact of policies which are written in non-English and which an English synopsis could be provided. I attach reference lists of included studies both for the review of youth policies and the review of adult policies. I also attach our inclusion/exclusion criteria. Our deadline for receiving literature is 31/12/12. Please let me know if you require any further information and I look forward to some hopeful replies and meeting you again in January. Very best wishes Tamara Tamara Brown Research Fellow Centre for Population Health Sciences University of Edinburgh Teviot Place Edinburgh EH8 9AG Scotland, UK Tel: 0131 650 3237 Fax: 0131 650 6909 Email: tbrown23@staffmail.ed.ac.uk 76 7.2 Appendix B WHO European countries and other stage 4 countries Albania Andorra Armenia Austria Azerbaijan Belarus Belgium Bosnia and Herzegovina Bulgaria Croatia Cyprus Czech Republic Denmark Estonia Finland France Georgia Germany Greece Hungary Iceland Ireland Israel Italy Kazakhstan Kyrgyzstan Latvia Lithuania Luxembourg Malta Monaco Montenegro Netherlands Norway Poland Portugal Republic of Moldova Romania Russian Federation San Marino Serbia Slovakia Slovenia Spain Sweden Switzerland Tajikistan The Former Yugoslav Republic of Macedonia Turkey Turkmenistan Ukraine United Kingdom of Great Britain and Northern Ireland Uzbekistan Other stage 4 countries: Australia, United States, New Zealand, Canada 77 7.3 Appendix C Inclusion/exclusion form Ref ID FIRST AUTHOR COD E ANSWE R 1 YEAR TYPE QUESTION population Is the study population 11 years of age or older? 2 Is it based in a WHO European country or nonEuropean country at stage 4 of the tobacco epidemic? 3 intervention/policy Is it an intervention or policy to reduce adult smoking or to prevent youth starting to smoke? 4 socio-economic inequalities Does it report outcomes for high vs. low socioeconomic group?* What type of study design is it? (highlight) Review RCT Non-randomised controlled study Observational cohort Qualitative Other What type of intervention is it? (highlight) taxation/pricing tobacco advertising and marketing bans smoking cessation support smoke free policies (public places, workplaces, home) school-based interventions mass media campaigns community programmes educational policies social and welfare policies employment policies multifaceted lifestyle interventions/policies (not just smoking cessation) other What type of SES indicator does it report? (highlight) Income Education Occupational social class Area-level socio-economic deprivation Housing tenure Subjective social class Health insurance Proxy measures for youth, i.e. Free School Meals, Family Affluences Scale (FAS) What type of outcomes does it report? (highlight) quit rates initiation rates changes in initiation/cessation or abstinence rates uptake and reach 78 use of quitting aids/services smoking status (self-reported/validated) number of quit attempts exposure prevalence changing attitudes passive smoking policy reach/awareness/comprehensiveness attitude/social norms intentions to smoke sources (i.e. vending machines) second hand smoke exposure other What is the length of follow up? (highlight) <3 months 3 months 6 months 12 months Other Is the intervention Youth or adult or both? (highlight) Individual support or population/policy or both? (highlight) What is the type of analyses? Population-level or individual level or both? (highlight) *INCLUDE? YES/NO/UNCLEAR (highlight) *To be included a paper must be rated as YES to 1 + 2 + 3 + 4 REVIEWER COMMENTS 79 7.4 Appendix D Included studies-Youth Reference Akhtar PC, Haw SJ, Levin KA, Currie DB, Zachary R, Currie CE. Socioeconomic differences in second-hand smoke exposure among children in Scotland after introduction of the smoke-free legislation. Journal of Epidemiology & Community Health 2010; 64(4):341-346. Source MEDLINE Bacon TP, Hilderbrand JA. Impact of a School-Based Drug Prevention Program on Students' Behaviors and Risk and Protective Factors. Paper presented at the Annual Conference of the American Educational Research Association (Seattle, WA, April 10-14, 2001). ERIC Biener L, Aseltine RH, Jr., Cohen B, Anderka M. Reactions of adult and teenaged smokers to the Massachusetts tobacco tax. American Journal of Public Health 1998; 88(9):1389-1391. MEDLINE *Campbell R, Starkey F, Holliday J, Audrey S, Bloor M, Parry-Langdon N et al. An informal school-based peer-led intervention for smoking prevention in adolescence (ASSIST): a cluster randomised trial. Lancet 2008; 371:1595-1602. Mercken 2012 *Crone MR, Reijneveld SA, Willemsen MC, van Leerdam FJ, Spruijt RD, Sing RA. Prevention of smoking in adolescents with lower education: a school based intervention study. Journal of Epidemiology & Community Health 2003; 57(9):675-680. Mercken 2012 *de Vries H, Dijk F, Wetzels J, Mudde A, Kremers S, Ariza C et al. The European Smoking prevention Framework Approach (ESFA): effects after 24 and 30 months. Health Education Research 2006; 21(1):116-132. Mercken 2012 Galan I, Diez-Ganan L, Mata N, Gandarillas A, Cantero JL, Durban M. Individual and contextual factors associated to smoking on school premises. Nicotine and Tobacco Research 2012; 14(4):2012. HAND SEARCH Gilpin EA, Pierce JP. Trends in adolescent smoking initiation in the United States: is tobacco marketing an influence? Tobacco Control 1997; 6(2):122-127. MEDLINE Glied S. Youth tobacco control: reconciling theory and empirical evidence. Journal of Health Economics 2000; 21:117-135. YORK REVIEW Gruber J. Youth smoking in the US:Prices and policies, working paper 7506. 2000. Cambridge, MA. National Bureau of Economic Research (NBER) Working Paper Series. YORK REVIEW Hammond DDJDSB-TM. Impact of Female-Oriented Cigarette Packaging in the United States. Nicotine & Tobacco Research 2011; 13(7):579-588. EXPERT Helakorpi S, Martelin T, Torppa J, Vartiainen E, Uutela A, Patja K. Impact of the 1976 Tobacco Control Act in Finland on the proportion of ever daily smokers by socioeconomic status. Preventive Medicine 2008; 46(4):340-345. MEDLINE 80 Kim H, Clark PI. Cigarette smoking transition in females of low socioeconomic status: impact of state, school, and individual factors. Journal of Epidemiology & Community Health 2006; 60:(Suppl II):ii13ii19. MEDLINE Lipperman-Kreda S, Grube JW, Friend KB. Contextual and community factors associated with youth access to cigarettes through commercial sources. Tobacco Control Online First. 2012. HANDSEARC H Menrath I, Mueller-Godeffroy E, Pruessmann C, Ravens-Sieberer U, Ottova V, Pruessmann M et al. Evaluation of school-based life skills programmes in a high-risk sample: A controlled longitudinal multi-centre study. Journal of Public Health (Germany) 2012; 20(2):159-170. EXPERT Madden D. Tobacco taxes and starting and quitting smoking: does the effect differ by education? Applied Economics 2007; 39:613-627. PHRC REVIEW Mackay D, Haw S, Ayres JG, Fischbacher C, Pell JP. Smoke-free legislation and hospitalizations for childhood asthma. New England Journal of Medicine 2010; 363(12):1139-1145. MEDLINE *Mercken L, Moore L, Crone MR, de VH, De Bourdeaudhuij I, Lien N et al. The effectiveness of school-based smoking prevention interventions among low- and high-SES European teenagers. Health Education Research 2012; 27(3):459-469. EXPERT Millett C, Lee JT, Gibbons DC, Glantz SA. Increasing the age for the legal purchase of tobacco in England: impacts on socio-economic disparities in youth smoking. Thorax 2011; 66(10):862-865. MEDLINE Millett C, Lee JT, Laverty AA, Glantz SA, Majeed A. Hospital admissions for childhood asthma after smoke-free legislation in England. Pediatrics 2013; 131(2):e495-e501. EXPERT Moore GF, Currie D, Gilmore G, Holliday JC, Moore L. Socioeconomic inequalities in childhood exposure to secondhand smoke before and after smoke-free legislation in three UK countries. Journal of Public Health 2012; 34(4):599-608. EXPERT Moore GF, Holliday JC, Moore LA. Socioeconomic patterning in changes in child exposure to secondhand smoke after implementation of smokefree legislation in Wales. Nicotine & Tobacco Research 2011; 13(10):903-910. MEDLINE Nabi-Burza E, Regan S, Drehmer J, Ossip D, Rigotti N, Hipple B et al. Parents smoking in their cars with children present. Pediatrics 2012; 130(6):e1471. EMBASE Noach MB, Steinberg DM, Rier DA, Goldsmith R, Shimony T, Rosen LJ. Ethnic Differences in Patterns of Secondhand Smoke Exposure Among Adolescents in Israel. Nicotine & Tobacco Research 2012; 14(6):648656. HAND SEARCH Pabayo R, O'Loughlin J, Barnett TA, Cohen JE, Gauvin L. Does intolerance of smoking at school, or in restaurants or corner stores HAND SEARCH 81 decrease cigarette use initiation in adolescents? Nicotine & Tobacco Research 2012; first published online February 21, 2012(7). Peretti-Watel P, Guagliardo V, Combes J-B, Obadia Y, Verger P. Young smokers' adaptation to higher cigarette prices: How did those daily smokers who did not quit react? The case of students of South-Eastern France. Drugs: Education, Prevention & Policy 2010; 17(5): 632-640. PsycINFO Pucci LG, Joseph HM, Jr., Siegel M. Outdoor tobacco advertising in six Boston neighborhoods. Evaluating youth exposure. American Journal of Preventive Medicine 1998; 15(2):155-159. MEDLINE Rodgers A, Corbett T, Bramley D, Riddell T, Wills M, Lin RB et al. Do u smoke after txt? Results of a randomised trial of smoking cessation using mobile phone text messaging. Tobacco Control 2005; 14(4):255-261. MEDLINE Schneider S, Gruber J, Yamamoto S, Weidmann C. What happens after the implementation of electronic locking devices for adolescents at cigarette vending machines? A natural longitudinal experiment from 2005 to 2009 in Germany. Nicotine & Tobacco Research 2011; 13(8):732-740. MEDLINE Vallone DM, Allen JA, Xiao H. Is socioeconomic status associated with awareness of and receptivity to the truth campaign? Drug & Alcohol Dependence 2009; 104:Suppl-20:S15-S20. MEDLINE White VM, Hayman J, Hill DJ. Can population-based tobacco-control policies change smoking behaviors of adolescents from all socioeconomic groups? Findings from Australia: 1987-2005. Cancer Causes & Control 2008; 19(6):631-640. MEDLINE Widome R, Brock B, Noble P, Forster JL. The relationship of point-ofsale tobacco advertising and neighborhood characteristics to underage sales of tobacco. Evaluation and the Health Professions 2012; 35(3):331345. EMBASE Woodruff SI. Effect of an eight week smoking ban on women at US Navy recruit training command. Tobacco Control 2009; 9:40-46. Ybarra ML, Holtrop JS, Prescott TL, Rahbar MH, Strong D. Pilot RCT results of Stop My Smoking USA: a text messaging–based smoking cessation program for young adults. Nicotine & Tobacco Research Advance Access. 2013. PsycINFO HANDSEARC H *Mercken 2012 is a secondary analysis paper of Campbell 2008, Crone 2003 and de Vries 2006. 82 7.5 Appendix E Excluded studies-Youth Reference Alwan N, Siddiqi K, Thomson H, Cameron I. Children's exposure to second-hand smoke in the home: a household survey in the North of England. Health & Social Care in the Community 2010; 18(3):257-263. Reason for exclusion Not an intervention or policy to reduce adult smoking or to prevent youth starting to smoke Centers for Disease Control and Prevention (CDC). Response to increases in cigarette prices by race/ethnicity, income, and age groups--United States, 1976-1993. MMWR - Morbidity & Mortality Weekly Report 1998; 47(29):605-609. Does not report outcomes for high versus low socioeconomic group (for youth) El Ansari W, Stock C. Factors associated with smoking, quit attempts and attitudes towards total smoking bans at university: a survey of seven universities in England, Wales and Northern Ireland. Asian Pacific Journal of Cancer Prevention 2012; 13(2):2012. Not an intervention or policy to reduce adult smoking or to prevent youth starting to smoke – attitudes towards possible total smoking ban Fardy PS, White RE, Clark LT, Amodio G, Hurster MH, McDermott KJ et al. Health promotion in minority adolescents: a Healthy People 2000 pilot study. Journal of Cardiopulmonary Rehabilitation 1995; 15(1):65-72. Does not report outcomes for high versus low socioeconomic group Flynn BS, Worden JK, Secker-Walker RH, Pirie PL, Badger GJ, Carpenter JH. Long-term responses of higher and lower risk youths to smoking prevention interventions. Preventive Medicine 1997; 26(3):389-394. Does not report outcomes for high versus low socioeconomic group Hamilton G, Cross D, Resnicow K, Hall M. A school-based harm Does not report minimization smoking intervention trial: outcome results. outcomes for high Addiction 2005; 100(5):689-700. versus low socioeconomic group Hawkins SS, Chandra A, Berkman L. The impact of tobacco control policies on disparities in children's secondhand smoke exposure: a comparison of methods. Maternal and Child Health Journal 2012; 16:S70-77. Included in adult policy review – examines tobacco use among households with schoolage children and adolescents Herbert RJ, Gagnon AJ, O'Loughlin JL, Rennick JE. Testing an empowerment intervention to help parents make homes smokefree: a randomized controlled trial. Journal of Community Health 2011; 36(4):650-657. Does not report outcomes for high versus low socioeconomic group Hublet A, Schmid H, Clays E, Godeau E, Gabhainn SN, Joossens L et al. Association between tobacco control policies and smoking behaviour among adolescents in 29 European countries. Addiction 2009; 104(11):1918-1926. Does not report outcomes for high versus low socioeconomic group Jensen R, Lleras-Muney A. Does staying in school (and not Not based in a WHO working) prevent teen smoking and drinking? Journal of Health European country or non-European country at 83 Economics 2012; 31(4):644-657. stage 4 of the tobacco epidemic – Dominican Republic. Linetzky B, Mejia R, Ferrante D, De Maio FG, Diez Roux AV. Socioeconomic status and tobacco consumption among adolescents: A multilevel analysis of Argentina's global youth Tobacco survey. Nicotine and Tobacco Research 2012; 14(9):1092-1099. Not based in a WHO European country or non-European country at stage 4 of the tobacco epidemic - Argentina. Mata HJ. Development and evaluation of a personalized normative feedback intervention for Hispanic youth at high risk of smoking. Dissertation Abstracts International Section A: Humanities and Social Sciences 73[4-A], 1295. 2012. Does not report outcomes for high versus low socioeconomic group Poulin CC. School smoking bans: do they help/do they harm? Does not report Drug & Alcohol Review 2007; 26(6):615-624. outcomes for high versus low socioeconomic group Schmitt CL. The effect of decision heuristics and ethnicity on cigarette sales to minor girls. Dissertation Abstracts International: Section B: The Sciences and Engineering 2002; .62(9-B). Not an intervention or policy to reduce adult smoking or to prevent youth starting to smoke Sims M, Bauld L, Gilmore A. England's legislation on smoking in Does not report indoor public places and work-places: Impact on the most outcomes for high exposed children. Addiction 2012;107(11): 2009-2016. versus low socioeconomic group regression analyses adjust for SES Straub DM, Hills NK, Thompson PJ, Moscicki AB. Effects of pro- and anti-tobacco advertising on non-smoking adolescents' intentions to smoke. Journal of Adolescent Health 2003; 32(1):36-43. Does not report outcomes for high versus low socioeconomic group Tangari AH, Tangari AH, Burton S, Andrews JC, Netemeyer RG. How do anti-tobacco campaign advertising and smoking status affect beliefs and intentions? Some similarities and differences between adults and adolescents. Journal of Public Policy & Marketing 2007; .26(1):60-74. Does not report outcomes for high versus low socioeconomic group Veldwijk J, Hoving C, van Gelder BM, Feenstra TL. Potential reach of effective smoking prevention programmes in vocational schools: Determinants of school directors' intention to adopt these programmes. Public Health 2012; 126(4):338-342. Not an intervention or policy to reduce adult smoking or to prevent youth starting to smoke - about theoretical intention to adopt a schools programme Weinman ML, Weinman ML. A comparison of three groups of Does not report young fathers and program outcomes. School Social Work outcomes for high Journal 2007; .32(1):1-13. versus low socioeconomic group Wildey MB, Clapp EJ, Woodruff SI, Kenney EM. Retailer Does not report 84 education to reduce the availability of single cigarettes. Journal of outcomes for high Health Education 1995; 26(5):297-302. versus low socioeconomic group 85 7.6 Appendix F Data extraction - Youth Details Method Results Comments Data sources Two surveys of 11 year olds, January 2006 and January 2007 General population impact After legislation cotinine levels fell across all groups Participant selection 11 year olds, final year of primary school. 2006 n=2559 (86%) 2007 n=2424 (85%), 116/170 (68%) schools participated at baseline and 111/170 (65%) schools at follow up Impact by SES variable The greatest absolute decline in cotinine levels was among the lowest SEC and FAS groups even after adjusting for parental smokers (e.g. 0.10ng/ml in SEC1 v 0.28ng/ml in SEC4). However a linear regression model suggests that relative inequality between groups has widened. SHS exposure declined among children from lower SES households, higher in absolute terms but lower in relative terms than among children from higher SES households. Internal validity FAS and SEC determined using child’s answers, including parental occupation and material affluence although questions on family affluence seem fairly simple, so should lead to few being incorrectly categorised. Biochemical measure of smoking. Smoking restriction in cars, workplaces, schools and other public places Author, year Akhtar, 2010 Age (years) 11 Study design Repeat cross-sectional surveys in same schools before and after legislation Objective Explore socioeconomic differences in child exposure to environmental tobacco smoke (CHETS) after Scottish smoke-free legislation Setting Primary schools, Scotland Intervention Smoke-free public and workplaces SES variables used Self-reported family socioeconomic classification (SEC) and family affluence scale (FAS) Study analysis Participant characteristics % low/medium/high FAS divided evenly. SEC mostly SEC1 and 2. FAS score for 96.6% of pupils in 2006 and 94.5% in 2007, and meaningful family SEC (family SEC 1-4) 79.1% in 2006 and 76.7% in 2007 Intervention details Smoking prohibited in almost all public and work places in Scotland from March 2006. Outcomes measured Parental smoking status Pupil’s smoking status Salivary cotinine levels Author’s conclusion of SES impact Smoke-free legislation has reduced exposure to SHS among all children. Although the greatest absolute reduction in cotinine is observed in the lowest SEC/FAS group, cotinine levels remain highest for this group and there is a suggestion of possible increases in inequalities, which may warrant longer-term monitoring External validity No bias detected in nonparticipation rates. Students absent from school on day of data collection were not included, though these represent a small proportion. Ignores those excluded from school, most likely to be low SES. Narrow age group limits generalisability. Same linear analyses as CHETS Wales (Moore 2011). Average cotinine concentrations among children in the Scottish CHETS were substantially higher than in Wales and children’s SHS 86 Details Method Smoking restriction in cars, workplaces, schools and other public places Analysis of variance and linear regression analyses, accounts for cluster and stratification. All results based on confirmed non-smoking pupils Results Comments exposure outside of the home was perhaps greater in Scotland, with impacts of legislation therefore greater overall than in Wales and distributed among all groups Validity of author’s conclusion Valid. Reviewer ratio calculations using reported mean concentrations also suggest a widening of relative inequality by FAS, but not by SEC. The impact of comprehensive smoking bans may differ depending on the pre-ban level of exposure and the balance between sources of exposure i.e. public places v home. 87 Details Method Results Comments Smoking restriction in cars, workplaces, schools and other public places Author, year Galan 2012 Age (years) 15-16 Setting 79 secondary schools, Madrid, Spain Study design Cross-sectional study Objective To evaluate the relationship of contextual factors with smoking on school premises SES variables used School-level: Socioeconomic status of the census tracts in which the school is located, estimated from an index based on aggregate data (unemployment, temporary workers, manual workers, and low educational level among the overall adult [age >15 years] and young adult [age 16–29 years] populations). Individual variables: Educational attainment of parents Data sources Surveillance System of Risk Factors associated with noncommunicable diseases targeting the adolescent population in the fourth year of compulsory secondary education in the Madrid region (15–16 years), 2004-2005. Participant selection Two-stage cluster sampling with stratification in the selection of schools according to area and type (public or private). Overall response rate (schools and students) was 83.1%. Participant characteristics 15-16 year olds in fourth year of compulsory education, N=1179 Outcomes measured Probability of smoking in school Intervention details Survey of smoking behaviour and individual and schoollevel contextual variables General population impact Among smokers, 50.6% had smoked on school premises during the last thirty days with significant variability (0% to 100%) between schools Impact by SES variable Model with school-level and individuallevel variables: a lower probability of smoking on school premises was found among adolescents whose fathers had a university education (OR 0.43, 95% CI: 0.19 to 0.96) or among those who did not know the level of studies of their father (OR 0.39, 95% CI: 0.16 to 0.94) compared with those with fathers who had a very low level of educational attainment. Adolescents with low academic achievement showed an OR of 1.51 (95% CI: 1.00–2.29). Employment status of either parent or educational level of mother was not significant. SES of the census tracts of the school was not significant, nor was written reference to smoking control policy or educational activities about smoking prevention. A lower probability of smoking on school premises was found for state subsidized private schools (odds ratio [OR]: 0.20; 95% CI: 0.11– 0.35) and nonsubsidized private schools (OR: 0.30; 95% CI: 0.14–0.62) when Internal validity The self-completed questionnaire was filled out in the classroom in the presence of previously trained staff. Smoking variable previously validated but potential for response bias. Some subgroups are not sufficiently powered. SES measured by census tracts of the school rather than the location of the home of the student so may not be accurate. External validity Should be representative and generalisable to other secondary schools in Spain and other similar countries. However, presence or absence of smoking policy did not include an evaluation of whether policy was implemented which limits applicability of this study. Validity of author’s conclusion Agreed, census tract of school may not be sensitive to school-level SES 88 Details Method Results Comments Smoking restriction in cars, workplaces, schools and other public places Employment status of parents compared with that for public schools Study analysis Multilevel logistic regression models of smoking population (n=1,179=32.6% analyses on 1,116=94.7% of sample of smokers) Author’s conclusion of SES impact A higher probability of smoking on school premises was found among adolescents whose fathers had a lower level of educational attainment. However, at the contextual level, no relationship was found with socioeconomic status 89 Details Method Results Comments General population impact Before the legislation was implemented, admissions for asthma were increasing at a mean rate of 5.2% per year (95% confidence interval [CI], 3.9 to 6.6). After implementation of the legislation, there was a reduction in the annual rate of 18.2% relative to the rate on March 26, 2006 (95% CI, 14.7 to 21.8; P<0.001), resulting in a net reduction in asthma admissions after implementation of the legislation of 13.0% per year (95% CI, 10.4 to 15.6). After adjustment for the potential confounding effects of sex, age group, urban or rural residence, and quintile of socioeconomic status, admissions for asthma before implementation of the legislation increased by a mean of 4.4% per year (95% CI, 3.3 to 5.5) relative to the rate in January 2000. After implementation of the legislation, there was a reduction of 19.5% (95% CI, 16.5 to 22.4; P<0.001) relative to the rate on March 26, 2006, resulting in a net reduction in admissions for asthma of 15.1% per year (95% CI, 12.9 to 17.2). The trends before the legislation varied according to age group, with a mean annual increase of 9.1% Internal validity Also accounts for deaths the decrease in admissions was not due to an increase in the incidence of deaths before arrival at the hospital. Smoking restriction in cars, workplaces, schools and other public places Author, year MacKay 2010 Age (years) Less than 15 years: 0 to 4 and 5 to 14 years Setting Hospitals, Scotland Study design Repeat cross-sectional (before and after) Objective to determine whether the risk of a hospital admission for childhood asthma has changed since the introduction of comprehensive smoke-free legislation in Scotland. SES variables used area deprivation score: quintiles 1 to 5 Index of Multiple Deprivation 2006 Study analysis negative binomial regression Data sources Scottish Morbidity Record (SMR01) collects information on all admissions to acute care hospitals in Scotland, General Register Office for Scotland collects death-certificate data on all deaths that occur in Scotland. The admission and death databases are linked at an individual level so that records relating to the same person can be identified. Combined SMR01 and deathcertificate data to identify all hospital admissions and deaths before arrival at the hospital that occurred from January 2000 through October 2009 Participant selection Emergency hospital admissions (plus deaths occurring before arrival at hospital) for childhood (0-14 years) asthma, from January 2000 through October 2009 Participant characteristics 21,415 hospital admissions: 11,796 (55.1%) occurred among preschool children and 9619 (44.9%) among school-age children. Outcomes measured admission rate, adjusted admission rate Intervention details National smokefree legislation in Scotland March 2006 External validity Comparable with English study on childhood asthma admissions. Validity of author’s conclusion Cannot determine the extent to which the observed reduction in asthma was due to reduced exposure to environmental tobacco smoke in the home, reduced exposure to environmental tobacco smoke in public places, or a reduction in active smoking among schoolage children. Cannot rule out impact of change in asthma treatments. 90 Details Method Results Comments Smoking restriction in cars, workplaces, schools and other public places among preschool children, as compared with no significant change over time among school-age children. However, the change after legislation was similar in the two groups, with a reduction of 18.4% among preschool children and 20.8% among school-age children relative to the rate on March 26, 2006 Very similar results based on admissions alone as few deaths. Impact by SES variable There were no significant interactions between hospital admissions for asthma and quintile of SES. All SES subgroups associated with significant reduction in admissions. Author’s conclusion of SES impact The additional change after implementation of the legislation was significant in all subgroups 91 Details Method Results Comments General population impact Before the implementation of the legislation, the admission rate for childhood asthma was increasing by 2.2% per year (adjusted rate ratio 1.02; 95% confidence interval [CI]: 1.02–1.03). After implementation of the legislation, there was a significant immediate change in the admission rate of -8.9% (adjusted rate ratio 0.91; 95% CI: 0.89–0.93) and change in time trend of -3.4% per year (adjusted rate ratio 0.97; 95% CI: 0.96–0.98). Overall, the legislation was associated with a net 12.3% reduction of hospital admissions for childhood asthma in the first year. This change was equivalent to 6802 fewer hospital admissions in the first 3 years after implementation. Internal validity ITS - estimates both the immediate change and change in time trend after policy implementation. Changes in diagnostic coding over the study period, may have underestimated the effect of smoke-free legislation if coding of childhood asthma admissions improved over the study period. Smoking restriction in cars, workplaces, schools and other public places Author, year Millett 2013 Age (years) preschool (0–4 years) and school age (5–14 years) Setting Hospitals, England Study design Interrupted time series (before and after legislation) Objective To assess whether the implementation of English smokefree legislation in July 2007 was associated with a reduction in hospital admissions for childhood asthma. SES variables used area deprivation score: quintiles 1 to 5 Index of Multiple Deprivation Study analysis negative binomial regression, multivariate Data sources Hospital Episode Statistics (HES): national administrative database for hospital activity in England Participant selection Nonplanned (emergency) hospital admissions for childhood (0-14 years) asthma, from April 1, 2002 and November 30, 2010 (8.5 years) Participant characteristics 217 381 hospital admissions for childhood asthma, evenly distributed between preschool (50.1%) and school age children (49.9%). The number of admissions was higher in boys (63.4%) than girls (36.6%). Most admissions occurred in children living in urban locations (86.5%), and there were a higher number of admissions in children living in the most deprived areas. Outcomes measured Admission rate, Adjusted admission rate ratio, (ratio of the actual admission rate in relation to the rate projected by the underlying trend) Intervention details National smokefree legislation in England July 2007 Impact by SES variable During the study period there were a higher number of admissions in children living in the most deprived areas. There were similar reductions in asthma admission rates among children from different SES groups. External validity Comparable with Scottish study on childhood asthma admissions. Validity of author’s conclusion One of few studies to report longer-term outcomes for children but does not measure SHS exposure. Cannot rule out impact of change in asthma treatments. Author’s conclusion of SES impact The findings suggest immediate as well as cumulative benefits over time 92 Details Method Results Comments Smoking restriction in cars, workplaces, schools and other public places applying across SES. 93 Details Method Results Comments General population impact There was no significant increase in inequality in the relative likelihood of a child’s sample containing a high level of cotinine (RRR = 1.03; 95% CI = 0.91– 1.17). Internal validity Biochemical measure of smoking. No significant differences between characteristics of pre- and post-legislation samples, nor were there significant differences between those providing useable saliva samples and those providing only questionnaire responses. Required imputation of random values for 47% of cases which limits reliability. Smoking restriction in cars, workplaces, schools and other public places Author , year Moore 2011 Data sources CHETS Wales study Age (years) 11 Participant selection In 2007, 1,611 pupils of an eligible 1,761 pupils within 75 schools completed the smoking questionnaire (91.5%), compared with 1,605 of an eligible 1,775 children within the same 75 schools in 2008 (90.4%). In total, 1,447 children pre-legislation (82.2% of those eligible) and 1,461 children post-legislation (82.3% of those eligible) from 71 schools provided useable saliva samples Setting Primary schools, Wales Study design Repeat cross-sectional surveys of 10-11 year old children in same schools before and after legislation Objective To assess socioeconomic patterning in changes in salivary cotinine concentrations, reports of parental smoking in the home and car and estimates of population-level smoking prevalence following introduction of smoke-free legislation Intervention Smoke-free legislation in Wales SES variables Family Affluence Scale (bedroom occupancy, car ownership, holidays, computer ownership) Participant characteristics Mean age 11 years. Pre-legislation, 422 (27.1%), 606 (39.0%), and 527 (33.9%) of children were assigned to low-, medium-, and high-SES tertiles, respectively. Post-legislation, a slightly smaller proportion of children were assigned to the low-SES group (n = 360, 23.6%), with 621 (40.6%) and 547 (35.8%) assigned to medium- and high-SES groups, respectively. Outcomes Salivary cotinine levels Parental smoking in the home Impact by SES variable The likelihood of providing a sample containing an undetectable level of cotinine increased significantly after legislation among children from high [relative risk ratio (RRR) = 1.44, 95% CI = 1.04–2.00,p=0.03] and medium SES households (RRR = 1.66, 95% CI = 1.20–2.30, p<0.01), while exposure among children from lower SES households remained unchanged (RRR=0.93, 95% CI=0.62-1.40, p=0.72). Parental smoking in the home, car-based SHS exposure, and perceived smoking prevalence were highest among children from low SES households. Parental smoking in the home and children’s estimates of adult smoking prevalence declined only among children from higher SES households. Author’s conclusion of SES impact Post-legislation reductions in SHS exposure were limited to children from higher SES households. Children from lower SES households continue to have External validity Generalisability limited by narrow age group and analyses restricted to children attending school and living with parents, a parent and stepparent or a single parent. Same linear analyses as CHETS Scotland (Akhtar 2010). Average cotinine concentrations among children in the Scottish CHETS were substantially higher than in Wales (Holliday et al., 2009) and children’s SHS exposure outside of the home was perhaps greater in 94 Details Method Smoking restriction in cars, workplaces, schools and other public places Study analysis Car-based SHS exposure Multinomial logistic regression analysis accounting for clustering Intervention details and adjusted for age, year and time Questionnaire plus cotinine assay of data collection. Analyses are limited to children living with parents, a parent and stepparent or a single parent, and who completed the FAS (smoking questionnaire n = 1,555/1,528; salivary cotinine n = 1,397/1,390 pre/post-legislation). Cotinine analyses are limited to children classified as non-smokers [i.e., who both reported being a non-smoker and provided saliva with a cotinine concentration <15 ng/ml (n = 1,362/1,364)]. Results Comments high levels of exposure, particularly in homes and cars, and to perceive that smoking is the norm among adults. Children’s SHS exposure did not worsen for any SES subgroup after introduction of legislation in Wales. However, the unanticipated reductions in children’s SHS exposure following legislation appear limited to children from more affluent households in Wales, whose exposure was already significantly lower prior to legislation, leading to increased socioeconomic disparity. Scotland, with impacts of legislation therefore greater overall than in Wales and distributed among all groups. Validity of author’s conclusion The impact of comprehensive smoking bans may differ depending on the pre-ban level of exposure and the balance between sources of exposure i.e. public places v home. 95 Details Method Results Comments General population impact Relative risk of children’s samples containing no detectable cotinine increased significantly following legislation. Percentages of children with undetectable concentrations increased from 31.0 (n = 1715) to 41.0% (n = 2251) following legislation overall, and from 20.1 to 34.2, 44.9 to 51.0 and from 38.6 to 42.9% in Scotland, Wales and NI, respectively. Relative risk of providing a sample containing a ‘high’ cotinine concentration also increased significantly. Internal validity Biochemical measure of smoking. Children reported on smoking restrictions in homes and cars. SES varied significantly between survey years (affluence higher at follow-up). Smoking restriction in cars, workplaces, schools and other public places Author , year Moore 2012 Age (years) 11.2 Setting Primary schools, Scotland, Northern Ireland, Wales Study design Repeat cross-sectional surveys of children in same primary schools before and after legislation Objective To pool data from 3 countries in order to assess socioeconomic patterning in SHS exposure and parental restrictions on smoking in homes and cars before and after smokefree legislation Intervention Smoke-free legislation in Scotland, Northern Ireland, Wales SES variables Family Affluence Scale (bedroom occupancy, car ownership, holidays, computer ownership) Data sources CHETS Scotland, Northern Ireland and Wales studies, questionnaire plus cotinine assay Participant selection Of 586 schools approached, 320/304 (54/51%) participated at baseline/follow-up. Participant characteristics 10 867 non-smokers (self-reported nonsmokers providing saliva samples containing <15 ng/ml cotinine) in their final year at 304 primary schools in Scotland (n = 111), Wales (n = 71) and NI (n = 122). Outcomes Salivary cotinine levels Smoking restrictions in the home Smoking restrictions in the car Intervention details National smokefree legislation prohibiting smoking in enclosed public places and workplaces (Scotland March 2006, Wales March 2007, Northern Ireland (NI) April 2007 Impact by SES variable Relative risk of children’s samples containing no detectable cotinine increased significantly as SES increased, whilst the relative risk of samples containing a ‘high’ cotinine concentration fell. These associations were almost identical in all countries, remaining significant after entry of terms for parental smoking and private smoking restrictions. This inequality appears to have widened following legislation (in the combined data set and trend in individual countries), with percentages of samples above the limit of detection ranging from 96.9 to 38.2% for the least and most affluent children, respectively, after legislation. Gradients for higher exposure levels remained relatively unchanged. External validity Generalisability limited by narrow age group and analyses restricted to children attending school and living with parents, a parent and stepparent or a single parent. However pools data from 3 CHETS studies. Validity of author’s conclusion Valid. Impact may differ between individual countries because baseline cotinine concentrations differed between countries. Difficult to compare results by SES pertaining to individual countries with other CHETS papers because analyses are different. 96 Details Method Results Comments Smoking restriction in cars, workplaces, schools and other public places Study analysis Multinomial logistic regression analysis accounting for clustering and adjusted for age and country. Binomial logistic regression for carbased smoking. In all countries, and the combined data set, as SES increased, the likelihood of partial or no home smoking restrictions (rather than full smoking restrictions), decreased significantly, whilst the odds of smoking being allowed inside the family car also decreased significantly. These trends remained after adjustment for parental smoking No change in inequality following legislation for home and car-based smoking restrictions (socioeconomic patterning remained stable). Author’s conclusion of SES impact Socioeconomic inequality in the likelihood of a child’s sample containing detectable traces of cotinine increased. Hence, declines in exposure occurred predominantly among children with low exposure before legislation, and from more affluent families. Substantial socioeconomic gradients in proportions of children with higher SHS exposure levels remained unchanged. Post-legislation changes in smoking restrictions in cars or homes were not patterned by socioeconomic status. 97 Details Method Results Comments Smoking restriction in cars, workplaces, schools and other public places Author , year Nabi-Burza 2012 Age (years) 26% (n=214) aged less than 1 year; 35% (n=288) aged 1 to 4 years; 19% (n=158) aged 5 to 9 years); 18% (n=147) aged 10 years or over Setting Paediatric clinics in 8 US states Study design Cross-sectional study Objective To determine prevalence and factors associated with strictly enforced smoke-free car policies among smoking parents. SES variable education (high school or less versus some college or college Data sources Baseline data collected at paediatric practices enrolled in the control arm of a cluster, randomized controlled trial, Clinical Effort Against Secondhand Smoke Exposure. Participant selection Participants were eligible to enrol in the study if they had accompanied a child to the office visit, had smoked at least a puff of a cigarette in the past 7 days, were the parent or legal guardian of the child seen that day, were at least 18 years old, and spoke English. Enrolled parents received $5 in cash for completing the baseline enrolment survey. Screening continued until 100 eligible parents were enrolled at each practice. Participant characteristics 817/981 parents reported having a car. The majority (70%) of the parents were in the age group 25 to 44 years, 77% were females, mostly mothers (98% vs 2% legal guardians), and 68% were non-Hispanic whites. Many parents (42%) had only a high school degree, and 16% had completed college. Most of the children (60%) were covered by Medicaid Outcomes Smokefree car policy Intervention details General population impact Of 795 parents, 73% reported that someone had smoked in their car in the past 3 months. Less than 1 in 3 parents who had a smoke-free car policy reported that it was violated in the past 3 months. Of the 562 parents who did not report having a smoke-free car policy, 48% reported that smoking occurred with children present in the car. Approximately one-fifth of all enrolled parents reported being asked by a paediatric health care provider about their smoking status. Only 14% of smoking parents reported being asked if they had a smoke-free car, and 12% reported being advised to have a smoke-free car policy by a paediatric health care provider. Internal validity Unable to ascertain how representative the study sample was. Self-reported outcome data. External validity Sample excludes non-car owners. Sample is derived from 8 US states. Validity of author’s conclusion Educated was not significantly associated with smokefree car policy on its own, only significant in interaction with child age and amount smoked. Impact by SES variable No association between parent’s age, race and ethnicity, education, and intention to quit smoking with having a strictly enforced smokefree car policy. Exploratory analyses assessed possible interactions between the 4 parent demographic variables (age, gender, race, and education) and the 3 significant predictors of car policy (child’s age, number of 98 Details Method Results Comments Smoking restriction in cars, workplaces, schools and other public places graduates) Questionnaire of smoking behaviour in cars cigarettes smoked per day by the and home parent, and having another smoker at home). Parent gender and Study analysis education interacted Logistic regression with child’s age: parents of children aged <1 year were more likely to have strict smoke-free car policies if they were female (OR: 3.00 [95% CI: 1.22– 7.38], P = .016) or college educated (OR:2.42 [95% CI: 1.21–4.83], P = .013). Strict smoke-free car policies were more common when parents were both light smokers (smoked 10 or less cigarettes per day) and college educated (OR: 2.88 [95% CI: 1.24–6.66], P = .013). Author’s conclusion of SES impact College educated parents of children aged <1 year were more likely to have strict smoke-free car policies. 99 Details Method Results Comments Smoking restriction in cars, workplaces, schools and other public places Author , year Noach 2012 Age (years) 15 Setting Schools, Israel Study design Cross-sectional study Objective To examine determinant of SHS exposure in Israeli adolescents SES variable Maternal and paternal education (<12 years, 12 years, College or University, other degree) Study analysis Logistic regression models Data sources Israel National Health and Nutrition Youth survey among 7-12th grade, 2003-2004 Participant selection Israel Ministry of Education provided list of approximately 1,000 schools from the statesponsored educational system. Sample stratified by population group (Jewish, Arab + Bedouin, Druze), stream (state, state religious), school level (7–9, 10–12), and SES (defined by the Ministry of Education as related to the school, as low, high). For each school chosen as a primary sampling unit, the grade level and then the class within each grade level were randomly selected. Response rates were high (school: 91.8%, child: 87.9%), with 6,274 participants. Participant characteristics Average age was 15 years (11–19 years). N=6,274 students: 55.7% girls, 44.3% boys; 70% Jews, 30% non-Jews (18% Moslem Arab, 4% Christian Arab, 6% Druze, and 1% Christian). Outcomes Correlates of exposure to SHS at home, school, entertainment, ‘other’ places General population impact Most Israeli adolescents were exposed to SHS (total: 85.6%; home: 40%; school: 31.4%; entertainment: 73.3%; other: 16.3%). Impact by SES variable Parental education is not a significant determinant of smoking in school Home: Teenagers whose fathers had less than 12 years of education (OR = 1.48; CI: 1.09, 1.99; p = .0111) were more exposed than were teenagers whose fathers had a degree from a university or college. Teenagers with lesseducated mothers (OR = 1.39; CI: 1.02, 1.90; p = .0366) were more exposed than teenagers with mothers with degrees from a university or college. Author’s conclusion of SES impact The high levels of SHS exposure among Israeli adolescents were characterized by different patterns of exposure among different population groups Internal validity The smoking question in the survey has not been validated by biochemical measures in Israel. Main aim of the survey was to assess nutritional status and so smoking question is basic yes/no. External validity Schools from the ultraorthodox Jewish, independent and private sectors were excluded, as were boarding schools. Israel is heterogeneous with broad range of ethnic, religious and socioeconomic populations and is not generalisable to other WHO European or stage 4 countries. Validity of author’s conclusion No comprehensive smokefree bans at time of survey so survey is not assessing impact of specific policy implementation but lending support to National Tobacco Control plan recently approved by Israeli government Intervention details Survey 100 Details Method Results Comments General population impact Among the 4393 recruits who provided entry and graduation survey data, 41.4% (n = 1819) reported being smokers at entry (that is, reported any smoking in the 30 days before entering). Twenty five per cent (n = 1110) of all women recruits reported being a smoker at graduation, a significant reduction from the 41% smoking rate at entry into RTC (McNemar ÷2 = 665.7, p < 0.001). Slightly over two thirds (n = 724) of “smokers” who responded to the follow up survey had resumed smoking three months after graduation, and 32% (n = 340) reported not smoking. Among past month smokers at entry to RTC, the relapse rate at the three month follow up was 81%. Daily smokers at entry had the highest relapse rate (89%)=11% follow-up cessation rate Internal validity Response bias is present; low response rate at 3 month follow-up, nonrespondents had a slightly higher past 30 day smoking rate at baseline than did respondents. Definition of ‘smoker’ differed at graduation (post 8 weeks) from baseline and 3 month follow-up. Group of smokers assessed for relapse was broadly defined and included daily smokers, occasional smokers, experimenters, or former smokers. Impact by SES variable Education did not significantly predict relapse Validity of author’s conclusion Study did not aim to assess differential impact by SES. Smoking restriction in cars, workplaces, schools and other public places Author, year Woodruff 2000 Data sources Intervention study Age (years) 19 Participant selection 5505/5197=93% response amongst recruits who volunteered to take part; 86% response rate among 5129 eligibles, n=4411/5129, eversmokers at entry=2820/4411, 39% response rate for 3 month follow-up, n=1077/2748 (72 left Navy before follow-up); volunteers entering Recruit Training Command Illinois March 1996-March 1997 Setting Recruit Training Command, US Study design Before and after experimental study Objective To examine the effect of a US Navy smoking ban in female recruits Intervention Organisational smoking ban for 8 weeks, unique as 24-hour ban with ‘live-in’ recruits SES variable Education (less than a high school education, high school, and greater than a high school education); Study analysis Predictors of changes in perceptions of being a smoker: stepwise logistic regression to determine the Participant characteristics All female. The mean (SD) age was 19 (2.75) years. The majority (94.5%) had at least a high school education. Recruits were ethnically diverse, with 42% belonging to ethnic groups other than white non-Hispanic. Outcomes Perceived smoking status Smoking relapse Intervention details 8-week 24-hour smoking ban External validity Not generalizable to civilian population or setting. All female. Author’s conclusion of SES impact None- Study did not aim to assess differential impact by SES 101 independent correlates of graduation smoking status. Predictors of relapse at 3 month follow-up: multivariate logistic analysis 102 Details Method Results Comments General population impact 1979 to 1984 adolescent initiation rates decreased but increased thereafter Internal validity Respondents are asked about how old they were when they started smoking (retrospective so potential for recall bias and underreporting) Controls on advertising, promotion and marketing of tobacco Author, year Gilpin & Pierce 1997 Age (years) 14-21 in 1979 to 1989 Setting US Study design Cross-sectional study Objective To investigate the possible association between increased tobacco marketing and increased smoking initiation by adolescents Intervention Examines trends in smoking initiation by inflation-adjusted cigarette prices and tobacco industry budget for marketing SES variables used Education (less than 12 years, 12 years with no college education, more than 12 years with some college education as adults) Data sources Combined data from 3 Current Population Surveys (September 1993, January 1993, May 1993) that contained special supplement on tobacco use. One quarter=in person interviews and ¾ = telephone interviews. Tobacco Institute for weighted average pack prices, US Federal Trade Commission for marketing expenditure; adjusted to 1989 dollars using Consumer Price Index Participant selection Civilian non-institutionalised population aged 15 years+, surveyed about 56,000 households per month Participant characteristics Analysis restricted to respondents 17-38(n=140,975) that would have been 14-21 in 1979 to 1989 Impact by SES variable Initiation rates highest among high school dropouts and lowest amongst those who eventually attended college. Only quadratic model significant for dropouts (p=0.035). Neither model was significant for highschool graduates and both models were significant for ‘some college’ (p=0.081 linear, p=0.014 quadratic). In 1988 initiation rate was 9.9% for those who did not graduate from high school, 6.9% for high-school graduates reporting no college and 3.7% for those reporting at least some college. Author’s conclusion of SES impact External validity Initiation rates are for decade 1979 to 1989 so relatively older study which limits its generalisability to current youth Validity of author’s conclusion Tentative because study links overall initiation rates by marketing budget but doesn’t assess marketing budget impact on initiation rates by education level Marketing expenditure may be associated with an increase in smoking initiation especially in young people with lower levels of education. Outcomes measured Initiation rates by education (rate calculated as number in an age group who reported starting smoking regularly in a year, divided by number of never-smokers at start of the year) Study analysis 103 Details Method Results Comments Controls on advertising, promotion and marketing of tobacco Linear or quadratic models fitted to Intervention details initiation rates Examines trends in smoking initiation by inflation-adjusted cigarette prices and tobacco industry budget for marketing 104 Details Method Results Comments General population impact Fully branded female packs were rated significantly more appealing than the same packs without descriptors, “plain” packs, and non – female- branded packs. Femalebranded packs were associated with a greater number of positive attributes including glamour, slimness, and attractiveness and were more likely to be perceived as less harmful. Approximately 40% of smokers and non-smokers requested a pack at the end of the study; female- branded packs were 3 times more likely to be selected than plain packs. Internal validity Reports significant sociodemographic predictors only, convenience sample Education varied by condition, with the highest level of education in the standard condition ( χ 2 = 18.0, p = .04), and number of smoked cigarettes per day was significantly higher in the plain condition ( M =10.6) compared with the standard condition ( M = 7.7, B = −0.14, p = .046) among current smokers Controls on advertising, promotion and marketing of tobacco Author, year Hammond 2011 Age (years) 18-19 Setting US Study design Randomised controlled trial Objective To examine the impact of cigarette pack design among young women Intervention Short online survey intervention looking at brand appeal of tobacco packaging SES variables Education level categorized as “low ” (grade school or some high school), “ medium ” (high school, technical school , or community college), and “ high ” (university). Income Study analysis Data sources Online survey of 18-19 year old women in US in February 2010 Participant selection Convenience sample of 826 female smokers and non-smokers aged 1819 years, recruited via email from a consumer panel through Global Market Insite Inc. (panel reach 2.8 million) participants received approximately $2USD for completing the survey. Randomised to four experimental conditions after ascertaining smoking status Participant characteristics 18-19 year old women, education varied by condition, with the highest level of education in the standard condition ( χ 2 = 18.0, p = .04), Outcomes measured Packs rated by participants on measures of appeal and health risk, also behavioural pack selection task Intervention details Online survey intervention. Participants viewed eight cigarette packages, one at a time, displayed in a random order. Packages were Impact by SES variable Participants in the high- income (B = 0 .11, p = .004) and high education (B = 0 .08, p = .05) categories endorsed a greater number of positive smoker traits (female/male, glamorous/not glamorous, cool/not cool, popular/not popular, attractive/unattractive, slim/overweight, and sophisticated/not sophisticated) than those in the low- income and low education categories. High- income respondents were more likely to endorse smoking and weight control beliefs compared with respondents reporting low ( OR = 1.70, 95% CI = 1.12 – 2.60) and medium income ( OR = 1.73, 95% CI = 1.09 – 2.73) and those who did not state their income ( OR = 2.17, 95% CI External validity Young women only limit generalisability. Validity of author’s conclusion The reactions to/perceptions of the different types of packs was the same by SES for nearly all the measures. Thus, very tentatively, plain packaging might have a neutral equity effect for young women. Equity impact was not a main aim of the study. 105 Details Method Controls on advertising, promotion and marketing of tobacco Regression models were used to displayed according to each examine the effect of experimental of the four experimental conditions: condition for three primary outcomes: ( 1) female-oriented packages pack ratings, smoker image ratings, (standard condition); ( 2) femaleand beliefs about smoking. For each oriented packages with brand outcome, regression models were imagery, including colours and conducted in two steps. In Step 1, graphics, but with descriptors (i.e., the model included only the slims) removed; ( 3) female-oriented “condition” variable. In Step 2 of the packages without brand imagery model, the following variables were and descriptors (i.e., plain packages); entered as covariates: age, and (4) popular U.S. brands of “ education, income, ethnicity, smoking regular ” or non – female- oriented status, and weight concerns. In Step packages 3, all two-way interactions with the “condition” variable were tested by entering each interaction term into the model one at a time. Results Comments = 1.29 – 3.65). No significant differences in pack selection were observed for smoking status, age, income, education, ethnicity, or weight concerns Author’s conclusion of SES impact Not stated 106 Details Method Results Comments General population impact The greatest number of sites for any neighbourhood was 22 in Roxbury, with Mattapan (21) second and East Boston (16) third. These three neighbourhoods also shared the top three positions for number of units: Mattapan (169), Roxbury (124), and East Boston (113). The overall advertising density for schools in all neighbourhoods combined was higher for middle (10.1) and high schools (9.9) than for elementary schools (6.3) Internal validity Uses actual observations of tobacco density and links to buffer zones. However study does not include point-ofpurchase advertising, advertising inside stores that is seen from the street, or advertising on taxis and buses. Controls on advertising, promotion and marketing of tobacco Author , year Pucci 1998 Age (years) 5-14, 15-19 Setting Boston, US Study design Cross-sectional study Objective To determine the prevalence, type and proximity to public schools of all stationary outdoor tobacco advertising in 6 Boston neighbourhoods Intervention Youth exposure to tobacco advertising density within FDA 1,000 foot buffer zones around schools SES variable Neighbourhoods defined by median income per household from Boston Neighborhood Health Status Report Data sources field survey using single observations in 1996. Six Boston neighbourhoods—two with the highest, two with middle, and two with the lowest median household incomes—were selected. July to August 1996, four observer teams (one adult and two to three youth), recruited from Boston summer youthemployment programs, participated in 2-day training. Observations made by the teams were validated by randomly selecting 8 sites. An independent observer who had attended the team training conducted follow- up observations within a week of the original observations. Participant selection The neighbourhoods, as defined in the Boston Neighborhood Health Status Report, are (from highest to lowest median income) Beacon Hill ($38,816), West Roxbury, Mattapan, North End, East Boston, Roxbury ($19,351). Impact by SES variable East Boston and Roxbury, the two neighbourhoods with the lowest median incomes, showed the highest number of advertising sites inside the buffer zones, 16 and 18, respectively External validity Unable to assess generalisability of these 6 Boston neighbourhoods as no details provided. Validity of author’s conclusion Valid but probably underestimates density. Author’s conclusion of SES impact The majority of outdoor tobacco advertising was in the neighbourhoods with the lowest median household incomes Participant characteristics 580 advertising units at the 94 sites Outcomes Advertising density by school level 107 Details Method Results Comments Controls on advertising, promotion and marketing of tobacco Study analysis and neighbourhood Advertising sites plotted using MapInfo, density calculated by Intervention details dividing number of advertising units Observational survey identifying by area of buffer zone advertising sites 108 Details Method Results Comments Data sources Seven waves of Legacy Media Tracking Survey data (telephone survey), collected from September 2000 through January 2004. The LMTS was developed to track awareness of, and receptivity to, American Legacy Foundation’s truth® campaign. General population impact N/A Internal validity Appends SES proxy measures (zip codes) to data as LMTS did not measure SES. Intervention methods differed over time: proportion of campaign broadcast on cable increased over time. Survey developed specifically for this campaign but repeated over 7 waves and 4 years. Mass media campaigns Author , year Vallone 2009 Age (years) 12-17 Setting US Study design Cross-sectional study Objective To determine whether SES is associated with awareness of and receptivity to the truth® campaign among youth aged 12–17. Intervention The truth® campaign is a branded countermarketing campaign SES variable Median household income and median household education at the zip code level. Study analysis This receptivity analysis using bivariable and multivariable analyses is limited to participants who Participant selection Response rates for the LMTS ranged from 60% to 30% per wave, with a general pattern of decline over time. The samples for each survey wave were generated by a combination of random digit dial (RDD) and supplementary lists. Listed sample was used to achieve target numbers within geographic and racial/ethnic populations. African American, Hispanic and Asian youth and young adults were oversampled in each survey wave in an effort to generate sufficient sample sizes among racial/ethnic groups. To evaluate the campaign, oversamples were also drawn in some survey waves from within three sentinel sites, from within states which had strong tobacco countermarketing campaigns, and those with variation across truth® gross ratings points Impact by SES variable Youth who lived in zip codes in which the median household income was less than or equal to US$ 35,000 had a lower level of confirmed awareness than respondents in each of the other income categories (p < 0.05). There were no statistically significant differences in confirmed awareness by median level of education, though there was a pattern in which the proportion of confirmed awareness increased with education. Similarly, there were no differences in receptivity by median household income or median household education, though there was a pattern of increasing receptivity with greater income and education Author’s conclusion of SES impact From 2000 to 2004, both female and male youth living in lower education zip codes had lower odds of having confirmed awareness of truth® as compared with youth living in more highly educated zip codes. Zip code level median household income was not associated with confirmed awareness. However, there were no differences in receptivity to the campaign by zip code level income or education. External validity Generalisability may be limited due to response rates; which ranged from 60% to 30% per wave, with a general pattern of decline over time. An examination of the sample demographics across the seven survey waves indicates that there are some statistically significant differences across waves over time; however, further analyses revealed no systematic bias with regard to demographic characteristics by response rate. Could such a huge, lengthy and expensive campaign be applied outside the US? Only national organisations are likely to run similar mass-media 109 Details Mass media campaigns demonstrated confirmed awareness of the campaign. Zip codes were appended to the data files by one of two means: (1) for the listed sample, zip codes were linked to street addresses; (2) for the RDD sample, the most probable zip code associated with that telephone exchange was selected. Method (GRPs). Participant characteristics 30,512, including 15,335 female and 15,177 male respondents. By age group, 51.5% age 12–14 and 48.5% age 15–17. 57.19% identified as white, 20.0% as Hispanic, 15.0% as African American and 7.9% as Asian American. Most of the sample had never smoked (76.3%); however, 16.1% were former smokers and 7.6% were current smokers. Youth watched a mean of 3.3 h of TV per day, and 80.9% had cable access. The median household income distribution by zip code was as follows: 25.0% of respondents lived in zip codes in which the median household income was less than or equal to US$ 35K per year; 26.0% lived in US$ 35–45K zip codes, 24.2% lived in US$ 45–60K zip codes and 24.9% lived in wealthier zip codes. The median household education distribution by zip code was as follows: 17.8% of respondents lived in zip codes in which the median household education was less than or equal to 12 years; 39.7% lived in zip codes in which the median household education was 13 years, 30.5% lived Results Comments campaigns due to prohibitive cost Validity of author’s conclusion Valid but awareness and receptivity do not inform us of changes in smoking behaviour. Difference in results between awareness according to income or education, and between awareness and receptivity outcomes, may indicate measurement issues of how or what study is measuring? 110 Details Method Results Comments Mass media campaigns in zip codes in which the median household education was 14 years and 12.0% lived in more educated zip codes. Outcomes Confirmed awareness and receptivity Intervention details The truth® campaign is a branded countermarketing campaign designed to prevent smoking among at-risk youth, primarily through edgy television advertisements with an anti-tobacco industry theme 111 Details Method Results Comments General population impact 26% (10.4,42.0) cut costs, 21% (9.3,31.9) considered quitting, 53% (36.8, 69.6) no response Internal validity 53% of the teenagers who continued to smoke denied having had any of the 3 potential reactions to price increase. Analysis restricted to small sample. Increases in price/tax of tobacco products Author, year Biener 1998 Age (years) 12-17 Setting Massachussetts, US Study design Cross-sectional study Objective Examines smokers perceptions of the impact of new tobacco taxes Intervention Statewide (Massachusetts) tobacco control programme SES variables used household income is dichotomised at the median, for teenagers=$50,000/y, obtained from the report of an adult household resident Data sources Telephone interviews from sample from random-digit-dialling, 1993-1994 Participant selection Screening interviews for 78% of sampled households (random-digit dialling), 75% response rate for youths=1606 youth interviews Participant characteristics Analysis restricted to 216 current teenage smokers who reported having ever bought cigarettes Outcomes measured Smoking behaviour Intervention details Survey retrospectively assessing reactions to 1993 tax increase Impact by SES variable Teenaged smokers from low income households were much more likely to cut costs of their smoking in response to the price increase, rather than do nothing (OR 7.57, 95%CI 1.55,36.98) or cut costs rather than consider quitting (OR 14.72, 95%CI 2.55,84.95), household income was unrelated to the choice between considering quitting and doing nothing (OR 0.51, 95% CI 0.13,2.77), these significant bivariate effects are still significant in multivariate model External validity No further details of teenager demographics although reports that age and sex not significantly related to reported response to price increase Validity of author’s conclusion Possible that study failed to measure an important variable. Author’s conclusion of SES impact Low-income teenagers more likely than more affluent teens to cut costs by cutting down on smoking or (less often) by switching to cheaper brands. Young lowincome smokers were not more likely than wealthier teenagers to consider quitting Study analysis Multinomial logistic regression using bivariate and multivariate models 112 Details Method Results Comments General population impact 1979 to 1984 adolescent initiation rates decreased but increased thereafter Internal validity Respondents are asked about how old they were when they started smoking (retrospective so potential for recall bias and underreporting) Increases in price/tax of tobacco products Author, year Gilpin & Pierce 1997 Age (years) 14-21 in 1979 to 1989 Setting US Study design Cross-sectional study Objective To investigate the possible association between increased tobacco marketing and increased smoking initiation by adolescents Intervention Examines trends in smoking initiation by inflation-adjusted cigarette prices and tobacco industry budget for marketing SES variables used Education (less than 12 years, 12 years with no college education, more than 12 years with some college education as adults) Data sources Combined data from 3 Current Population Surveys (September 1993, January 1993, May 1993) that contained special supplement on tobacco use. One quarter=in person interviews and ¾ telephone interviews. Tobacco Institute for weighted average pack prices, US Federal Trade Commission for marketing expenditure; adjusted to 1989 dollars using Consumer Price Index Participant selection Civilian non-institutionalised population aged 15 years+, surveyed about 56,000 households per month Participant characteristics Analysis restricted to respondents 17-38(n=140,975) that would have been 14-21 in 1979 to 1989 Impact by SES variable Initiation rates highest among high school dropouts and lowest amongst those who eventually attended college. Only quadratic model significant for dropouts (p=0.035). Neither model was significant for highschool graduates nor both models were significant for ‘some college’ (p=0.081 linear, p=0.014 quadratic). In 1988 initiation rate was 9.9% for those who did not graduate from high school, 6.9% for high-school graduates reporting no college and 3.7% for those reporting at least some college. Author’s conclusion of SES impact Increase in cigarette taxes did not reduce smoking initiation rates. External validity Initiation rates are for decade 1979 to 1989 so relatively older study which limits its generalisability to current youth Validity of author’s conclusion Tentative because study links overall initiation rates by marketing budget but doesn’t assess marketing budget impact on initiation rates by education level Outcomes measured Initiation rates by education (rate calculated as number in an age group who reported starting smoking regularly in a year, divided by number of never-smokers at start of the year) Study analysis 113 Linear or quadratic models fitted to initiation rates Intervention details Examines trends in smoking initiation by inflation-adjusted cigarette prices and tobacco industry budget for marketing 114 Details Method Results Comments General population impact Longitudinal data: Taxes at age 14 had a significant negative impact on later smoking behaviour (elasticity -0.66, p<0.05) although this effect reduced over time. This result was confirmed by the fixed effect analysis. Cross-sectional data: Taxes at age 14 had a significant negative impact on current smoking at ages 19-28 (elasticity -0.96, p<0.01) and late initiation (p<0.10), but no effect on quitting. Internal validity Longitudinal data and crosssectional data appear to be similar and similar for general population and for low-income population Increases in price/tax of tobacco products Author, year Glied 2002 Age (years) 14-23 in 1979 Setting US Study design Prospective longitudinal cohort study with cross-sectional analysis (econometric) Objective To test the assumption that policies targeting youth to reduce smoking initiation will reduce lifetime smoking propensities Intervention Estimates the effect of cigarette taxes at age 14 on future overall smoking behaviour, quitting and initiation SES variables used Family income in 1979 below the sample median (about $12,000 in Data sources Smoking data from the National Longitudinal Survey of Youth (1979, 84, 92 and 94). Cigarette tax rates and tax policies from the Tobacco Institute 1996 Participant selection No details Participant characteristics N=7,605; Sixty percent had tried cigarettes by age 16, mean (SD): age 17.5 (2.2), age began smoking 13.6 (3.4); 53% female; 30% black; 18% Hispanic; mean (SD) family income in 1979 $18,270 ($11,747) Outcomes measured Smoking participation, quitting, initiation Intervention details Assesses relationship (price elasticity) between tax and smoking behaviour over time and across time Impact by SES variable Longitudinal data Low income (< $12,000 median in 1979) -0.65, p<0.10 (at age 14) -0.33 (at age 24) -0.01 (at age 34) 0.15 (at age 39) Tax at age 14 had a statistically significant negative effect on current smoking overall, for low income people. Elasticities declined over time for low income people indicating that by age 39 the effect of taxes at age 14 has largely disappeared. Cross-sectional data Current smoking at age 19 to 28 -1.00, p<0.05 (low income) Taxes at age 14 had most effect on low income people at ages 19-28 although this External validity Not clear if National Longitudinal Survey of Youth was representative as minorities were oversampled, and the analysis was restricted to only those surveyed in 1979, 84, 92 and 94. Validity of author’s conclusion Valid. 115 Details Method Increases in price/tax of tobacco products 1979) Study analysis Model: using longitudinal data: (1) probit model including the effects of time and how taxes change over time, with adjustment for clustering within an individual; (2) ordinary least squares regression using individual fixed effects with an interaction term between tax at and time since age 14. Using cross-sectional data (analysing 1984, 92 and 94 separately) to estimate the effect of taxes at age 14 on overall smoking behaviour, quitting and initiation. Results Comments reduced and was no longer significant in later years. Quitting Taxes at age 14 had a positive but not significant effect on quitting by the age of 27 to 37 for low income people. Late initiation (starting after age 16) Taxes at age 14 did not have a significant effect on late initiation for low income people. Author’s conclusion of SES impact These results suggest that reducing smoking among teens through tax policy may not be sufficient to substantially reduce smoking in adulthood 116 Details Method Results Comments General population impact N/A – all results stratified by age There is no public policy (clean air or access) variable other than price which is significant for either age group in all three data sets, or even in both the data sets representing the full teen population (MTF and YRBS). Internal validity Parental education is used as a proxy for income. Increases in price/tax of tobacco products Author, year Gruber 2000 Age (years) 13-18 Setting US Study design Cross-sectional study (econometric) Objective To provide a comprehensive analysis of the impact of prices and other public policies on youth smoking in the 1990s Intervention State-level measures of prices, clean air regulations and youth access restrictions SES variable Parental education Study analysis Econometric analysis Model: linear regression models with standard errors corrected for within Data sources Monitoring the Future (MTF: University of Michigan) providing smoking behaviour, race, age, sex and state data for 8th, 10th, 12th graders (1991-97); Youth Behaviour Risk Survey (YBRS) data (CDC) for 1991, 3, 5, and 7 for 9th-12th graders; Vital Statistics Natality Detail Files from 1989 onwards providing smoking behaviour of women during pregnancy. Participant selection Participant characteristics Number=641,759 (MTF); 106,556 (YBRS); 3,970 (Natality, aged 13-18) Outcomes Smoking participation Smoking intensity Intervention details Econometric analysis using repeated cross-sectional data Impact by SES variable Parental education (YRBS data only) For seniors the elasticity of participation was -4.39* for those whose parents were high school dropouts or graduates and -.24 for parents with some college education. For smoking intensity this trend was reversed with elasticities of -0.40 for high school and -2.39* for college education. There was no pattern for younger teenagers, although participation elasticity was positive and statistically significant for high school educated parents (2.72*). [* p<0.05] External validity No information on high-school dropouts who may be differentially price sensitive. State by year dropout rates were controlled for in regression analysis which suggests no selection bias due to dropout related to tax. Validity of author’s conclusion In cross-sectional data it is impossible to disentangle price and policy impacts from other underlying long-run determinants of smoking attitudes. Sensitivity to price suggests cross-elasticity between price and income Author’s conclusion of SES impact These results suggest that the single greatest policy determinant of youth smoking is the price of cigarettes. Older teenagers are more sensitive to prices with a central elasticity estimate of 0.67. This price sensitivity rises for more socioeconomically disadvantaged 117 Details Method Increases in price/tax of tobacco products state-year correlation (to account for variation across states and years). Separate models built for each dataset. (MTF, YBRS, Natality) Outcome variables: smoking participation (any smoking over past months); conditional intensity (quantity smoked) Explanatory variables: price per pack (including taxes); clean air regulations (private workplace, public workplace, restaurants, schools, other e.g. public transport); youth access index (score across 9 categories including minimum purchase age, vending machine availability, which is added to create a total index with high scores indicating more restrictions); state and year (as fixed effects to account for between state and between year price differences). Results Comments groups such as blacks or those with less educated parents. 118 Details Method Result Comments General population Higher tax levels are associated with later initiation and earlier cessation. SES Taxation has a stronger effect to prevent or delay initiation among those with intermediate education, and weakest among those with the lowest education. Taxation has the strongest effect on cessation among those with the lowest education, an equal impact on those with other levels of education. Author’s conclusion of SES impact Results are extremely tentative, but it appears that the greater impact is among those with intermediate education. Greatest effect on quitting for the lowest levels of education. Internal validity Potential for recall bias, going back up to 40 years in some cases. Doesn’t capture failed attempts to quit. External validity Revenue Commissioners does not break down the tax component into excise and VAT for the period up to 1973. Thus, authors have taken the total tax component of the retail price and deflated it by the personal consumption deflator to arrive at a real tax on tobacco. Tax was relatively low through the study period, unclear whether the relationship would continue with further increases from current levels of taxation. Potential quitters had less cessation support available. Only covers Irish females. Covers a period of increasing awareness of the impact of smoking, unclear whether cessation was linked to taxation or increased awareness. Validity of author’s conclusion Results are extremely tentative Increases in price/tax of tobacco products Author, year Madden, 2007 Age 19 (when started smoking) Country Ireland Design Single cross-sectional survey containing retrospective cohort data Objective To investigate the role of tobacco taxes in starting and quitting smoking and explores how tax effect differs by education SES variables Education (primary, junior (age 16), secondary (age 18), University) Analyses Duration analyses – various parametric duration models Data sources Retrospective data from a survey on women’s knowledge, understanding and awareness of lifetime health needs (Saffron Survey, 1998). Participant selection All survey respondents who were born after 1950 (so that sample’s exposure matches price data). Participant characteristics N=703. Average age 34, ex-smokers slightly older. 10% primary education, 27% junior education, 40% secondary, 21% university. Eversmokers and current smokers more likely to have lower levels of education. 55% employment rate, 47.5% among current smokers. Intervention Tobacco taxation from 1960 onwards. Length of study 1960 to 1998 Outcomes Ever smoked, age of initiation, and cessation. 119 Details Method Results Comments General population impact 32% did not react to price increase, 33% reduced costs of smoking(purchasing in foreign countries/smuggling, cheaper brand, hand-rolled), 35% reduced consumption or tried to quit Internal validity Student’s report of parent’s educational level may be prone to bias. Study was powered for a response rate of 70% but small sample size for this analysis with statistical significance threshold of 10%. Retrospective questions after price increase. Increases in price/tax of tobacco products Author , year Perretti-Watel 2010 Age (years) 19.5 Setting South-Eastern France Study design Cross-sectional study Objective To investigate young smokers retrospective reactions to an increase in cigarette prices Intervention Price increase on tobacco SES variable Students report of parental education Study analysis Restricted to 427 daily smokers, Data sources Survey on Provencal Students’ Health conducted by The Southeastern Health Regional Observatory between November 2005 and June 2006 (unpublished). random sample of 2455 students stratified by university and academic department Participant selection Response rate 71%, n=1753, excluded another 30 due to incomplete survey, n=1723 Participant characteristics First year University students in 6 Universities, 58% were girls and 42% were boys (mean age: 19.5 years old,). 32% current smokers (daily smokers: 25%, occasional smokers: 7%), and 6% were former smokers. Outcomes Smoking behaviour: no reaction, cheaper smoking, smoking less Impact by SES variable Daily smokers with low-educated parents were less likely to react to the price increase, daily smokers who had at least one parent that completed high school were more prone to react to higher cigarette price (OR=2.5, 95% CI=1.6,4.0 for cheaper smoking vs no reaction; and OR=2.1, 95% CI 1.4,3.3 for smoking less vs no reaction; in multivariate analysis, p < 0.001 and p< 0.01, respectively) Students who reported difficulties in financing their studies were significantly more likely to purchase cheaper cigarettes (OR=1.9,95% CI=1.0,3.7; p< 0.1). External validity Regional not national survey so may not be generalisable to whole of France; also reactions to price increase are only relevant to daily smokers who did not quit. Validity of author’s conclusion Valid but small specific sample Author’s conclusion of SES impact Young smokers with a lower socioeconomic status were less likely to react to the price increase Intervention details Survey 120 Details Method Results Comments General population impact N/A Internal validity Study is longitudinal but 7 year gap in data used to assess transition from adolescence to young adulthood may have missed other important mediators. Missing values for family income were imputed. We don’t know how demographic characteristics at each wave compare. Controls on access to tobacco products Author, year Kim 2006 Age (years) 15 Setting US Study design Prospective cohort study Objective To examine whether young especially low SES females are influenced by tobacco control policies in terms of smoking initiation and transition Intervention State level tobacco control policies and state cigarette excise tax SES variables Parents level of education and income (parents questionnaire) Study analysis multilevel logistic regressions comparing initiators to never smokers Data sources State level tobacco policy scores developed by US National Cancer Institute, evaluating 9 items for each state each year= statewide enforcement, random inspections, graduated penalties, photo identification, free distribution, minimum age, packaging, vending machines, and clerk intervention. Dataset, the national longitudinal study of adolescent health (Add Health), is a school based survey of the health related behaviours of adolescents. Participant selection Add Health surveys individual adolescents from 132 schools, grades 7 to 12, using a sampling frame stratified by region, level of urbanisation, school type, school size, and by school racial compositions. In 1994–5 (wave 1), data from 18 924 adolescents were collected; in 1996 (wave 2) and in 2001–2 (wave 3), follow up in-home surveys were conducted to interview again 15 197 of the respondents from wave 1 about their health behaviours and life experience as young adults. Impact by SES variable Stronger state level tobacco policies were associated with lower likelihood of smoking initiation and adverse transition among low SES women, although the effect sizes were small. The positive policy effects for initiation were strongest for low SES females, whose odds ratio was 0.95 (0.98 for middle SES, 1.00 for high SES). For initiation, school level smoking rates did not vary substantially across low, middle, and high SES groups (OR=1.01, 0.99 and 1.00, respectively. For statewide enforcement, the odds ratios of initiation were significantly lower for the low (0.89) and middle (0.91) SES female groups; on the other hand, the policy had no effect on the high SES female group (OR=1.00). For random inspections the odds ratios of initiation were significantly lower for low (0.88) and middle (0.90) SES female groups. Photo identification had a significant positive effect on the low SES female group (OR=0.85), but not on the middle SES female group (OR=0.95, NS) and on high SES females (OR=1.10, NS). other policies had a pattern similar to the significant ones External validity 2697 females only-no further information on how representative this sample is. Study adopted a measure of comprehensive state tobacco control efforts based on a score developed by the National Cancer Institute evaluating nine items for each state each year; enables future studies to use similar rating scores for policy. Validity of author’s conclusion Valid but effect size is small. Author’s conclusion of SES impact 121 Details Method Controls on access to tobacco products Participant characteristics Restricted to female adolescents younger than 18 at baseline=2697 females from 33 states,126 schools Sample sizes were 1245 for low SES, 812 for middle SES, and 640 for high SES female adolescents. Outcomes measured Smoking initiation and transition Results Comments Tobacco control policies have the biggest impact on reducing the likelihood of smoking initiation in low SES females, less of an impact on the likelihood of middle SES female group, and the least impact on high SES females. Stronger tobacco control policies are positively related to lower likelihood of adverse transition in smoking, especially for the low SES female group Intervention details National longitudinal school-based survey ‘Add Health’ of individual adolescents about their health behaviours and life experience as young adults 122 Details Method Results Comments General population impact Overall rate of retailer non-compliance with underage tobacco sales laws in the 997 selected outlets was 14.3%. Buyer’s actual age, a male clerk and asking young buyers about their age were related to successful cigarette purchases. Buyer’s actual age and minimum age signs increased the likelihood that clerks will request identification (ID). Internal validity There were no significant differences between the sampled and the unsampled cities in relation to population size, ethnic diversity, household size and median household incomes. Controls on access to tobacco products Author, year Lipperman-Kreda 2012 Data sources Access surveys Age (years) Underage tobacco sales – 4 confederate buyers (2 men and 2 women), who were over 18 years of age, but judged to appear younger by an independent panel, mean age 19 years. Participant selection purposive geographic sample Setting 997 Tobacco outlets in 50 mid-sized California cities, USA Study design Cross-sectional Objective To examine contextual and community-level characteristics associated with youth access to tobacco through commercial sources Intervention underage tobacco sales laws SES variables Median family income, % population with college education (city level n=50) Participant characteristics 997 Tobacco outlets in 50 mid-sized California cities, USA Outcomes measured Retailer compliance with underage tobacco sales laws Intervention details Purchase attempts were made at 997 tobacco outlets in 50 mid-sized California cities by a team of two buyers. At each outlet a single buyer attempted to purchase a pack of Marlboro or Newport cigarettes, which are the most popular cigarette brands among high school-aged students. Each buyer asked for Marlboro in one outlet and Newport in the next one. If asked about their age they stated that they were over 18 years old, and if asked for an age ID they indicated they had none. If a sale was refused, the buyers left without attempting to pressure the clerk. Impact by SES variable Retailer compliance with underage tobacco sales laws: at the community level, a greater percentage of residents with at least a college degree were associated with increased likelihood of noncompliance. Predictors of clerks requesting ID: at the community level, lower percentage of residents with at least a college degree was associated with retailers asking for an ID. Asking young buyers about their age was positively associated with successful purchases. Predictors of cigarette pack prices: higher cigarette prices of Marlboro but not Newport, were associated with higher median household income. External validity Only 2 buyers conducted the surveys in each city which limits ability to consider characteristics of the buyers other than gender and age. Also limited to 2 brands. Validity of author’s conclusion Higher education was a significant predictor of underage tobacco sales. So stricter enforcement of laws would not reduce gap between low and high SES in terms of smoking prevalence? Unclear how access to tobacco translates into smoking prevalence. Author’s conclusion of SES impact Youth in communities with higher educational levels may have easier access 123 Details Method Results Comments Controls on access to tobacco products Study analysis Multilevel logistic and linear regression to cigarettes from retail stores. The relationships between community characteristics and cigarette prices varied by cigarette brand. Higher median household income was associated with higher prices of Marlboros. 124 Details Method Results Comments Students receiving FSM were more likely to smoke (adjusted OR for FSM: 1.87, p<0.001). Internal validity Pupil records with missing values (e.g., not answering) for outcome variables and covariates were removed (10.4%). Baseline differences in age, gender and ethnicity but controlled for in analyses. Self-report smoking status but reported within schools rather than at home. Cross-sectional but response bias is likely to be low because the pupil response rate to the survey was very high (88% in 2008) in participating schools. Sample size was sufficient to detect a 10% relative reduction in smoking prevalence in the non-FSM group compared with the FMS group (at 80% power at the 5% level of significance). However, the sample size did not permit examination of whether the legislation reduced the volume of cigarettes smoked. Controls on access to tobacco products Author, year Millett 2011 Age (years) 13 Setting Secondary schools, England Study design Repeat cross-sectional surveys of children in same schools before and after legislation Objective To determine whether the law had a differential impact on the likelihood of regular smoking depending on FSM status among youth in England Intervention Legislation in England, Scotland and Wales increasing minimum age for legal purchase of tobacco from 16 to 18 years, October 2007 SES variables Free school meals (FSM) (eligibility assessed on basis of parental employment and status and income level) Data sources Smoking, Drinking and Drug Use Among Young People in England (SDDU) annual survey of 11-15 year olds, by National Centre for Social Research and the National Foundation for Educational Research, National Foundation for Educational Research database Participant selection In 2008, 264 schools agreed to take part (response rate 58%) and within these schools 7798 pupils aged between 11 and 15 years completed the survey (response rate 88%). Participant characteristics FSM group was significantly younger (mean age: 13.1 vs 13.2 years, p=0.002), more likely to be female (53% vs 49%,P=0.042) and contained significantly more pupils from ethnic minorities (22% vs 13% non-white, p<0.001) than the nonFSM group in 2008. Outcomes measured Regular smoking status Usual source of tobacco Ease of tobacco purchase General population impact Increasing the minimum age for purchase was associated with a significant reduction in regular smoking among youth (adjusted OR 0.67; 95% CI 0.55 to 0.81, P=0.0005). Impact by SES variable Regular smoking was not significantly different in pupils eligible for FSM compared with those that were not (adjusted OR 1.29; 95% CI 0.95 to 1.76, p=0.10). Percentage of regular smokers who usually bought cigarettes from a vending machine decreased significantly in the non-FSM but not in the FSM group. Percentage of regular smokers who usually bought cigarettes from friends and relatives or from other people increased significantly in the non-FSM but not the FSM group after the introduction of age restriction. Regular smokers eligible for FSM were significantly more likely to be given cigarettes by their parents in 2006 External validity Although the response rate for schools was only 58% in 2008, the sampling frame ensured 125 Details Method Controls on access to tobacco products Intervention details Study analysis Data used from 2003 to 2008 excluding 2007. Multivariate logistic regression analysis adjusted for previous time trends, age, gender, ethnicity, alcohol and drug use Results Comments (p<0.001) but this was no longer the case in 2008 (p=0.42). Percentage of pupils who stated that they found it difficult to buy cigarettes from a shop did not increase in those eligible for FSM (25.2% to 33.3%; p=0.21) but did increase significantly in others (21.2% to 36.9%; p<0.01) between 2006 and 2008. that schools participating in the survey closely reflect the composition of schools in England generally. The survey did not include 16 and 17 year olds who were most directly affected by the increase in age for the legal purchase of tobacco. Percentage of regular smokers who were successful in buying cigarettes from a shop during their latest attempt decreased significantly in the non-FSM but not the FSM group between 2006 and 2008. Validity of author’s conclusion Smokefree ban and alcohol restrictions also introduced during this time which may confound these results. No differences in ease of purchase were found between pupils eligible for FSM and those not before or after the legislation (2006: p=0.34, 2008: p=0.55). Author’s conclusion of SES impact Increasing the minimum age for the purchase of tobacco in England was associated with a significant reduction in youth smoking and was neutral with regard to disparities. 126 Details Method Results Comments General population impact Number of commercial sources declined by 12% from 2005 to 2009 resulting mainly from removal of 44% of outdoor cigarette vending machines (indoor machines decreased by 5%). Convenience cigarette sources reduced by only 0.9%, supermarket and drug stores +2.6%. Internal validity Potential for limited interrater reliability between 3 geocoders Controls on access to tobacco products Author , year Schneider 2011 Age (years) 17.6% aged 0-20 years Setting Cologne, Germany Study design Before and after observational study Objective To compare number of vending machines and other commercial sources before and after new legislation and to examine association between commercial cigarette sources and area SES Intervention Electronic locking devices on vending machines to prevent underage (<16 years) purchasing SES variable Income Unemployment Social welfare Low-qualifying schools Data sources German Sources of Tobacco for Pupils (STOP) study, observational Participant selection Cologne selected because had existing sociogeographical data Participant characteristics 17.6% aged 0-20 years Outcomes Density of sources before and after legislation according to SES of each district Impact by SES variable The lower the income level in a district, the higher the availability of cigarettes (Pearson’s r = .595; p = .009). The same occurred for the alternative indicators such as youth unemployment (Pearson’s r = .548; p = .019), the percentage of people receiving social welfare (Pearson’s r = .485; p = .041), and the percentage of pupils attending low-qualifying schools (Pearson’s r = .473; p = .048). In 2005 as well as in 2009, we found significantly fewer commercial cigarette sources in districts with above-average SES than in districts with below-average SES. This can be seen in terms of absolute as well as relative numbers. The density of commercial cigarette sources in 2005 in districts with above-average SES was 3.20 per 1,000 inhabitants and 4.84 per 1,000 inhabitants in the districts with belowaverage SES. In 2009, the numbers were 2.63 per 1,000 inhabitants and 4.44. per 1,000 inhabitants, respectively. The differences between socially advantaged and disadvantaged districts appeared to be External validity ‘natural experiment’ design is real life, but limited to one city so not representative of all German cities but appears comparable with Germany as a whole Validity of author’s conclusion Valid 127 Details Method Controls on access to tobacco products Study analysis Inventory of commercial cigarette sources in 2005 and 2007 and 2009 and mapped using Geographic Information System Results Comments significant in both years (2005: t(15) = 9.017, p < .001 and 2009: t(17) = 6.915, p < .001). Author’s conclusion of SES impact In districts with above-average SES, the supply density was lower than in districts with below-average SES, even at the beginning of the study. Decreases in the number of cigarette sources were reflected more sharply in regions of higher SES, which also emphasizes the social inequalities between these two areas. 128 Details Method Results Comments General population impact No association found between tobacco point-of-sale marketing and compliance check failure. Of a total of 467 stores, 48 failed compliance check. Tobacco shops were most likely to fail compliance checks (44%). Supermarkets were least likely to fail (3%). Internal validity Completion of a full store assessment was not significantly associated with whether stores passed their compliance check (p = .931). Each store assessed by one assessor. Impact by SES variable Poverty of stores block group was not associated with compliance failure of stores. Stores in block groups with greater percentage of people living in poverty were not more likely to fail compliance check. External validity Authors report that Minnesota has less racial/ethnic diversity compared to other urban centres. Compliance checks may not be a very valid measure of commercial tobacco accessibility for minors. Only vendors with a current license can sell tobacco in state of Minnesota but this is not the case across all US states. Also stores who repeatedly violate youth access laws have license rescinded. Study was cross-sectional so cannot assess whether change in advertising leads to change in compliance check failure. Controls on access to tobacco products Author , year Widome 2012 Age (years) Minors aged 15-18 years used for compliance checks Setting Minnesota, US Study design Cross-sectional Objective To test the association between point-of-sale advertising intensity and likelihood that a store would fail a compliance check Intervention Age-of-sale tobacco checks SES variable Poverty (below 150% poverty level) Study analysis Description of compliance check failure proportions for various types of stores and by census block group demographics. Failure proportions calculated. Chi-square tests to test Data sources (1) Observations of the advertising environment in establishments (2) a record of age-of-sale tobacco checks where an undercover minor working with law enforcement attempts to purchase tobacco (3) Demographic data from the Year 2000 U.S. census. Participant selection 655 licensed tobacco vendors, both interior and exterior assessments were completed on 485 establishments (74.0%). Analyses conducted on 467 establishments that had complete assessments. Participant characteristics Outcomes Compliance -failure defined as the sale of tobacco to a youth, regardless of whether the store clerk examined the minor’s ID. Author’s conclusion of SES impact There was no association between store advertising characteristics or poverty and stores’ compliance check failure. The relationship between advertising and real youth sales may be more nuanced as compliance checks do not perfectly simulate the way youth attempt to purchase cigarettes. Validity of author’s conclusion Valid as considers weakness of 129 Details Method Controls on access to tobacco products whether failure was associated with a store being situated in a block group that was in the top decile of each demographic item. Top decile used as a cut-off to examine more extreme examples of census block groups that had relatively high proportions of certain demographics, and t tests to examine whether the percentage of people in a block group for each demographic item was associated with compliance check failure. X2 tests to examine whether specific advertising practices were associated with failure. Results Comments the compliance check measure. 130 Details Method Results Comments Data sources General population impact 8% 48/588 in intervention group indicated greater likelihood of actual tobacco use at end of programme compared to 12% (45/375) in control, p=0.04. No statistically significant difference between groups at 20 weeks follow-up. Internal validity Confounding influences of other interventions were not observed; 16-17% attrition; test of equivalence of attrition rates by treatment condition did not show attrition bias for students predisposition towards future tobacco use behaviours School-based prevention Author, year Bacon 2001 Age (years) 11 (6th grade) Setting 6 middle schools in Florida, US Study design Cluster randomised controlled trial Objective To examine effectiveness of ‘Too Good for Drugs II’ (TGFD II) programme Intervention 9 week prevention curriculum and follow-up after further 20 weeks, school-based curriculum and also involves community partners and parents; theoretical basis includes Social Learning Theory, Problem Behaviour Theory and Social Development Theory. SES variables used free/reduced lunch status Participant selection Randomly selected Participant characteristics 1318 sixth grade students, 52% female, 48% white, 33% AfricanAmerican, 13% Hispanic, 6% Asian; 51% in receipt of free or reduced school lunches; 84% participated in 20-week follow-up Outcomes measured Intentions, attitudes and perceptions towards tobacco use Intervention details 9 lesson units (40 minutes each) at each grade by trained classroom teacher or TGFD II instructor; social and emotional competencies, reducing risk factors and building protective factors; emphasise cooperative learning activities, roleplay and skills building methods; Impact by SES variable The overall findings of the comparison of change scores for treatment students indicates the programme was similarly effective in impacting students risk and protective factors regardless of economic status (perception of peer resistance skills; positive attitudes toward non-drug use, perceptions of peer normative substance use, perceptions of peer disapproval of substance use, association with prosocial peers, perceptions of locus of control selfefficacy) Student scores at end of programme and at 20 weeks follow-up showed significant multivariate overall effects for SES (before and after intervention). External validity Impact by SES only relates to scores for substance use not just tobacco use which limits comparability Validity of author’s conclusion Equity impact unclear Author’s conclusion of SES impact The findings suggest the programme was equally effective for students regardless of SES Study analysis - RCT 131 Details Method Results Comments Data sources RCT A Stop Smoking in Schools Trial (ASSIST) General population impact At 1-year follow-up, the odds ratio of being a smoker in intervention compared with control group was 0·77 (95% CI 0·59– 0·99). At 2-year follow-up, the corresponding odds ratio of 0·85 (0·72–1·01) was not significant (p=0·067) which suggests an attenuation of this intervention effect over time. For the high-risk group (occasional, experimental, or ex-smokers at baseline), the odds ratios at 1-year follow-up of 0·75 (0·56–0·99) and at 2-year follow-up of 0·85 (0·70–1·02). In a three-tier multi-level model using data from all three follow-ups (immediately after the intervention (N = 10047), after 1 year (N = 9909) and after 2 years (N = 9666)) the odds of being a smoker in the intervention group compared with the control group was 0.78 (95% CI = 0.64– 0.96) Internal validity A slightly larger proportion of students in control schools came from less affluent backgrounds and did not have a family car than did those in intervention schools Saliva cotinine levels obtained which minimised reporting bias. Results may depend on the SES indicator used. School-based prevention Mercken 2012 Author, year Campbell 2008 (from Mercken 2012) Age (years) 12-13 Setting 59 secondary schools in England & Wales Study design RCT Objective To assess the effectiveness of a peer-led intervention that aimed to prevent smoking uptake in secondary schools Intervention school-based, peer-led – influential students trained to act as peer supporters outside of the classroom SES variables used FAS and FSM (above 19% and equal or below 19%), area deprivation Participant selection Schools were randomly assigned to the control group to continue their usual smoking education (29 schools with 5372 adolescents) and intervention group (30 schools with 5358 adolescents) by stratified block randomization. Participant characteristics Not reported Outcomes measured smoking behaviour in the past week Intervention details Training influential students to act as peer supporters during informal interactions outside the classroom to encourage peers not to smoke. During the 10-week intervention period, peer supporters undertook informal conversations about smoking with their peers when travelling to and from school, in External validity Results are specific to study interventions Validity of author’s conclusion Valid Impact by SES variable Reported in primary study: subgroup analyses showed no evidence of intervention having differential effect according to deprivation measured by FSM (0·99 [0·65–1·51]). However, the intervention does seem to have had a more pronounced effect in schools located in 132 Details Method Results breaks, at lunchtime and after school in their free time. Peer supporters logged a record of all conversations in a diary. Trainers visited schools four times to meet with peer supporters to provide support, trouble shooting and monitoring of peer supporters’ diaries south Wales valleys (0·58 [0·36–0·93]. Comments School-based prevention Mercken 2012 Study analysis Data of the assist trial were reanalysed according to methods reported in the ASSIST study. Multilevel modelling was used to explore intervention effects on adolescent smoking in different SES categories. Data from the three follow-up periods were modelled using a using a three-level multilevel model with schools at Level 3, students at Level 2 and follow-up measurements at Level 1. Models were estimated using the RIGLS estimation procedure combined with first-order penalized quasi-likelihood within MLWin 2.10 beta. Separate analyses were conducted for adolescents in the low, medium and high categories of the included SES indicators. Reported in secondary analyses: A significant main effect of intervention was found among adolescents scoring low (chisquare (df = 1) =5.97, P < 0.05, OR = 0.71, 95% CI = 0.54–0.93) and high (chi-square (df = 1) = 7.28, P < 0.05, OR = 0.68, 95% CI = 0.52–0.90) on the FAS. No significant main effects of the intervention on adolescent smoking behaviour were found in either group. However, a trend is visible among adolescents in schools with a low free school meal entitlement (chi-square (df = 1) = 3.56, P = 0.06, OR = 0.80, 95% CI = 0.63–1.01). The intervention was significant among adolescents in schools located in the valleys which can be considered to be a more deprived area (chi-square (df = 1) = 5.68, P < 0.05, OR = 0.53, 95% CI = 0.32– 0.89) but not among adolescents in schools on other locations. Among adolescents in Valley schools, the intervention was also effective among those with low FAS scores (chi-square (df = 1) = 5.97, P < 0.05, OR = 0.71, 95% CI = 0.54–0.93). The additional analyses stratified by SES and gender showed that the ASSIST intervention was mostly effective among lower SES girls. Author’s conclusion of SES impact The results were mixed depending on the specific SES indicator used. The ASSIST 133 Details Method Results Comments School-based prevention Mercken 2012 study showed the strongest results for adolescents in the Valley schools, located in a deprived area. Social network approach allowing youngsters to deliver the intervention themselves seems promising in preventing the uptake of smoking in deprived adolescents. 134 Details Method Results Comments Author, year Crone 2003 (from Mercken 2012) Data sources RCT Age (years) 13 Participant selection Schools were ranked by size, stratified by use of a national drug education programme and subsequently randomly assigned to the control and intervention group. At baseline, a sample of 2562 adolescents participated General population impact 9.6% of the nonsmokers started to smoke in the intervention group, whereas 14.2% started to smoke in the control group (N = 1388, OR = 0.61, 95% CI = 0.41–0.90). After 1-year follow-up, the effect was no longer significant. Internal validity The percentage of boys in the control group was higher than in the intervention group at baseline but this was adjusted for in analyses. Nonresponse was higher among smokers, especially in the control group but selective dropout was assessed using ITT under 3 different assumptions. Results may depend on the indicator used School-based prevention Mercken 2012 Setting 26 junior secondary education schools in the Netherlands Study design RCT (an independent person tossed a coin) Objective To investigate whether a peer group pressure and social influence intervention reduced the percentage of adolescents who start to smoke Intervention school-based social influence and peer group pressure to prevent smoking with a class-based competition SES variables used parental education Study analysis Participant characteristics Not reported Outcomes measured experimenting with smoking or smoking daily or weekly Intervention details Three lessons on knowledge, attitudes and social influence, followed by a class agreement not to start smoking or to stop smoking for the next 5 months. Video lessons on smoking and social influence were available as an optional extra during these 5 months. Classes having fewer than 10% smokers after 5 months were entered in the competition. The final activity of the Impact by SES variable At 5 months, smoking behaviour was significantly lower in adolescents who indicated that their parents had mid to high completed educations (chi-square (df = 1) = 4.21, P < 0.05, OR = 0.35, 95% CI = 0.13–0.95). The intervention did not result in smoking fewer cigarettes among adolescents who indicated that their parents had lower education (chi-square (df = 1) = 0.33, P > 0.05, OR = 0.80, 95% CI = 0.37–1.72). All significant intervention effects disappeared at 12 months followup. The additional analyses stratified by gender and SES furthermore showed that the intervention was only effective at 5 months follow-up among boys with higher parental educational levels (chi-square (df = 1) = 5.56, P < 0.05, OR = 0.24, 95% CI = 0.07–0.79). External validity Results are specific to study interventions. Validity of author’s conclusion Valid. Author’s conclusion of SES impact The Dutch class competition study only had a significant effect among higher SES 135 Details Method Results class was to make a photo expressing the idea of a non-smoking class. There were competition prizes for six classes with less than 10% smokers and a photo best expressing a non-smoking class adolescents and appeared to widen the inequalities Comments School-based prevention Mercken 2012 Data from follow-up at 5 and 12 months were modelled using threelevel multilevel models with school at Level 3, class at Level 2 and adolescent at Level 1. Models were estimated using the restricted iterative generalized least squares (RIGLS) estimation procedure combined with first-order penalized quasi-likelihood within MLWin 2.10 beta. The multilevel model was tested separately for adolescents in each of the categories of the two included SES indicators. 136 Details Method Results Comments Data sources RCT - the European Smoking Prevention Framework (ESFA) study General population impact At 24 months significantly fewer eversmokers were found in the Portuguese experimental group (33.8%) than the control group (41.5%) (OR=0.73, 95% CI = 0.57–0.94). At 30 months 41.8% of the never smokers started to smoke 30 months later in the intervention group, whereas 53.8% of the never smokers in the control group (N = 1304, OR = 0.62, 95% CI = 0.48–0.80) In terms of non-smokers becoming weekly smokers in experimental vs control groups; 7.3% vs 9.1% respectively at 24 months (OR = 0.74, 95% CI = 0.41–1.34) and 7.9% vs 12.4% at 30 months (OR = 0.56, 95% CI = 0.37–0.84). Internal validity Response rates differed between experimental and control groups; 41.7% vs 39.1% respectively. May not be a strong association between indicators such as adolescents’ pocket money and household income. ‘mid to high’ spending money subgroup relatively small (n=182) which explains wide CI’s and probably why result not significant – so intervention might not decrease inequalities in smoking School-based prevention Mercken 2012 Author, year De Vries 2006 (from Mercken 2012) Age (years) 13.5 Setting 25 schools in 2 regions of Portugal Study design RCT Objective Not stated Intervention Social influence intervention which was school-based with wider community. Interventions were developed for four levels: the individual adolescent level, the school level, the parental level and the out-of-school level. SES variables used spending money Study analysis Multilevel modelling techniques were used to test for intervention effects Participant selection Two regions, consisting of 14 and 11 schools, respectively, were randomly assigned to the experimental and control condition. At baseline, 3102 adolescents participated in the intervention study in Portugal Participant characteristics Not reported Outcomes measured ever smoking/never smoking Intervention details Lessons on effects of tobacco, reasons for (not) smoking, social influence processes, refusal skills and decision making and a smokefree competition. Teachers received 48 hours of teacher training, manual and smoking cessation materials. Schools received the ESFA nosmoking policy manual and nonsmoking posters. To the parents, information was offered on how to Impact by SES variable The intervention was significant in reducing smoking uptake among adolescents who indicated to have no to only a low amount of spending money (chi-square (df = 1) = 9.85, P < 0.01, OR = 0.62, 95% CI = 0.46– 0.84). This effect was not seen among adolescents reporting to receive mid to high amounts of spending money (chisquare (df = 1) = 3.51, P > 0.05, OR = 0.57, 95% CI = 0.32–1.03). Additional analyses stratified by gender and SES showed that the intervention was mostly effective among girls. External validity Process evaluation included pupil report of exposure to each element of the intervention and showed it reasonably likely that the observed effects were attributable to the school-based elements of the intervention. Interventions differed between countries and Portugal received the most intensive teacher training and pharmacists of smoking 137 Details Method Results Comments School-based prevention Mercken 2012 on smoking behaviour in different SES categories. Data from follow-up at 30 months were modelled using three-level multilevel models with region at Level 3, school at Level 2 and adolescent at Level 1. Models were estimated using the RIGLS estimation procedure combined with first-order penalized quasi-likelihood within MLWin 2.10 beta. The multilevel model was tested separately for adolescents in each of the categories of the three included SES indicators. discuss non-smoking with their adolescents. Pharmacists furthermore offered cessation courses for 150 parents. At the community level, the Portuguese Health Minister and mayor of the community introduced the ESFA study on the national no smoking day Author’s conclusion of SES impact The results were mixed depending on the specific SES indicator used. When using spending money as a SES indicator, the intervention did appear to decrease inequalities in smoking. cessation support for 150 parents; so results may only be generalisable to that type of intervention in that country. Validity of author’s conclusion Valid Comments The ESFA study was a community-based intervention that took place in six European countries. In Finland, Denmark, UK and Portugal schools or regions were randomly assigned. In Spain and The Netherlands it was quasirandomisation. Due to the fact that peer-led programmes were uncommon in the ESFA countries, programmes were teacher-led. Since the strongest and significant long-term effects after 24 and 30 months were found in the Portuguese sample, only data of the ESFA study in Portugal were reanalysed on the impact by SES (Mercken 2012) and so only results for Portugal are 138 Details Method Results Comments School-based prevention Mercken 2012 extracted here. Details Method Results Comments Data sources General population impact In the EGC analysis the effect of the intervention was observed with regard to smoking (cigarettes per week and 30-day smoking prevalence). In the ITT analysis only the effect on the 30-day smoking prevalence was significant. Internal validity Over 50% of the schools eligible for the study initially agreed to participate. Authors report did ITT analysis and analysis of classes with 60% programme participation (EGC analysis). The intervention group included significantly more pupils who reported a higher SES. Loss to follow-up was 23%. Schools in the intervention group were asked to conduct one of the two programmes in classes 5 or 6. School-based prevention Author, year Menrath 2012 Age (years) 12 Setting 53 public secondary general schools in Northern Germany (rural federal state of Schleswig-Holstein) Study design Quasi randomised multicentre trial (6 schools included without randomisation to intervention group) Objective To evaluate the effects of two validated school-based life skills programmes (Fit and Strong for Life and Lions Quest) in a high-risk sample of socially disadvantaged pupils. SES variables Family Affluence Scale Participant selection Oversampled pupils with low SES by only including secondary general schools. 2/102 classes lost to followup at end of school year and 7 more lost to follow-up at six months Participant characteristics 102 classes with a total of 1,561 pupils. 25% of the pupils had a low SES Outcomes measured Self-report cigarettes smoked per week 30-day smoking prevalence Intervention details “Fit and Strong for Life” and “Lions Quest”. Both programmes foster life skills and self-efficacy and include the prevention of substance abuse (cigarettes, alcohol, and drug consumption). Fit and Strong for Life is a modular life skills programme for Impact by SES variable ANOVA with SES as a factor revealed no influence of SES on the effect of the intervention (SES* time*group). Author’s conclusion of SES impact School-based life skills programmes have a positive effect on smoking prevention regardless of socioeconomic status. Socially disadvantaged children benefit from such programmes to a similar extent as other pupils. External validity Analyses do not appear to account for specific life skills programmes (“Fit and Strong for Life” and “Lions Quest”.) Validity of author’s conclusion Does not report data for results by SES and does not assess effects of each life skills 139 Details Method Results Comments School-based prevention Mercken 2012 Study analysis Repeated standardised interviews before and after school year and at 6 months follow-up, repeated measures analyses of variance primary and secondary schools. Each module covers the following six topics: (1) self-esteem and empathy, (2) coping with stress and negative emotions, (3) communication skills, (4) resistance skills and critical thinking, (5) problem solving and decision making, (6) health-related knowledge. The consecutive modules are not interdependent and may start at any grade regardless of whether the pupils have participated in the programme before or not. In this study we used the module for grades 5 and 6. Lions Quest has a comparable curriculum. It may be used in secondary schools from class 5 to 10. Based on the life skills approach it consists of seven major content areas: (1) behaviour in classes/groups, (2) self-esteem, (3) coping with emotions, (4) peerrelationships, (5) family-relationships, (6) decision making and (7) selfefficacy. In our study both programmes Fit and Strong for Life and Lions Quest were carried out by classroom teachers. Beforehand all teachers had to attend a one- or twoday training workshop. programme separately so difficult to assess equity impact of each specific programme. 140 Details Method Results Comments Data sources National Public Health Institute annual cross-sectional postal surveys from 1978 to 2002. Unique personal identification codes were used to link information on socioeconomic group from population censuses (every fifth year starting 1970 except 1985) General population Among men the secular cohort trend in smoking declined only in upper white collar workers, whereas in other socioeconomic groups the secular cohort trend was nonsignificant. A clear decline in the prevalence of male ever daily smokers concurrent with the TCA was found in all socioeconomic groups except farmers. The differences between the three largest socioeconomic groups in the effect of the TCA were statistically significant (p=0.007 for the interaction between SES and the TCA) among men. Smoking decline corresponding to the 1976 TCA was most marked among white collar employees. In the three largest socioeconomic groups, the secular cohort trend remained unchanged after TCA (p=0.60 for the cohort trend after TCA, controlling for the general secular cohort trend) and there was no difference between the three largest socioeconomic groups in this respect (p=0.64 for the interaction between SES and cohort trend after the TCA). Among women an increasing secular cohort trend in ever daily smoking was found in each socioeconomic group before the impact of the 1976 TCA (birth cohorts born in 1926–1962). A reversal of the female ever daily smoking trend concurrent with the introduction of the 1976 TCA was found in each examined socioeconomic group. The impact of the legislation was Internal validity Average response rate 1978– 2002 was 70% among men and 79% among women. Multiple policy interventions Author, year Helakorpi 2008 Age Range for smoking initiation defined as 13 - 20 years Setting Finland Study design Repeat cross-sectional Objective To assess the impact of the 1976 Tobacco Control Act (TCA) on smoking initiation across socioeconomic groups. Intervention 1976 Tobacco Control Act SES variables Upper white collar workers (upper level employees), lower white collar workers (lower level employees), blue collar workers (manual workers), farmers and entrepreneurs (other self-employed persons than farmers). Analyses Participant selection Each year an independent random sample (n=5000) of the population aged 15–64 years was drawn from the National Population Register. Participant characteristics 33,080 adults aged 25 to 64 years born between 1926 and 1975 Intervention The 1976 TCA prohibited smoking in most public places, including public transport, and the sale of tobacco products to those below 16 years of age, and required obligatory health warnings on packages Length of study 14 years – 1978 to 2002 Outcomes Smoking prevalence (ever External validity The response rate has declined over the past 25 years in both genders and all age groups. The decline has been faster among men than women, and in younger than older age groups – this may have biased the results. Validity of author’s conclusion There have been two major steps in Finnish tobacco control policy: the 1976 TCA, supplemented by a total tobacco advertising ban in 1978, and the environmental tobacco smoke amendment of the TCA in 1995. A significant rise in the price of tobacco products almost coincided with the 1976 TCA; tobacco prices rose substantially (real price increase 27%) in 1975–1976, (but since then annual increases have been either modest or negligible) and could explain some of the variability 141 Details Method Results Comments Multiple policy interventions Logistic regression smoked daily for at least a year) even in the three largest socioeconomic groups (p=0.14 for the interaction between SES and the TCA). Moreover, the general cohort trend after the TCA differed from the secular cohort trend before TCA (p<0.001) and there were differences between the three largest SES groups in this respect (p=0.002 for the interaction between SES and the cohort trend after the TCA). in results by SES. SES In cohorts reaching the smoking initiation age after the TCA, the prevalence of ever smoking remained relatively stable among white collar female workers but tended to decline among blue collar female workers (odds ratio=0.88, 95% confidence interval 0.72 to 1.02), in contrast to the sharply increasing trend in older cohorts. Author’s conclusion of SES impact Among men, whose prevalence of ever smoking was potentially influenced by the 1976 TCA (those born in 1956 or later) the 1976 TCA appears to have had the greatest impact on male white collar employees. Among women, the apparent effect was very pronounced in all socioeconomic groups and among blue collar female workers the cohort trend tended to decline. 142 Details Method Results Comments Data sources ‘The Natural History of Nicotine Dependence in Teens Study’. Selfreport questionnaires administered in classroom, every 3 months from 1999 to 2005 in 1, 293 grade 7, age 12-13, students in 10 secondary schools. 7 English and 3 French language secondary public schools, General population impact Students in smoking-intolerant schools (access and restrictions) were less likely to initiate smoking than students in smokingtolerant schools (Hazard ratio [HR] = 0.83, 0.68, 1.01); attending schools located in neighbourhoods with smoking intolerant restaurants, HR=0.85 (0.68, 1.07). There was no association between corner store smoking intolerance and smoking initiation Internal validity 25% (219/868) lost to follow-up over 5 years, more likely to attend a low SES school (OR 1.7, 95% CI 1.2, 2.4; p<0.01) Multiple policy interventions Author , year Pabayo 2012 Age (years) 12.7 Setting Montreal, Canada Study design Prospective cohort study Objective To describe the association between smoking intolerance in schools, restaurants and corner stores near schools and the initiation of smoking in adolescents SES variable Parental education Schools classified as low/medium/high SES based on mean household income Participant selection Convenience sample, 54.5% student response Participant characteristics Mean age 12.7 (SD 0.5), range 1116; 51% male Outcomes Smoking initiation Impact by SES variable HR for cigarette use initiation for low SES school, in schools=1.11 (0.88, 1.36), p=0.40; in restaurants=1.04 (0.83,1.31)p=0.74; in corner stores=1.10 (0.88, 1.37) p=0.59 External validity Convenience sample limits generalisability of this study Validity of author’s conclusion Study did not aim to assess differential impact by SES. Author’s conclusion of SES impact Not stated Intervention details Longitudinal cohort and direct observation Study analysis Cox proportional hazards modelling, limited to n=868 never smokers at baseline 143 Details Method Results Comments Data sources Random sample students aged 1217 years from each Australian state and territory and three main education sectors, questions on smoking were part of a larger survey assessing use of alcohol and illicit drugs, 1987-2005, 19,000-22,000 students sampled each year General population impact There was a significant and substantial reduction in the likelihood of smoking among all SES groups for older (16-17) and younger students (12-15) between 1987 and 2005 (all p <0.01). Internal validity Over the study period, Year 12 retention rates increased from 53% in 1987 to 75% in 2002 and 2005 so the characteristics of the student sample in Years 11 and 12 are likely to differ systematically across survey years. Individual students SES may not match the area IRSD. Self-reported smoking status so potential for bias Multiple policy interventions Author, year White 2008 Age (years) 12-17 Setting Australia Study design Cross-sectional study Objective To examine whether SES was associated with changes in smoking prevalence among Australian adolescents during 3 phases of tobacco control activity between 1987 and 2005 Intervention 3 periods of tobacco control activity: low tobacco-control funding (19921996), high tobacco-control activity (1984-1991, and 1997-2005) which included smoking restrictions and increased tax SES variable Index of relative socio-economic disadvantage (IRSD) associated with Participant selection School acceptance rate has decreased over time but has stayed around 65% since 1999, Variation in school participation rates did not systematically co-vary with smoking prevalence Participant characteristics students aged 12-17 years Outcomes Self-reported smoking prevalence Intervention details Self-report anonymous surveys of cigarette use administered at school Impact by SES variable For younger students the reductions differed by SES (interactions p <0.01), with reductions in all smoking behaviours, greater for students from higher SES groups. Among older students, only the reductions in committed smoking differed across SES groups (interaction p < 0.01), and again reductions were greater among students from higher SES groups. Between 1990 and 1996 the proportion of younger and older students involved with smoking increased significantly. Among younger students, the increase in monthly and weekly smoking was greater among lower SES students (interactions p < 0.05). Between 1996 and 2005 the prevalence of monthly and weekly smoking decreased significantly among both younger and older students, and these decreases were consistent across SES groups. For committed smoking, the interaction between year and SES was of borderline significance for students from both age groups, suggesting that the decrease may not be consistent across SES groups. External validity Co-operation rate of schools was 85% in 1987 and 63% in 2005 Validity of author’s conclusion Unclear because changing prevalence estimates may be the result of different survey samples 144 Details Multiple policy interventions residential postcode Study analysis Logistic regression analysis, controlled for sex, age and state and weighted to reduce the influence of under- or over-sampling of any state, education sector, age, or sex grouping Method Results Comments Author’s conclusion of SES impact The magnitude of the decreases in smoking prevalence between 1996 and 2005 did not differ significantly between SES groups for most indicators of tobacco involvement. These findings suggest that the tobacco-control policies adopted in the late 1990s and early 2000s were effective in reducing smoking among Australian secondary students from all SES groups. 145 Details Method Results Comments General population impact Not smoking in past week: RR at 6 weeks = 2.20 (1.79 to 2.70) RR at 12 weeks = 1.55 (1.30 to 1.84) RR at 26 weeks = 1.07 (0.91 to 1.26) All participants with missing status are assumed to be smoking. Current non-smoking at 6 weeks = 28.1% vs 12.8%;assuming rate of true quitters is same as sample assessed for cotinine then current non-smoking at 6 weeks = 13.9% vs 6.2%; absolute difference in quit rates at 6 weeks is reduced to 7.7% from 15.3%; Internal validity Random sampling for salivary cotinine showed over-reporting of quit rates but not different between active and control group; 74% (n=1265) follow-up rate at 26 weeks which was different between groups (69% in intervention group vs 79% in control group), meant there was some uncertainty about between group differences at 26 weeks; for example reported quit rates increased amongst control group from 13% at 6 weeks to 24% at 26 weeks (this would have led to underestimating of treatment effects); Individual smoking cessation support Author, year Rodgers 2005 Data sources RCT Age (years) Mean=25, median = 22 (IQR 19-30) Included persons from 16 years Participant selection Recruited from adverts on websites, media, email and text messaging mailing lists and posters at tertiary education institutions Setting New Zealand Study design RCT Objective To determine the effectiveness of a mobile phone text messaging smoking cessation programme Intervention Regular personalised text messages providing smoking cessation advice, support, distraction SES variable Income Study analysis Logistic regression Participant characteristics 1705 smokers who wanted to quit, 58% female, mean number cigarettes smoked per day = 15 average previous quit attempts=2 per person; Outcomes Self-reported smoking status Biochemically verified abstinence on random selection Intervention details Free five text messages per day for week prior to negotiated quit date and for four weeks after quit date. Control group received free month of text messaging if participated until 26 weeks. Impact by SES variable Effect was consistent across income level Author’s conclusion of SES impact Text messaging can double quit rates and this effect was consistent across major subgroups including income level External validity Participants had to be in the contemplative stage of change to be included; participants could use other smoking cessation strategies and were informed of quitline and government subsidy for NRT at baseline; participants had to own a mobile phone Validity of author’s conclusion valid 146 Details Method Results Comments General population impact 40% of the participants in the intervention arm had a verified quit status compared with 30% in the control arm at 3 months post quit. The observed difference was not statistically significant (OR = 1.62, 95% CI:0.82, 3.21). Participants in the intervention were significantly more likely to have quit at 4 weeks post quit (39%) than those in the control group (21%; aOR = 3.33, 95% CI: 1.48, 7.45); this was true also for 7-day point prevalence (44% vs. 27%; aOR = 2.55, 95% CI: 1.22, 5.30). Cessation rate among intervention participants was stable between 4 weeks and 12 weeks, but increased among control participants Internal validity Feasibility sample – small sample size so not sufficiently powered particularly for subgroup results. Imbalance in the minimum number of participants intended for each study arm within each subgroup (e.g., male heavy smokers). As a result, allocation concealment was broken for the last eight participants enrolled. To rectify the imbalance, these participants were manually assigned to the arm subgroup that required additional participants to become balanced. Eighty-seven percent of participants responded at 4 weeks post quit and 80% at 3 months post quit. Differential follow-up between the intervention and control groups was not observed at either follow-up time. Employment status differed between groups at baseline – does not add up to 100% in control group in Table 2. Study reports that allocation Individual smoking cessation support Author, year Ybarra 2013 Data sources RCT Age (years) 18-25 Participant selection Purposefully targeted a diversity of communities. Recruited nationally through online advertisements (e.g., Craigslist) between May 3, 2011 and August 4, 2011. Eligibility criteria included the following: being between the ages of 18–25, able to read and write in English, owning cell phone, being cognizant of how to send and receive text messages, being currently enrolled or intending to enrol in an unlimited text messaging plan, smoking 24 cigarettes or more per week (at least four per day on at least 6 days/week), seriously thinking about quitting in the next 30 days, and agreeing to smoking cessation status verification by a significant other (e.g., family member, friend). Setting National, text-based, USA Study design Pilot Quasi RCT Objective To address the lack of smoking cessation programs available to young adults, Stop My Smoking (SMS) USA, a text messaging–based smoking cessation program, was developed and pilot tested Intervention 6-week text messaging intervention SES variable Income (<$35,000 vs. higher); Education (enrolled/not enrolled in higher education) Study analysis Participant characteristics 1,916 people expressed interest in participating, 585 (31%) of whom appeared eligible based upon the online screener form. Of these 585, contact was not made with 49% (n = 284 ‘passive refusals’). Fifteen percent (n = 90) declined to Impact by SES variable The intervention appeared to be helpful for young adults not currently enrolled in higher education settings (45% vs. 26% control had quit at 3 months; p = .07). Enrolment in higher education settings was an effect modifier within the context of other potentially influential characteristics (arm assignment × school status; aOR = 4.7, 95% CI: 1.01, 22.3). Author’s conclusion of SES impact 147 Details Method Individual smoking cessation support Logistic regression participate. n = 211 consented to participate and were randomized into the study. Final sample n = 164 (47 did not complete online baseline survey following randomisation): 101 in the intervention and 63 in the control groups. Mean age 22, daily smokers, 44% female, 84-90% low income (<$35,000) Outcomes 3-month continuous abstinence (reported smoking five or fewer cigarettes since their quit date and verified by phone with significant other), smoking five or fewer cigarettes since quit day at 4 weeks post quit (verified by a significant other); 7-day point prevalence abstinence at 4 weeks; Acceptability Intervention details Tailored to young adult smokers based on quitting stage. 2 weeks of Pre-Quit messages aimed at encouraging them to clarify reasons for quitting and to understand their smoking patterns and tempting Results Comments The intervention appeared to be more influential for intervention participants not enrolled in higher education compared with control participants not enrolled in higher education aOR of verified quit at 3 months =2.7, 95% CI: (1.0, 7.4). ‘unknown’ for 47 participants who did not complete baseline survey but looking at numbers in each group it is possible that majority of these participants were from control group although all participants were blinded to treatment External validity Participants had to be seriously thinking about quitting in next 30 days – motivated sample. Financial incentives for completing follow-up surveys. Sample classed as ‘low income’ and low income defined as <$35,000! However, 43% report an annual household income of less than $15,000. Majority were male which is unusual. Having this type of control group suggests content of text messages is important. Validity of author’s conclusion Overall significant increased quit rates in intervention group vs control group at 6-weeks were not sustained at 3 months. Tailored text messaging appears to benefit 148 Details Method Individual smoking cessation support situations/triggers/urges. Early Quit messages, sent on Quit Day and through the first week post quit, talked about common difficulties and discomforts associated with quitting and emphasized the use of coping strategies. Late Quit messages encouraged participants to recognize relapse in a different way (e.g., situations, confidence) and provided actionable information about how to deal with issues that arise as a nonsmoker (e.g., stress, moods). Text message at Post-Quit Day 2 and 7 that asked their smoking status. At either time point, if participants reported smoking, they were pathed to Relapse messages that focused on helping them get back on track and to recommit to quitting. If participants were smoking at both days, they were pathed to an Encouragement arm that focused on norms for quitting and suggested that participants try quitting again at later time. Participants received four messages per day during the 2-week Pre-Quit stage, with the exception of Day 1 and Day 14 when they received five and six messages, respectively. In the Early Quit stage, participants received nine messages on both Quit Day and Post-Quit Day 2, eight messages on the third day, and then Results Comments youth not enrolled in higher education. 149 Details Method Results Comments Individual smoking cessation support one fewer message each day until the last day of the week when four messages were received. In Late Quit, participants received two messages per day for 2 weeks and then one message per day during the final week. Participants in Relapse received two messages per day; those in Encouragement received one message per day for 4 days. Intervention group participants had access to two program components first used in the STOMP NZ program (Rodgers et al., 2005): (a) Text Buddy (another person in the program that a participant was assigned to so they could text one another for support anonymously during the program; assignment was sequential so that buddies would be in similar stages during the quitting process); (b) Text Crave (immediate, on-demand messages aimed at helping the participant through a craving). A project Web site (StopMySmoking.com) provided additional quitting resources, technical support, and a discussion forum. Control group received similar number of text messages, message content was aimed at improving sleep and exercise habits within the context of how it would help the participant quit smoking. Messages 150 Details Method Results Comments Individual smoking cessation support were not tailored based on quitting stage nor were Text Buddy and Text Crave components available 151 7.7 Appendix G Quality assessment Generalisability+ to Attributability intervention††† Attrition rate†† Credibility of collection instruments† Comparability*** data Quality of execution## Randomisation** Study design# Representativeness* Study Smoking restriction in schools, workplaces, and other public places Akhtar 2010 1.2 yes n/a n/a yes yes Galan 2012 1.1 yes n/a n/a yes n/a regional MacKay 2010 1.2 yes n/a n/a yes yes national Millett 2013 1.2 yes n/a n/a yes yes national Moore 2011 1.2 yes n/a n/a yes yes yes national Moore 2012 1.2 yes n/a n/a yes yes yes national Nabi-Burza 2012 1.1 n/a n/a yes n/a Noach 2012 1.1 n/a n/a yes n/a Woodruff 2000 2.1 n/a n/a yes national yes yes national Controls on advertising, promotion and marketing of tobacco Gilpin & Pierce 1997 1.1 yes n/a Hammond 2011 3.1 yes Pucci 1998 1.1 n/a n/a yes n/a yes n/a n/a yes n/a n/a n/a yes yes national yes Mass media campaigns Vallone 2009 1.2 Increases in price/tax of tobacco products Biener 1998 1.1 yes n/a n/a Gilpin & Pierce 1997 1.1 yes n/a n/a Glied 2002 1.4 n/a Gruber 2000 1.4 Madden 2007 1.3 Perretti-Watel 2010 1.1 yes yes n/a regional yes n/a national n/a yes yes n/a n/a yes yes n/a n/a yes n/a n/a n/a regional n/a n/a yes yes national n/a n/a yes n/a n/a n/a yes yes n/a n/a yes n/a n/a n/a yes n/a yes yes yes yes yes yes national Controls on access to tobacco products Kim 2006 1.3 Lipperman-Kreda 2012 1.1 Millett 2011 1.2 Schneider 2011 1.2 Widome 2012 1.1 yes yes yes yes national yes regional School-based prevention Bacon 2001 3.1 yes Campbell 2008++ 3.1 yes yes Crone 2003++ 3.1 yes yes yes 152 Generalisability+ to yes Attributability intervention††† yes Attrition rate†† 3.3 data Menrath 2012 yes Credibility of collection instruments† 3.1 Comparability*** De Vries 2006++ Quality of execution## Randomisation** Study design# Representativeness* Study yes yes yes yes Multiple policy interventions Helakorpi 2008 1.2 Pabayo 2012 1.3 White 2008 1.2 yes yes n/a n/a yes yes n/a n/a yes yes n/a n/a yes yes national yes national Individual smoking cessation support Rodgers 2005 3.1 Ybarra 2013 3.3 yes yes yes yes yes ++study identified in Mercken 2012 #Study designs see Table 1 ## Quality of execution *Representativeness: Were the study samples randomly recruited from the study population with a response rate of at least 60% or were they otherwise shown to be representative of the study population? **Randomisation: Were participants, groups or areas randomly allocated to receive the intervention or control condition? ***Comparability: Were the baseline characteristics of the comparison groups comparable or if there were important differences in potential confounders were these appropriately adjusted for in the analysis? If there is no comparison group this criterion cannot be met. †Credibility of data collection instruments: Were data collection tools shown to be credible, e.g. shown to be valid and reliable in published research or in a pilot study, or taken from a published national survey, or recognized as an acceptable measure (such as biochemical measures of smoking). ††Attrition Rate: Were outcomes studied in a panel of respondents with an attrition rate of less than 30% or were results based on a cross-sectional design with at least 200 participants included in analysis in each wave? †††Attributability to intervention: Is it reasonably likely that the observed effects were attributable to the intervention under investigation? This criterion cannot be met if there is evidence of contamination of a control group in a controlled study. Equally, in all types of study, if there is evidence of a concurrent intervention that could also have explained the observed effects and was not adjusted for in analysis, this criterion cannot be met. + Generalisability: Is the study generalisable at National, State/Regional, or Local level? Randomisation and comparability are not applicable (N/A) for all study designs except controlled trials coded 3.1, 3.2 or 3.3. Attrition rate is N/A to cross-sectional studies coded 1.1. 153 7.8 Appendix H Summary of equity impact of youth polices/interventions Author, year Age Study design Setting, country SES variable policy/intervention outcome Equity impact Smoking restriction in schools, workplaces and other public places Akhtar 2010 11 Repeat crosssectional Primary schools, Scotland SEC, FAS Smokefree national legislation SHS exposure Greatest absolute reduction for low SES, but relative inequalities may have widened Galan 2012 15-16 Crosssectional Secondary schools, Spain Census tract of school, parental education Voluntary compliance Smoking on school premises A higher probability of smoking on school premises among adolescents whose fathers had a lower level of educational attainment. However, at the school level there was no significant impact MacKay 2010 0-14 Repeat crosssectional Hospitals, Scotland Area deprivation score (IMD) Smokefree national legislation Admission rates There were no significant interactions between hospital admissions for asthma and quintile of SES. All SES subgroups associated with significant reduction in admissions Millett 2013 0-14 Interrupted time series Hospitals, England Area deprivation score (IMD) Smokefree national legislation Admission rates Significant and similar reductions in asthma admission rates among children from different SES groups Moore 2011 11 Repeat crosssectional Primary schools, Wales FAS Smokefree national legislation SHS exposure Reductions limited to children from more affluent households, whose exposure was already significantly lower prior to legislation, leading to increased socioeconomic disparity Moore 2012 11.2 Repeat crosssectional Primary schools, Scotland, Northern Ireland, Wales FAS Smokefree national legislation SHS exposure Smoking restrictions in the home and car Declines in exposure occurred predominantly among children with low exposure before legislation, and from more affluent families. Substantial socioeconomic gradients in proportions of children with higher 154 Author, year Age Study design Setting, country SES variable policy/intervention outcome Equity impact SHS exposure levels remained unchanged. No change in inequality following legislation for home and car-based smoking restrictions (socioeconomic patterning remained stable). Nabi-Burza 2012 0-18? Single crosssectional Paediatric practices, USA Parental education Noach 2012 15 Crosssectional Secondary schools, Israel Parental education Woodruff 2000 19 Before and after experimental study US Navy recruitment centre, females only Education Voluntary smokefree policy smoking behaviour in cars and home Parental education level was not significantly associated with strictly enforced smokefree car policy on its own, only significant in interaction with child age and amount smoked. College educated parents of children aged <1 year were more likely to have strict smoke-free car policies. Voluntary compliance SHS exposure Parental education was a significant predictor of smoking in the home but not at school, exposure was significantly greater amongst adolescents whose parents had less education 8-week 24-hour smoking ban Smoking relapse Education did not predict smoking relapse car Controls on advertising, promotion and marketing of tobacco Gilpin Pierce 1997 & Hammond 2011 14-21 in 197989 Crosssectional US population surveys Education Tobacco marketing Smoking initiation Level of education impacted on initiation rates with initiation rates highest among high school dropouts and lowest amongst those who eventually attended college 18-19 RCT, convenience US online survey, Education Cigarette packaging Brand appeal Reactions to/perceptions of different types of packs was the same by 155 Author, year Age Pucci 1998 5-14 15-19 Study design SES variable sample Setting, country females only policy/intervention outcome Equity impact Crosssectional US field observation Median income household Advertising buffer zones around schools Advertising density Neighbourhoods with the lowest median household incomes showed highest advertising density inside school buffer zones US population survey Median household income, median household education at zip code level American Legacy Foundation’s truth® campaign Awareness, receptivity to the campaign Youth who lived in zip codes in which the median household income was less than or equal to US$ 35,000 had a lower level of confirmed awareness than respondents in other income categories. Zip code level median household income was not associated with confirmed awareness and there were no differences in receptivity by zip code level income or education SES for nearly all the measures Mass media campaigns Vallone 2009 12-17 Crosssectional Increases in price/tax of tobacco products Biener 1998 Gilpin Pierce 1997 & Glied 2002 12-17 Crosssectional US statewide survey Household income Cigarette increase tax Smoking behaviour Low-income teenagers more likely than more affluent teens to cut costs by cutting down on smoking or (less often) by switching to cheaper brands. Young low-income smokers were not more likely than wealthier teenagers to consider quitting 14-21 in 19791989 Crosssectional US population surveys Education Cigarette increase tax Smoking initiation Level of education impacted on initiation rates with initiation rates highest among high school dropouts and lowest amongst those who eventually attended college 14-23 in 1979 Cohort with longitudinal and cross- US population Family income Cigarette increase tax Smoking behaviour Tax at age 14 had a statistically significant negative effect on current smoking including initiation for low 156 Author, year Age Study design sectional data Setting, country survey SES variable Parental education Cigarette prices, clean air, access Price elasticity Price is the most important determinant of smoking by teens aged 16-18 years but not younger teenagers. Sensitivity to prices increases for those with less educated parents, sensitivity to price intensity increased for those with more educated parents Education Cigarette taxes Smoking initiation Increased cigarette prices were associated with later initiation among those with an intermediate education, but not those with only a primary education. Parental education Tobacco increase price Smoking behaviour Smokers with a lower SES were less likely to react to the price increase Gruber 2000 13-18 Crosssectional, econometric US surveys Madden 2007 19 Retrospective longitudinal Ireland, survey women PerrettiWatel 2010 19.5 Crosssectional France, regional survey, university students policy/intervention outcome Equity impact income people. Elasticities declined over time for low income people. By age 39 the effect of taxes at age 14 has largely disappeared. of Controls on access to tobacco products Kim 2006 15 Cohort US schoolbased survey, females only Parental education, parental income Statewide tobacco control policies, statewide cigarette excise tax Smoking behaviour Stronger state level tobacco policies on age of sale were associated with lower likelihood of smoking initiation and adverse transition among low SES girls, although the effect sizes were small. LippermanKreda-2012 19 Crosssectional Tobacco retailers, California, USA percentage of population with a college education, median household Underage tobacco sales laws Compliance Higher education was a significant predictor of underage tobacco sales. 157 Author, year Age Study design Setting, country SES variable policy/intervention outcome Equity impact Significant reduction in regular smoking among youth, regular smoking was not significantly different in pupils eligible for FSM compared with those that were not. Higher access reported for other sources by FSM eligible pupils. Following increase in age of sale significant reduction in access in non-FSM but not FSM. income Millett 2011 13 Repeat crosssectional Secondary schools, England Free school meals Legislation in England, Scotland and Wales increasing minimum age for legal purchase of tobacco from 16 to 18 years Smoking behaviour Schneider 2011 17.6% aged 020 Before & after City-wide (Cologne), Germany, observational Income, unemployment, social welfare, low-qualifying schools Electronic locking devices on vending machines to prevent underage (<16 years) purchasing Density vending machines Widome 2012 15-18 Crosssectional Licensed tobacco vendors, Minnesota, US Below 150% poverty level Age-of-sale tobacco checks Compliance There was no association between store advertising characteristics or poverty and stores’ compliance check failure. Free/reduced lunch status ‘Too Good Drugs II’ for Intentions, attitudes and perceptions towards tobacco use Programme was similarly effective in impacting students risk and protective factors regardless of SES FAS, FSM Peer-led network smoking prevention social based uptake Smoking in past week The results were mixed depending on the specific SES indicator used. The intervention was most effective for adolescents in the Valley schools, located in a deprived area, particularly low SES girls. of The lower the income level in a district, the higher the availability of cigarettes, significant difference both before and after locking devices School-based prevention Bacon 2001 11 Cluster RCT Middle schools, Florida, US Campbell 2008* 12-13 RCT England Wales & 158 Author, year Age Study design Setting, country SES variable policy/intervention outcome Equity impact Crone 2003* 13 RCT Netherlands Parental education Anti-smoking classbased intervention Experimenting with smoking or smoking daily or weekly The intervention had a significant effect among higher SES adolescents and appeared to widen the inequalities in the short-term. All significant intervention effects disappeared at 12 months follow-up. De Vries 2006* 13.5 RCT Portugal Spending money Smoking prevention school policies, also parents and community Ever/never smoking The results were mixed depending on the SES indicator used. When using spending money as a SES indicator, the intervention appeared to decrease inequalities in smoking but results unclear due to small number in ‘mid to high’ spending money subgroup and use of ‘spending money’ as proxy measure of SES. Menrath 2012 12 Quasi randomised Public secondary general schools, Northern Germany FAS Two validated life skills programmes including element of smoking prevention Self-report cigarettes smoked per week, 30-day smoking prevalence The two school-based life skills programmes had a positive effect on smoking prevention and benefitted children of all SES equally. Multiple policy interventions Helakorpi 2008 13-20 Repeat crosssectional Finland, national postal survey Occupation 1976 Tobacco Control Act (smokefree, age of sale, health warnings) Smoking prevalence (ever smoked daily for at least one year) 1976 TCA appears to have had the greatest impact on male white collar employees. Among women, the apparent effect was very pronounced in all socioeconomic groups and among blue collar female workers the cohort trend tended to decline. Pabayo 2012 12.7 Cohort, convenience Canada, school-based Household income Smoking intolerance Smoking initiation No significant impact on smoking initiation by SES for smoking in 159 Author, year Age Study design sample White 2008 12-17 Crosssectional Setting, country observational study SES variable policy/intervention outcome Australia, school-based survey Area-based Index of Relative SocioEconomic Disadvantage (IRSD) 3 periods of tobacco control activity: low tobacco-control funding (19921996), high tobacco-control activity (1984-1991, and 1997-2005) which included smoking restrictions and increased tax Smoking prevalence The magnitude of the decreases in smoking prevalence between 1996 and 2005 did not differ significantly between SES groups for most indicators of smoking behaviour. Less impact on younger low SES in period of low tobacco control funding. schools, restaurants and corner stores near schools Equity impact intolerance in schools, restaurants or corner stores Individual smoking cessation support Rodgers 2005 25 (mean) RCT New Zealand, any setting, any location Income level Text-messaging Smoking cessation Text messaging doubled quit rates and this effect was consistent across major subgroups including income level Ybarra 2013 22 (mean) RCT USA, national Enrolment in higher education Text-messaging Continuous abstinence, 7-day point prevalence Significant increase in quit rates in intervention group vs control group at 6-weeks were not sustained at 3 months. Tailored text messaging appeared to benefit youth not enrolled in higher education. *study identified in Mercken 2012 160 7.9 Appendix I Equity impact model of youth policies/interventions by SES measure First author Income pos neu neg Area-level deprivation Education pos pos neu neg neu Occupation neg pos neu neg Smoking restriction in cars, schools, workplaces and other public places Akhtar 2010 Galan 2012 MacKay 2010 Millett 2013 Moore 2011 Moore 2012 Nabi-Burza 2012 Noach 2012 Woodruff 2000 Controls on advertising, promotion and marketing of tobacco Gilpin 1997 Hammond 2011 Pucci 1998 Mass media campaigns Vallone 2009 Increases in price/tax of tobacco products Biener 1998 Gilpin 1997 Glied 2002 Gruber 2000 Madden 2007 Perretti-Watel 2010 Controls on access to tobacco products Kim 2006 Lipperman-Kreda 2012 Millett 2011 Schneider 2011 Widome 2012 School-based prevention Bacon 2001 Campbell 2008** Crone 2003** DeVries 2006** Menrath 2012 Multiple policy interventions Helakorpi 2008 Pabayo 2012 White 2008 Individual smoking cessation support 161 First author Income pos Rodgers 2005 Ybarra 2013 **Study identified in Mercken 2012 neu neg Area-level deprivation Education pos pos neu neg neu Occupation neg pos neu This equity impact model of youth studies should be read in conjunction with the text in Section 2.2.5 This matrix is based upon a hypothesis-testing model adapted from a model used in the York review16: The null hypothesis of a neutral equity impact that for any given socio-economic characteristic related to education, occupation or income, there is no social gradient in the effectiveness of the intervention. The hypothesis of a positive equity impact defined as evidence that groups such as lower occupational groups, those with a lower level of educational attainment, the less affluent, those living in more deprived areas, are more responsive to the intervention. The hypothesis of a negative equity impact defined as evidence that groups such as higher occupational groups, those with a higher level of educational attainment, the more affluent, or those who live in more affluent areas are more responsive to the intervention. Key to symbol colour = “hard outcome” such as smoking prevalence or consumption; = “intermediate outcome” such as beliefs and attitudes Neu = evidence supports null hypothesis i.e. neutral equity impact Pos = evidence supports hypothesis of positive equity impact Neg = evidence supports hypothesis of negative equity impact 162 neg