Table S1. Demographics and clinical data of High and Low-PM traumatic brain injury patients
PM
Age
Sex
Severity1
Cause
Lowest
PTA
GCS
Medication at time of
Structural MRI findings
scanning
recorded
Low
25
M
Mod/Sev
Assault
13
NK
Nil
NAD
Low
37
M
Mod/Sev
Fall
4
52d
Nil
MB
Low
50
M
Mod/Sev
RTA
4
42d
Ramipril 10mg OD, and
Amlodipine 10mg OD
R fronto-temporal
contusions and SS
Low
49
M
Mod/Sev
Assault
NK
NK
Nil
Bifrontal and R temporal SS
Low
48
M
Mod/Sev
Assault
NK
5d
Anti-TNF alpha
Bifrontal contusions and L
temporal contusion and SS
Low
47
F
Mod/Sev
RTA
5
42d
Nil
MB
Low
36
M
Mod/Sev
RTA
NK
10d
Nil
MB
Low
66
F
Mod/Sev
RTA
NK
77d
Amitriptyline OD and
tramadol QDS
L frontal contusion and
bilateral parietal SS
Low
34
M
Mod/Sev
RTA
14
8h
Theophylline 300mg OD,
and Seretide inhaler BD
L frontal, L parietal and L
temporal contusions; and
MB
Low
42
F
Mod/Sev
RTA
12
56d
Co-codamol QDS
NAD
Low
50
M
Mod/Sev
Assault
NK
5d
Nil
MB
Low
22
F
Mod/Sev
RTA
15
8h
Propranolol 40mg BD
L temporal SS
Low
34
F
Mod/Sev
RTA
15
5m
Thyroxine OD
R temporal contusion
Low
39
M
Mod/Sev
RTA
NK
Nil
Citalopram 40mg OD and
Omeprazole 20mg OD
Bifrontal contusions and SS
Low
26
F
Mod/Sev
RTA
14
6h
Nil
R frontal contusion
Low
34
M
Mod/Sev
Assault
14
12h
Nil
L fronto-temporal
contusions and SS
Low
67
M
Mod/Sev
Assault
NK
NK
Citalopram 20mg OD,
Simvastatin 10mg OD,
Aspirin 75mg OD and
Glucosamine 1g OD
Bifrontal contusions
Low
50
F
Mod/Sev
Fall
9
21d
Amitriptyline OD,
Salbutamol and Becotide
R frontal contusion with SS,
L frontal SS, R occipital
BD, Thiamine OD and
Vit-B-Co-strong OD
contusion and SS, and MB
Low
36
M
Mod/Sev
Fall
NK
28d
Glargine 30u BD, and
Humalog 16u TDS
Bifrontal contusions, R
temporal contusion and R
parietal SS
Low
20
F
Mod/Sev
RTA
NK
28d
OCP OD
MB
Low
32
F
Mod/Sev
Fall
14
16h
Salbutamol BD
R silvian fissure SS
Low
21
F
Mod/Sev
Fall
NK
3d
Nil
R temporal contusion and R
frontal SS
Low
41
M
Mod/Sev
RTA
NK
7d
Diclofenac 75mg BD and
co-dydramol 500mg BD
L frontal contusion
High
18
M
Mod/Sev
Fall
15
<1m
Nil
NAD
High
23
M
Mod/Sev
Assault
15
12d
Nil
Bifrontal contusions,,and L
hemisphere SS
High
54
M
Mod/Sev
Fall
NK
Nil
Alpha blockers
R fronto-temporal
contusions and SS
High
56
M
Mod/Sev
Fall
3
NK
Telmisartan 80mg OD
MB and left frontal SS
High
41
M
Mod/Sev
RTA
6
30d
Nil
MB
High
39
F
Mod/Sev
RTA
6
30d
Nil
MB, pontine and L temporooccipital SS
High
33
F
Mod/Sev
Fall
NK
NK
Nil
Bifrontal SS
High
33
M
Mod/Sev
RTA
3
42d
Nil
Bifrontal contusions
High
23
M
Mild
Sport
injury
NK
30m
Nil
MB
High
53
M
Symp
Fall
15
Nil
Nil
NAD
High
29
F
Mod/Sev
NK
NK
NK
NK
MB, R occipital and
temporal contusions, R
parietal SS
High
52
M
Mod/Sev
NK
3
NK
Nil
R fronto-temporal
contusions, SS and MB
High
34
M
Mod/Sev
Assault
14
42d
Nil
MB, bifrontal contusions, L
fronto-temporal contusions,
L SDH and SS
High
53
F
Symp
Sport
injury
15
Nil
Nil
NAD
High
24
M
Mod/Sev
Assault
NK
2d
Nil
Bifrontal contusions
High
45
M
Mod/Sev
Assault
8
30d
Thiamine 100mg OD
NAD
High
26
M
Mod/Sev
Fall
15
5m
Nil
Bifrontal contusions
High
33
M
Mod/Sev
Assault
NK
12h
Ciprofloxacin 250mg Od
L temporal and R frontal
contusions
High
49
M
Mod/Sev
Assault
NK
1d
Nil
Bifronto-temporal
contusions and bifrontal SS
High
44
M
Mod/Sev
Fall
9
1d
Nil
MB and L temporal SS
High
25
M
Mod/Sev
Assault
NK
NK
Tramadol QDS, Codeine
QDS, and Paracetamol
QDS
Bifrontal and R temporal
contusions with SS
High
48
M
Mild
RTA
NK
1h
Nil
NAD
High
50
M
Mod/Sev
Fall
NK
2d
Amlodipine 10mg
NAD
High
29
M
Mod/Sev
RTA
NK
2d
Nil
L frontal and bitemporal
contusions
High
53
F
Mod/Sev
Sport
injury
NK
1.5d
Methotrexate 25md once
weekly, Folic acid,
MB, bifrontal contusion and
pontine SS
Etanercept 50 mg once
weekly, and
Levothyroxine 25mcg OD
High
55
M
Mod/Sev
RTA
3
1d
Nil
MB and R fronto-temporal
contusions
High
21
M
Mod/Sev
Sport
injury
15
3d
Amitriptyline 20 mg OD,
Tramadol QDS,
Diclofenac (TDS), and
Paracetamol QDS
NAD
High
32
M
Mod/Sev
Fall
NK
7d
Carbamazepine MR
400mg BD
MB and bifrontal contusions
High
37
M
Mod/Sev
Assault
NK
8h
Phenytoin 200/300mg BD,
and Levetiracetam
250/500mg BD
MB, bifrontal and
bitemporal contusions,,and
L parietal SS
High
33
M
Mild
RTA
NK
1.5h
Nil
NAD
High
21
M
Mod/Sev
Sport
injury
NK
1h
Nil
NAD
High
46
F
Mild
RTA
NK
5m
Gabapentin TDS
NAD
High
35
F
Mod/Sev
RTA
NK
1d
Thyroxine 100mcg OD,
and Levothyroxine 50mcg
NAD
OD
High
33
M
Mod/Sev
Assault
7
1d
Nil
Bifrontal and R temporal
contusion, R temporal and
occipital SS
High
22
M
Mod/Sev
Fall
6
16d
Salbutamol BD
R fronto-temporal contusion
with SS
High
21
M
Mod/Sev
Assault
3
35d
Nil
MB, L temporal contusion
and SS, left frontal SS, and
pontine SS
High
49
M
Mod/Sev
RTA
15
7d
Nil
Left temporal contusion
High
47
M
Mild
RTA
NK
1h
Amitriptyline 50mg TDS
L midbrain and pontine SS
High
36
M
Mod/Sev
RTA
3
30d
Citalopram 20mg OD
MB, and R frontal contusion
with SS
High
35
M
Mod/Sev
Assault
NK
2d
Nil
MB, R frontal and temporal
SS
1
Severity classification based on MAYO criteria (Malec et al. , 2007). Moderate-Severe (Mod/Sev), Mild/Probable (Mild),
Symptomatic/Possible (Symp). Not Know (NK). Road Traffic Accident (RTA), Glasgow Coma Scale (GCS), Post-traumatic amnesia
(PTA), days (d), hours (h), minutes (m), Oral Contraceptive pill (OCP), once daily (OD), twice daily (BD), three times daily (TDS),
four times daily (QDS). Structural findings on MR imaging: micro-bleeds on gradient echo imaging (MB), superficial siderosis (SS),
no anomalies detected (NAD), right (R), left (L). Performance monitoring (PM) was defined as either Low or High indicating inclusion
in the Low and High-PM groups respectively.
Malec JF, Brown AW, Leibson CL, Flaada JT, Mandrekar JN, Diehl NN, et al. The mayo classification system for traumatic brain injury
severity. J Neurotrauma 2007; 24:1417-24.