GRUPOS DE INVESTIGACIÓN DEL IBBTEC
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Nombre del grupo:
GENOMICA Y BIOINFORMATICA
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Investigador/a principal :
Dr. JESUS SAINZ, Científico Titular CSIC
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Otro personal:
Dr. IGNACIO VARELA
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Tema de investigación:
GENETICA DE POBLACIONES DE ENFERMEDADES COMPLEJAS
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Financiación:
o FUNDACION LEONARDO TORRES QUEVEDO 2010-2011
o MINISTERIO DE EDUCACION 2011-2013
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Publicaciones relevantes (últimos 10 años)
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J Sainz, S. Gudjonsson, K. Agnarsson, O. Atladottir, U. Benitez, S. Einarsson, E.
Gonzalez, O. Traustason, S. Palsson, G. Sigurðsson, A. Kong, K. Stefansson, J.
Gulcher (2001). Human physical map version 05 and discrepancies with the UCSC
sequence draft assembly. American Journal of Human Genetics 69 (suppl): 467
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G Gudmundsson, SE Matthiasson, H Arason, H Johannsson, F Runarsson, H
Bjarnason, K Helgadottir, S Thorisdottir, G Ingadottir, K Lindpaintner, J Sainz, V
Gudnason, ML Frigge, A Kong, JR Gulcher, K Stefansson. (2002). Localization of a
gene for peripheral arterial occlusive disease to chromosome 1p31. American
Journal of Human Genetics 70:586-92
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S Gretarsdottir, S Sveinbjornsdottir, HH Jonsson, F Jakobsson, E Einarsdottir, U
Agnarsson, D Shkolny, G Einarsson, HM Gudjonsdottir, Valdimarsson EM, OB
Einarsson, G Thorgeirsson, R Hadzic, S Jonsdottir, ST Reynisdottir, SM Bjarnadottir,
T Gudmundsdottir, GJ Gudlaugsdottir, R Gill, K Lindpaintner, J Sainz, HH Hannesson,
GT Sigurdsson, ML Frigge, A Kong, V Gudnason, K Stefansson, JR Gulcher (2002).
Localization of a susceptibility gene for common forms of stroke to 5q12. American
Journal of Human Genetics 70:593-603
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A Kong, D Gudbjartsson, J Sainz, G Jonsdottir, S Gudjonsson, B Richardsson, S
Sigurdardottir, B Hallbeck, G Masson, A Shlien, S Palsson, ML Frigge, TE
Thorgeirsson, JR Gulcher, Kstefansson (2002). A High Resolution Recombination
Map of the Human Genome. Nature Genetics 31: 241-7.
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H Stefansson, E Sigurdsson, V Steinthorsdottir, S Bjornsdottir, T Sigmundsson, S
Ghosh, J Brynjolfsson, S Gunnarsdottir, O Ivarsson, TT Chou, O Hjaltason, B
Birgisdottir, H Jonsson, VG Gudnadottir, E Gudmundsdottir, A Bjornsson, B
Ingvarsson, A Ingason, S Sigfusson, H Hardardottir, RP Harvey, D Lai, M Zhou, D
Brunner, V Mutel, G Acuňa, G Lemke, J Sainz, G Johannesson, T Andresson, D
Gudbjartsson, A Manolescu, ML Frigge, ME Gurney, A Kong, JR Gulcher, H
Petursson, and K Stefansson (2002). Neuregulin 1 and Susceptibility to
Schizophrenia. American Journal of Human Genetics 71:877-892
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A Hicks, H Peturson, T Jonsson, H Stefansson, J Sainz, M L. Frigge, A Kong, JR.
Gulcher, K Stefansson (2002). A Susceptibility Gene for Late-onset Idiopatic
Parkinson Disease Mapped on Chromosome 1. Annals of Neurology 52:549-555.
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A Jonasdottir, T Thorlacius, R Fossdal, K Benediktsson, J Benedikz, HH Jonsson, J
Sainz, H Einarsdottir, S Sigurdardottir, G Kristjansdottir, S Sawcer, A Compston, K
Stefansson, J Gulcher (2003 ) A whole genome association study in Icelandic
multiple sclerosis patients with 4804 markers. Journal of Neuroimmunology.
143:88-92.
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A Helgadottir, A Manolescu, G Thorleifsson, S Gretarsdottir, H Jonsdottir, U
Thorsteinsdottir, NJ Samani, G Gudmundsson, SF Grant, G Thorgeirsson, S
Sveinbjornsdottir, EM Valdimarsson, SE Matthiasson, H Johannsson, O
Gudmundsdottir, ME Gurney , J Sainz, M Thorhallsdottir, M Andresdottir, ML Frigge,
EJ Topol, A Kong, V Gudnason, H Hakonarson, JR Gulcher, K Stefansson (2004). The
gene encoding 5-lipoxygenase activating protein confers risk of myocardial
infarction and stroke. Nature Genetics. 36:233-9.
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H Stefansson, A Helgason, G Thorleifsson, V Steinthorsdottir, G Masson, J Barnard,
A Baker, A Jonasdottir, A Ingason, VG Gudnadottir, N Desnica, A Hicks, A Gylfason,
DF Gudbjartsson, GM Jonsdottir, J Sainz, K Agnarsson, B Birgisdottir, S Ghosh, A
Olafsdottir, JB Cazier, K Kristjansson, ML Frigge, TE Thorgeirsson, JR Gulcher, A
Kong, K Stefansson (2005). A common inversion under selection in Europeans.
Nature Genetics. 37:129-37.
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J Sainz, P Rovensky, S Gudjonsson, G Thorleifsson, K Stefansson, JR Gulcher. (2006)
Segmental duplication density decrease with distance to human-mouse breaks of
synteny European Journal of Human Genetics 14:216-21.
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A Helgadottir, A Manolescu, A Helgason, G Thorleifsson, U Thorsteinsdottir, D
Gudbjartsson. S Grant, J Sainz, SJ O’Brien, SE Matthiasson, AI Levey, JL Abramson, M
Reilly, V Vaccarino, M Wolfe, V Gudnason, AA Quyyumi, EJ Topol, DJ Rader, G
Thorgeirsson, JR Gulcher, H Hakonarson, A Kong, K StefanssoN (2006) A variant of
the gene encoding leukotriene A4 hydrolase confers ethnic specific risk of
myocardial infarction. Nature Genetics 38:68-74.
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S F.A. Grant, G Thorleifsson, I Reynisdottir, R Benediktsson, A Manolescu, J Sainz, A
Helgason, H Stefansson, V Emilsson, A Helgadottir, U Styrkarsdottir, G. B Walters, E
Palsdottir, T Jonsdottir, T Gudmundsdottir, A Gylfason, J Saemundsdottir, M P.
Reilly, D J. Rader, Y Bagger, C Christiansen, V Gudnason, G Sigurdsson, U
Thorsteinsdottir, J R. Gulcher, A Kong, K Stefansson (2006) Variant of the
transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nature
Genetics 38:320-3.
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Amundadottir LT, Sulem P, Gudmundsson J, Helgason A, Baker A, Agnarsson BA,
Sigurdsson A, Benediktsdottir KR, Cazier JB, Sainz J, Jakobsdottir M, Kostic J,
Magnusdottir DN, Ghosh S, Agnarsson K, Birgisdottir B, Le Roux L, Olafsdottir A,
Blondal T, Andresdottir M, Gretarsdottir OS, Bergthorsson JT, Gudbjartsson D,
Gylfason A, Thorleifsson G, Manolescu A, Kristjansson K, Geirsson G, Isaksson H,
Douglas J, Johansson JE, Balter K, Wiklund F, Montie JE, Yu X, Suarez BK, Ober C,
Cooney KA, Gronberg H, Catalona WJ, Einarsson GV, Barkardottir RB, Gulcher JR,
Kong A, Thorsteinsdottir U, Stefansson K (2006) A common variant associated with
prostate cancer in European and African populations. Nature Genetics 38:652-8.
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Deardorff MA, Sainz J, Grant SF (2011). Another tool in the genome-wide
association study arsenal: population-based detection of somatic gene conversion.
BMC Med. 3;9:13.
Contacto:
Jesús Sainz
Instituto de Biomedicina y Biotecnologia de Cantabria (IBBTEC), CSIC-UC-SODERCAN
Ave. Cardenal Herrera Oria s/n (Facultad de Medicina)
39011 Santander, Spain
Phone (cell): +34-655-437267
Phone (office): +34-942-201577
FAX: +34-942-201945
sainzjv@unican.es