1
Table S-4. Exploratory analysis of the association of PCK1 polymorphisms with BMI in the three psychiatric samples.
Discovery Sample#
rs11552145
n
BMI [kg/m2] (SE)
Baseline BMI
rs707555
n
BMI [kg/m2] (SE)
rs8123020
n
BMI [kg/m2] (SE)
rs2071023
n
BMI [kg/m2] (SE)
AA
G-allele
22
354
22.4 (0.7)
24.3 (0.3)
GG
10
C-allele
366
23.6 (6.7)
24.2 (5.1)
TT
10
C-allele
366
23.4 (3.1)
24.2 (5.2)
CC
122
G-allele
277
23.6 (0.5)
24.4 (0.3)
Replication 1
p-value$
0.36
AA
131
24.3 (1.4)
25.5 (0.4)
CC
33
G-allele
106
24.8 (0.6)
25.6 (0.5)
rs11552145
BMI [kg/m2] (SE)
Current BMI
rs707555
n
BMI [kg/m2] (SE)
rs8123020
n
BMI
[kg/m2]
(SE)
rs2071023
n
AA
G-allele
12
421
22.8 (2.9)
25.4 (5.4)
CC
12
G-allele
421
25.1 (6.1)
25.3 (5.4)
TT
C-allele
10
423
25.8 (2.6)
25.3 (5.4)
CC
143
G-allele
333
p-value
0.49
AA
G-allele
10
169
23.8 (0.7)
25 (0.4)
CC
46
G-allele
130
24.5 (0.7)
25.0 (0.5)
Combined Sample*
p-value
0.46
AA
G-allele
40
654
23.1 (0.5)
24.7 (0.2)
CC
194
G-allele
496
24.0 (0.4)
24.8 (0.2)
p-value
0.05
p-value$
1.00
p-value$
1.00
p-value$
0.28
Discovery Sample#
n
G-allele
8
Replication 2
p-value
0.66
Replication 1
p-value$
0.08
AA
G-allele
8
160
27.1 (1.3)
28.2 (0.4)
CC
39
G-allele
128
p-value
0.58
Replication 2
p-value
0.57
AA
G-allele
11
170
26.9 (1.6)
27.3 (0.4)
CC
49
G-allele
132
p-value
0.048
Combined Sample*
p-value
0.80
AA
G-allele
30
742
23.3 (0.6)
25.7 (0.2)
CC
287
G-allele
722
p-value
0.01
p-value$
1.00
p-value$
1.00
p-value$
p-value
p-value
0.018
0.41
0.88
24.5 (0.5)
25.7 (0.3)
27.5 (0.7)
28.3 (0.5)
26.9 (0.7)
27.3 (0.5)
25.3 (0.3)
26.4 (0.2)
BMI [kg/m2] (SE)
# For current BMI, only significant findings in the discovery sample were further tested for replication. The same SNPs were also tested for replication at the baseline BMI.
*Only patients treated for up to 24 months.
$
p-corrected value for the discovery sample.
p-value
0.003