HEPATIC PATHWAYS Females NES Nominal P-value FDR q-value 2.210 1.737 2.005 1.947 1.843 1.847 1.776 1.730 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.001 0.002 0.004 0.011 0.013 0.024 0.036 2.371 2.272 2.221 1.957 1.878 1.855 1.807 1.766 1.751 1.676 1.711 1.694 1.677 1.681 1.695 0.000 0.000 0.000 0.000 0.000 0.001 0.002 0.007 0.009 0.007 0.004 0.008 0.008 0.004 0.007 0.000 0.000 0.000 0.005 0.013 0.015 0.022 0.029 0.029 0.039 0.040 0.041 0.042 0.043 0.044 KEGG PATHWAYS Enriched in control group KEGG CELL CYCLE KEGG OOCYTE MEIOSIS KEGG DNA REPLICATION KEGG MISMATCH REPAIR KEGG ECM RECEPTOR INTERACTION KEGG NUCLEOTIDE EXCISION REPAIR KEGG SPLICEOSOME KEGG PROGESTERONE MEDIATED OOCYTE MATURATION BIOCARTA PATHWAYS Enriched in control group BIOCARTA CELLCYCLE PATHWAY BIOCARTA G2 PATHWAY BIOCARTA MCM PATHWAY BIOCARTA G1 PATHWAY BIOCARTA RAC1 PATHWAY BIOCARTA EDG1 PATHWAY BIOCARTA TPO PATHWAY BIOCARTA EIF4 PATHWAY BIOCARTA HCMV PATHWAY BIOCARTA P53HYPOXIA PATHWAY BIOCARTA FCER1 PATHWAY BIOCARTA BCR PATHWAY BIOCARTA GH PATHWAY BIOCARTA RACCYCD PATHWAY BIOCARTA GCR PATHWAY BIOCARTA ECM PATHWAY 1.647 0.009 0.049 1.933 1.934 1.928 1.936 1.893 1.894 1.901 1.897 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.001 0.001 0.001 0.001 0.002 0.002 0.002 0.002 1.882 0.000 0.002 1.877 1.855 1.852 1.822 1.792 1.788 1.768 1.765 1.769 1.753 1.755 1.745 1.730 1.726 1.722 0.000 0.000 0.002 0.000 0.000 0.001 0.001 0.000 0.000 0.000 0.000 0.000 0.001 0.000 0.000 0.002 0.003 0.003 0.004 0.007 0.007 0.009 0.009 0.009 0.009 0.010 0.010 0.012 0.012 0.013 REACTOME PATHWAYS Enriched in control group REACTOME CELL CYCLE MITOTIC REACTOME MRNA SPLICING REACTOME GLUCOSE TRANSPORT REACTOME GLOBAL GENOMIC NER REACTOME SNRNP ASSEMBLY REACTOME E2F TRANSCRIPTIONAL TARGETS AT G1 S REACTOME REV MEDIATED NUCLEAR EXPORT OF HIV1 RNA REACTOME ELONGATION AND PROCESSING OF CAPPED TRANSCRIPTS REACTOME FORMATION AND MATURATION OF MRNA TRANSCRIPT REACTOME PLC BETA MEDIATED EVENTS REACTOME METABOLISM OF RNA REACTOME DOUBLE STRAND BREAK REPAIR REACTOME G2 M TRANSITION REACTOME RNA POLYMERASE II TRANSCRIPTION REACTOME TELOMERE MAINTENANCE REACTOME SMOOTH MUSCLE CONTRACTION REACTOME PLATELET DEGRANULATION REACTOME MITOTIC M M G1 PHASES REACTOME S PHASE REACTOME CELL CYCLE CHECKPOINTS REACTOME HIV LIFE CYCLE REACTOME DUAL INCISION REACTION IN GG NER REACTOME PLATELET ACTIVATION REACTOME GENE EXPRESSION REACTOME CENTROSOME MATURATION REACTOME DEADENYLATION OF MRNA REACTOME RNA POLYMERASE I PROMOTER OPENING REACTOME SYNTHESIS OF DNA REACTOME RNA POLYMERASE I CHAIN ELONGATION REACTOME DNA REPAIR REACTOME G1 S TRANSITION REACTOME LATE PHASE OF HIV LIFE CYCLE REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES REACTOME NUCLEOTIDE EXCISION REPAIR REACTOME TRANSCRIPTION REACTOME TRANSLATION INITIATION COMPLEX FORMATION REACTOME MUSCLE CONTRACTION REACTOME TRANSCRIPTION COUPLED NER REACTOME GENERIC TRANSCRIPTION PATHWAY REACTOME DNA REPLICATION PRE INITIATION REACTOME RNA POLYMERASE I PROMOTER CLEARANCE REACTOME HIV INFECTION REACTOME FORMATION OF PLATELET PLUG REACTOME ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 REACTOME MRNA SPLICING MINOR PATHWAY REACTOME PYRIMIDINE METABOLISM REACTOME FURTHER PLATELET RELEASATE REACTOME METABOLISM OF MRNA REACTOME OPIOID SIGNALLING REACTOME TRANSLATION REACTOME GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT REACTOME NCAM1 INTERACTIONS REACTOME INFLUENZA LIFE CYCLE 1.714 1.703 1.696 1.691 1.680 1.692 1.680 1.681 1.682 1.685 1.683 1.646 1.647 1.650 1.648 1.643 1.639 1.627 1.614 1.616 1.601 1.588 1.586 1.582 1.583 1.579 1.571 0.000 0.009 0.001 0.000 0.005 0.000 0.000 0.000 0.000 0.001 0.000 0.002 0.003 0.004 0.011 0.000 0.001 0.000 0.000 0.009 0.010 0.016 0.012 0.007 0.003 0.001 0.002 0.014 0.015 0.016 0.016 0.016 0.016 0.016 0.016 0.017 0.017 0.017 0.022 0.022 0.022 0.022 0.022 0.023 0.025 0.028 0.028 0.032 0.035 0.035 0.035 0.036 0.036 0.038 1.572 1.558 0.007 0.001 0.038 0.042 REACTOME APOPTOTIC EXECUTION PHASE REACTOME FORMATION OF THE EARLY ELONGATION COMPLEX REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX REACTOME SIGNAL AMPLIFICATION REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE REACTOME HIV1 TRANSCRIPTION INITIATION REACTOME RNA POLYMERASE I. III AND MITOCHONDRIAL TRANSCRIPTION 1.550 1.551 0.009 0.017 0.043 0.044 1.544 0.009 0.045 1.545 1.534 0.021 0.033 0.045 0.048 1.535 1.530 0.018 0.001 0.048 0.049