supplementary table s1. - Springer Static Content Server
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SUPPLEMENTARY TABLE S1. List of differentially expressed genes in TREM2-/- vs. WT Adj P-value Log Fold Change 6-weeks 3.80E-02 -2.091 10572130 LPL lipoprotein lipase Cytoplasm enzyme 6-weeks 1.55E-02 -1.476 10343839 XPO6 exportin 6 Cytoplasm transport er 6-weeks 1.55E-02 -1.435 10344340 CSDE1 Cytoplasm enzyme 6-weeks 1.55E-02 1.409 10448559 D330041H03 Rik Other Other 6-weeks 1.55E-02 1.549 10350758 CPSF3 Nucleus enzyme 6-weeks 1.55E-02 1.599 10561453 ZFP36 cold shock domain containing E1, RNA-binding RIKEN cDNA D330041H03 gene cleavage and polyadenylation specific factor 3, 73kDa ZFP36 ring finger protein Nucleus transcripti on regulator 6-weeks 1.55E-02 1.677 10565609 THRSP thyroid hormone responsive Nucleus other 6-weeks 2.56E-02 1.872 10498367 P2RY13 Plasma Membrane G-protein coupled receptor 6-weeks 3.45E-02 1.945 10524338 DEF6 Extracellular Space other 6-weeks 1.55E-02 2.093 10498371 P2RY12 purinergic receptor P2Y, Gprotein coupled, 13 differentially expressed in FDCP 6 homolog (mouse) purinergic receptor P2Y, Gprotein coupled, 12 Plasma Membrane G-protein coupled receptor 6-weeks 1.82E-02 2.128 10532741 TMEM119 transmembrane protein 119 Cytoplasm other 6-weeks 1.55E-02 2.226 10553559 Siglech sialic acid binding Ig-like lectin H Plasma Membrane other Time point ID Symbol Entrez Gene Name Location Type(s) 6 WEEKS 1.55E-02 3.015 10608711 Erdr1 erythroid differentiation regulator 1 Other Other 12-weeks 3.48E-03 -2.041 10445781 TREM2 triggering receptor expressed on myeloid cells 2 Plasma Membrane transmem brane receptor 12-weeks 2.37E-02 -1.72 10362186 MOXD1 Cytoplasm other 12-weeks 4.07E-02 -1.656 10341721 MOB1A monooxygenase protein 1 MOB kinase activator 1A Plasma Membrane other 12-weeks 4.31E-02 -1.314 10572130 LPL lipoprotein lipase Cytoplasm enzyme 12-weeks 3.91E-02 -1.174 10583669 C19orf38 chromosome 19 open reading frame 38 Other other 12-weeks 4.43E-02 -1.142 10463875 SORCS3 sortilin-related VPS10 domain containing receptor 3 Nucleus transport er 12-weeks 3.91E-02 1.003 10597268 TDGF1 teratocarcinomaderived growth factor 1 Extracellular Space growth factor 12-weeks 3.73E-02 1.046 10433197 COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) Cytoplasm other 12-weeks 4.74E-02 1.051 10414537 ERN1 endoplasmic reticulum to nucleus signaling 1 Cytoplasm kinase 12-weeks 1.52E-02 1.066 10538802 NDNF neuron-derived neurotrophic factor Extracellular Space other 12-weeks 4.74E-02 1.068 10563178 CD37 CD37 molecule Plasma Membrane other 12-weeks 3.91E-02 1.068 10444780 HLA-A major Plasma other 6-weeks 12 WEEKS histocompatibilit y complex, class I, A Membrane 12-weeks 3.91E-02 1.08 10574259 GPR56 G proteincoupled receptor 56 Plasma Membrane G-protein coupled receptor 12-weeks 2.87E-02 1.081 10524621 Oasl2 2'-5' oligoadenylate synthetase-like 2 Other enzyme 12-weeks 4.65E-02 1.118 10541885 SCNN1A sodium channel, non-voltagegated 1 alpha subunit Plasma Membrane ion channel 12-weeks 3.91E-02 1.158 10510516 SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 Plasma Membrane transport er 12-weeks 2.16E-02 1.162 10562709 CD33 antigen Plasma Membrane other 12-weeks 2.81E-02 1.164 10496580 guanylate binding protein 4 Cytoplasm enzyme 12-weeks 1.17E-02 1.178 10530393 GABRG1 gammaaminobutyric acid (GABA) A receptor, gamma 1 Plasma Membrane ion channel 12-weeks 1.98E-02 1.198 10461979 PREPL prolyl endopeptidaselike Other peptidase 12-weeks 1.05E-02 1.201 10466521 Gcnt1 Other other 12-weeks 4.43E-02 1.205 10385500 Irgm1 Beta-1,3galactosyl-Oglycosylglycoprotein beta-1,6-Nacetylglucosamin yltransferase immunity-related GTPase family M member 1 Cytoplasm other Cd33 GBP4 12-weeks 3.00E-02 1.22 10388902 Lgals9 Galectin-9 Extracellular Space other 12-weeks 3.48E-03 1.231 10462618 LAMB2 laminin, beta 2 (laminin S) Extracellular Space enzyme 12-weeks 1.98E-02 1.276 10500808 OLFML3 olfactomedin-like 3 Extracellular Space other 12-weeks 3.00E-02 1.296 10361234 HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 Cytoplasm enzyme 12-weeks 4.22E-03 1.332 10462621 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) Nucleus other 12-weeks 3.27E-02 1.347 10556528 PDE3B phosphodiesteras e 3B, cGMPinhibited Cytoplasm enzyme 12-weeks 2.18E-02 1.355 10366153 RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 Cytoplasm transport er 12-weeks 4.22E-03 1.36 10565609 THRSP thyroid hormone responsive Nucleus other 12-weeks 1.84E-02 1.386 10455961 Iigp1 Cytoplasm enzyme 12-weeks 3.20E-02 1.402 10532744 SELPLG interferon inducible GTPase selectin P ligand Plasma Membrane other 12-weeks 3.44E-02 1.413 10433101 GPR84 G proteincoupled receptor 84 Plasma Membrane G-protein coupled receptor 12-weeks 3.31E-02 1.427 10547906 LAG3 lymphocyteactivation gene 3 Plasma Membrane transmem brane receptor 12-weeks 4.74E-02 1.438 10527638 ALOX5AP arachidonate 5lipoxygenaseactivating protein Plasma Membrane other 12-weeks 1.37E-02 1.46 10446965 RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) Cytoplasm other 12-weeks 2.17E-02 1.468 10385583 LTC4S leukotriene C4 synthase Cytoplasm enzyme 12-weeks 1.37E-02 1.501 10524338 DEF6 differentially expressed in FDCP 6 homolog (mouse) Extracellular Space other 12-weeks 3.48E-03 1.55 10434778 RTP4 Other other 12-weeks 1.18E-02 1.554 10446282 EMR1 receptor (chemosensory) transporter protein 4 egf-like module containing, mucin-like, hormone receptor-like 1 Plasma Membrane G-protein coupled receptor 12-weeks 3.48E-03 1.593 10471721 PTGS1 prostaglandinendoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) Cytoplasm enzyme 12-weeks 4.22E-03 1.613 10498367 P2RY13 purinergic receptor P2Y, Gprotein coupled, 13 Plasma Membrane G-protein coupled receptor 12-weeks 3.48E-03 1.665 10458303 DCTN3 dynactin 3 (p22) Nucleus other 12-weeks 2.37E-02 1.691 10416505 KCTD4 potassium channel tetramerization domain containing 4 Other ion channel 12-weeks 3.48E-03 1.78 10498371 P2RY12 purinergic receptor P2Y, Gprotein coupled, 12 Plasma Membrane G-protein coupled receptor 12-weeks 4.22E-03 1.783 10557862 ITGAM integrin, alpha M Plasma transmem (complement component 3 receptor 3 subunit) Membrane brane receptor 12-weeks 4.22E-03 1.806 10532741 TMEM119 transmembrane protein 119 Cytoplasm other 12-weeks 4.38E-02 1.815 10601385 Tlr13 toll-like receptor 13 Cytoplasm other 12-weeks 1.25E-02 1.849 10598750 FZD7 frizzled class receptor 7 Plasma Membrane G-protein coupled receptor 12-weeks 4.22E-03 1.861 10462623 IFIT1B interferoninduced protein with tetratricopeptide repeats 1B Cytoplasm other 12-weeks 1.18E-02 1.934 10499189 Fcrls Fc receptor-like S, scavenger receptor Plasma Membrane other 12-weeks 1.25E-02 1.944 10523120 CXCL5 chemokine (C-XC motif) ligand 5 Extracellular Space other 12-weeks 1.99E-02 1.997 10531415 CXCL10 chemokine (C-XC motif) ligand 10 Extracellular Space cytokine 12-weeks 1.25E-02 2.011 10379530 PEA15 phosphoprotein enriched in astrocytes 15 Cytoplasm transport er 12-weeks 1.26E-03 2.142 10553559 Siglech sialic acid binding Ig-like lectin H Plasma Membrane other 12-weeks 2.87E-02 2.145 10531407 Cxcl9 chemokine (C-XC motif) ligand 9 Extracellular Space cytokine