Clinical Lab Medicine Partners Microcytic RBC Normocytic RBC Macrocytic MCV Microcytic Hypochromic Anemia Microcytic Hyperchromic Anemia Thalassemia Macrocytic Anemia Liver disease Pernicious anemia Normocytic Anemia Normocytic Hemolytic Anemia CEA PSA CA125 CA19-9 AFP HCG Bone Alk. Phos. Prostatic Acid Phosphatase CSF amyloid precursor Beta 2 microglobulin Myelin Basic Protein Oligoclonal bands Paroxysmal Nocturnal Hemoglobinuria (flow cytometry) MCV < 80 MCV = 80-100 MCV > 100 -Fe deficiency -Thalassemia Congenital spherocytosis Target Cells -Pernicious anemia -Folate/ Vit. B 12 deficiency -Hypothyroidism -Liver disease Target cells -Anti-parietal/IF -Hypersegmented PMN -Normal Haptoglobin (differentiating from hemolytic anemia; low) -Positive Schilling Test -Hemolytic -Aplastic -Bone marrow replacement -Acute blood loss -Chronic disease -G6PD deficencies -Hbopathies (sickle cell) -Autoimmune -Membrane defects (PNH) GI tumor Prostate tumor Ovarian surface tumor Pancreatic, stomach, hepatobilliary carcinoma Hepatocellular carcinoma Choriocarcinoma -Osteoblastic Metastatic Lesions -Paget’s disease (osteolytic stage) Metastatic Prostate Cancer Alzheimer disease -AIDS -Dementia complex syndrome Multiple Sclerosis Multiple Sclerosis CD55 and CD59 negative Clinical Lab Medicine Partners 1 Paroxysmal Nocturnal Hemoglobinuria (Historical Test) Artificial Increase in Serotonin Increase in insulin resistance (food) Increase in Gamma Glutamictranspeptidase Increase in osmotic fragility Autosplenectomy Gilbert/Crigler Najar Type I Criglar Najar Type II Bite Cells Dry Bone Marrow Tap Pure red cell aplasia Tear Drop Cells Heat Stable Alk. Phos. Homogenous ANA pattern Speckled ANA pattern Peripheral ANA pattern Nucleolar ANA pattern Nucleolar ANA pattern disease Speckled ANA pattern diseases Anti-dsDNA Anti-smith Anti-DNA Anti-Ro Anti-La Anti-Scl70 Anti-Jo Pernicious Anemia Ab Autoimmune Hepatitis HAM Test Bananas Onions EtOH Congenital spherocytocysis Sickle cell anemia AR AD Glucose 6 Phosphate Dehydrogenase Deficiency -Hairy Cell Leukemia -Aplastic Anemia -Megaloblastic anemia Thymoma Myelofibrosis -Liver Alk. Phos. -Elevated with obstruction Anti-histone Anti-RNP Anti-dsDNA Anti-RNA polymerase Scleroderma -Anti-smith -Anti-RNP -Anti-Ro (SSA) -Anti-La (SSB) -Anti-DNA -Anti-Scl70 -Anti-Jo Systemic Lupus Erythematousus (SLE) SLE SLE -Sjogren syndrome -Intrauterine heart block -Sjogren syndrome Scleroderma Polymyositis -Anti-IF -Anti-parietal -Anti- smooth muscle -Anti-LKM (liver, kidney, microsome) Clinical Lab Medicine Partners 2 Primary Billiary Cirrhosis Ab Hashimoto’s Thyrdoiditis Anti-mitochondrial -Anti-thyroglobulin -Anti-thryoperoxidase Clinical Lab Medicine Partners 3