Supplementary Table 2. Meta-analysis for the TNFRSF1Brs1061622 polymorphism and risk of developing RA.
Polymorphism : rs1061622 (M196R)
Fixed effects ( Mantel-Haenszel ) meta-analysis
Genetic model : RR+MR vs. MM (dominant)
Authors
Arlestig L
Dahlqvist SR
Fabris M
Ghelani AM
Potter C
Barton A
Plenge RM
Canet LM
PMID
Population
18173921
12428254
12233877
20401725
16059898
11212177
16380915
-
Sweden
Sweden
Italy
UK
UK
UK
Sweden
European
RA( RR+MR vs. MM) Control( RR+MR vs. MM)
189/278
70/99
68/107
85/42
79/101
136/104
624/834
475/851
292/377
69/114
27/57
72/68
59/71
63/74
381/472
403/732
OR ( 95% CI )
0.878 (0.691, 1.116)
1.168 (0.762, 1.792)
1.342 (0.774, 2.325)
1.911 (1.163, 3.14)
0.941 (0.598, 1.482)
1.536 (1.007, 2.342)
0.927 (0.782, 1.099)
1.014 (0.859, 1.196)
Polymorphism : rs1061622 (M196R)
Fixed effects ( Mantel-Haenszel ) meta-analysis
Authors
Arlestig L
Dahlqvist SR
Fabris M
Ghelani AM
Potter C
Barton A
Plenge RM
Canet LM
PMID
Population
18173921
12428254
12233877
20401725
16059898
11212177
16380915
-
Sweden
Sweden
Italy
UK
UK
UK
Sweden
European
Genetic model : RR vs. MM+MR (recessive)
RA( RR+MR vs. MM) Control( RR+MR vs. MM)
OR ( 95% CI )
30/437
10/159
8/167
18/109
8/172
29/211
84/1374
66/1260
Dominant model:
Summary OR (Mantel-Haenszel)=1.02 95%CI (0.929-1.121), P-value=0.6743.
Test of heterogeneity:
(1) Cochran Q test: Q=13.95, df=7, P-value=0.0521.
(2) Woolf’s test: X^2 = 13.95, df = 7, P-value = 0.0521.
(3) I^2 statistic: I^2 [95% CI]=49.82% [0%-77.59%].
Recessive model:
Summary OR (Mantel-Haenszel)=1.09 95%CI (0.898-1.333), P-value=0.3706.
Test of heterogeneity:
(1) Cochran Q test: Q=14.41, df=7, P-value=0.0444.
(2) Woolf’s test: X^2 = 14.41, df = 7, P-value = 0.0454.
(3) I^2 statistic: I^2 [95% CI]=51.42% [0%-78.23%].
45/624
8/175
1/83
7/133
5/125
7/130
61/792
54/1081
0.952 (0.59, 1.535)
1.376 (0.53, 3.572)
3.976 (0.489, 32.323)
3.138 (1.264, 7.787)
1.163 (0.372, 3.639)
2.552 (1.087, 5.995)
0.794 (0.564, 1.116)
1.049 (0.725, 1.516)