Table S2. Regional Coronary Blood Flow and Myocardial Metabolism
Reperfusion
Baseline
CBF (mL/min)
CBF (mL/beat)
MVO2 (µmol/min)
MVO2 per beat (µmol/beat)
CVC (ml/min/mmHg)
Lactate Production (µmol/L/min)
O2 Extraction (%)
Lactate Extraction (%)
Sham
LNNA+Sham
LNNA+VNS
Sham
LNNA+Sham
LNNA+VNS
Sham
LNNA+Sham
LNNA+VNS
Sham
LNNA+Sham
LNNA+VNS
Sham
LNNA+Sham
LNNA+VNS
Sham
LNNA+Sham
LNNA+VNS
Sham
LNNA+Sham
LNNA+VNS
Sham
LNNA+Sham
LNNA+VNS
16
13
22
0.17
0.15
0.23
66
61
98
0.67
0.66
1.03
0.20
0.13
0.21
-11
-11
-21
70
79
80
24
28
38
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
2
1
1
0.02
0.03
0.02
4
5
8
0.06
0.11
0.09
0.02
0.02
0.03
1
2
3
2
1
1
3
3
7
15 min
33
17
28
0.34
0.20
0.30
41
23
38
0.42
0.26
0.42
0.51
0.32
0.38
7
7
-3
19
24
40
-5
-13
2
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
4
3
13
0.04
0.05
0.12
3*
4*
4*
0.04*
0.05*
0.05*
0.05*
0.06
0.09
4*
4*
4*
2*
3*
9*
3*
6*
4*
120 min
22
29
27
0.20
0.29
0.24
17
46
35
0.16
0.48
0.31
0.38
0.36
0.30
-7
-6
-18
25
33
24
12
-1
13
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
4
9
3
0.03
0.06
0.03
3*
10†
5*‡
0.03*
0.11
0.04*‡
0.08*
0.05
0.03
2
7
5
4*
15*
8*
2*
5*
2*
Data are mean  SEM; Sham group, n=8; LNNA+Sham, n=5; LNNA+VNS group, n=6. Except for MVO2 (LNNA+VNS vs
Sham, p<0.001 and LNNA+VNS vs LNNA+Sham, p<0.001) and MVO 2 per beat ( LNNA+VNS vs Sham, p<0.001 and
LNNA+VNS vs LNNA+Sham, p=0.001), no differences between groups at baseline; *p<0.05 vs. corresponding baseline;
†p<0.05 change by LNNA+Sham vs Sham; ‡p<0.05 change by LNNA+VNS vs LNNA+Sham. CBF = coronary blood
flow; CVC = coronary vascular conductance (CBF/MAP); MVO2 = myocardial oxygen consumption; O2 Extraction
= myocardial oxygen extraction.