Table S3. Potentially novel raw trait pairs revealed by CPAG and a lack of any cooccurrences in PubMed. The link between Crohn’s disease and palmitoleic acid
(highlighted in yellow) was examined experimentally in a zebrafish model of intestinal
inflammation, as described in the text.
Trait 1
Trait 2
PubMed Query Trait1
PubMed Query Trait2
AIDS progression
Psoriasis
AIDS progression
Psoriasis
AIDS progression
Drug-induced liver injury
(flucloxacillin)
Soluble E-selectin levels
AIDS progression
Drug-induced liver
injury
Soluble E-selectin
371
Trait
2 Hits
2809
6
1093
969
686
Soluble ICAM-1
969
596
Intracranial aneurysm
3019
2833
F-cell distribution
26
3
2831
4
2831
4
8437
55
1014
39
5740
3
4087
9
3059
3
3059
3
46
3
1519
2
6
729
Angiotensin-converting
enzyme activity
Angiotensin-converting
enzyme activity
Ankle-brachial index
Beta
thalassemia/hemoglobin E
disease
Bilirubin levels
Soluble ICAM-1
Intracranial aneurysm
F-cell distribution
Angiotensin-converting
enzyme activity
Angiotensin-converting
enzyme activity
Ankle-brachial index
Beta
thalassemia/hemoglobin E
disease
Bilirubin
Bilirubin levels
Methotrexate clearance (acute
lymphoblastic leukemia)
Circulating cell-free DNA
Celiac disease
Type 1 diabetes autoantibodies
Celiac disease
Chronic Hepatitis C
infection
Coagulation factor levels
Ribavirin-induced anemia
End-stage coagulation
Chronic Hepatitis C
infection
Coagulation factor
Methotrexate
clearance
Circulating cell-free
DNA
Type 1 diabetes
autoantibodies
Ribavirin-induced
anemia
End-stage coagulation
Coronary heart disease
End-stage coagulation
Coronary heart disease
End-stage coagulation
Crohns disease
Type 1 diabetes autoantibodies
Crohn's disease
Crohns disease
Crohn's disease
Dietary macronutrient intake
Palmitoleic acid (16:1n-7) plasma
levels
Retinal vascular caliber
Type 1 diabetes
autoantibodies
Palmitoleic acid
Duodenal ulcer
Phytosterol levels
Dietary macronutrient
intake
Duodenal ulcer
Retinal vascular
caliber
Phytosterol
Dupuytrens disease
Inflammatory bowel disease
Dupuytrens disease
End-stage coagulation
Venous thromboembolism
End-stage coagulation
Eosinophil counts
Tetralogy of Fallot
Eosinophil counts
Inflammatory bowel
disease
Venous
thromboembolism
Tetralogy of Fallot
E-selectin levels
Red blood cell count
E-selectin
Glycated hemoglobin levels
Iron status biomarkers
Hepatitis B vaccine
response
Hypothyroidism
Hepatitis C induced liver cirrhosis
Idiopathic pulmonary
fibrosis
Idiopathic pulmonary
fibrosis
Inflammatory bowel disease
Testicular germ cell cancer
Type 1 diabetes autoantibodies
Idiopathic pulmonary
fibrosis
Idiopathic pulmonary
fibrosis
Inflammatory bowel disease
Iris color
Tanning
Liver enzyme levels
(alkaline phosphatase)
Magnesium levels
Magnesium levels
Bilirubin
Trait1
Hits
371
152
6
6
742
125
1957
2610
8
1242
0
6799
Red blood cell count
6308
1242
Glycated hemoglobin
Iron status
3617
4018
Hepatitis B vaccine
response
Hypothyroidism
Hepatitis C induced
liver cirrhosis
Type 1 diabetes
autoantibodies
Testicular germ cell
cancer
Red blood cell count
17
10
2415
2
4344
6
4344
1242
2610
8
234
6
Iris color
Type 1 diabetes
autoantibodies
Tanning
Soluble E-selectin levels
Liver enzyme
Soluble E-selectin
4367
686
Renal function-related traits (sCR)
Magnesium
Renal function-related
37
Magnesium
Renal function-related
Magnesium levels
Renal function-related traits
(eGRFcrea)
Renal function-related traits (BUN)
Magnesium
Renal function-related
Major mood disorders
Osteoarthritis
Major mood disorders
Osteoarthritis
4569
8
4569
8
4569
8
130
Myocardial infarction (early
onset)
Oleic acid (18:1n-9) plasma
levels
Progranulin levels
Myocardial infarction
Progranulin
Resting heart rate
Oleic acid
Resting heart rate
Type 1 diabetes autoantibodies
Red blood cell count
3
1376
64
1120
6
244
2043
37
37
3870
3
588
2705
Palmitoleic acid (16:1n-7)
plasma levels
Platelet counts
Platelet counts
Palmitoleic acid
Platelet counts
742
9217
Sex hormone-binding globulin levels
Platelet counts
9217
5051
Red blood cell count
Soluble E-selectin levels
Red blood cell count
Sex hormone-binding
globulin
Soluble E-selectin
1242
686
Renal function-related traits
(urea)
Retinal vascular caliber
Urate levels
Renal function-related
Urate
37
5890
Tetralogy of Fallot
Retinal vascular caliber
Tetralogy of Fallot
125
6799
Rheumatoid arthritis
Type 1 diabetes autoantibodies
Rheumatoid arthritis
Venous thromboembolism
Soluble E-selectin
8155
4
686
6
Soluble E-selectin levels
Type 1 diabetes
autoantibodies
White blood cell count
Vitiligo
Type 1 diabetes
autoantibodies
White blood cell count
Type 1 diabetes
autoantibodies
Venous
thromboembolism
Vitiligo
6
1242
0
4867
White blood cell types
7455
23
White blood cell types