Supplementary Material
Table S1 Carbohydrate absorption and digestion
Gene Title
Gene ID
yo23f11r1 Soares adult brain N2b5HB55Y cDNA clone IMAGE:178797 5'
AKT2
phospholipase C, beta 2 (PLCB2)
PLCB2
T98887 ye65e11.s1 Soares fetal liver spleen 1NFLS cDNA clone IMAGE:122636 3' similar to gb:U01120 GLUCOSE-6-PHOSPHATASE (HUMAN);
G6PC
phosphoinositide-3-kinase, regulatory subunit, polypeptide p101, mRNA (cDNA clone MGC:39947 IMAGE:5215094)
PIK3R5
taste receptor, type 1, member 2 (TAS1R2), mRNA
TAS1R2
FXYD domain containing ion transport regulator 2 (FXYD2), transcript variant a
FXYD2
solute carrier family 5 (sodium/glucose cotransporter), member 1 (SLC5A1)
SLC5A1
solute carrier family 37 (glycerol-6-phosphate transporter), member 4 (SLC37A4)
SLC37A4
ATPase, Na+/K+ transporting, beta 2 polypeptide (ATP1B2), mRNA
ATP1B2
phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma) (PIK3R3)
PIK3R3
phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma) (PIK3R3)
PIK3R3
solute carrier family 2 (facilitated glucose/fructose transporter), member 5 (SLC2A5)
SLC2A5
Table S2, Glycolysis/gluconeogenesis
Gene Title
Gene ID
T98887 ye65e11.s1 Soares fetal liver spleen 1NFLS cDNA clone IMAGE:122636 3' similar to gb:U01120 GLUCOSE-6-PHOSPHATASE (HUMAN);
G6PC
triosephosphate isomerase 1 (TPI1)
TPI1
triosephosphate isomerase 1 (TPI1)
TPI1
lactate dehydrogenase B (LDHB)
LDHB
glyceraldehyde-3-phosphate dehydrogenase (GAPD)
GAPDH
yf89e06r1 Soares infant brain 1NIB cDNA clone IMAGE:29564 5' similar to gb:M18172 PHOSPHOGLYCERATE MUTASE, MUSCLE FORM (HUMAN);
PGAM2
enolase 1, (alpha) (ENO1)
ENO1
602297976F1 NIH_MGC_87 cDNA clone IMAGE:4392259 5'
BPGM
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic (GAPDS)
GAPDHS
aldehyde dehydrogenase 9 family, member A1 (ALDH9A1)
ALDH9A1
pyruvate kinase, liver and RBC (PKLR), nuclear gene encoding mitochondrial protein, transcript variant 1
PKLR
acetyl-Coenzyme A synthetase 2 (ADP forming) (ACAS2), transcript variant 1
ACSS2
ye82e03r1 Soares fetal liver spleen 1NFLS cDNA clone IMAGE:124252 5'
DLAT
aldehyde dehydrogenase 3 family, member B1 (ALDH3B1)
ALDH3B1
cDNA FLJ46657 fis, clone TRACH3006264
ALDOB
galactose mutarotase (aldose 1-epimerase) (GALM)
GALM
K-EST0054326 S2SNU668s1 cDNA clone S2SNU668s1-19-E02 5'
LDHA
DKFZp434J094_r1 434 (synonym: htes3) cDNA clone DKFZp434J094 5'
PFKL
Table S3, Pentose phosphate pathway
Gene Title
Gene ID
cDNA FLJ46657 fis, clone TRACH3006264
ALDOB
DKFZp434J094_r1 434 (synonym: htes3) cDNA clone DKFZp434J094 5'
PFKL
transketolase-like 1 (TKTL1)
TKTL1
1
Table S4, Insulin signaling pathway
Gene Title
Gene ID
cDNA FLJ45567 fis, clone BRTHA3010135, highly similar to LAR protein precursor
PTPRF
yo23f11r1 Soares adult brain N2b5HB55Y cDNA clone IMAGE:178797 5'
AKT2
T98887 ye65e11.s1 Soares fetal liver spleen 1NFLS cDNA clone IMAGE:122636 3' similar to gb:U01120 GLUCOSE-6-PHOSPHATASE (HUMAN);
G6PC
protein kinase, AMP-activated, beta 1 non-catalytic subunit (PRKAB1)
PRKAB1
phosphoinositide-3-kinase, regulatory subunit, polypeptide p101, mRNA (cDNA clone MGC:39947 IMAGE:5215094)
PIK3R5
ik84d05x1 Human insulinoma cDNA clone IMAGE:6027296 3'
PDE3B
tuberous sclerosis 1 (TSC1)
TSC1
or32c08x1 NCI_CGAP_GC3 cDNA clone IMAGE:1597550 3'
ACACA
growth factor receptor-bound protein 2 (GRB2), transcript variant 1
GRB2
yx39a03r1 Soares melanocyte 2NbHM cDNA clone IMAGE:264076 5'
PPP1R3B
son of sevenless homolog 1 (Drosophila) (SOS1)
SOS1
protein tyrosine phosphatase, non-receptor type 1 (PTPN1)
PTPN1
forkhead box O1A (rhabdomyosarcoma) (FOXO1A)
FOXO1
oj35g02s1 NCI_CGAP_Lu5 cDNA clone IMAGE:1500338 3' similar to gb:X67309_rna1 40S RIBOSOMAL PROTEIN S6 (HUMAN);
RPS6
pyruvate kinase, liver and RBC (PKLR), nuclear gene encoding mitochondrial protein, transcript variant 1
PKLR
602571553F1 NIH_MGC_77 cDNA clone IMAGE:4696021 5'
SORBS1
Rap guanine nucleotide exchange factor (GEF) 1 (RAPGEF1), transcript variant 2
ov39g03x1 Soares_testis_NHT cDNA clone IMAGE:1639732 3' similar to gb:M34182 CAMP-DEPENDENT PROTEIN KINASE, GAMMA-CATALYTIC
SUBUNIT (HUMAN);
calmodulin-like 3 (CALML3)
RAPGEF1
suppressor of cytokine signaling 2 (SOCS2)
SOCS2
glycogen synthase 1 (muscle) (GYS1)
GYS1
phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma) (PIK3R3)
PIK3R3
phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma) (PIK3R3)
PIK3R3
protein kinase, cAMP-dependent, catalytic, gamma (PRKACG)
PRKACG
insulin receptor substrate 4 (IRS4)
IRS4
lipase, hormone-sensitive (LIPE)
LIPE
QV2-NN0045-051200-516-a11 NN0045 Homo sapiens cDNA
SORBS1
2
PRKACG
CALML3
Table S5, Neuroactive ligand-receptor binding
Gene Title
5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) (HTR7), transcript variant a
Gene ID
HTR7
cysteinyl leukotriene receptor 2 (CYSLTR2)
CYSLTR2
growth hormone releasing hormone receptor (GHRHR)
growth hormone secretagogue receptor (GHSR), transcript variant 1b
arginine vasopressin receptor 1B (AVPR1B)
GHRHR
GHSR
AVPR1B
G protein-coupled receptor 83 (GPR83)
Soares_testis_NHT cDNA clone IMAGp998N084409
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) (CHRNB2)
GPR83
LHCGR
CHRNB2
arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal) (AVP)
cholinergic receptor, nicotinic, alpha polypeptide 3 (CHRNA3)
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1)
AVP
CHRNA3
NR3C1
glutamate receptor, ionotropic, kainate 2 (GRIK2), transcript variant 1
coatomer protein complex, subunit alpha (COPA)
tachykinin receptor 1 (TACR1), transcript variant long
GRIK2
COPA
TACR1
apelin, AGTRL1 ligand (APLN)
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) (CHRNA1)
cannabinoid receptor 2 (macrophage) (CNR2)
APLN
CHRNA1
CNR2
cDNA FLJ43372 fis, clone NTONG2006324, highly similar to ACETYLCHOLINE RECEPTOR PROTEIN, GAMMA CHAIN PRECURSOR
ye56b08r1 Soares fetal liver spleen 1NFLS cDNA clone IMAGE:121719 5' similar to gb:X05199 PLASMINOGEN PRECURSOR (HUMAN);
G protein-coupled receptor 14 (GPR14)
CHRNG
PLG
UTS2R
glucagon-like peptide 2 receptor (GLP2R)
parathyroid hormone receptor 2 (PTHR2)
UI-H-BI3-akq-g-06-0-UIs1 NCI_CGAP_Sub5 cDNA clone IMAGE:2735410 3'
GLP2R
PTH2R
GPR156
tachykinin receptor 3 (TACR3)
cholinergic receptor, nicotinic, delta polypeptide (CHRND)
leukotriene B4 receptor 2 (LTB4R2)
TACR3
CHRND
LTB4R2
adrenergic, alpha-2A-, receptor (ADRA2A)
cholinergic receptor, muscarinic 1 (CHRM1)
602854489F1 NIH_MGC_10 cDNA clone IMAGE:4995743 5'
platelet-activating factor receptor (PTAFR)
cysteinyl leukotriene receptor 1 (CYSLTR1)
NEUROBLASTOMA COT 25-NORMALIZED cDNA clone CS0DC028YK07 3-PRIME
ADRA2A
CHRM1
S1PR2
PTAFR
CYSLTR1
PRLHR
neuromedin U receptor 2 (NMUR2)
cholecystokinin A receptor (CCKAR)
melanocortin 3 receptor (MC3R)
ys80d07s1 Soares retina N2b4HR cDNA clone IMAGE:221101 3'
V1-vascular vasopressin receptor AVPR1A gene, promoter region and partial cds
gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 3
secretin receptor (SCTR)
dopamine receptor D2 (DRD2), transcript variant 2
G protein-coupled receptor 10 (GPR10)
5-hydroxytryptamine (serotonin) receptor 1A (HTR1A)
transient receptor potential cation channel, subfamily V, member 1 (TRPV1), transcript variant 1
chorionic somatomammotropin hormone 1 (placental lactogen) (CSH1), transcript variant 2
G protein-coupled receptor 51 (GPR51)
glucagon-like peptide 1 receptor (GLP1R)
pancreatic polypeptide receptor 1 (PPYR1)
G protein-coupled receptor 8 (GPR8)
gamma-aminobutyric acid (GABA) A receptor, gamma 1 (GABRG1)
zx68h08s1 Soares_total_fetus_Nb2HF8_9w cDNA clone IMAGE:796671 3'
cDNA FLJ42048 fis, clone SPLEN2041700
5-hydroxytryptamine (serotonin) receptor 6 (HTR6)
G protein-coupled receptor 86 (GPR86), transcript variant 1
melanocortin 5 receptor (MC5R)
G protein-coupled receptor 145 (GPR145)
gamma-aminobutyric acid (GABA) A receptor, alpha 3 (GABRA3)
hypocretin (orexin) receptor 1 (HCRTR1)
adrenergic, beta-3-, receptor (ADRB3)
histamine receptor H3 (HRH3)
gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1), transcript variant 1
trace amine receptor 4 (TRAR4)
glutamate receptor, ionotropic, kainate 5 (GRIK5)
gamma-aminobutyric acid (GABA) A receptor, epsilon (GABRE), transcript variant 4
NMUR2
CCKAR
MC3R
GRIA4
GABRG2
SCTR
DRD2
PRLHR
HTR1A
TRPV1
CSH1
GABBR2
GLP1R
PPYR1
NPBWR2
GABRG1
TACR1
THRB
HTR6
MC5R
MCHR2
GABRA3
HCRTR1
ADRB3
HRH3
GABBR1
TAAR6
GRIK5
-
3
G protein-coupled receptor 50 (GPR50)
GPR50
gastrin-releasing peptide receptor (GRPR)
dopamine receptor D3 (DRD3), transcript variant a
pyrimidinergic receptor P2Y, G-protein coupled, 4 (P2RY4)
GRPR
DRD3
P2RY4
follicle stimulating hormone receptor (FSHR), transcript variant 2
putative neurotransmitter receptor (PNR)
cholinergic receptor, nicotinic, gamma polypeptide (CHRNG)
FSHR
TAAR5
CHRNG
adenosine A3 receptor (ADORA3)
zj82a02s1 Soares_fetal_liver_spleen_1NFLS_S1 cDNA clone IMAGE:461354 3'
oxytocin receptor (OXTR)
ADORA3
PRLR
OXTR
G protein-coupled receptor 58 (GPR58)
wi52f04x1 NCI_CGAP_Co16 cDNA clone IMAGE:2393887 3'
TAAR2
GRIN2D
gamma-aminobutyric acid (GABA) A receptor, delta (GABRD)
GABRD
UI-E-EJ0-ahf-f-10-0-UIs1 UI-E-EJ0 cDNA clone UI-E-EJ0-ahf-f-10-0-UI 3'
cholinergic receptor, nicotinic, alpha polypeptide 5 (CHRNA5)
glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A)
CHRNA2
CHRNA5
GRIN2A
prostaglandin E receptor 4 (subtype EP4) (PTGER4)
PTGER4
4
Table S6, MAPK signaling pathway
Gene Title
yo23f11r1 Soares adult brain N2b5HB55Y cDNA clone IMAGE:178797 5'
Gene ID
AKT2
BM cDNA clone BMFAOA07 5'
CDC42
602723047T1 NIH_MGC_106 cDNA clone IMAGE:4849714 3'
mitogen-activated protein kinase 11 (MAPK11), transcript variant 1
heat shock 70kDa protein 8 (HSPA8), transcript variant 1
RASGRP1
MAPK11
HSPA8
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1
fibroblast growth factor 23 (FGF23)
calcium channel, voltage-dependent, gamma subunit 7 (CACNG7)
RAC1
FGF23
CACNG7
mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1)
zx69c11r1 Soares_total_fetus_Nb2HF8_9w cDNA clone IMAGE:796724 5' similar to gb:M37825 PROTEIN FGF-5 PRECURSOR (HUMAN);
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) (RAC2)
MAPK8IP1
FGF5
RAC2
growth factor receptor-bound protein 2 (GRB2), transcript variant 1
mitogen-activated protein kinase kinase kinase 12 (MAP3K12)
son of sevenless homolog 1 (Drosophila) (SOS1)
GRB2
MAP3K12
SOS1
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) (FGFR1), transcript variant 9
cell division cycle 42 (GTP binding protein, 25kDa) (CDC42), transcript variant 1
serine/threonine kinase 4 (STK4)
mitogen-activated protein kinase kinase kinase 9 (MAP3K9), mRNA
MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) (MEF2C)
platelet-derived growth factor receptor, beta polypeptide (PDGFRB)
calcium channel, voltage-dependent, gamma subunit 4 (CACNG4)
hypothetical protein LOC283439 (LOC283439)
aj26a12s1 Soares_testis_NHT cDNA clone 1391422 3'
FGFR1
CDC42
STK4
MAP3K9
MEF2C
PDGFRB
CACNG4
CACNA1C
FGF6
cDNA clone MGC:71700 IMAGE:30344890
ov39g03x1 Soares_testis_NHT cDNA clone IMAGE:1639732 3' similar to gb:M34182 CAMP-DEPENDENT PROTEIN KINASE, GAMMA-CATALYTIC
SUBUNIT (HUMAN);
calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2)
mitogen-activated protein kinase 8 interacting protein 2 (MAPK8IP2), transcript variant 1
mitogen-activated protein kinase kinase 4 (MAP2K4)
interleukin 1 receptor, type II (IL1R2), transcript variant 1
mitogen-activated protein kinase 4 (MAPK4)
dual specificity phosphatase 16 (DUSP16)
ELK4, ETS-domain protein (SRF accessory protein 1) (ELK4), transcript variant a
TGFBR1
PRKACG
CACNA2D2
MAPK8IP2
MAP2K4
IL1R2
MAPK4
DUSP16
ELK4
calcium channel, voltage-dependent, alpha 2/delta subunit 4 (CACNA2D4)
TNF receptor-associated factor 6 (TRAF6), transcript variant 2
cDNA FLJ36326 fis, clone THYMU2005576, moderately similar to Mus musculus group IIF secreted phospholipase A2 (Pla2g2f) mRNA
epidermal growth factor (beta-urogastrone) (EGF)
tumor necrosis factor (TNF superfamily, member 2) (TNF)
protein kinase, cAMP-dependent, catalytic, gamma (PRKACG)
calcium channel, voltage-dependent, gamma subunit 5 (CACNG5), transcript variant 2
mitogen-activated protein kinase 8 interacting protein 3 (MAPK8IP3), transcript variant 1
mitogen-activated protein kinase kinase kinase 4 (MAP3K4), transcript variant 1
mitogen-activated protein kinase 14 (MAPK14), transcript variant 1
mitogen-activated protein kinase kinase 6 (MAP2K6), transcript variant 2
dual specificity phosphatase 14 (DUSP14)
mRNA; cDNA DKFZp762E193 (from clone DKFZp762E193)
mRNA; cDNA DKFZp761J1323 (from clone DKFZp761J1323)
filamin B, beta (actin binding protein 278) (FLNB)
(clone HHT-1 variant harboring HH-05) cardiac L-type voltage dependent calcium channel alpha 1 subunit (CACNL1A1) mRNA
UI-HF-BN0-aet-g-01-0-UIr1 NIH_MGC_50 cDNA clone IMAGE:3065640 5'
activating transcription factor 4 (tax-responsive enhancer element B67) (ATF4), transcript variant 1
KIAA0313 gene, complete cds
yy52h12s1 Soares_multiple_sclerosis_2NbHMSP cDNA clone IMAGE:277223 3'
fibroblast growth factor 2 (basic) (FGF2)
phospholipase A2, group IID (PLA2G2D)
calcium channel, voltage-dependent, L type, alpha 1C subunit (CACNA1C)
tumor protein p53 (Li-Fraumeni syndrome) (TP53)
neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) (NF1)
Regulation of actin cytoskeleton
Gene Title
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3), transcript variant b
cDNA FLJ41980 fis, clone SMINT2007391
BM cDNA clone BMFAOA07 5'
insulin receptor-related receptor (INSRR)
5
CACNA2D4
TRAF6
PLA2G2F
EGF
TNF
PRKACG
CACNG5
MAPK8IP3
MAP3K4
MAPK14
DUSP14
GNG12
FLNB
CACNA1C
RASGRF2
ATF4
RAPGEF2
RPS6KA2
FGF2
PLA2G2D
CACNA1C
TP53
NF1
Gene ID
ITGA3
MYL5
CDC42
INSRR
diaphanous homolog 2 (Drosophila) (DIAPH2), transcript variant 156
DIAPH2
phosphoinositide-3-kinase, regulatory subunit, polypeptide p101, mRNA (cDNA clone MGC:39947 IMAGE:5215094)
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1
fibroblast growth factor 23 (FGF23)
PIK3R5
RAC1
FGF23
profilin 1 (PFN1)
yf92g12r1 Soares infant brain 1NIB cDNA clone IMAGE:30184 5'
zx69c11r1 Soares_total_fetus_Nb2HF8_9w cDNA clone IMAGE:796724 5' similar to gb:M37825 PROTEIN FGF-5 PRECURSOR (HUMAN);
PFN1
CYFIP2
FGF5
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) (RAC2)
IQ motif containing GTPase activating protein 2 (IQGAP2)
p21(CDKN1A)-activated kinase 6 (PAK6)
RAC2
IQGAP2
PAK6
actin related protein 2/3 complex, subunit 2, 34kDa (ARPC2), transcript variant 2
son of sevenless homolog 1 (Drosophila) (SOS1)
ARPC2
SOS1
IQ motif containing GTPase activating protein 3 (IQGAP3)
IQGAP3
IQ motif containing GTPase activating protein 1 (IQGAP1)
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) (FGFR1), transcript variant 9
cell division cycle 42 (GTP binding protein, 25kDa) (CDC42), transcript variant 1
IQGAP1
FGFR1
CDC42
cholinergic receptor, muscarinic 1 (CHRM1)
hematopoietic protein 1 (HEM1)
phosphatidylinositol-4-phosphate 5-kinase, type II, gamma (PIP5K2C)
CHRM1
NCKAP1L
PIP4K2C
dedicator of cytokinesis 1 (DOCK1), mRNA
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) (ITGAL)
paxillin (PXN)
DOCK1
ITGAL
PXN
platelet-derived growth factor receptor, beta polypeptide (PDGFRB)
actinin, alpha 4 (ACTN4)
ws16d07x1 NCI_CGAP_Kid11 cDNA clone IMAGE:2497357 3'
PDGFRB
ACTN4
ENAH
HUM423G02B Human fetal brain (TFujiwara) cDNA clone GEN-423G02 5'
cDNA FLJ45181 fis, clone BRAWH3047644, highly similar to Homo sapiens Rho guanine nucleotide exchange factor (GEF) 4 (ARHGEF4)
aj26a12s1 Soares_testis_NHT cDNA clone 1391422 3'
integrin, alpha 5 (fibronectin receptor, alpha polypeptide) (ITGA5)
integrin, alpha 11 (ITGA11)
WAS protein family, member 1 (WASF1)
Rho guanine nucleotide exchange factor (GEF) 1 (ARHGEF1), transcript variant 2
integrin, alpha 6 (ITGA6)
vinculin (VCL), transcript variant meta-VCL
cDNA FLJ42535 fis, clone BRACE3003595, highly similar to CRK-associated substrate
cDNA FLJ45529 fis, clone BRTHA2027546
FGD1 family, member 3 (FGD3)
CYFIP2
ARHGEF4
FGF6
ITGA5
WASF1
ARHGEF1
ITGA6
VCL
BCAR1
FGD3
clone 23612 mRNA sequence
phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma) (PIK3R3)
protein phosphatase 1, regulatory (inhibitor) subunit 12A (PPP1R12A)
phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma) (PIK3R3)
integrin, alpha 10 (ITGA10)
cDNA FLJ45059 fis, clone BRAWH3023274
epidermal growth factor (beta-urogastrone) (EGF)
DCA cDNA clone DCAADG05 5'
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) (ITGA2)
mRNA; cDNA DKFZp762E193 (from clone DKFZp762E193)
diaphanous homolog 3 (Drosophila) (DIAPH3)
xp41a12x1 NCI_CGAP_HN11 cDNA clone IMAGE:2742910 3'
zh65b12r1 Soares_fetal_liver_spleen_1NFLS_S1 cDNA clone IMAGE:416927 5'
fibroblast growth factor 2 (basic) (FGF2)
solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive) (SLC9A1)
integrin, alpha X (antigen CD11C (p150), alpha polypeptide) (ITGAX)
6
TIAM1
PIK3R3
PPP1R12A
PIK3R3
ITGA10
BCAR1
EGF
TMSB4X
ITGA2
GNG12
DIAPH3
EZR
PIKFYVE
FGF2
SLC9A1
ITGAX
Table S7 Regulation of actin cytoskeleton
Gene Title
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3), transcript variant b
cDNA FLJ41980 fis, clone SMINT2007391
Gene ID
ITGA3
MYL5
BM cDNA clone BMFAOA07 5'
insulin receptor-related receptor (INSRR)
diaphanous homolog 2 (Drosophila) (DIAPH2), transcript variant 156
CDC42
INSRR
DIAPH2
phosphoinositide-3-kinase, regulatory subunit, polypeptide p101, mRNA (cDNA clone MGC:39947 IMAGE:5215094)
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1
fibroblast growth factor 23 (FGF23)
PIK3R5
RAC1
FGF23
profilin 1 (PFN1)
yf92g12r1 Soares infant brain 1NIB cDNA clone IMAGE:30184 5'
zx69c11r1 Soares_total_fetus_Nb2HF8_9w cDNA clone IMAGE:796724 5' similar to gb:M37825 PROTEIN FGF-5 PRECURSOR (HUMAN);
PFN1
CYFIP2
FGF5
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) (RAC2)
IQ motif containing GTPase activating protein 2 (IQGAP2)
p21(CDKN1A)-activated kinase 6 (PAK6)
RAC2
IQGAP2
PAK6
actin related protein 2/3 complex, subunit 2, 34kDa (ARPC2), transcript variant 2
son of sevenless homolog 1 (Drosophila) (SOS1)
IQ motif containing GTPase activating protein 3 (IQGAP3)
ARPC2
SOS1
IQGAP3
IQ motif containing GTPase activating protein 1 (IQGAP1)
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) (FGFR1), transcript variant 9
cell division cycle 42 (GTP binding protein, 25kDa) (CDC42), transcript variant 1
IQGAP1
FGFR1
CDC42
cholinergic receptor, muscarinic 1 (CHRM1)
hematopoietic protein 1 (HEM1)
phosphatidylinositol-4-phosphate 5-kinase, type II, gamma (PIP5K2C)
CHRM1
NCKAP1L
PIP4K2C
dedicator of cytokinesis 1 (DOCK1), mRNA
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) (ITGAL)
paxillin (PXN)
DOCK1
ITGAL
PXN
platelet-derived growth factor receptor, beta polypeptide (PDGFRB)
actinin, alpha 4 (ACTN4)
ws16d07x1 NCI_CGAP_Kid11 cDNA clone IMAGE:2497357 3'
HUM423G02B Human fetal brain (TFujiwara) cDNA clone GEN-423G02 5'
cDNA FLJ45181 fis, clone BRAWH3047644, highly similar to Homo sapiens Rho guanine nucleotide exchange factor (GEF) 4 (ARHGEF4)
aj26a12s1 Soares_testis_NHT cDNA clone 1391422 3'
PDGFRB
ACTN4
ENAH
CYFIP2
ARHGEF4
FGF6
integrin, alpha 5 (fibronectin receptor, alpha polypeptide) (ITGA5)
integrin, alpha 11 (ITGA11)
WAS protein family, member 1 (WASF1)
Rho guanine nucleotide exchange factor (GEF) 1 (ARHGEF1), transcript variant 2
integrin, alpha 6 (ITGA6)
vinculin (VCL), transcript variant meta-VCL
cDNA FLJ42535 fis, clone BRACE3003595, highly similar to CRK-associated substrate
cDNA FLJ45529 fis, clone BRTHA2027546
FGD1 family, member 3 (FGD3)
clone 23612 mRNA sequence
phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma) (PIK3R3)
protein phosphatase 1, regulatory (inhibitor) subunit 12A (PPP1R12A)
phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma) (PIK3R3)
integrin, alpha 10 (ITGA10)
cDNA FLJ45059 fis, clone BRAWH3023274
epidermal growth factor (beta-urogastrone) (EGF)
DCA cDNA clone DCAADG05 5'
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) (ITGA2)
mRNA; cDNA DKFZp762E193 (from clone DKFZp762E193)
diaphanous homolog 3 (Drosophila) (DIAPH3)
xp41a12x1 NCI_CGAP_HN11 cDNA clone IMAGE:2742910 3'
zh65b12r1 Soares_fetal_liver_spleen_1NFLS_S1 cDNA clone IMAGE:416927 5'
fibroblast growth factor 2 (basic) (FGF2)
solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive) (SLC9A1)
integrin, alpha X (antigen CD11C (p150), alpha polypeptide) (ITGAX)
ITGA5
WASF1
ARHGEF1
ITGA6
VCL
BCAR1
FGD3
TIAM1
PIK3R3
PPP1R12A
PIK3R3
ITGA10
BCAR1
EGF
TMSB4X
ITGA2
GNG12
DIAPH3
EZR
PIKFYVE
FGF2
SLC9A1
ITGAX
7
Table S8 Calcium signaling pathway
Gene Title
5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) (HTR7), transcript variant a
Gene ID
HTR7
cDNA clone IMAGE:5297372
SLC25A4
GNAS complex locus (GNAS), transcript variant 4
cysteinyl leukotriene receptor 2 (CYSLTR2)
phospholipase C, beta 2 (PLCB2)
GNAS
CYSLTR2
PLCB2
phospholipase C, delta 3 (PLCD3)
arginine vasopressin receptor 1B (AVPR1B)
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 (ATP2A1), transcript variant b
PLCD3
AVPR1B
ATP2A1
Soares_testis_NHT cDNA clone IMAGp998N084409
tachykinin receptor 1 (TACR1), transcript variant long
adenylate cyclase 2 (brain) (ADCY2)
LHCGR
TACR1
ADCY2
phospholipase C, gamma 1 (PLCG1), transcript variant 1
tachykinin receptor 3 (TACR3)
leukotriene B4 receptor 2 (LTB4R2)
PLCG1
TACR3
LTB4R2
cholinergic receptor, muscarinic 1 (CHRM1)
nitric oxide synthase 3 (endothelial cell) (NOS3)
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 (SLC25A5)
CHRM1
NOS3
SLC25A5
Homo sapiens B CELLS (RAMOS CELL LINE) COT 25-NORMALIZED cDNA clone CS0DL003YN01 3-PRIME
platelet-activating factor receptor (PTAFR)
PTK2B protein tyrosine kinase 2 beta (PTK2B), transcript variant 2
CD38
PTAFR
PTK2B
cysteinyl leukotriene receptor 1 (CYSLTR1)
cholecystokinin A receptor (CCKAR)
platelet-derived growth factor receptor, beta polypeptide (PDGFRB)
CYSLTR1
CCKAR
PDGFRB
V1-vascular vasopressin receptor AVPR1A gene, promoter region and partial cds
cDNA FLJ44318 fis, clone TRACH3000780
hypothetical protein LOC283439 (LOC283439)
ERBB4
CACNA1C
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (ERBB4)
ov39g03x1 Soares_testis_NHT cDNA clone IMAGE:1639732 3' similar to gb:M34182 CAMP-DEPENDENT PROTEIN KINASE, GAMMA-CATALYTIC
SUBUNIT (HUMAN);
guanine nucleotide binding protein (G protein), alpha 11 (Gq class) (GNA11)
ERBB4
guanine nucleotide binding protein (G protein), q polypeptide (GNAQ)
phospholipase C, delta 4 (PLCD4)
calmodulin-like 3 (CALML3)
GNAQ
PLCD4
CALML3
cDNA FLJ45529 fis, clone BRTHA2027546
zx68h08s1 Soares_total_fetus_Nb2HF8_9w cDNA clone IMAGE:796671 3'
5-hydroxytryptamine (serotonin) receptor 6 (HTR6)
adrenergic, beta-3-, receptor (ADRB3)
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha (CAMK2A), transcript variant 1
protein kinase, cAMP-dependent, catalytic, gamma (PRKACG)
gastrin-releasing peptide receptor (GRPR)
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma (CAMK2G), transcript variant 1
solute carrier family 8 (sodium-calcium exchanger), member 3 (SLC8A3), transcript variant f
(clone HHT-1 variant harboring HH-05) cardiac L-type voltage dependent calcium channel alpha 1 subunit (CACNL1A1) mRNA
ATPase, Ca++ transporting, ubiquitous (ATP2A3), transcript variant 1
oxytocin receptor (OXTR)
mRNA; cDNA DKFZp686P0211 (from clone DKFZp686P0211)
CD38 antigen (p45) (CD38)
wi52f04x1 NCI_CGAP_Co16 cDNA clone IMAGE:2393887 3'
glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A)
calcium channel, voltage-dependent, L type, alpha 1C subunit (CACNA1C)
TACR1
HTR6
ADRB3
CAMK2A
PRKACG
GRPR
CAMK2G
SLC8A3
CACNA1C
ATP2A3
OXTR
ATP2A2
CD38
GRIN2D
GRIN2A
CACNA1C
8
PRKACG
GNA11
Table S9 OXPHOS
Gene Title
13kDa differentiation-associated protein (DAP13)
Gene ID
NDUFA12
AGENCOURT_8681878 Lupski_sciatic_nerve cDNA clone IMAGE:6197311 5'
NDUFA3
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9) isoform 3 (ATP5G3)
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1 (ATP5G1)
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 2 (ATP5G2)
ATP5G3
ATP5G1
ATP5G2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit e (ATP5I)
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6 (ATP5J), nuclear gene encoding mitochondrial protein
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g (ATP5L)
ATP5I
ATP5J
ATP5L
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit (ATP5E), nuclear gene encoding mitochondrial protein
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein) (ATP5O), nuclear gene encoding
mitochondrial protein
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H (ATP6V1H), transcript variant 2
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 1 (Renal tubular acidosis with deafness) (ATP6V1B1)
ATPase, H+/K+ exchanging, alpha polypeptide (ATP4A)
ATP5E
ATPase, H+/K+ exchanging, beta polypeptide (ATP4B)
cDNA FLJ34400 fis, clone HCHON2001434, highly similar to NADH-UBIQUINONE OXIDOREDUCTASE 42 KDA SUBUNIT, MITOCHONDRIAL
PRECURSOR (EC 16.5.3)
COX17 homolog, cytochrome c oxidase assembly protein (yeast) (COX17), nuclear gene encoding mitochondrial protein
cytochrome c oxidase subunit Va (COX5A), nuclear gene encoding mitochondrial protein
cytochrome c oxidase subunit VIb (COX6B)
cytochrome c oxidase subunit VIb, testes-specific (COXVIB2)
cytochrome c oxidase subunit VIIb (COX7B), nuclear gene encoding mitochondrial protein
ATP4B
cytochrome c oxidase subunit VIIc (COX7C), nuclear gene encoding mitochondrial protein
fs17e11y1 Human Lens cDNA (Normalized): fs cDNA clone fs17e11 5'
low molecular mass ubiquinone-binding protein (95kD) (QP-C), nuclear gene encoding mitochondrial protein
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa (NDUFA4), nuclear gene encoding mitochondrial protein
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 145kDa (NDUFA7)
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa (NDUFAB1)
NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) (NDUFS5)
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) (NDUFS7)
RC6-CT0204-220999-011-C03_2 CT0204 Homo sapiens cDNA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA), nuclear gene encoding mitochondrial protein
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a isoform 3 (TCIRG1), transcript variant 2
COX7C
NDUFB4
UQCRQ
NDUFA4
NDUFA7
NDUFAB1
NDUFS5
NDUFS7
ATP5C1
SDHA
TCIRG1
ubiquinol-cytochrome c reductase complex (72 kD) (HSPC051)
ubiquinol-cytochrome c reductase hinge protein (UQCRH)
UCRC
UQCRH
9
ATP5O
ATP6V1H
ATP6V1B1
ATP4A
NDUFA10
COX17
COX5A
COX6B1
COX6B2
COX7B
Table S10 Cell cycle
Gene Title
UI-CF-EC1-abx-d-13-0-UIs1 UI-CF-EC1 cDNA clone UI-CF-EC1-abx-d-13-0-UI 3'
ataxia-telangiectasia locus protein (ATM) mRNA, 3'UTR sequence
Gene ID
HDAC2
ATM
PM2-DT0042-030200-004-h10 DT0042 Homo sapiens cDNA
MCM2 minichromosome maintenance deficient 2, mitotin (S cerevisiae) (MCM2)
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide (YWHAE)
PLK1
MCM2
YWHAE
au63d02y1 Schneider fetal brain 00004 cDNA clone IMAGE:2519427 5' similar to SW:AR21_HUMAN O15145 ARP2/3 COMPLEX 21 KD SUBUNIT ;
fs24h03y1 Human Lens cDNA (Normalized): fs cDNA clone fs24h03 5'
S-phase kinase-associated protein 1A (p19A) (SKP1A), transcript variant 1
ANAPC7
CDC20
SKP1
AGENCOURT_6709652 NIH_MGC_122 cDNA clone IMAGE:5750638 5'
fizzy/cell division cycle 20 related 1 (Drosophila) (FZR1)
cDNA FLJ30695 fis, clone FCBBF2000782, weakly similar to ORIGIN RECOGNITION COMPLEX SUBUNIT 4
MAD2L2
FZR1
ORC4L
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide (YWHAZ), transcript variant 1
cyclin-dependent kinase 4 (CDK4)
transcription factor Dp-1 (TFDP1)
YWHAZ
CDK4
TFDP1
E2F transcription factor 5, p130-binding (E2F5)
cDNA FLJ10423 fis, clone NT2RP1000259
anaphase promoting complex subunit 13 (ANAPC13)
E2F5
ANAPC13
ANAPC13
CDC16 cell division cycle 16 homolog (S cerevisiae), mRNA (cDNA clone IMAGE:5735063)
AGENCOURT_7983154 NIH_MGC_113 cDNA clone IMAGE:6215410 5'
yr94e07r1 Soares fetal liver spleen 1NFLS cDNA clone IMAGE:212964 5'
CCND3
PTTG1
SMC1 structural maintenance of chromosomes 1-like 2 (yeast) (SMC1L2)
tumor protein p53 (Li-Fraumeni syndrome) (TP53)
SMC1B
TP53
10
Table S11 Spliceosome
Gene Title
Gene ID
nad12a03x1 NCI_CGAP_Lu24 cDNA clone IMAGE:3365260 3'
AQR
zr48e07r1 Soares_NhHMPu_S1 cDNA clone IMAGE:666660 5' similar to WP:F01F1.7 CE01233 RNA HELICASE ;
DDX23
hypothetical protein FLJ37562 (FLJ37562)
DDX46
hypothetical protein FLJ37562 (FLJ37562)
DDX46
DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 (DDX46)
DDX46
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 (DDX5)
DDX5
DEAH (Asp-Glu-Ala-His) box polypeptide 16 (DHX16)
DHX16
DEAH (Asp-Glu-Ala-His) box polypeptide 38 (DHX38)
DHX38
DEAH (Asp-Glu-Ala-His) box polypeptide 8 (DHX8)
DHX8
heterogeneous nuclear ribonucleoprotein A1 (HNRPA1), transcript variant 2
HNRNPA1
heterogeneous nuclear ribonucleoprotein C (C1/C2) (HNRPC), transcript variant 1
HNRNPC
CM3-MT0343-170101-665-f10 MT0343 Homo sapiens cDNA
HNRNPC
heat shock 70kDa protein 8 (HSPA8), transcript variant 1
HSPA8
LSM3 homolog, U6 small nuclear RNA associated (S cerevisiae) (LSM3)
LSM3
NHP2 non-histone chromosome protein 2-like 1 (S cerevisiae) (NHP2L1)
NHP2L1
peptidylprolyl isomerase (cyclophilin)-like 1 (PPIL1)
PPIL1
mRNA; cDNA DKFZp434L162 (from clone DKFZp434L162)
PRPF18
PRP3 pre-mRNA processing factor 3 homolog (yeast) (PRPF3)
PRPF3
xj64d02x1 Soares_NFL_T_GBC_S1 cDNA clone IMAGE:2661987 3'
PRPF40A
RNA binding motif protein 8A (RBM8A)
RBM8A
RNA binding motif protein, X-linked (RBMX)
RBMX
splicing factor 3a, subunit 3, 60kDa (SF3A3)
SF3A3
splicing factor 3b, subunit 5, 10kDa (SF3B5)
SF3B5
U5 snRNP-specific protein, 200-KD (U5-200KD)
SNRNP200
small nuclear ribonucleoprotein polypeptide A' (SNRPA1)
SNRPA1
small nuclear ribonucleoprotein polypeptides B and B1 (SNRPB), transcript variant 1
SNRPB
EST40322 Epididymus Homo sapiens cDNA 5' end similar to similar to small nuclear ribonucleoprotein, polypeptide B & B'
SNRPB
small nuclear ribonucleoprotein D2 polypeptide 165kDa (SNRPD2), transcript variant 1
SNRPD2
small nuclear ribonucleoprotein polypeptide F (SNRPF)
SNRPF
cDNA FLJ10896 fis, clone NT2RP5003461, weakly similar to RLR1 PROTEIN
THOC2
mRNA; cDNA DKFZp586L1121 (from clone DKFZp586L1121)
THOC2
K-EST0034196 S1SNU5 cDNA clone S1SNU5-38-H01 5'
U2AF2
WW domain binding protein 11 (WBP11)
WBP11
11