Article: Variations in Disrupted-in-Schizophrenia 1 gene modulate long-term longitudinal differences in cortical thickness in patients
with a first-episode of psychosis.
Journal: Brain Imaging and Behavior
Javier Vázquez-Bourgon*a,b,c, Roberto Roiz-Santiañeza,b,c, Sergi Papiolb,d,e, Adele Ferrof, Noemí Varelaa,b,c, Lourdes Fañanásb,d, Benedicto
Crespo-Facorroa,b,c
a
University Hospital Marqués de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
b
CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain
c
IDIVAL, Instituto de Investigación Marqués de Valdecilla, Santander, Spain
d
Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona. Institut de Biomedicina de la Universitat de Barcelona
(IBUB), Barcelona, Spain.
e
Institute of Psychiatric Phenomics and Genomics (IPPG) and Department of Psychiatry-Molecular Neurobiology. Ludwig Maximilian
University of Munich, Munich, Germany.
f
Department of Experimental Clinical Medicine, Inter-University Center for Behavioral Neurosciences (ICBN), University of Udine, Udine,Italy.
*Corresponding autor: Javier Vázquez-Bourgon, MD; E-mail: javazquez@humv.es
ESM 2. Longitudinal and cross-sectional results of rs821616 and combined rs6675281/rs821616
Table S1. Effect of rs821616 polymorphism in cortical thickness progression over 3 years follow-up.
Baseline
3 years
Ser/Ser
Cys/Car
Stat.
Ser/Ser
Cys/Car (n=56)
Stat.
(n=4)
(n=56)
(n=4)
Mean (SD)
Mean (SD) F (p)
Mean (SD)
Mean (SD)
F (p)
Total cortical
4.16 (0.36)
3.97 (0.37) 1.13 (0.29) 4.08 (0.21)
3.98 (0.33)
0.26 (0.61)
thickness (CT)
Frontal CT
4.32 (0.40)
4.15 (0.42) 0.66 (0.42) 4.28 (0.26)
4.19 (0.39)
0.05 (0.83)
Temporal CT
3.31 (0.29)
3.20 (0.33) 0.41 (0.53) 3.35 (0.25)
3.17 (0.33)
1.21 (0.28)
Parietal CT
3.95 (0.41)
3.72 (0.35) 2.00 (0.16) 3.84 (0.22)
3.72 (0.32)
0.43 (0.52)
Occipital CT
4.51 (0.49)
4.27 (0.49) 0.89 (0.35) 4.33 (0.29)
4.24 (0.43)
0.16 (0.69)
Time x genotype
F (p)
0.82 (0.37)
0.72 (0.39)
0.21 (0.67)
1.06 (0.31)
0.85 (0.36)
Table S2. Combined effect of rs6675281 andrs821616 polymorphismson cortical thickness progression over 3 years follow-up.
Baseline
Leu/Leu
+Ser/Ser
(n=4)
Total cortical
thickness (CT)
Frontal CT
Temporal CT
Parietal CT
Occipital CT
3-years
Phe/Car +
Cys/Car
(n=15)
Stat.
Leu/Leu
+Ser/Ser
(n=4)
Mean (SD)
4.16 (0.36)
Leu/Leu or
Ser/Ser +
Phe/Car or
Cys/Car
(n=37)
Mean (SD)
4.02 (0.41)
Mean (SD)
3.86 (0.30)
F (p)
0.77 (0.46)
4.32 (0.40)
3.31 (0.29)
3.95 (0.41)
4.51 (0.49)
4.21 (0.45)
3.19 (0.36)
3.75 (0.38)
4.35 (0.54)
4.04 (0.38)
3.21 (0.30)
3.64 (0.27)
4.08 (0.37)
0.63 (0.54)
0.03 (0.97)
0.49 (0.61)
1.19 (0.31)
Time x
genotype
Phe/Car +
Cys/Car
(n=15)
Stat.
Mean (SD)
4.08 (0.21)
Leu/Leu or
Ser/Ser +
Phe/Car or
Cys/Car
(n=37)
Mean (SD)
3.97 (0.37)
Mean (SD)
3.99 (0.26)
F (p)
0.46 (0.63)
F (p)
3.99 (0.025)
4.28 (0.26)
3.35 (0.25)
3.84 (0.22)
4.33 (0.29)
4.19 (0.43)
3.14 (0.32)
3.71 (0.35)
4.24 (0.47)
4.21 (0.32)
3.20 (0.32)
3.71 (0.22)
4.24 (0.37)
0.43 (0.65)
1.33 (0.27)
0.41 (0.66)
0.16 (0.85)
3.67 (0.032)
0.36 (0.70)
1.67 (0.19)
4.73 (0.013)