Course Information
Course title
Semester
Department
Instructor
Introduction to Cellular BioMEMS and
Biomicrofluidics
102-2
Institute of Applied Mechanics
許聿翔
Administrative Curriculum
543M5310
Number
Teaching Curriculum
Number
Class
Credits
AM7166
應 107
3
Full/Half Yr.
Half Yr.
Required/Elective
Required
Time
Tue.678
Remarks
The upper limit of the number of students: 35
Ceiba Web Server
Table of Core Capabilities
A、B、D、F
and Curriculum Planning
Course Syllabus
Course Description
課程名稱: 細胞微機電及微流體導論
(Introduction to Cellular BioMEMS and
Biomicrofluidics)
1. Cellular biomechanics: anatomy and physiology of
cells, mechanics of cytoskeleton, cell-matrix
interaction, focal adhesions, mechanical model,
mechanoreceptors, mechanical behavior of cells:
mitosis, migration, and introduction to infection
induced cell abnormality.
2. Tissue Engineering: microcirculation, capillary
anatomy, diffusion and convection, Starling law,
osmotic pressure, interstitial flow, basics of
angiogenesis and vasculogenesis.
3. BioMEMS: Photolithography, bulk
micromachining, surface micromachining,
micro-molding, plastic manufacturing.
4. Microfluidics: scaling laws, surface to volume ratio,
hydraulic resistance, wall shear stress, diffusion,
capillary flow, hydrodynamics in porous media.
5. Special topic: Cell-based chip for biotechnology bioreactors, studies of mechanics of abnormal cells,
cell sorting, cell trapping.
6. Special topic: BioMEMS for cell biology substrate dependency of cells, cell-cell contact, cell
migration.
7. Special topic: Tissue microengineering - 3D
culture, angiogenesis, vasculogenesis, organ on a
chip.
Course Objective
The course objective is two:
(1) describes how the basic mechanics applied on the
basis of biomechanical analysis of cells and
tissues, and from its main function and explain the
physical meaning; (2) describes how the basic
mechanics in micro-electromechanical systems
and biological microfluidic flow channel design,
and applied medical research and application of
cell mechanics.
(2) Project presentation 30%; Midterm 30%; Final
project report & Presentation 40 %
Course Requirement
Office Hours
References
Major Reference textbook: Introduction to BioMEMS,
Albert Folch, CRC Press; 1st ed. (August 21, 2012)
Ch1 How do we make small things?
Ch2 Micropatterning of substrates and cells
Ch3 Microfluidics
Ch5 Cell-based chips for biotechnology
Ch6 BioMEMS for cell biology
Ch7 Tissue microengineering
Other Reference book：Essential Cell Biology, Bruce
Albert, et al. Garland Science, 2nd ed. (September 25,
2003)
Ch17 Cytoskeleton
Ch19 Cell division
Introductory Biomechanics - From Cells to
Organisms,
C. Ross Ethier and Craig A. Simmons, Cambridge
University Press (April 9, 2007)
Ch2 Cellular biomechanics
Ch3 Hemodynamics
Ch4 The circulatory system
Ch5 Interstitial fluid flow
Fundamental of Microfabrication, Marc Madou, CRC
Press
Ch1 Lithography
Ch2 Pattern transfer with dry etching technologies
Ch4 Wet bulk micromachining
Ch5 Surface micromachining.
Theoretical Microfluidics, HenrikBruus, Oxford
University Press, (Nov 17, 2007)
Ch2 Governing equations
Ch3 Basic flow solutions
Ch4 Hydraulic resistance and compliance
Ch5 Diffusion
Designated reading
Grading
1. Lecture notes
2. Representative journal papers for the Lab-on-Chip
system designed for studying cells and tissues.
No. Item
%
Explanations for the conditions
Progress
Week
Date
Topic
Week 1
2/18
Introduction to Lab-on-a-Chip systems
Week 2
2/25
BioMEMS-Photolithography, bulk micromachining, surface
micromachining, micro-molding, plastic manufacturing
3/04
BioMEMS-Photolithography, bulk micromachining, surface
micromachining, micro-molding, plastic manufacturing;
Introduction to BioMicrofluidics
Week 3
Week 4
Week 5
3/11
BioMicrofluidics - scaling laws, surface to volume ratio,
hydraulic resistance, wall shear stress, diffusion, capillary flow,
hydrodynamics in porous media.
3/18
Cellular biomechanics: anatomy and physiology of cells,
mechanics of cytoskeleton, cell-matrix interaction, focal
adhesions, mechanical model, mechanoreceptors, mechanical
behavior of cells: mitosis, migration, and introduction to
infection induced cell abnormality.
Cellular biomechanics: anatomy and physiology of cells,
mechanics of cytoskeleton, cell-matrix interaction, focal
Week 6
3/25
adhesions, mechanical model, mechanoreceptors, mechanical
behavior of cells: mitosis, migration, and introduction to
infection induced cell abnormality.
4/01
Tissue Engineering: microcirculation, capillary anatomy,
diffusion and convection, Starling law, osmotic pressure,
interstitial flow, basics of angiogenesis and vasculogenesis.
Week 8
4/08
Tissue Engineering: microcirculation, capillary anatomy,
diffusion and convection, Starling law, osmotic pressure,
interstitial flow, basics of angiogenesis and vasculogenesis.
Week 9
4/15
Midterm
4/22
Special topics: Cell-based chip for biotechnology - bioreactors,
studies of mechanics of abnormal cells, cell sorting, cell
trapping.
4/29
Special topics: Cell-based chip for biotechnology - bioreactors,
studies of mechanics of abnormal cells, cell sorting, cell
trapping.
Week 7
Week 10
Week 11
Week 12
5/06
Special topics: Cell-based chip for biotechnology - bioreactors,
studies of mechanics of abnormal cells, cell sorting, cell
trapping.
Week 13
5/13
6. Special topic: BioMEMS for cell biology - substrate
dependency of cells, cell-cell contact, cell migration.
Week 14
5/20
6. Special topic: BioMEMS for cell biology - substrate
dependency of cells, cell-cell contact, cell migration.
Week 15
5/27
6. Special topic: BioMEMS for cell biology - substrate
dependency of cells, cell-cell contact, cell migration.
Week 16
6/03
7. Special topic: Tissue microengineering - 3D culture,
angiogenesis, vasculogenesis, organ on a chip.
Week 17
6/10
7. Special topic: Tissue microengineering - 3D culture,
angiogenesis, vasculogenesis, organ on a chip.