Program
Time: November 18-20, 2014
Place: Tongli Lakeview Hotel, Suzhou, China
Registration
Time: 09:00-22:00, Nov 17, 2014 (Monday); Place: Registration Desk, 1st Floor, No.1 Building
Time: 08:00-18:00, Nov 18, 2014 (Tuesday); Place: Registration Desk, 1 st Floor, No.2 Building
Group Photo
Time: 08:20-08:30, Nov 18, 2014 (Tuesday); Place: Outside Square of Kafka on the Shore
Opening Ceremony
Time: 09:00-09:30, Nov 18, 2014 (Tuesday); Place: Laurel International Ballroom, 2nd Floor, No.2 Building
Keynote Forum
Time: 09:30-12:05, Nov 18, 2014 (Tuesday); Place: Laurel International Ballroom, 2nd Floor, No.2 Building
Moderator
Dr. Guo-Ping Zhou, Professor and Senior Principal Investigator, Gordon Life Science Institute, USA
09:30-09:35
Moderator’s Instroduction
09:35-10:05
Title: SGLT2 Inhibitors for the Treatment of Type 2 Diabetes – A Promising New Class
Dr. Michael Mark, Vice President, Boehringer Ingelheim Pharma GmbH & Co. KG, Germany
10:05-10:35
Title: Integrating Big Data into Translational Medicine: The Value of Legacy Data and Open Innovation
Networks
Dr. Patrice P. Denefle, Associate Professor, Paris Descartes University; Senior Partner & Co-founder,
MedBioMix Partners, France
10:35-11:05
Title: Biopharmaceutical Manufacturing: Where Do We Come from, Where are We Going?
Dr. Alain Bernard, Vice President, UCB Pharma SA, Belgium
11:05-11:35
Title: The Future of Medicinal Chemistry
Dr. Hans-Joachim Bohm, Global Head of Small Molecule Research, Roche, Switzerland
11:35-12:05
Title: Transforming Innovation in Drug Discovery through Collaboration and Partnership
Dr. Tao Guo, Vice President, WuXi AppTec, China
Track 1: Frontier of Chemical Biology and Targeting Medichem
Session 1-1: Chemical Genetic Approaches, Chemoinformatics, Structural Biology
Time: 13:30-17:10, Nov 18, 2014 (Tuesday) Place: H Conference Room, 2nd Floor , No.1 Building
Chair
Co-Chair
Dr. Ignasi Belda, CEO, Intelligent Pharma, Spain
Dr. Timothy J. Miller, CEO, Abeona Therapeutics, USA
13:30-13:35
Chair’s Introduction
13:35-14:00
14:00-14:25
14:25-14:50
14:50-15:15
15:15-15:30
15:30-15:55
Title: Ubiquitination Enzymes as Novel Cancer Therapeutic Targets
Dr. Amit Banerjee, Adjunct Professor, Wayne State University, USA
Title: Pythia, the Way to Polypharmacology
Dr. Ignasi Belda, CEO, Intelligent Pharma, Spain
Title: Gene Therapy and Disruptive Technology – Developing Treatments for Rare Genetic Diseases
Dr. Timothy J. Miller, President & CEO, Abeona Therapeutics, USA
Title: Novel Sultam Chemotypes for Probing New Regions of Biological Space
Dr. Paul R. Hanson, Professor, University of Kansas, USA
Coffee Break
Title: New Targets for Steroid-Resistant Inflammation: Where and How to Look
Dr. Alastair Stewart, Professor, University of Melbourne, Australia
15:55-16:20
Title: The Role of Research Institutes: How Chemistry Drives Technology, Innovation and Progress
16:20-16:45
16:45-17:10
Dr. Charles Johannes, Principle Scientist II & Head, A*STAR Institute of Chemical and Engineering
Sciences, Singapore
Title: Systems Biology Approaches to Cellular Metabolism: New Possibilities for Biopharma Industry
Dr. Francisco J. Planes, Head, Centre of Studies and Technical Research, Spain
Title: QF_ABC : A Full Solution for Both Ligand and Structure-based Computer Aided Drug Design
Dr. Tong Zhu, Autobiocadd-Tech Co.,Ltd., China
Session 1-2: Challenges and New Opportunities of Medichem
Time: 13:30-15:15, Nov 19, 2014 (Wednesday) Place: H Conference Room, 2nd Floor, No.1 Building
Chair
Dr. Haishan Wang, Group Leader, Drug Development Unit, Institute of Molecular and Cell Biology
(IMCB), Singapore
13:30-13:35
13:35-13:55
Chair’s Introduction
Title: Addressing Toxicity Risk When Designing and Selecting Compounds in Early Drug Discovery
Dr. Edmund Champness, Chief Scientific Officer, Optibrium Ltd, UK
Title: Design, Synthesis and SAR of Novel HDAC Inhibitors
Dr. Haishan Wang, Group Leader, Drug Development Unit, Institute of Molecular and Cell Biology
(IMCB), Singapore
Title: Drug Discovery Based on Diversified Plant Natural Compounds
Dr. Hongjie Zhang, Associate Professor, Hong Kong Baptist University, Hong Kong, China
Title: Discovery of Small Molecule NLRP3 Inhibitor and its Potential Applications
Dr. Shijun Zhang, Associate Professor, Virginia Commonwealth University, USA
Title: Development of N-Hydroxycinnamamide-based HDAC 1/3 Selective Inhibitors
Dr. Yingjie Zhang, Lecturer, Department of Medicinal Chemistry, Shandong University, China
13:55-14:15
14:15-14:35
14:35-14:55
14:55-15:15
Track 2: Hot Topics on Drug Discovery Chemistry
Session 2-1: New Opportunities in Lead Discovery and Optimization Strategies
Time: 13:30-16:45, Nov 18, 2014 (Tuesday) Place: I Conference Room, 2nd Floor, No.1 Building
Chair
Dr. Jin Li, Chairman and CEO, HitGen Ltd., China
Co-Chair
Dr. Robert Scoffin, Chief Executive Officer, Cresset, UK
13:30-13:35
13:35-14:00
14:00-14:25
14:25-14:50
14:50-15:15
15:15-15:30
15:30-15:55
15:55-16:20
16:20-16:45
16:45-17:10
Chair’s Introduction
Title: Fragment Based Drug Discovery: Sweating the Small Stuff is Worth It
Dr. Gavin Hirst, Vice President, Takeda California Inc., USA
Title: Discovery of Non ATP Competitive Kinase Inhibitors
Dr. Jin Li, Chairman & CEO, HitGen Ltd., China
Title: Computer-Aided Drug Design in the 21st Century: SAR Analysis, Scaffold-Hopping and Compound
Re-Profiling
Dr. Robert Scoffin, Chief Executive Officer, Cresset, UK
Title: The Use of Virtual Screening, DSF and MicroScale Thermophoresis for the Rapid Identification of
Fragments Active Against MEK1
Dr. Alexey Rak, Head, Sanofi R& D, France
Coffee Break
Title: Combining Automated Docking Tools and Experimental Assays to Identify, Evaluate, and Improve
Lead Compounds for Drug Discovery
Dr. Kimberly A Stieglitz, Professor, Roxbury Community College, USA
Title: Computer Aided Drug Design in Lead Discovery and Optimization Strategies: Case Study on
Anti-Alzheimer’s Agents
Dr. Anil K. Saxena, Professor, Central Drug Research Institute, India
Title: Hybrid Drug Design: A Missile to Multiple Targets
Dr. K. G. Bothara, Professor & Head, Sinhgad Institute of Pharmacy, India
Title: Imaging Myelin Pathology in the Gray Matter in Multiple Sclerosis
Dr. Yanming Wang, Director, Case Western Reserve University, USA
Session 2-2:Chemistry Strategies for Anti-Infectives and the Resistance
Time: 13:30-15:15, Nov 18, 2014 (Tuesday) Place: C Conference Room, 2nd Floor, No.1 Building
Chair
Dr. Kevin Chen, Executive Director, WuXi AppTec, China
13:30-13:35
13:35-14:00
Chair’s Introduction
Title: From Boceprevir to Sofosbuvir: Progress of Anti-HCV Therapies and Implications of Drug
Resistance
Dr. Kevin Chen, Executive Director, WuXi AppTec, China
14:00-14:25
14:25-14:50
14:50-15:15
Title: Nanoparticle Formulations of Decoquinate Increase Bioavailability and Antimalarial Efficacy
against Liver Stage Plasmodium Infections in Mice
Dr. Hongxing Wang, Scientist, Walter Reed Army Institute of Research, USA
Title: Recent Advances in Design of Potential Quinoxaline Anti-Infectives
Dr. Josef Jampilek, Associate Professor, University of Veterinary and Pharmaceutical Sciences Brno,
Czech Republic
Title: A New Paradigm for Developing Anti-Viral Drugs Exemplified by the Development of a Supremely
High Anti-HIV Active EfdA
Dr. Hiroshi Ohrui, Professor, Yokohama College of Pharmacy, Japan
Track 3: Master Medicinal Chemistry of Biotherapy
Time: 15:30-17:40, Nov 18, 2014 (Wednesday) Place: C Conference Room, 2nd Floor, No.1 Building
Chair
Dr. Francis S. Markland, Professor, University of Southern California, USA
15:30-15:35
15:35-16:00
Chair’s Introduction
Title: Novel Cell-based Protein-Protein Interaction Kinase Assays and Applications for Identifying Kinase
Inhibitors and Receptor Modulators
Dr. Haifeng Eishingdrelo, Chief Technology Officer, BioInvenu Corp., USA
Title: A Novel Integrin-Targeted Peptide Delivered Intraperitoneally for Ovarian Cancer Therapy
Dr. Francis S. Markland, Professor, University of Southern California, USA
Title: TRH and TSA Promote Bone Marrow Sem Cell Differentiation into Islet-like Insulin Positive Cells
Dr. Luguang Luo, Professor, Roger Williams Hospital, USA
Title: Research and Development of Antibody-Drug Conjugate (ADC)
Dr. Bainian Feng, Professor, Jiangnan University, China
16:00-16:25
16:25-16:50
16:50-17:15
17:15-17:40
Title: Mimics of Catalase as Attenuator of HIF and Glycolysis
Dr. Qiu-Yun Chen, Professor, Jiangsu University, China
Track 4: Case Studies of Medichem on Drug Candidates on Major Diseases
Session 4-1: New Anti-Cancer Drugs
Time: 08:30-12:10, Nov 19, 2014 (Wednesday) Place: H Conference Room, 2nd Floor, No.1 Building
Chair
Co-Chair
Dr. Ananda M. Chakrabarty, Professor, University of Illinois at Chicago, USA
Dr. Jun Pang, President & CEO, Northernchem Inc, Canada
08:30-08:35
08:35-09:00
Chair’s Introduction
Title: Bacterial Proteins and Peptides in Cancer Therapy: Moving Forward
Dr. Ananda M. Chakrabarty, Professor, University of Illinois at Chicago, USA
Title: Fluorescent Small Molecule Inhibitors for Imaging of Kinases
Dr. Wei Zhang, Professor & Director of the Center for Green Chemistry, University of Massachusetts
Boston, USA
Title: Zebrafish Phenotype-based Screening for Selective Drug Leads
Dr. Jijun Hao, Assistant Professor, Western University of Health Sciences, USA
Title: Copper(II) Complexes with Amidrazone-based Chelators: A Potent Anticancer Agents
Dr. Liliana Mazur, Researcher, Maria Curie-Sklodowska University, Poland
Coffee Break
Title: The Role of Valproato Ligands in the Enhanced Efficacy of Antitumor Pt(IV) Prodrugs
Dr. Viktor Brabec, Professor, Institute of Biophysics ASCR, v.v.i., Czech Republic
Title: A Small-Molecule Library Targeting AML Stem Cells
Dr. Yue Chen, Professor, Nankai University, China
Title: S-Triazine and Quinazoline Derivatives: Potential Anticancer PC3 Cells
Dr. Premlata Kumari, Assistant Professor, S V National Institute of Technology, India
Title: New Progress in Small Molecule Anti-Cancer Drug R & D
Dr. Jun Pang, President & CEO, Northernchem Inc., Canada
09:00-09:25
09:25-09:50
09:50-10:15
10:15-10:30
10:30-10:55
10:55-11:20
11:20-11:45
11:45-12:10
Session 4-2: Drugs against CNS Diseases
Time: 08:30-11:45, Nov 19, 2014 (Wednesday) Place: I Conference Room, 2nd Floor, No.1 Building
Chair
Co-Chair
Dr. Jian Jeffrey Chen, Scientific Director, Amgen Inc. USA
Dr. Patricia Melnyk, Director, Lille 2 University, France
08:30-08:35
08:35-09:00
Chair’s Introduction
Title: Drug Discovery at Lundbeck. Approaches to New Treatments for Brain Diseases
09:00-09:25
09:25-09:50
09:50-10:15
10:15-10:30
10:30-10:55
10:55-11:20
11:20-11:45
Dr. Klaus Bek Simonsen, VP & Global Head, Lundbeck, Denmark
Title: Development of 2-Aminooxazoline 3-Azaxanthenes as Orally Active-Secretase Inhibitors for the
Treatment of Alzheimer’s Disease
Dr. Jian Jeffrey Chen, Scientific Director, Amgen Inc., USA
Title: Discovery of Non-Oxime Reactivators Using an Insilico Pharmacophore Model of Oxime
Reactivators for Tabun-Inhibited Acetylcholinesterase
Dr. Apurba K. Bhattacharjee, Senior Scientist, Walter Reed Army Institute of Research, USA
Title: Fused Isoquinoline-Hydantoin as a Powerful Scaffold for the Design of Selective Sigma-1 Ligands
Dr. Patricia Melnyk, Director, Lille 2 University, France
Coffee Break
Title: Charnolo Pharmacon Therapeutices of Chronic Multidrug Resistant Diseases
Dr. Sushil Sharma, Professor, Saint James School of Medicine Kralendijk, The Netherlands
Title: Cyclic Glycine-Proline(cGP) Regulates Homeostasis of Insulin-like Growth Factor- 1(IGF1)
Dr. Jian Guan, Senior Research Fellow, The University of Auckland, New Zealand
Title: Small, Special-Issue-Focused Libraries Pry on CNS Targets
Dr. Rifang Yang, Associate Professor, Beijing Institute of Pharmacology and Toxicology, China
Session 4-3: Small Molecule Drugs R & D
Time: 08:30-11:45, Nov 20, 2014 (Thursday) Place: H Conference Room, 2nd Floor, No.1 Building
Chair
Co-Chair
08:30-08:35
08:35-09:00
09:00-09:25
09:25-09:50
09:50-10:15
10:15-10:30
10:30-10:55
10:55-11:20
11:20-11:45
Dr. Wei-Dong Pan, Professor, Natural Products of Guizhou Province and Chinese Academy of Sciences,
China
Title: Targeting Peripheral Opioid Receptors to Induce Analgesic and Anti-inflammatory Actions
Dr. Susan Hua, Therapeutic Targeting Research Group Leader, The University of Newcastle, Australia
Chair’s Introduction
Title: Discovery of Eliquis/Apixaban, a Novel Factor Xa Anticoagulant
Dr. Patrick Y. S. Lam, Adjunct Professor, Drexel University College of Medicine, USA
Title: Targeting Peripheral Opioid Receptors to Induce Analgesic and Anti-inflammatory Actions
Dr. Susan Hua, Therapeutic Targeting Research Group Leader, The University of Newcastle, Australia
Title: Anti-Liver Cancer Drug Candidate Origined from Natural Product Fanchinoline with Novel
Machanism of Action
Dr. Wei-Dong Pan, Professor, Natural Products of Guizhou Province and Chinese Academy of Sciences,
China
Title: Diarylpyrimidine-Quinolone Hybrids as Dual Inhibitors of Non-Nucleoside HIV Reverse
Transcriptase and Integrase
Dr. Qiu-Qin He, Director, Fudan University, China
Coffee Break
Title: Design and Synthesis of Primaquine Glycoconjugates as Potent Tissue Schizonticides for the
Treatment of Malaria Relapse
Dr. Mridula Saxena, Professor, Amity University, India
Title: Antimicrobial and Hypoglycemic Activities of Novel N-Mannich Bases Derived from
5-(1-Adamantyl)-4-Substituted-1,2,4-Triazoline-3-Thiones
Dr. Ali A. El-Emam, Professor, King Saud University, Saudi Arabi
Title: Anti Inflammatory and Immuno-modulatory Role of Nanocurcumin: An Overview
Dr. Palanisamy Sankar, Assistant Professor, Tamilnadu Veterinary and Animal Sciences University, India
Track 5: Green Approaches in Bioactive Compounds and Manufacturing Process
Session 5-1: Natural Products Chemistry and Asymmetric Synthesis of Bioactive Compounds
Time: 13:30-16:30, Nov 19, 2014 (Wednesday) Place: I Conference Room, 2nd Floor, No.1 Building
Chair
Co-Chair
Dr. Janine Cossy, Professor, ESPCI ParisTech, France
Dr. Wei Zhang, Professor and Director of the Center for Green Chemistry, University of Massachusetts
Boston, USA
13:30-13:35
13:35-13:55
Chair’s Introduction
Title: Organometallic Chemistry, Asymmetric Synthesis of Bioactive Compounds and Chiral Drugs
Dr. Janine Cossy, Professor, ESPCI ParisTech, France
Title: Development of Novel Anticancer Agents that Target Prohibitins and the Translation Initiation
Factor EIF4a
Dr. Laurent Desaubry, Director, University of Strasbourg, France
Title: Antioxidant Activities of Chemical Constituents Isolated from Some Origanum Species
Dr. Ramazan Erenler, Professor, Gaziosmanpasa University, Turkey
Title: Streamlined Fluorous Synthesis of Diverse Heterocyclic Scaffolds
Dr. Wei Zhang, Professor and Director of the Center for Green Chemistry, University of Massachusetts
13:55-14:15
14:15-14:35
14:35-14:55
14:55-15:15
15:15-15:30
15:30-15:50
15:50-16:10
16:10-16:30
Boston, USA
Title: Medicinal Inorganic Chemistry is Growing Significance in both Therapeutic and Diagnostic
Medicine
Dr. Sirasani Satyanarayana, Professor, Osmania University, India
Coffee Break
Title: Dead Ends and Detours: Challenges in Total Synthesis of Natural Products
Dr. Rodney A. Fernandes, Associate Professor, Indian Institute of Technology Bombay, India
Title: Potential Phytomolecules against Cardiovascular Diseases
Dr. Sarada D. Tetali, Associate Professor, University of Hyderabad, India
Title: Chemical Investigation of Tropical Marine Invertebrates
Dr. Novriyandi Hanif, Assistant Professor, Bogor Agricultural University, Indonesia
Session 5-2: Frontiers in Drug Synthesis and Green Chemistry
Time: 08:30-11:30, Nov 20, 2014 (Thursday) Place: I Conference Room, 2nd Floor, No.1 Building
Chair
Co-Chair
Dr. Wei Zhang, Professor & Director of the Center for Green Chemistry, University of Massachusetts
Boston, USA
Dr. Patrick Y. S. Lam, Adjunct Professor, Drexel University College of Medicine, USA
08:30-08:35
08:35-08:55
Chair’s Introduction
Title: Recyclable Organoctalysis for Asymmetric Synthesis
Dr. Wei Zhang, Professor & Director of the Center for Green Chemistry, University of Massachusetts
Boston, USA
08:55-09:15
Title: Light-Activated Reagents for Double-Strand DNA Cleavage with Built-in Selectivity for Hypoxic
Cancer Tissues
Dr. Igor V. Alabugin, Professor, Florida State University, USA
09:15-09:35
Title: The Use of Novel Green Catalysts for the Production of Precursor Compounds for Drug
Manufacturing
Dr. Kimberly Stieglitz, Professor, Roxbury Community College, USA
09:35-09:55
09:55-10:15
10:15-10:30
10:30-10:50
10:50-11:10
11:10-11:30
Title: Prodrug Approaches for the Rational Design of New DXR Inhibitors: Novel Antitubercular Drugs
Dr. Catherine Grosdemange-Billiard, Professor, Universite de Strasbourg, France
Title: One-Pot Three Components Domino Reaction: Diversity Oriented Synthesis of Imidazolone Alkaloid
Framework
Dr. Chung-Ming Sun, Professor, National Chiao Tung University, Taiwan
Coffee Break
Title: Hybrid ROMP Reagents: Generation and Use in Synthesis
Dr. Paul R. Hanson, Professor, University of Kansas, USA
Title: Molecular Recognition in Innovative Drug Design
Dr. Patrick Y. S. Lam, Adjunct professor, Drexel University College of Medicine, USA
Panel Discussion