Supplementar Material: Baclofen in GHB relapse prevention Supplement Table B: Pattern of GHB abuse 11 patients Case(m/w) Years GHB abuse Number Emergency admission last year(where) Number detoxifications GHB Withdrawal symptoms abstinence after detox before relapse Case 1(m) 4y several ( ICU ) 2 Delirium, agitation, insomnia and depressive feelings several days Case 2 (m) 6y 3(ER ), several (MHI) 3 Anxiety, muscle pain, diarrhoea and depressive feelings < 3 weeks Case 3 (w) 2 Non 2 Agitation, tremors and insomnia within the 1st week Case 4 (m) 4.5 y 2 ( ER) 2 Anxiety, visual hallucinations , hypertension and tremors 2 weeks Case 5 (w) 3y 2( ER) , 1( ICU) 4 Paranoid psychosis with visual hallucinations and convulsion attacks 3 days -1 week Case 6 (w) 2y Non 2 Anxiety, tremors and diaphoresis max 3 weeks Case 7 (m) 2y 2 (ER) 2 Visual hallucinations, muscle pain and itching several days Case 8 (w) 6y Non 2 Anxiety, tremors , agitation and visual and auditory hallucination 3 weeks Case 9 (w) 5y 1 (ER) 4 Agitation, panic and insomnia 4 weeks Case 10 (m) 4y 1 (ER) 4 Tremors and diaphoresis 1-2 weeks Case 11 (m) 3y 2(ER) 3 Anxiety, depressive feelings sweat, insomnia, paranoid 2 weeks 1