Hydrobromic Acid SOP

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Standard Operating Procedure

Hydrobromic Acid

This is an SOP template and is not complete until: 1) lab specific information is entered into the box below 2) lab specific protocol/procedure is added to the protocol/procedure section and

3) SOP has been signed and dated by the PI and relevant lab personnel.

Print a copy and insert into your

Laboratory Safety Manual

and

Chemical Hygiene Plan

.

Refer to instructions for assistance.

Department:

Chemistry

Date SOP was written:

11/26/2012

Date SOP was approved by PI/lab supervisor:

11/27/2012

Principal Investigator:

Office Phone:

Richmond Sarpong

Internal Lab Safety Coordinator/Lab Manager:

Rebecca Murphy

Lab Phone:

510-643-2485

510-643-6312

Emergency Contact:

Location(s) covered by this SOP:

Richmond Sarpong 626-644-2407

(Name and Phone Number)

Latimer 834, 836, 837, 838, 839, 842, 844, 847, 849,

907

(Building/Room Number)

Type of SOP:

Process

Hazardous Chemical

Hazardous Class

Purpose

Hydrobromic acid is mainly used for the production of inorganic bromides, especially the bromides of zinc, calcium, and sodium. It is a useful reagent for generating organobromine compounds. Certain ethers are cleaved with HBr. It also catalyzes alkylation reactions and the extraction of certain ores. Industrially significant organic compounds prepared from hydrobromic acid include allyl bromide, tetrabromobis(phenol), and bromoacetic acid.

Physical & Chemical Properties/Definition of Chemical Group

CAS#: 10035-10-6

Class:

Corrosive

Hydrobromic Acid 1

SOP Template developed by The UC Center for Laboratory Safety

Date: 1/11/2013

Molecular Formula: HBr

Form (physical state): liquid

Color: Liquid, light brown color

Boiling point: 122

O

C

Potential Hazards/Toxicity

Toxic if Inhaled, Material is Extremely Destructive to the Tissue of the Mucous Membranes and Upper

Respiratory Tract. Harmful through Skin Absorption and Ingestion, Causes Skin and Eye Burns.

Engineering Controls

NOTE: Lab-specific information on engineering controls may be included in the Protocol/Procedure section.

Work with hydrobromic acid should be conducted in a fume hood unless other controls are designated in the Protocol/Procedure section. Sash height should be kept low to minimize escaping fumes and provide a physical barrier. Consider using a face shield in addition to safety goggles when handling HBr.

Personal Protective Equipment (PPE)

Respiratory Protection

NOTE : Lab personnel intending to use/wear a respirator mask must be trained and fit-tested by EH&S.

This is a regulatory requirement.

Respirators should be used only under any of the following circumstances:

As a last line of defense (i.e., after engineering and administrative controls have been exhausted).

When Permissible Exposure Limit (PEL) has exceeded or when there is a possibility that PEL will be exceeded.

Regulations require the use of a respirator.

An employer requires the use of a respirator.

There is potential for harmful exposure due to an atmospheric contaminant (in the absence of

PEL)

As PPE in the event of a chemical spill clean-up process

Hand Protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. For dilute solutions of hydrobromic acid (less than 6M) use normal nitrile, neoprene or polyvinyl chloride. For solutions of greater concentration, use neoprene, polyvinyl chloride, or thicker nitrile or double glove nitrile.

For glove selection, go to: http://ehs.berkeley.edu/hs/63-laboratory-safety/94-glove-selection-andusage.html.

NOTE: Lab-specific information on glove selection may be included in the Protocol/Procedure section.

Hydrobromic Acid 2

SOP Template developed by The UC Center for Laboratory Safety

Date: 1/11/2013

Eye Protection

Safety glasses with side shields or tightly fitting safety goggles. Use face shield (8-inch minimum) when appropriate (such as for pouring concentrated acid). Use equipment for eye protection tested and approved under appropriate government standards such as ANSI Z87.1, NIOSH (US) or EN 166(EU).

Skin and Body Protection

Long pants, closed toed-shoes, shirt and apron/lab coat must be worn for protecting against chemical hazards. Use chemical resistant apron/lab coat where appropriate (such as for pouring concentrated acid).

Hygiene Measures

Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

First Aid Procedures

Notify supervisor and EH&S immediately. Follow up with a call to 510-642-9090 to report the incident.

If inhaled

Move person into fresh air. If not breathing, give artificial respiration. Consult a physician immediately.

In case of skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water for 15 minutes. Take victim immediately to hospital. Consult a physician immediately.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes using an emergency eyewash station, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

If swallowed

Do not induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Immediately consult a physician.

Special Handling and Storage Requirements

NOTE: Lab-specific information on handling and storage may be included in the Protocol/Procedure section.

Working alone

Certain extremely hazardous operations should not be performed if the PI or Lab Safety

Contact(s) are not present. Never work alone with extremely hazardous materials/operations. See the

Protocol/Procedure section below for specific prohibitions (if any) on working alone.

Precautions for safe handling:

Cover all exposed skin areas with proper PPE. Avoid contact with the skin and eyes. Work with the chemical in a fume hood to avoid inhalation of vapor or mist.

Conditions for safe storage:

Keep the container tightly closed in a dry and well-ventilated area.

Containers which are opened must be carefully resealed and kept in an upright position to prevent leakage. Since Hydrobromic Acid is a strong acid, please store in secondary containment at all times.

Avoid storing with strong bases and oxidizing agents.

Hydrobromic Acid 3

SOP Template developed by The UC Center for Laboratory Safety

Date: 1/11/2013

Spill and Accident Procedure

Chemical Spill Dial

911

and510-642-9090

Spill

– Assess the extent of danger. Help contaminated or injured persons. Evacuate the spill area.

Avoid breathing vapors. If possible, confine the spill to a small area using a spill kit or absorbent material.

Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.).

Small (<1 L)

– If you have training, you may assist in the clean-up effort. Use appropriate personal protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear plastic bags, label and take to the next chemical waste pick-up.

Large (>1 L)

– Dial

911

and EH&S at 510-642-9090 for assistance.

Chemical Spill on Body or Clothes

– Remove clothing and rinse body thoroughly in emergency shower for at least 15 minutes. Seek medical attention.

Notify supervisor and EH&S immediately at 510-642-

9090.

Chemical Splash Into Eyes

– Immediately rinse eyeball and inner surface of eyelid with water from the emergency eyewash station for 15 minutes by forcibly holding the eye open. Seek medical attention.

Notify supervisor and EH&S immediately at 510-642-9090.

Medical Emergency Dial

911

and 510-642-9090

Life Threatening Emergency, After Hours, Weekends And Holidays

– Dial

911

or go to the nearest emergency room.)

Note: All serious injuries must be reported to EH&S at 510-642-9090 within 8 hours.

Non-Life Threatening Emergency

– Go to the Occupational Health Facility (OHF). After hours go to the nearest emergency room.

Note: All serious injuries must be reported to EH&S at 510-642-9090 within 8 hours.

Needle stick/puncture exposure

(as applicable to chemical handling procedure)

– Wash the affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick nurse \ and then enter your extension. After hours go to the nearest emergency room.

Note: All needle stick/puncture exposures must be reported to EH&S at 510-642-9090 within 8 hours.

Decontamination/Waste Disposal Procedure

NOTE: Lab-specific information on decontamination/waste disposal may be included in the

Protocol/Procedure section.

Wearing proper PPE, please decontaminate equipment and bench tops using soap and water. Please dispose of the spent hydrobromic acid and disposables contaminated with hydrobromic acid as hazardous waste.

Hydrobromic Acid 4

SOP Template developed by The UC Center for Laboratory Safety

Date: 1/11/2013

General hazardous waste disposal guidelines:

Label all containers with the label provided at http://ehs.berkeley.edu/hm/279-newhazardous-waste-program-hwp.html

.

See the EH&

S Fact Sheet, “Hazardous Waste Management” for general instructions on procedures for disposing of hazardous waste.

Dispose of Waste

Dispose of regularly generated chemical waste within 6 months.

Call EH&S for questions.

Safety Data Sheet (SDS) Location

SDS can be accessed online at http://ucmsds.com

Hydrobromic Acid 5

SOP Template developed by The UC Center for Laboratory Safety

Date: 1/11/2013

Preparation

Lab-specific

Information

List any other particular preparation requirements needs for this procedure (e.g., location of spill kit or keep water or ignition sources away from procedure area).

Know the location of the nearest fire extinguisher, eyewash, and safety shower before beginning work.

Hydrobromic acid (HBr) (concentrated HBr = 48% aqueous solution, or 8.89 M) is a strong acid that should be handled carefully, using appropriate PPE.

Add lab-specific information not included above if needed (e.g., all work for this procedure is to take place in the designated fume hood.)

HBr vapors are extremely hazardous, and consequently all work with HBr should be carried out in a properly functioning fume hood.

Procedure/Use Scale

Creating stock solutions of dilute

HBr

When used a reagent in organic reactions, hydrobromic acid

(HBr) can be used in quantities ranging from <1 mL up to 1

L, and across a wide range of temperatures and concentrations.

Calculate the amount of concentrated

HBr to prepare the desired dilute solution of the acid.

Engineering

Controls/Equipment

All work with

concentrated

HBr must be performed in a fume hood while wearing goggles and a face shield.

The face shield will not be needed when working with dilute solutions in a chemical fume hood

.

PPE (eye, face, gloves, clothing)

Eye protection

Face protection

: Face shield when handling concentrated

HBr.

: Chemical goggles, not safety glasses, when handling concentrated

HBr. Safety glasses may be worn with dilute solutions.

Gloves

: Nitrile, neoprene, or latex gloves are recommended when working with concentrated HBr and dilute solutions.

Clothing

: Long pants, closed-toed and closedheeled shoes, cotton-

Procedure Steps and Special

Precautions for this Procedure

Be sure to have a pipette and a container ready for making dilutions.

Determine the volume of solution you need before dispensing acid.

Measure out the required amount of water needed for the solution.

Transfer acid into a temporary beaker to make handling easier.

Using the pipetet

slowly

add the required amount of acid to the water until desired concentration is reached. Always add the acid to the water in any dilution process.

Hydrobromic Acid 6

SOP Template developed by The UC Center for Laboratory Safety

Date: 1/11/2013

based clothing/attire, apron/lab coat of a chemically resistant material.

Notes

Initials of individuals using this procedure

Any deviation from this SOP requires approval from PI.

Hydrobromic Acid 7

SOP Template developed by The UC Center for Laboratory Safety

Date: 1/11/2013

NOTE

Any deviation from this SOP requires approval from PI.

Documentation of Training

(signature of all users is required)

Prior to conducting any work with Hydrobromic Acid .

, designated personnel must provide training to his/her laboratory personnel specific to the hazards involved in working with this substance, work area decontamination, and emergency procedures.

The Principal Investigator must provide his/her laboratory personnel with a copy of this SOP and a copy of the SDS provided by the manufacturer.

The Principal Investigator must ensure that his/her laboratory personnel have attended appropriate laboratory safety training or refresher training within the last one year.

I have read and understand the content of this SOP:

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Hydrobromic Acid 8

SOP Template developed by The UC Center for Laboratory Safety

Date: 1/11/2013

Hydrobromic Acid 9

SOP Template developed by The UC Center for Laboratory Safety

Date: 1/11/2013

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