Supplementary Material for Online Publication
Table S1. Search Strategy for systematic reviews
Databases
searched
Step
Search terms
PubMed
1
"Cardiovascular diseases"[Mesh] OR “Cardiovascular disease*” OR
“CVD”[Title/Abstract]
2
“Coronary disease"[Mesh] OR “Coronary disease*” OR “Coronary heart disease*” OR
“CHD”[Title/Abstract]
3
"Cerebrovascular disorders"[Mesh] OR “Cerebrovascular disorder*[Title/Abstract]”
4
“Myocardial infarction"[Mesh] OR “Myocardial infarction” OR “MI”[Title/Abstract]
5
“Stroke"[Mesh] OR “Stroke”[Title/Abstract]
6
#1 OR #2 OR #3 OR #4 OR #5
7
"Hydroxymethylglutaryl-CoA reductase inhibitors"[Mesh] OR "Anticholesteremic
agents"[Mesh] OR "Hypolipidemic agents"[Mesh]
8
“Statin*”[Title/Abstract]OR “Hydroxymethylglutaryl-CoA reductase
inhibitor*”[Title/Abstract] OR “Hydroxymethylglutaryl-coenzyme A reductase
inhibitor*”[Title/Abstract] OR “HMG-CoA reductase inhibitor*”[Title/Abstract] OR
“Anticholesteremic agent*”[Title/Abstract]) OR “Hypolipidemic agent*”[Title/Abstract]
OR “Antilipemic agent*”[Title/Abstract]
9
"Atorvastatin"[Supplementary Concept]) OR “Atorvastatin” OR “Lipitor”[Title/Abstract]
10
"Fluvastatin"[Supplementary Concept] OR “Fluvastatin” OR “Lescol”[Title/Abstract]
11
"Lovastatin"[Mesh] OR “Lovastatin” OR “Mevacor”[Title/Abstract]
12
"Pravastatin"[Mesh]) OR “Pravastatin” OR “Pravachol”[Title/Abstract]
13
"Rosuvastatin"[Supplementary Concept] OR “Rosuvastatin” OR “Crestor”[Title/Abstract]
14
“Simvastatin”[Mesh] OR “Zocor”[Title/Abstract] OR "Simvastatin"
15
#7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14
16
#6 AND #15
17
#16 AND systematic [sb] AND Filters: Past 5 years; Humans; English
Table S2. Search Strategy for randomized controlled trials
Databases
searched
Step
Search terms
PubMed
1
"Cardiovascular diseases"[Mesh] OR “Cardiovascular disease*” OR
“CVD”[Title/Abstract]
2
“Coronary disease"[Mesh] OR “Coronary disease*” OR “Coronary heart disease*” OR
“CHD”[Title/Abstract]
3
"Cerebrovascular disorders"[Mesh] OR “Cerebrovascular disorder*”[Title/Abstract]
4
“Myocardial infarction"[Mesh] OR “Myocardial infarction” OR “MI”[Title/Abstract]
5
“Stroke"[Mesh] OR “Stroke”[Title/Abstract]
6
#1 OR #2 OR #3 OR #4 OR #5
7
"Hydroxymethylglutaryl-CoA reductase inhibitors"[Mesh] OR "Anticholesteremic
agents"[Mesh] OR "Hypolipidemic agents"[Mesh]
8
“Statin*”[Title/Abstract]OR “Hydroxymethylglutaryl-CoA reductase
inhibitor*”[Title/Abstract] OR “Hydroxymethylglutaryl-coenzyme A reductase
inhibitor*”[Title/Abstract] OR “HMG-CoA reductase inhibitor*”[Title/Abstract] OR
“Anticholesteremic agent*”[Title/Abstract]) OR “Hypolipidemic agent*”[Title/Abstract]
OR “Antilipemic agent*”[Title/Abstract]
9
"Atorvastatin"[Supplementary Concept]) OR “Atorvastatin” OR “Lipitor”[Title/Abstract]
10
"Fluvastatin"[Supplementary Concept] OR “Fluvastatin” OR “Lescol”[Title/Abstract]
11
"Lovastatin"[Mesh] OR “Lovastatin” OR “Mevacor”[Title/Abstract]
12
"Pravastatin"[Mesh]) OR “Pravastatin” OR “Pravachol”[Title/Abstract]
13
"Rosuvastatin"[Supplementary Concept] OR “Rosuvastatin” OR “Crestor”[Title/Abstract]
14
“Simvastatin”[Mesh] OR "Simvastatin" OR “Zocor”[Title/Abstract]
15
#7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14
16
#6 AND #15
17
Randomized controlled trial[Publication Type]
18
Controlled clinical trial[Publication Type]
19
Randomized[Title/Abstract]
20
Randomly[Title/Abstract]
21
Clinical Trials as Topic[Mesh:noexp]
22
Trial[Title]
23
#17 OR #18 Or #19 OR #20 OR #21 OR #22
24
#16 AND #23
25
"Animals"[Mesh] NOT "Humans"[Mesh]
26
#24 NOT #25
27
#26 Filters: Publication date from 2012/01/01 to 2014/03/27; English