Dra. Isabel Quijada Garrido
Científica Titular
Departamento de Química Física de Polímeros
Instituto de Ciencia y Tecnología de Polímeros
C/Juan de la Cierva 3, Madrid 28006, España
Tel.: +34-91-5622900 ext 254
Fax: +34-91-5644853
E-mail:iquijada@ictp.csic.es
Isabel Quijada es Científica Titular (2007) en el Instituto de Ciencia y Tecnología de
Polímeros (ICTP) del Consejo Superior de Investigaciones (CSIC) en Madrid. Desde
enero de 2011 es Vicedirectora Científica del ICTP. Obtuvo el grado de doctor (1996)
en la Universidad Complutense de Madrid por su trabajo realizado en el ICTP sobre la
difusión de aditivos en polipropileno y nylon 12 y el estudio de sus mezclas. Después de
su Tesis doctoral, realizó una estancia postdoctoral en el Instituto Max Planck para la
Investigación de Polímeros de Mainz (Alemania) bajo la supervisión del Dr. Hans W.
Spiess y el Dr. Manfred Wilhelm. Posteriormente estuvo dos años (1997-1999) en el
Instituto de Química Macromolecular de Friburgo (Alemania) trabajando en el grupo de
la Dra. Claudia Schmidt. Durante su período postdoctoral en Friburgo, estuvo dedicada
al estudio del comportamiento reológico de cristales líquidos poliméricos de cadena
lateral termotrópicos y disoluciones de surfactantes liotrópicos. Desde el 2007 forma
parte de la plantilla del CSIC como Científica Titular.
Su grupo de investigación trabaja en el desarrollo de sistemas sensibles a estímulos
como la temperatura, pH y luz, así como en el desarrollo de sistemas inteligentes con
biodegradabilidad. Explotando técnicas avanzadas como la MRI (imagen por resonancia
magnética) han investigado la cinética de hinchamiento y el estudio de la difusión de
fármacos y sustancias activas en función de estímulos. Sustratos biocompatibles
basados en polihidroxialcanoatos se han modificado para el crecimiento celular y la
regeneración de diversos tejidos (urotelial, óseo, tejido nervioso). También se han
desarrollado metodologías para la modificación superficial de diferentes materiales con
polímeros sensibles a estímulos para controlar la adhesión de películas celulares en
función de la temperatura y en terapias de mínima invasión. Actualmente, están
trabajando en la integración de los polímeros sensibles al pH y temperaturas con
materiales micro y nano-estructurados.
Listado de Publicaciones:[1-51]
[1] J.M. García-García, I. Quijada-Garrido, L. López, R. París, M.T. Núñez-López, E. De La Peña
Zarzuelo, L. Garrido, The surface modification of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)
copolymers to improve the attachment of urothelial cells, Materials Science and Engineering C, 33 (2013)
362-369.
[2] I. Mora-Barrantes, J.L. Valentín, A. Rodríguez, I. Quijada-Garrido, R. Paris, Poly(styrene)/silica
hybrid nanoparticles prepared via ATRP as high-quality fillers in elastomeric composites, Journal of
Materials Chemistry, 22 (2012) 1403-1410.
[3] J.M. García-García, L. López, R. París, M.T. Núñez-López, I. Quijada-Garrido, E. De La Peña
Zarzuelo, L. Garrido, Surface modification of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer
films for promoting interaction with bladder urothelial cells, Journal of Biomedical Materials Research Part A, 100 A (2012) 7-17.
[4] J.M. García-García, L. Garrido, I. Quijada-Garrido, J. Kaschta, D.W. Schubert, A.R. Boccaccini,
Novel poly(hydroxyalkanoates)-based composites containing Bioglass® and calcium sulfate for bone
tissue engineering, Biomedical Materials (Bristol), 7 (2012).
[5] C. García-Aparicio, I. Quijada-Garrido, L. Garrido, Diffusion of small molecules in a chitosan/water
gel determined by proton localized NMR spectroscopy, Journal of Colloid and Interface Science, 368
(2012) 14-20.
[6] R. París, I. Quijada-Garrido, O. García, M. Liras, BODIPY-conjugated thermo-sensitive fluorescent
polymers based on 2-(2-methoxyethoxy)ethyl methacrylate, Macromolecules, 44 (2011) 80-86.
[7] R. París, I. Quijada-Garrido, Synthesis and aggregation properties in water solution of comblike
methacrylic polymers with oligo(propylene glycol)-block-oligo(ethylene glycol) as side chains, Journal of
Polymer Science, Part A: Polymer Chemistry, 49 (2011) 1928-1932.
[8] R. París, M. Liras, I. Quijada-Garrido, Thermoresponsive behavior of mixtures of epoxy
functionalized oligo(ethylene glycol) methacrylate copolymers, Macromolecular Chemistry and Physics,
212 (2011) 1859-1868.
[9] R. París, J. García, I. Quijada-Garrido, Thermo- and pH-sensitive hydrogels based on 2-(2methoxyethoxy)ethyl methacrylate and methacrylic acid, Polymer International, 60 (2011) 178-185.
[10] S. Medel, J. Manuel García, L. Garrido, I. Quijada-Garrido, R. París, Thermo- and pH-responsive
gradient and block copolymers based on 2-(2-methoxyethoxy)ethyl methacrylate synthesized via atom
transfer radical polymerization and the formation of thermoresponsive surfaces, Journal of Polymer
Science, Part A: Polymer Chemistry, 49 (2011) 690-700.
[11] M. Liras, J.M. García-García, I. Quijada-Garrido, A. Gallardo, R. París, Thermo-responsive allylfunctionalized 2-(2-methoxyethoxy)ethyl methacrylate-based polymers as versatile precursors for smart
polymer conjugates and conetworks, Macromolecules, 44 (2011) 3739-3745.
[12] M. Liras, O. García, I. Quijada-Garrido, R. París, Transformation of the bromine end group into thiol
in (Meth)acrylic polymers synthesized by atom transfer radical polymerization, Macromolecules, 44
(2011) 1335-1339.
[13] J.M. García-García, M. Liras, I. Quijada-Garrido, A. Gallardo, R. París, Swelling control in thermoresponsive hydrogels based on 2-(2-methoxyethoxy)ethyl methacrylate by crosslinking and
copolymerization with N-isopropylacrylamide, Polymer Journal, 43 (2011) 887-892.
[14] J.M.B. De Ojeda, I. Quijada-Garrido, J.M. Barrales-Rienda, Synthesis, characterization and
properties of N-maleimide side-chain liquid crystalline copolymers, Journal of Polymer Science, Part A:
Polymer Chemistry, 49 (2011) 495-510.
[15] M.M. Bernal, M. Liras, R. Verdejo, M.A. López-Manchado, I. Quijada-Garrido, R. París,
Modification of carbon nanotubes with well-controlled fluorescent styrene-based polymers using the
Diels-Alder reaction, Polymer, 52 (2011) 5739-5745.
[16] R. París, I. Quijada-Garrido, Temperature- and pH-responsive behaviour of poly(2-(2methoxyethoxy)ethyl methacrylate-co-N,N-dimethylaminoethyl methacrylate) hydrogels, European
Polymer Journal, 46 (2010) 2156-2163.
[17] R. París, J.M. García, I. Quijada-Garrido, Synthesis and characterization of a new acrylic polymeric
ibuprofen prodrug, Journal of Applied Polymer Science, 117 (2010) 3271-3276.
[18] G. Frutos, A. Prior-Cabanillas, R. París, I. Quijada-Garrido, A novel controlled drug delivery system
based on pH-responsive hydrogels included in soft gelatin capsules, Acta Biomaterialia, 6 (2010) 46504656.
[19] I. Quijada-Garrido, A. Prior-Cabanillas, R. Paris, G. Frutos, J.M. Barrales-Rienda, Water transport
properties of pH-responsive hydrogels based on poly(methacrylic acid) with polyether side chains by
magnetic resonance imaging, Macromolecular Chemistry and Physics, 210 (2009) 520-530.
[20] R. París, I. Quijada-Garrido, Swelling and hydrolytic degradation behaviour of pH-responsive
hydrogels of poly[(N-isopropylacrylamide)-co-(methacrylicacid)] crosslinked by biodegradable
polycaprolactone chains, Polymer International, 58 (2009) 362-367.
[21] R. París, I. Quijada-Garrido, Swelling behaviour of thermo-sensitive hydrogels based on
oligo(ethylene glycol) methacrylates, European Polymer Journal, 45 (2009) 3418-3425.
[22] R. París, J.M. Barrales-Rienda, I. Quijada-Garrido, Dynamic swelling of hydrogels based on random
terpolymers of N-isopropylacrylamide, methacrylic acid and poly(ethylene glycol) macromonomer,
Polymer, 50 (2009) 2065-2074.
[23] H. Siebert, I. Quijada-Garrido, J. Vermant, L. Noirez, W.R. Burghardt, C. Schmidt, Director
orientation of nematic side-chain liquid crystalline polymers under shear flow: Comparison of a flowaligning and a non-flow-aligning polysiloxane, Macromolecular Chemistry and Physics, 208 (2007)
2161-2172.
[24] I. Quijada-Garrido, V. Iglesias-González, J.M. Mazón-Arechederra, J.M. Barrales-Rienda, The role
played by the interactions of small molecules with chitosan and their transition temperatures. Glassforming liquids: 1,2,3-Propantriol (glycerol), Carbohydrate Polymers, 68 (2007) 173-186.
[25] A. Prior-Cabanillas, J.M. Barrales-Rienda, G. Frutos, I. Quijada-Garrido, Swelling behaviour of
hydrogels from methacrylic acid and poly(ethylene glycol) side chains by magnetic resonance imaging,
Polymer International, 56 (2007) 506-511.
[26] I. Quijada-Garrido, B. Laterza, J.M. Mazón-Arechederra, J.M. Barrales-Rienda, Characteristic
features of chitosan/glycerol blends dynamics, Macromolecular Chemistry and Physics, 207 (2006) 17421751.
[27] R.G. Sousa, A. Prior-Cabanillas, I. Quijada-Garrido, J.M. Barrales-Rienda, Dependence of
copolymer composition, swelling history, and drug concentration on the loading of diltiazem
hydrochloride (DIL.HCl) into poly[(N-isopropylacrylamide)-co-(methacrylic acid)] hydrogels and its
release behaviour from hydrogel slabs, Journal of Controlled Release, 102 (2005) 595-606.
[28] I. Quijada-Garrido, A. Prior-Cabanillas, L. Garrido, J.M. Barrales-Rienda, Swelling monitorization
of poly[(N-isopropylacrylamide)-co-(methacrylic acid)] copolymers by magnetic resonance imaging,
Macromolecules, 38 (2005) 7434-7442.
[29] A. Prior-Cabanillas, I. Quijada-Garrido, G. Frutos, J.M. Barrales-Rienda, Influence of the swelling
history on the swelling kinetics of stimuli-responsive poly[(N-isopropylacrylamide)-co-(methacrylic
acid)] hydrogels, Polymer, 46 (2005) 685-693.
[30] E. Díez-Peña, I. Quijada-Garrido, J.M. Barrales-Rienda, I. Schnell, H.W. Spiess, Advanced 1H solidstate NMR spectroscopy on hydrogels, 1: The effect of hydrogen bonding in the collapse of
poly(methacrylic acid) (PMAA) hydrogels, Macromolecular Chemistry and Physics, 205 (2004) 430-437.
[31] E. Díez-Peña, I. Quijada-Garrido, J.M. Barrales-Rienda, I. Schnell, H.W. Spiess, Advanced 1H solidstate NMR spectroscopy on hydrogels, 2 a: The formation of hydrogen bonds in hydrogels based on Nisopropylacrylamide (NiPAAm) and methacrylic acid (MAA), Macromolecular Chemistry and Physics,
205 (2004) 438-447.
[32] E. Díez-Peña, P. Frutos, G. Frutos, I. Quijada-Garrido, J.M. Barrales-Rienda, The influence of the
copolymer composition on the diltiazem hydrochloride release from a series of pH-sensitive poly[(Nisopropylacrylamide)-co-(methacrylic acid)] hydrogels, AAPS PharmSciTech [electronic resource]. 5
(2004).
[33] E. Díez-Peña, P. Frutos, G. Frutos, I. Quijada-Garrido, J.M. Barrales-Rienda, The influence of the
copolymer composition on the diltiazem hydrochloride release from a series of pH-sensitive poly[(Nisopropycrylamide)-co-(meth-acrylic acid) hydrogels, AAPS PharmSciTech, 5 (2004).
[34] E. Díez-Pena, I. Quijada-Garrido, P. Frutos, J.M. Barrales-Rienda, Analysis of the swelling
dynamics of crosslinked P(N-iPAAm-co-MAA) copolymers, the corresponding homopolymers and their
interpenetrating networks. Kinetics of water penetration into the gel above the pKa of MAA
comonomeric units, Polymer International, 52 (2003) 956-965.
[35] E. Díez-Peńa, I. Quijada-Garrido, J.M. Barrales-Rienda, Analysis of the swelling dynamics of crosslinked P(N-iPAAm-co-MAA) copolymers and their homopolymers under acidic medium. A kinetics
interpretation of the overshooting effect, Macromolecules, 36 (2003) 2475-2483.
[36] H. Siebert, P. Becker, I. Quijada-Garrido, D.A. Grabowski, C. Schmidt, In situ deuteron NMR
investigations of sheared liquid crystalline polymers, Solid State Nuclear Magnetic Resonance, 22 (2002)
311-326.
[37] E. Díez-Peña, I. Quijada-Garrido, P. Frutos, J.M. Barrales-Rienda, Thermal properties of crosslinked poly(N-isopropylacrylamide) [P(N-iPAAm)], poly(methacrylic acid) [P(MAA)], their random
copolymers [P(N-iPAAm-co-MAA)], and sequential interpenetrating polymer networks (IPNs),
Macromolecules, 35 (2002) 2667-2675.
[38] E. Díez-Peña, I. Quijada-Garrido, J.M. Barrales-Rienda, M. Wilhelm, H.W. Spiess, NMR studies of
the structure and dynamics of polymer gels based on N-isopropylacrylamide (NiPAAm) and methacrylic
acid (MAA), Macromolecular Chemistry and Physics, 203 (2002) 491-502.
[39] E. Díez-Peña, I. Quijada-Garrido, J.M. Barrales-Rienda, On the water swelling behaviour of poly(Nisopropylacrylamide) [P(N-iPAAam)], poly(methacrylic acid) [P(MAA)], their random copolymers and
sequential interpenetrating polymer networks (IPNs), Polymer, 43 (2002) 4341-4348.
[40] E. Díez-Peña, I. Quijada-Garrido, J.M. Barrales-Rienda, Hydrogen-bonding effects on the dynamic
swelling of P(N-iPAAm-co-MAA) copolymers. A case of autocatalytic swelling kinetics,
Macromolecules, 35 (2002) 8882-8888.
[41] E. Díez-Peña, I. Quijada-Garrido, J.M. Barrales-Rienda, Hydrogels based on N-isopropylacrylamide
and methacrylic acid: Thermal stability and glass transition behaviour, Polymer Bulletin, 48 (2002) 8391.
[42] S.E. Cramer, I. Quijada-Garrido, R. Ulrich, J.M. Barrales-Rienda, H.W. Spiess, Dynamic mechanical
and dielectric properties of ORMOCER® incorporating functionalized poly(styrene) latexes, Journal of
Polymer Science, Part B: Polymer Physics, 39 (2001) 860-867.
[43] I. Quijada-Garrido, H. Siebert, C. Friedrich, C. Schmidt, Flow behavior of two side-chain liquid
crystal polymers studied by transient rheology, Macromolecules, 33 (2000) 3844-3854.
[44] I. Quijada-Garrido, M. Fernández De Velasco-Ruiz, J.M. Barrales-Rienda, Fickian diffusion of
erucamide (13-cis-docosenamide) in poly(laurolactam) (Nylon 12) (PA-12), Macromolecular Chemistry
and Physics, 201 (2000) 375-381.
[45] M. Fernández De Velasco-Ruiz, I. Quijada-Garrido, R. Benavente, J.M. Barrales-Rienda, Miscibility
studies of erucamide (13-cis-docosenamide)/poly(laurolactam) (nylon 12) (PA-12) blends, Polymer, 41
(2000) 5819-5828.
[46] I. Quijada-Garrido, H. Siebert, P. Becker, C. Friedrich, C. Schmidt, Transient rheological behavior of
tumbling side-chain liquid crystal polymers and determination of their λ parameters, Rheologica Acta, 38
(1999) 495-502.
[47] I. Quijada-Garrido, M. Wilhelm, H.W. Spiess, J.M. Barrales-Rienda, Solid-state NMR studies of
structure and dynamics of erucamide/ isotactic poly(propylene) blends, Macromolecular Chemistry and
Physics, 199 (1998) 985-995.
[48] I. Quijada-Garrido, J.M. Barrales-Rienda, J.M. Pereña, G. Frutos, Dynamic mechanical and
dielectric behavior of erucamide (13-Cis-Docosenamide), isotactic poly(propylene), and their blends,
Journal of Polymer Science, Part B: Polymer Physics, 35 (1997) 1473-1482.
[49] I. Quijada-Garrido, J.M. Barrales-Rienda, J.M. Pereña, G. Frutos, Solubility of erucamide (13-cisdocosenamide) in isotactic poly(propylene) and thermal behaviour of their blends, Polymer, 38 (1997)
5125-5135.
[50] I. Quijada-Garrido, J.M. Barrales-Rienda, G. Frutos, Diffusion of erucamide (13-cis-docosenamide)
in isotactic polypropylene, Macromolecules, 29 (1996) 7164-7176.
[51] I. Quijada-Garrido, Desorption of erucamide vapor in vacuum from erucamide/isotactic
polypropylene films, Macromolecules, 29 (1996) 8791-8797.