Yong /CV
CURRICULUM VITAE
NAME:
Eu Leong YONG
LIST OF PUBLICATIONS:
Peer Review Journals-International
2013
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Lim VW, Li J, Gong Y, Jin A, Yuan JM, Yong EL, Koh WP. Serum estrogen receptor
bioactivity and breast cancer risk among postmenopausal women. Endocr Relat Cancer.
2013 Dec 9. doi: 10.1530/ERC-13-0233
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Indran IR, Zhang SJ, Zhang ZW, Sun F, Gong Y, Wang X, Li J, Erdelmeier CA, Koch E, Yong
EL. Selective Estrogen Receptor Modulator Effects of Epimedium Extracts on Breast Cancer
and Uterine Growth in Nude Mice. Planta Med. 2013 Dec 5. DOI http://dx.doi.org/10.1055/s0033-1360112.
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Chelvi SK, Zhao J, Chen L, Yan S, Yin X, Sun J, Yong EL, Wei Q, Gong Y. Preparation and
characterization
of
4-isopropylcalix[4]arene-capped
(3-(2-O-β-cyclodextrin)-2hydroxypropoxy)-propylsilyl-appended silica particles as chiral stationary phase for highperformance liquid chromatography. J Chromatogr A. 2013 Nov 16. pii: S00219673(13)01796-2. doi: 10.1016/j.chroma.2013.11.025.
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Tan MH, Zhou XE, Soon FF, Li X, Li J, Yong EL, Melcher K, Xu HE. The crystal structure of
the orphan nuclear receptor NR2E3/PNR ligand binding domain reveals a dimeric autorepressed
conformation.
PLoS
One.
2013
Sep
12;8(9):e74359.
doi:
10.1371/journal.pone.0074359.
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Soh SF, Huang CK, Lee SO, Xu D, Yeh S, Li J, Yong EL, Gong Y, Chang C. Determination of
androgen receptor degradation enhancer ASC-J9(®) in mouse sera and organs with liquid
chromatography tandem mass spectrometry. J Pharm Biomed Anal. 2014 Jan;88:117-22.
doi: 10.1016/j.jpba.2013.08.020.
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Huang Z, Yong EL. Application of science to medicine--the clinician-scientist. Ann Acad Med
Singapore. 2013 Jul;42(7):313-4.
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Chen C, Ke J, Zhou XE, Yi W, Brunzelle JS, Li J, Yong EL, Xu HE, Melcher K. Structural
basis for molecular recognition of folic acid by folate receptors. Nature. 2013 Aug
22;500(7463):486-9. doi: 10.1038/nature12327.
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2012
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Soon FF, Suino-Powell KM, Li J, Yong EL, Xu HE, Melcher K. Abscisic acid signaling:
thermal stability shift assays as tool to analyze hormone perception and signal transduction.
PLoS One. 2012;7(10):e47857. doi: 10.1371/journal.pone.0047857.
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Chaudhuri K, Chang QC, Tan EK, Yong EL. Listeriosis in pregnancy with placental abruption.
J Obstet Gynaecol. 2012 Aug;32(6):594. doi: 10.3109/01443615.2012.690787.
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Mok ZW, Yong EL, Low JJ, Ng JS. Clinical outcomes in endometrial cancer care when the
standard of care shifts from open surgery to robotics. Int J Gynecol Cancer. 2012
Jun;22(5):819-25. doi: 10.1097/IGC.0b013e31824c5cd2.
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Zhou XE, Soon FF, Ng LM, Kovach A, Suino-Powell KM, Li J, Yong EL, Zhu JK, Xu HE,
Melcher K. Catalytic mechanism and kinase interactions of ABA-signaling PP2C
phosphatases. Plant Signal Behav. 2012 May;7(5):581-8. doi: 10.4161/psb.19694.
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Lim VW, Li J, Gong Y, Yuan JM, Wu TS, Hammond GL, Jin A, Koh WP, Yong EL. Serum free
estradiol and estrogen receptor-α mediated activity are related to decreased incident hip
fractures in older women. Bone. 2012 Jun;50(6):1311-6. doi: 10.1016/j.bone.2012.03.006.
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Tiong CT, Chen C, Zhang SJ, Li J, Soshilov A, Denison MS, Lee LS, Tam VH, Wong SP, Xu
HE, Yong EL. A novel prenylflavone restricts breast cancer cell growth through AhRmediated destabilization of ERα protein. Carcinogenesis. 2012 May;33(5):1089-97. doi:
10.1093/carcin/bgs110.
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Lim L, Wong H, Yong E, Singh K. Profiles of women presenting for abortions in Singapore:
focus on teenage abortions and late abortions. Eur J Obstet Gynecol Reprod Biol. 2012
Feb;160(2):219-22.
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Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases.
Soon FF, Ng LM, Zhou XE, West GM, Kovach A, Tan MH, Suino-Powell KM, He Y, Xu Y,
Chalmers MJ, Brunzelle JS, Zhang H, Yang H, Jiang H, Li J, Yong EL, Cutler S, Zhu JK,
Griffin PR, Melcher K, Xu HE. Science. 2012 Jan 6;335(6064):85-8.
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Malapaka RR, Khoo S, Zhang J, Choi JH, Zhou XE, Xu Y, Gong Y, Li J, Yong EL, Chalmers
MJ, Chang L, Resau JH, Griffin PR, Chen YE, Xu HE. Identification and Mechanism of 10Carbon Fatty Acid as Modulating Ligand of Peroxisome Proliferator-activated Receptors. J
Biol Chem. 2012 Jan 2;287(1):183-95.
2011
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Ng LM, Soon FF, Zhou XE, West GM, Kovach A, Suino-Powell KM, Chalmers MJ, Li J, Yong
EL, Zhu JK, Griffin PR, Melcher K, Xu HE. Structural basis for basal activity and
autoactivation of abscisic acid (ABA) signaling SnRK2 kinases. Proc Natl Acad Sci U S A.
2011 Dec 27;108(52):21259-64.
Wang L, Soon GH, Seng KY, Li J, Lee E, Yong EL, Goh BC, Flexner C, Lee L.
Pharmacokinetic Modeling of Plasma and Intracellular Concentrations of Raltegravir in
Healthy Volunteers. Antimicrob Agents Chemother. 2011 Jul 11. [Epub ahead of print]
Tan SK, Lin ZH, Chang CW, Varang V, Chng KR, Pan YF, Yong EL, Sung WK, Cheung E.
AP-2γ regulates oestrogen receptor-mediated long-range chromatin interaction and gene
transcription. EMBO J. 2011;30:2569-81.
Ng JS, Fong YF, Tong PS, Yong EL, Low JJ. Gynaecologic Robot-Assisted Cancer and
Endoscopic Surgery (GRACES) in a Tertiary Referral Centre. Ann Acad Med Singapore.
2011;40:208-5.
Tan HM, Soh SF, Zhao J, Yong EL, Gong Y. Preparation and application of
methylcalix[4]resorcinarene-bonded silica particles as chiral stationary phase in highperformance liquid chromatography. Chirality. 2011;23 Suppl 1:E91-7. doi:
10.1002/chir.20983.
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2010
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Zhao J, Tan D, Chelvi SK, Yong EL, Lee HK, Gong Y. Preparation and application of
rifamycin-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica
particles as chiral stationary phase for high-performance liquid chromatography. Talanta.
2010;83:286-90.
Melcher K, Xu Y, Ng LM, Zhou XE, Soon FF, Chinnusamy V, Suino-Powell KM, Kovach A,
Tham FS, Cutler SR, Li J, Yong EL, Zhu JK, Xu HE. Identification and mechanism of ABA
receptor antagonism. Nat Struct Mol Biol. 2010;17:1102-8.
Tong P, Yeoh CJ, Yong EL. Abdominal mass and a forgotten haemorrhagic fever. Lancet.
2010;376:140.
Tong TY, Yong RY, Goh VH, Liang S, Chong AP, Mok HP, Yong EL, Yap EP, Moochhala S.
Association between an intronic apolipoprotein E polymorphism and bone mineral density in
Singaporean Chinese females. Bone. 2010;47:503-10.
Lee LS, Soon GH, Shen P, Yong EL, Flexner C, Pham P. Darunavir/ritonavir and efavirenz
exert differential effects on MRP1 transporter expression and function in healthy
volunteers.Antivir Ther. 2010;15:275-9.
Soon GH, Shen P, Yong EL, Pham P, Flexner C, Lee L. Pharmacokinetics of Darunavir
900mg and Ritonavir 100mg Once Daily when Co-administered with Efavirenz 600mg Once
Daily in Healthy Volunteers. Antimicrob Agents Chemother. 2010 Apr 12.
Thamarai Chelvi SK, Yong EL, Gong Y. Application of bromoacetate-substituted beta-CDbonded silica particles as chiral stationary phase for HPLC. J Sep Sci. 2010 ;33(1):74-8.
Zhou XE, Suino-Powell KM, Li J, He Y, Mackeigan JP, Melcher K, Yong EL, Xu HE.
Identification of SRC3/AIB1 as a preferred coactivator for hormone-activated androgen
receptor. J Biol Chem. 2010 Mar 19;285(12):9161-71.
2009
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Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM, Park SY, Weiner JJ, Fujii H,
Chinnusamy V, Kovach VA, Li J, Wang Y, Li J , Peterson FC, Davin R. Jensen DR, Yong EL,
Volkman BF, Cutler SR, JZhu JK, H. Eric Xu HE. A Gate-Latch-Lock Mechanism for Signal
Transduction by Abscisic Acid Receptors. Nature 2009;462;602-610
Pregnancy and H1N1 infection. Su LL, Chan J, Chong YS, Choolani M, Biswas A, Yong EL.
Lancet. 2009;374:1417
Wong SP, Shen P, Lee L, Li J, Yong EL. Pharmacokinetics of prenylflavonoids and
correlations with the dynamics of estrogen action in sera following ingestion of a standardized
Epimedium extract. J Pharm Biomed Anal. 2009 Sep 8;50(2):216-23.
Li J, Lee L, Gong Y, Shen P, Wong SP, Wise SD, Yong EL. Bioassays for Estrogenic Activity:
Development and Validation of Estrogen Receptor (ERalpha/ERbeta) and Breast Cancer
Proliferation Bioassays to Measure Serum Estrogenic Activity in Clinical Studies. Assay Drug
Dev Technol. 2009 ;7(1):80-9.
Huang A, Tai BC, Wong LY, Lee J, Yong EL. Differential risk for early breastfeeding jaundice
in a multi-ethnic Asian cohort. Ann Acad Med Singapore. 2009;38(3):217-24.
Hong X, Wang X, Yong EL, Gong Y. Determination of breviflavone A and B in Epimedium
herbs with liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal.
2009;49(3):853-7.
Shen P, Wong SP, Li J, Yong EL. Simple and sensitive liquid chromatography-tandem mass
spectrometry assay for simultaneous measurement of five Epimedium prenylflavonoids in rat
sera. J Chromatogr B Analyt Technol Biomed Life Sci. 2009;877(1-2):71-8.
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2008
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Liu MH, Li J, Shen P, Husna B, Tai ES, Yong EL. A Natural Polymorphism in Peroxisome
Proliferator-Activated Receptor-α Hinge Region Attenuates Transcription due to Defective
Release of Nuclear Receptor Corepressor from Chromatin. Molecular Endocrinology
2008;22:1078-92.
E.L. Yong, J. Li, M.H. Liu. Single gene contributions: genetic variants of peroxisome
proliferator-activated receptor (isoforms alpha, beta/delta and gamma) and mechanisms of
dyslipidemias. Current Opinion in Lipidology 2008;19:106–112
Thamarai Chelvi SK, Yong EL, Gong Y. Preparation and evaluation of calix[4]arene-capped
beta-cyclodextrin-bonded silica particles as chiral stationary phase for high-performance
liquid chromatography. Journal Chromatography A. 2008;1203:54-8..
2007
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Shen P, Guo BL, Gong Y Hong Y, Yong EL. Taxonomic, genetic, chemical and estrogenic
characteristics of Epimedium species. Phytochemistry. 2007;68:1448-58.
Wong SP, Li J, Shen P, Gong Y, Yap SP, Yong EL. Ultrasensitive cell-based bioassay for the
measurement of global estrogenic activity of flavonoid mixtures revealing additive, restrictive,
and enhanced actions in binary and higher order combinations. Assay Drug Development
Technologies 2007 Jun;5(3):355-62.
Yap SP, Shen P, Li J, Lee LS, Yong EL. Molecular and pharmacodynamic properties of
estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. Journal of
Ethnopharmacology 2007 Sep 5;113(2):218-24.
Shen P, Wong SP, Yong EL. Sensitive and rapid method to quantify icaritin and
desmethylicaritin in human serum using gas chromatography-mass spectrometry. Journal of
Chromatography B: Analytical Technology Biomedical Life Science. 2007 Sep 15;857(1):4752.
Yong EL, Wong SP, Shen P, Gong YH, Li J, Hong Y. Standardization and evaluation of
botanical mixtures: lessons from a traditional Chinese herb, Epimedium, with oestrogenic
properties. Novartis Foundation Symposium. 2007;282:173-88.
Gong Y, Yip SC, Thamarai SK, Zhang J, Lee HK, Yong EL. Trace analysis of icariin in human
serum with dansyl chloride derivatization after oral administration of Epimedium decoction by
liquid chromatography tandem mass spectrometry. Journal of Chromatography B: Analytical
Technology Biomedical Life Science. 2007;860:166-72.
2006
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Lim LS, Shen P, Gong YH, Lee LS, Yong EL. Dynamics of progestogenic activity in serum
following administration of Ligusticum chuanxiong. Life Science. 2006 22;79(13):1274-80
Lim LS, Shen P, Gong YH, Yong EL. Dimeric progestins from rhizomes of Ligusticum
chuanxiong. Phytochemistry. 2006;67:728-34.
Shen P, Liu MH, Ng TY, Chan YH, Yong EL. Differential effects of isoflavones, from
Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARalpha,
PPARgamma, and adipocyte differentiation in vitro. Journal of Nutrition. 2006;136:899-905.
.
2005
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Yap SP, Shen P, Butler MS, Gong Y, Loy CJ, Yong EL. New Estrogenic Prenylflavone from
Epimedium brevicornum Inhibits the Growth of Breast Cancer Cells. Planta Medica
(Germany). 2005;71:114-9.
Singh K, Yong EL, Wong PC. The teaching of obstetrics and gynaecology in Singapore from
1905 to the present. Annals Academy of Medicine, Singapore. 2005; 34:121C-125C.
Loy CJ, Evelyn S, Lim FK, Liu MH, Yong EL. Growth dynamics of human leiomyoma cells
and inhibitory effects of the peroxisome proliferator-activated receptor-{gamma} ligand,
pioglitazone. Molecular Human Reproduction 2005;11:561-6.
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2004
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S Bayen, YH Gong, HS Chin, HK Lee, EL Yong, Obbard JP. Androgenic and estrogenic
response of green mussel extracts from Singapore’s coastal environment using a human cellbased bioassay. Environmental Health Perspectives (USA) 2004;112:1467-71.
Tang SY, Whiteman M, Zhao FP, Jenner A, Yong EL, Halliwell B. Characterization of
antioxidant and antiglycation properties and isolation of active ingredients from Traditional
Chinese Medicines. Free Radical Biology & Medicine (USA) 2004; 36:1575-87.
2003
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Gong Y, Chin HS, Lim LS, Loy CJ, Obbard JP, Yong EL. Clustering of Sex Hormone
Disruptors in Singapore's Marine Environment. Environmental Health Perspectives (USA)
2003;111:1448-53.
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Loy CJ, Sim KS, Yong EL. Filamin-A localizes to the nucleus to regulate androgen receptor
and coactivator functions. Proceedings of the National Academy of Sciences (USA).
2003:100: 4562-4567.
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Casella R, Maduro MR, Misfud A, Lipshultz LI, Yong EL, Lamb DJ. Androgen Receptor Gene
Polyglutamine Length is Associated With Testicular Histology in Infertile Patients. Journal of
Urology (USA). 2003;169:224-227.
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Yong EL, Loy CJ, Sim KS. Androgen
Human Reproduction Update (UK). 2003;9:1-7.
receptor
gene
and
male
infertility.
2002
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Ong YC, Kolatkar PR, Yong EL. Androgen receptor mutations causing human androgen
insensitivity syndromes show a key role of residue M807 in Helix 8/Helix 10 interactions and
in receptor ligand-binding domain stability. Molecular Human Reproduction (UK). 2002;
8:101-108.
2001
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Liow SL, Yong EL, Ng SC. Prognostic value of Y deletion analysis: How reliable is the
outcome of Y deletion analysis in providing a sound prognosis? Human Reproduction (USA)
2001;16:9-12
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Wang Q, Lu JH Yong EL. Ligand- and coactivator-mediated transactivation function (AF2) of
the androgen receptor ligand-binding domain is inhibited by the cognate hinge region. Journal
of Biological Chemistry (USA) 2001; 276: 7493-7499.
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Mifsud A, Sim CKS, Boettger-Tong H, Moreira S, Lamb DJ, Lipshultz LI, Yong EL.
Trinucleotide (CAG) repeat polymorphisms in the androgen-receptor gene: Molecular markers
of male infertility risk. Fertility Sterility (USA) 2001; 75:275-281
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C.J. Loy, E. L. Yong. Sex, infertility and the molecular biology of the androgen receptor.
Current Opinion in Obstetrics & Gynecology (UK), 2001;13:315-321
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Mifsud A, TC Aw, Dong F. Yong EL Prostate-specific antigen, testosterone, sex-hormone
binding globulin and androgen receptor CAG repeat polymorphisms in subfertile and normal
men.. Molecular Human Reproduction (UK) 2001, 7:1007-13.
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2000
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Yong EL, Lim J, Wang Q, Ong V, Mifsud A. Molecular basis of androgen receptor diseases.
Annals of Medicine (Finland). 2000; 32: 15-22.
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Mifsud A, Ramirez S, Yong EL. Androgen receptor gene CAG trinucleotide repeats in
anovulatory infertility amd polycystic ovaries. J Clinical Endocrinology & Metabolism (USA).
2000: 85:3484-8.
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Ong YC, Yong EL. Panax (Ginseng): Panacea or Placebo? Panax (ginseng) - Panacea or
Placebo? Molecular and cellular basis of its pharmacological activity. Annals Academy of
Medicine, Singapore 2000; 29:42-6 .
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Yong E.L. Joyce Lim, Wang Qi,, Amparo Mifsud. Genetics of male infertility. Annals Academy
of Medicine, Singapore 2000;29:396-400
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Lim J, Ghadessy FJ, AAR Abdullah, Pinsky L, Trifiro M, Yong EL. Human androgen receptor
mutations disrupts ternary interactions between ligand, receptor domains and the coactivator
TIF2. Molecular Endocrinology (USA) 2000: 14: 1187-1197.
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Yong EL, Lim LSE, Wang Q, Mifsud A, Lim J, Ong YC, Sim KS. Androgen receptor
polymorphisms and mutations in male infertility. Journal of Endocrinological investigation
(Italy) 2000; 23:573-577.
1999
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Ghadessy FJ, Liow SL, Yong EL. Mutations in the promoter region of the androgen receptor gene
are uncommon in males with idiopathic infertility. Molecular Human Reproduction (UK)
1999:5:287-290.
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Razvi K, Chew S, Yong EL, Kumar J, Ng SC. The clinical management of male infertility.
Singapore Medical Journal 1999 40:291-297.
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Ghadessy FJ, Lim J, Abdullah AAR, Panet-Raymond V, Choo CK, Lumbroso R, Tut TG, Gottlieb
B, Pinsky L, Trifiro MA, Yong EL. Oligospermic infertility associated with an androgen receptor
mutation that disrupts interdomain and coactivator (TIF2) interactions. Journal Of Clinical
Investigation (USA) 1999 ;103:1517-1525.
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Dowsing AT, Yong EL, McLachlan RI, de Kretser D, Trounson A. Linkage between male infertility
and trinucleotide expansion in the androgen receptor gene. Lancet (UK) 1999; 354: 640-43
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Razvi K, Sonoda K, Lee YS, Tham KF, Lim FK, Yong EL. A preliminary study of the
immunohistochemical detection of a novel tumour marker, 2-1-1 antigen, in gynaecological
cancer specimens. Annals Academy of Medicine, Singapore. 1999; 28:392-4.
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Razvi K, Chew S, Yong EL, Kumar J, Ng SC. The clinical management of male infertility.
Singapore Med J 1999 ;40:291-7
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Ong YC, Wong HB, Adaikan G, Yong EL. Directed pharmacological therapy of ambiguous
genitalia due to an androgen receptor gene mutation. Lancet (UK). 1999;354:1444-5
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1998
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Yong EL, Tut TG, Ghadessy FJ, Prins G, Ratnam SS. Partial androgen insensitivity and
correlations with the predicted three dimensional structure of the androgen receptor ligand-binding
domain. Molecular Cellular Endocrinology (UK) 1998: 137:41-50
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Wang Q., Ghadessy FJ, Yong EL. Analysis of the transactivation domain of the androgen receptor
in patients with defective spermatogenesis. Clinical Genetics (USA) 1998: 54:185-192.
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Liow SL, Ghadessy FJ, Ng SC, Yong EL. Y-chromosome microdeletions, in azoospermic or nearazoospermic subjects, are located in the AZFc (DAZ) subregion. Molecular Human Reproduction
(UK). 1998:4: 763-768
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Yong EL, Ghadessy FJ, Wang Q, Mifsud A, Ng SC. Androgen receptor transactivation domain
and control of spermatogenesis. Reviews in Reproduction (UK). 1998:3:141-144.
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Wang Q, Ghadessy FJ, Trounson A, Kretser D, McLachlan R, Ng SC, Yong EL. Azoospermia
associated with a mutation in the ligand-binding domain of an androgen receptor displaying
normal ligand binding, but defective transactivation. Journal of Clinical Endocrinology and
Metabolism (USA) 1998:83:4303-4309.
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Chan CL, Kumar J, Yong EL, Fong CY, Bongso A, Ng SC. The first 2 case reports of frozen
embryo donation twin pregnancies in Singapore: hormonal profiles and obstetrical outcome.
Journal of Obstetrical Gynaecology Research (Japan) 1998;24:203-9.
1997
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Yong EL, Ng SC, Chan CLK, Kumar J, Teo LS, Ratnam SS. Chronic low dose follicle stimulating
hormone and clomiphene/human menopausal gonadotrophin for induction of ovulation.
Gynaecological Endocrinology (UK) 1997;11: 35-42.
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Yong E.L., Ng S C, Chan C, Kumar J, Ratnam SS. Responses of polycystic ovarian syndrome
and related variants to low dose follicle stimulating hormone. International Journal of Obstetrics
and Gynaecology (USA) 1997;57:305-311. .
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Yong EL, Lee KO, Ng SC, Ratnam SS. Induction of spermatogenesis in isolated
hypogonadotrophic hypogonadism with gonadotrophins and early intervention with
intracytoplasmic sperm injection (ICSI). Human Reproduction (UK) 1997;12:1230-1232.
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Lim J, Farid J Ghadessy, Yong EL. A novel splice site mutation in the androgen receptor gene
results in exon skipping and a non-functional protein. Molecular Cellular Endocrinology (UK)
1997;131:205-2210 .
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Tut TG, Ghadessy F, Trifiro MA, Pinsky L, Yong EL. Long polyglutamine tracts in the androgen
receptor are associated with reduced transactivation, defective sperm production and male
infertility. Journal of Clinical Endocrinology Metabolism (USA) 1997:82, 3777-3782.
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Yong E.L., Wang Q., Tut T.G., Ghadessy F.J., Ng S.C. Male infertility and the Androgen receptor:
Molecular, clinical and therapeutic aspects. Reproductive Medicine Reviews 1997:6, 113-131.
1995-1996
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Ng SC, Liow SL, Ahmadi A, Yong EL, Bongso A, Ratnam SS. Intracytoplasmic sperm injection-is
there a need for an animal model, especially in assessing the genetic risks involved? Human
Reproduction (UK) 1995:10;2523-2525.
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Yong EL, Abdullah AAR, Choo CK, Lim J, Tut TG, Lumbroso R, Trifiro, Pinsky L. Mild androgen
insensitivity and male infertility: substitution in the ligand-binding domain of the androgen receptor
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that impairs transactivation but not androgen binding. American Journal of Human Genetics (USA)
1996;59(4):A43 (suppl)
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1994
Ng S C, Kumar J, Yong E L, Chan C K L, Liow S L, Tok V, et al. Novel approaches to the
management of male infertility. Singapore Journal of Obstetrics and Gynaecology 1994:25; 26-29.
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Yong E L. Polycystic ovarian syndrome and ovarian follicular development. Singapore Journal of
Obstetrics and Gynaecology 1994:25; 9-18.
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Yong E L, Yang M, Roy A, Yun G, Ratnam S S. Testicular feminising syndrome in two siblings is
caused by an inherited mutation in the androgen receptor gene. Singapore Journal of Obstetrics
and Gynaecology. 1994 :25;109.
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Yong E L, Turner M , Hillier S G, Baird D T, Reichert L E, Ng S C, Bongso A, Ratnam S S.
Differential regulation of cholesterol side chain cleavage (P450 SCC) and aromatase(P450
AROM) enzyme messenger ribonucleic acid expression by cyclic adenosine 3',5'-monophosphate
in human granulosa cells. Journal of Molecular Endocrinology (U.K.) 1994:12; 239-249
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Yong E L, Chua K L, Yang M, Roy A, Ratnam S S. Complete androgen insensitivity due to a
splice-site mutation in the androgen receptor gene and genetic screening with single stranded
conformation polymorphism (SSCP). Fertility Sterility (USA) 1994: 61;856-862.
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Yong E L, Ng S C, Roy A C, Yun G, Ratnam S S. Pregnancy after hormonal correction of severe
spermatogenic defect due to mutation in androgen receptor gene. Lancet (U.K.) 1994: 344; 826827.
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Kelly RW, Linan C, Thong J, Yong EL, Baird DT. Prostalglandin inactivation is increased in
endometrium after exposure to clomiphene. Prostalglandins, Leukotrienes, and essential Fatty
Acids. 1994: 50; 235-238.
1992
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Yong E L, Turner M, Baird D T, Hillier S G. Molecular basis of gonadotrophin action on human
granulosa cell function. Annals Academy Medicine, Singapore. 1992:21;510-516.
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Yong E L, Glasier A, Hillier H et al. Effect of cyclofenil on hormonal dynamics, follicular
development, and cervical mucus in normal and oligomenorrhoeic women. Human Reproduction
(U.K.) 1992 :7;39-43
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Yong E L, Baird D T, Yates R, Reichert L E, Hillier S G. Hormonal regulation of the growth and
steroidogenic function of human granulosa cells. Journal of Clinical Endocrinology and
Metabolism (U.S.A.)1992:74;842-849.
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Yong E L, Baird D T, Hillier S G. Mediation of gonadotrophin stimulated growth and differentiation
of human granulosa cells by adenosine 3',5'-monophosphate: one molecule, two messages.
Clinical Endocrinology (U.K.) 1992:37;51-58.
1991
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Hillier S G, Yong E L, Illingworth P, Baird D T, Schwall R H, Mason A J. Effect of recombinant
inhibin on androgen synthesis in cultured human theca cells. Molecular and Cellular
Endocrinology.(U.K.) 1991:75;R1-R6
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Hillier S G, Yong E L, Illingworth, P I, Baird D T, Schwall, R H, Mason A J. Effect of recombinant
activin on androgen synthesis in cultured human theca cells. Journal of Clinical Endocrinology and
Metabolism (U.S.A.) 1991:72;1206-1211.
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Hillier S G, Wickings E J, Illingworth P I, Yong E L, Reichert L E, Baird D T, McNeilly A S. Control
of immunoactive inhibin production by human granulosa cells. Clinical Endocrinology (U.K.)
1991:35;71-78
1983-1990

Yong E L, Lim P H C, Chng H C, Ng B K. Penetrating wounds of the abdomen and chest: An
analysis of 107 consecutive cases. Singapore Medical Journal 1983:24;337.

Yong, E L, Lim P H C. A case of seminoma occurring in an undescended (intra-abdominal) testis.
The Family Practitioner (Singapore) 1983: 6; 67.

Anandakumar C, Wong, Y C, Yong E L, Chia D, Leong H, Ratnam S S. Obstetrical outcome after
first and early second trimester bleeding: The prognostic value of ultrasound. Singapore Journal of
Obstetrics and Gynaecology (Singapore) 1987:18;122.

Yong E L, Wong P C. Danazol for endometriosis and associated infertility - The drug of choice?
Therapeutic Bulletin - National University Hospital (Singapore) 1988:1;19.

Yong E L, Prabhakharan K, Lee, Y S, Ratnam, S S. Peritonitis following diagnostic laparoscopy
due to injury to a vesico-urachal diverticulum: A case report. British Journal of Obstetrics and
Gynaecology (U.K.):1989:96;365-368.

Yong E L, Wong P C, Anandakumar C, Wong Y C, Goh H H, Hagglund L, Ratnam S S. Simple
office methods to predict ovulation: The clinical usefulness of a new urine luteinising hormone kit
compared to basal body temperature, cervical mucus and ultrasound. Australia & New Zealand
Journal of Obstetrics and Gynaecology (Australia)1989:29;155-160.

Angell R R, Ledger W R, Yong E L, Harkness L, Baird D T. Cytogenetic analysis of unfertilised
human oocytes. Human Reproduction.(U.K.) 1991: 6:4;568-573
9