Supplementary Table 1. Univariate Competing Risk Analysis of Out-of-Field Failures
Variable
SHR (95% CI)
P Value
Sex
Male
Female
1.44 (0.51-4.08)
0.491
0.95 (0.91-0.99)
0.007
Ethnicity
Non-Caucasian
Caucasian
2.18 (0.99-4.81)
0.053
History of alcohol consumption
Frequenta
Occasional
None
2.01 (0.85-4.75)
1.18 (0.39-3.58)
0.112
0.771
Smoking status
Current
Everb
Never
1.21 (0.47-3.13)
0.80 (0.35-1.82)
0.691
0.599
Baseline body mass index
>30
≤30
1.37 (0.69-2.72)
0.368
Tumor status
T3/T4
T1/T2
3.58 (0.89-14.4)
0.072
Nodal status
N1
N0
6.85 (2.15-21.9)
0.001
Metastatic status
M1
M0
1.90 (0.96-3.76)
0.067
Tumor site
Middle
Lower
Cervical/upper
7.41 (0.87-63.3)
5.28 (0.67-41.8)
0.067
0.115
Age
(continuous variable)
Table 2, continued
Tumor grade
G3 (poorly diff.)
G2 (moderately diff.)
2.80 (1.37-5.76)
0.005
Tumor histology
Squamous
Adenocarcinoma
0.67 (0.30-1.51)
0.338
Induction Chemotherapy
Yes
No
1.82 (0.97-3.43)
0.063
Radiation Dose
>50.4 Gy
≤50.4 Gy
2.23 (1.06-4.69)
0.035
1.97 (0.97-4.03)
0.062
1.01 (0.98-1.14)
0.186
2.17 (1.05-4.47)
0.035
1.17 (1.06-1.29)
0.001
0.84 (0.42-1.67)
0.615
1.01 (0.97-1.05)
0.640
Tumor length
≥5 cm
<5 cm
2.11 (1.08-4.12)
0.029
In-field failures
Yes
No
0.41 (0.16-1.09)
0.074
Pre-treatment SUV
>10
≤10
(continuous variable)
Post-treatment SUV
>3.5
≤3.5
(continuous variable)
SUV Change
≥6.3
<6.3
(continuous variable)
Abbreviations: CI, confidence interval, diff., differentiated; SUV, standardized uptake
value
a
Alcohol status: frequent (≥1 drink/day), occasional (<7 drinks/week)
b
Smoking status: ever (quit >1 year)
Supplementary Table 2. Multivariate Competing Risk Analysis for Out-of-Field
Failures
Variable
Sex
Male
Female
In-Field Failures
SHR (95% CI)
P Value
2.48 (0.26-23.66)
0.429
0.95 (0.89-1.00)
0.072
Ethnicity
Non-Caucasian
Caucasian
1.67 (0.53-5.25)
0.384
Tumor status
T3/T4
T1/T2
3.16 (0.75-13.40)
0.119
Nodal status
N1
N0
5.89 (1.30-26.66)
0.021
Metastatic status
M1
M0
0.80 (0.27-2.40)
0.694
Tumor grade
G3 (poorly diff.)
G2 (moderately diff.)
2.38 (0.77-7.30)
0.130
Tumor histology
Squamous
Adenocarcinoma
0.17 (0.03-1.05)
0.056
Induction Chemotherapy
Yes
No
1.62 (0.52-5.03)
0.407
Radiation Dose
>50.4 Gy
≤50.4 Gy
4.01 (0.60-26.89)
0.152
Age
(continuous variable)
Pre-treatment SUV
>10
≤10
1.51 (0.54-4.22)
0.436
Post-treatment SUV
>3.5
≤3.5
1.32 (0.52-3.36)
0.565
Tumor length
≥5 cm
<5 cm
1.08 (0.36-3.24)
0.892
Abbreviations: CI, confidence interval, diff., differentiated; SUV, standardized uptake
value
Supplementary Table 3. Univariate Competing Risk analysis for All Failures
Variable
SHR (95% CI)
P Value
Sex
Male
Female
1.67 (0.73-3.83)
0.227
0.96 (0.94-0.99)
0.003
Ethnicity
Non-caucasion
Caucasian
2.53 (1.62-3.93)
<0.001
History of alcohol consumption
Frequenta
Occasional
None
2.82 (1.35-5.91)
1.62 (0.64-4.10)
0.006
0.308
Smoking status
Current
Ever
Never
0.95 (0.48-1.90)
0.77 (0.45-1.33)
0.890
0.353
Baseline body mass index
>30
≤30
0.64 (0.37-1.13)
0.123
Tumor status
T3/T4
T1/T2
4.37 (1.71-11.16)
0.002
Nodal status
N1
N0
2.11 (1.27-3.50)
0.004
Metastatic status
M1
M0
1.53 (0.94-2.47)
0.085
Tumor site
Middle
Lower
Cervical/upper
1.43 (0.60-3.44)
1.22 (0.55-2.70)
0.420
0.632
Age
(continuous variable)
Table 2, continued
Tumor grade
G3 (poorly diff.)
G2 (moderately diff.)
1.95 (1.23-3.09)
0.005
Tumor histology
Squamous
Adenocarcinoma
0.76 (0.43-1.32)
0.326
Induction Chemotherapy
Yes
No
1.52 (0.98-2.36)
0.062
Radiation Dose
>50.4 Gy
≤50.4 Gy
1.59 (0.91-2.79)
0.105
1.87 (1.16-3.01)
0.011
1.02 (0.99-1.04)
0.140
1.95 (1.22-3.12)
0.006
1.11 (1.05-1.18)
0.001
0.70 (0.43-1.11)
0.131
1.00 (0.97-1.02)
0.694
1.85 (1.17-2.92)
0.009
Pre-treatment SUV
>10
≤10
(continuous variable)
Post-treatment SUV
>3.5
≤3.5
(continuous variable)
SUV Change
≥6.3
<6.3
(continuous variable)
Tumor length
≥5 cm
<5 cm
Abbreviations: CI, confidence interval, diff., differentiated; SUV, standardized uptake
value
a
Alcohol status: frequent (≥1 drink/day), occasional (<7 drinks/week)
Supplementary Table 4. Multivariate Competing Risk Analysis for All Failures
Variable
Sex
Male
Female
All Failures
SHR (95% CI)
P Value
1.39 (0.48-4.02)
0.538
0.96 (0.93-0.99)
0.008
Ethnicity
Non-Caucasian
Caucasian
2.55 (1.50-4.32)
0.001
Tumor status
T3/T4
T1/T2
3.56 (1.34-9.47)
0.011
Nodal status
N1
N0
2.05 (1.06-3.99)
0.034
Metastatic status
M1
M0
0.78 (0.38-1.59)
0.494
Tumor grade
G3 (poorly diff.)
G2 (moderately diff.)
1.32 (0.71-2.44)
0.381
Tumor histology
Squamous
Adenocarcinoma
0.42 (0.19-0.94)
0.035
Induction Chemotherapy
Yes
No
0.96 (0.48-1.88)
0.895
Radiation Dose
>50.4 Gy
≤50.4 Gy
2.10 (0.92-4.81)
0.078
Pre-treatment SUV
>10
≤10
1.21 (0.67-2.18)
0.519
Age
(continuous variable)
Post-treatment SUV
>3.5
≤3.5
1.41 (0.85-2.34)
0.189
Tumor length
≥5 cm
<5 cm
1.00 (0.54-1.87)
0.995
Abbreviations: CI, confidence interval, diff., differentiated; SUV, standardized uptake
value