Table S3. List of all deletion mutants that appear sensitive to caffeine treatment in 4
independent repeats of the genetic screen.
REPEAT 1
SPBC530.01
SPAC11G7.02
SPBC19G7.10c
gyp1
pub1
topoisomerase II-associated deadenylationdependent mRNA-decapping factor (predicted)
adn1
png1
prefoldin subunit 3 (predicted)
cph1
spt20
meu29
conserved hypothetical
transmembrane transporter (predicted)
clr1
poly(A) binding protein Nab2 (predicted)
leu1
S. pombe specific DUF999 protein family 8
sequence orphan
SNARE Sft1 (predicted)
mitochondrial ribosomal protein subunit L1
60S ribosomal protein L17
Rad23 homolog Rhp23
alg5
oxa101
sequence orphan
hob3
shf1
mfm2
SPBC30B4.03c
SPAC3G9.08
SPAC3H8.07c
SPAC16C9.05
SPAC4D7.10c
SPAC25H1.05
SPBC20F10.07
SPBC887.17
SPBC2D10.17
SPAC14C4.06c
SPBC1A4.02c
SPBPB2B2.14c
SPAC1834.10c
SPAC31A2.13c
SPAC1610.02c
SPCC364.03
SPBC2D10.12
SPBC56F2.10c
SPAC9G1.04
SPCC16C4.20c
SPBC725.09c
SPAC22F8.12c
SPAC513.03
REPEAT 2
SPAC4G9.19
SPAC27E2.01
SPBC16H5.03c
SPAC2F3.12c
SPCC188.02
SPBC3D6.10
SPBC725.10
SPBC31F10.12
SPBC2F12.11c
SPBC29A10.14
SPBC2F12.12c
SPAC23E2.01
SPAC824.04
SPBC23E6.08
SPBC543.10
SPAC3H5.08c
SPAC26F1.01
SPBC21B10.13c
SPAC1F8.04c
SPBC25D12.06
SPAC2C4.17c
SPAC4F10.02
fub2
par1
apn2
rep2
rec8
fep1
sat1
sec74
DNAJ domain protein DNAJB family
alpha-amylase homolog
SUMO E1-like activator enzyme Fub2
conserved eukaryotic protein
protein phosphatase regulatory subunit Par1
AP-endonuclease Apn2
tspO homolog
RNA-binding protein Tma20
transcriptional activator Rep2
meiotic cohesin complex subunit Rec8
conserved eukaryotic protein
iron-sensing transcription factor Fep1
WD repeat protein
Golgi membrane exchange factor subunit Sat1
GET complex subunit
WD repeat protein Wdr44 family
guanyl-nucleotide exchange factor Sec74
transcription factor
hydrolase
RNA helicase
MS ion channel protein 2
aspartyl aminopeptidase
SPCC613.01
SPAC6F12.09
SPAC5H10.11
SPAC4F8.10c
SPCC63.02c
SPAC4H3.07c
SPCC188.07
SPCC18B5.01c
SPAC13G7.05
SPCC74.02c
rdp1
gmh1
stg1
aah3
ccq1
bfr1
SPBP4H10.11c
SPAC30D11.10
SPAC29A4.20
lcf2
rad22
SPBC20F10.07
SPAC1A6.09c
SPAC29B12.05c
SPAC630.14c
SPBC14C8.17c
SPBC428.08c
SPAC959.04c
SPBC3B9.11c
lag1
tup12
clr4
ctf1
SPAC1D4.03c
SPAC57A7.07c
SPBPB2B2.14c
SPBC1921.04c
SPBC29A10.16c
SPAC30D11.04c
SPBC215.03c
SPBP35G2.07
SPBC3H7.09
SPBC56F2.10c
SPBP18G5.03
SPBC577.11
SPAC144.06
SPBC1778.05c
SPAC1805.07c
REPEAT 3
SPBC16A3.07c
SPAC30C2.05
SPBC4C3.12
SPBC354.03
SPAC11G7.02
SPBC16A3.08c
SPBC21B10.10
SPBC2F12.11c
SPAC18G6.15
SPAC3G9.08
SPBC31F10.09c
SPAC3H5.08c
SPAC16.01
aut12
nup124
csn1
ilv1
mug142
alg5
toc1
apl5
dad2
nrm1
erv14
01-Sep
swd3
pub1
rps402
rep2
mal3
png1
nut2
rho2
membrane transporter
RNA-directed RNA polymerase Rdp1
alpha-1,2-galactosyltransferase Gmh1
SM22/transgelin-like actin modulating protein Stg1
alpha-amylase homolog Aah3
protein phosphatase Fmp31
telomere maintenence protein
brefeldin A efflux transporter Bfr1
acyl-coA-sterol acyltransferase
mRNA cleavage and polyadenylation specificity factor
complex associated protein
long-chain-fatty-acid-CoA ligase
DNA repair protein Rad22
RNA polymerase II elongator complex, histone
acetyltransferase subunit
GRAM domain protein
sphingosine N-acyltransferase Lag1
S-adenosylmethionine-dependent methyltransferase
transcriptional corepressor Tup12
SAGA complex subunit Spt8
histone H3 methyltransferase Clr4
mannosyltransferase complex subunit
mRNA cleavage and polyadenylation specificity factor
complex subunit Ctf1
autophagy associated protein Aut12
homocysteine methyltransferase
S. pombe specific DUF999 protein family 8
sequence orphan
cytochrome b5
nucleoporin Nup124
COP9/signalosome complex subunit Csn1
acetolactate synthase catalytic subunit
palmitoyltransferase
dolichyl-phosphate beta-glucosyltransferase Alg5
sequence orphan
sequence orphan
AP-3 adaptor complex subunit Apl5
sequence orphan
DASH complex subunit Dad2
negative regulator of MBF
cornichon family protein Erv14
fork head transcription factor Sep1
WD repeat protein Swd3
ubiquitin-protein ligase E3
nuclear telomere cap complex subunit
40S ribosomal protein S4
transcriptional activator Rep2
EB1 family Mal3
ING family homolog Png1
mediator complex subunit Med10
WD repeat protein Wdr44 family
Rho family GTPase Rho2
SPBPJ4664.06
SPCC338.16
SPAC4D7.03
SPAC5H10.11
SPBC146.13c
SPCC63.02c
SPCC1739.14
SPAC22A12.07c
SPAC4D7.10c
SPBP4H10.11c
SPAC1805.14
SPBC17D1.05
SPAC30D11.10
SPCC594.02c
SPBC20F10.07
SPCC757.09c
SPAC20G4.07c
SPAC1A6.09c
SPCC4F11.04c
SPCC794.12c
SPAC6F12.06
SPAC630.14c
SPAC25B8.17
SPAC959.04c
SPAC6B12.12
SPAC977.05c
SPAC3G9.07c
SPCC1739.05
SPAC14C4.06c
SPBC8D2.18c
SPAC57A7.07c
SPAC3C7.14c
SPAC57A10.10c
SPBC1921.04c
SPBC29A10.16c
SPAP8A3.07c
SPBC215.03c
SPAC31A2.13c
SPAC17A5.14
SPAC1F12.07
SPBC29B5.01
SPBC56F2.10c
SPBC3H7.09
SPAC8F11.02c
SPAC17D4.04
REPEAT 4
SPCC4G3.04c
SPAC513.03
SPBC1778.05c
SPBC1718.03
SPBC2D10.12
SPAP8A3.07c
SPBP4H10.05c
gpt1
pof3
pop2
gmh1
myo1
aah3
npp106
ogm1
lcf2
rad22
rnc1
sts1
lag1
mae2
tup12
tom70
hos2
set5
obr1
sla1
csn1
sft1
exo2
atf1
alg5
mug142
coq5
mfm2
ker1
rhp23
spe2
UDP-glucose-glycoprotein glucosyltransferase Gpt1
F-box protein Pof3
F-box/WD repeat protein Pop2
alpha-1,2-galactosyltransferase Gmh1
myosin type I
alpha-amylase homolog Aah3
nucleoporin Npp106
protein O-mannosyltransferase Ogm1
SAGA complex subunit Spt20
long-chain-fatty-acid-CoA ligase
sequence orphan
sequence orphan
DNA repair protein Rad22
conserved fungal protein
GRAM domain protein
RNA-binding protein that suppresses calcineurin deletion Rnc1
C-24(28) sterol reductase Sts1
sphingosine N-acyltransferase Lag1
mannosyltransferase complex subunit
malic enzyme
Rho GDP dissociation inhibitor Rdi1
transcriptional corepressor Tup12
peptidase family A22
mannosyltransferase complex subunit
mitochondrial TOM complex subunit Tom70
conserved fungal protein
histone deacetylase (class I) Hos2
histone lysine methyltransferase Set5
poly(A) binding protein Nab2
adenosylhomocysteinase
homocysteine methyltransferase
ubiquitinated histone-like protein Uhp1
La protein homolog
sequence orphan
cytochrome b5
phospho-2-dehydro-3-deoxyheptonate aldolase
COP9/signalosome complex subunit Csn1
SNARE Sft1
exonuclease II Exo2
phosphoserine aminotransferase
transcription factor Atf1
dolichyl-phosphate beta-glucosyltransferase Alg5
palmitoyltransferase
diphthamide biosynthesis protein Dph3
tRNA (cytosine-5-)-methyltransferase
C-methytransferase
M-factor precursor Mfm2
sequence orphan
RNA polymerase I transcription factor subunit Ker1
Rad23 homolog Rhp23
phospho-2-dehydro-3-deoxyheptonate aldolase
S-adenosylmethionine decarboxylase proenzyme Spe2
SPBC1D7.04
SPBC409.16c
SPAC14C4.06c
SPAC5D6.02c
SPAC14C4.09
SPAC57A7.08
SPCC594.04c
SPBC691.04
SPAC20G4.07c
SPBP22H7.04
SPCC24B10.11c
SPAC688.11
SPAC20G4.08
SPBC3E7.08c
SPCC1840.05c
SPBC1778.09
SPBC4F6.06
SPAC922.03
SPCC663.01c
SPBC2F12.11c
SPAC18G6.15
SPAC3G9.08
SPBC31F10.09c
SPBC4C3.12
SPBC354.03
SPAC11G7.02
SPBC16A3.08c
SPAC1782.11
SPBC26H8.05c
SPBC26H8.12
SPAC144.02
SPAC1486.04c
SPBC725.10
mlo3
mug165
agn1
pzh1
sts1
end4
rad13
kin1
ekc1
rep2
mal3
png1
nut2
01-Sep
swd3
pub1
met14
alm1
RNA annealing factor Mlo3
sequence orphan
poly(A) binding protein Nab2
sequence orphan
glucan endo-1,3-alpha-glucosidase Agn1
serine/threonine protein phosphatase Pzh1
steroid oxidoreductase superfamily protein
mitochondrial ATP-dependent RNA helicase Mss116
C-24(28) sterol reductase Sts1
sequence orphan
THO complex subunit 7
Huntingtin-interacting protein homolog
sequence orphan
DNA repair nuclease Rad13
phosphomannomutase
GTPase activating protein
microtubule affinity-regulating kinase Kin1
1-aminocyclopropane-1-carboxylate deaminase
protein phosphatase regulatory subunit Ekc1
transcriptional activator Rep2
EB1 family Mal3
ING family homolog Png1
mediator complex subunit Med10
fork head transcription factor Sep1
WD repeat protein Swd3
ubiquitin-protein ligase E3
nuclear telomere cap complex subunit
adenylyl-sulfate kinase
serine/threonine protein phosphatase
cytochrome c heme lyase
transcription factor
medial ring protein Alm1
tspO homolog