Its all Phenotyping -- Resources for lots of research
Cory Brayton, D.V.M., Diplomate, A.C.L.A.M., A.C.V.P.
Johns Hopkins University School of Medicine
The term phenotyping is often considered to be restricted to assessments done to characterize
genetically engineered mice. In a broader sense it can be applied to any assessments of any organisms.
Resources on mouse genetics, phenotypes and phenotyping continue to increase. Multi site,
international coordinated mouse genome projects and phenotyping efforts have been making mice,
protocols, and data publicly accessible, in searchable databases. The international knockout mouse
consortium IKMC is nearing its goal of creating knockout mice with null mutations in every functional
gene, many of these tagged for expression analysis.
The international mouse phenotyping consortium IMPC aims to conduct high throughput phenotyping
on viable mice from IKMC, as well as embryo phenotyping on embryonic lethal or subviable mice from
IKMC. There has been substantial bioinformatics investment in these and related efforts to provide
broadly relevant and translatable data in highly searchable data bases.
FIND GEM (and other mice)
 IKMC https://www.mousephenotype.org/
GEM & ES cell lines avail thru GenOway/EUCOMM (2014)
 IMSR International Mouse Strain Resource http://www.findmice.org/
Find mice (+ ES cells) in multiple repositories Many types of mutations
FIND PROTOCOLS & PHENOTYPE DATA
 IMPC international Mouse Phenotyping consortium http://www.mousephenotype.org/impress
 MPD Mouse Phenome Database http://phenome.jax.org/ (Protocols & Data (J strains + GEM) –
most in peer reviewed literature also)
Find GENE info & correct/current names
 MGI
Mouse Genome Informatics http://www.informatics.jax.org/genes.shtml
Tumor and pathology resources
 MMHCC Mouse Models of human Cancer consortium, an initiative of NCI, more at
http://emice.nci.nih.gov/ (Coming soon NCIPhub)
 MTB Mouse Tumor Biology Database http://www.informatics.jax.org/mtbwi/index.do
also links to ‘tumor frequency grid’ by strain – with references
 PATHBASE European mutant mouse pathology database http://eulep.pdn.cam.ac.uk/