Supplementary information S4 | Reliability, clinical validity and norms for measures of social behaviour Test Frontal Systems Behavior Scale (FrSBe)1 Reliability Internal consistency α = range 0.71–0.81,2 0.84– 0.95,3 0.70–0.934 and 0.86– 0.94.5 For the apathy subscale, an α of 0.85 has also been reported.6 Test-retest Mean intervals of: 1 week, rs = 0.42–0.74,4 3 months, rs = 0.65–0.78.5 Inter-rater α = 0.79–0.92.5 Frontal Behavioural inventory (FBI)12 Internal consistency α = 0.93,13 0.97,14 and 0.89.12 Test-retest Mean intervals of: 2 weeks, r = 0.9013 3 weeks, rs of 0.86 to 0.97.14 Inter-rater ks = 0.9213 and 0.90.12 ICCs range from 0.91–0.92.14 Internal consistency α = 0.98.22 Clinical validity Ratings of disinhibition differentiate between people with FTD and those with other dementias.7,8 In people with frontal lobe damage, the FrSBe identifies significant post-lesion behaviour changes relative to premorbid levels. Frontal patients also score higher on the FrSBe than patients with non-frontal brain damage and controls.9 TBI is associated with elevated FrSBe scores relative to published norms10 and controls.11 People with schizophrenia exhibit impairment on all FrSBe scales.5 Many clinical studies have focused on dementia. The FBI consistently differentiates between patients with FTD and those with other dementias.12–18 The FBI also has good longitudinal validity in FTD,19–20 and is more sensitive to FTD than cognitive testing.21 Norms Extensive research base. Normative tables provided in the FrSBe manual.1 Population Adults Extensive research base. Published cut-off scores.12,18 Adults Only one Adults published study to date. Norms not available. Peer ratings are correlated with executive Only two Adults Peer-Report Internal consistency α = 0.75–0.92.23 decline,23 and are sensitive to early dementia.24 published studies Social to date. Norms not Functioning Scale23 available Sensitive to FTD, with different types of social Only one Adults Social Inter-rater ICCs = 0.71–0.95.25 impairment linked to atrophy in distinct published study to Impairment Rating Scale25 corticolimbic networks.25 date. Intra-rater 25 ICCs = 0.94–0.99. Norms not available. α refers to Cronbach’s alpha, mean interval refers to average interval between testing occasions, ICC refers to intraclass correlation coefficient, k refers to kappa. Abbreviations: bv-FTD, behavioural-variant FTD; FTD, frontotemporal dementia; TBI, traumatic brain injury. Socioemotional Dysfunction Scale22 1. 2. 3. 4. 5. 6. 7. Discriminates between patients with bvFTD and those with early-onset dementia.22 Grace, J. & Malloy, P.F. Frontal Systems Behavior Scale. Professional Manual (Psychological Assessment Resources, Lutz, FL 2001). Simpson, G.K. et al. 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