1 HEALTH CARE ABROAD Iringa Regional Hospital Projet d’intégration en sciences IRINGA, TANZANIA This project was written both in French and in English since we are graduating from an International program at Collégial International Sainte-Anne de Lachine During the month of April and May 2013, we had the chance to travel to Iringa, in Tanzania, for a premedical internship at the Iringa Regional Hospital. The placement was done through the organization Gap Medics. This was truly a valuable experience, during which we have learned a lot about many departments in medicine. Also, it was an eye-opening experience that allowed us to discover a whole new health care system that is quite different than the one in Québec. Ce projet est écrit en français et en anglais puisque nous graduons3 d’un cégep international au Collégial International Sainte-Anne de Lachine Médecine - Système médical Lors de notre séjour en Tanzanie, nous avons eu la chance de suivre plusieurs médecins dans divers départements. Ainsi, les informations apprises durant ce stage sont diversifiées et sont regroupées dans ce document en différentes capsules qui tentent à la fois d’expliquer ce que nous avons appris et de comparer brièvement des caractéristiques de notre système de santé et celui de Tanzanie. Il est possible de retrouver des capsules sur le cheminement nécessaire pour arriver à un diagnostic, les différentes maladies traitées, des informations sur le département d’obstétrique et différentes facettes du VIH que nous avons pu observer dans les départements. 2 Index Introduction…………………………………………………………………………….………1 Présentation de l’équipe……………………………………………………………………….2 A Day to CTC……………………………………………………………………………….3 - 5 Mother-To-Child Transmission of HIV/AIDS…………………………………………6 - 11 Prevention of Transmission of HIV…………………………………………………….12 - 17 Un manque de ressources influençant la pratique………………………………… 18 - 23 Les principales maladies et les ressources mises en place pour les patients………24 - 26 En conclusion………………………………………………………………………………….27 Références………………………………………………………………………………….28-29 3 THE TEAM Authors of this work I have currently graduated from collegial SainteAnne de Lachine in health science. Biology and chemistry are two subjects that I find particularly interesting. I believe that the human body is an incredible and wide field of study that I am passionate to learn all about. I would like to continue my studies in university in the domain of health science and medicine. I love to travel and I am happy that this project will allow me to do so. I am hoping to learn more about the science, cultural and social aspects of the country during this project. I personally believe that this placement has brought me so many positive things. To begin, I am very fortunate to have had the change to visit a new country. Since I love learning about cultures and traveling, discovering Tanzania and its rich culture was a blessing. In addition, it is inevitable that the internship was an amazing learning experience. Not only will it help me in my future studies and profession, but it was also a huge eye opener. I will never forget this experience and I am grateful for all I have learned and the friendships I have made. I am a student at Collégial international SainteI am a student Collégial international Sainte-Anne Anne and I am finishingatmy last year in health sciences. and I this am finishing last year in health I chose this I chose program my because the two main sciences. courses of it; program the two main courses of it; biology and biology andbecause chemistry, interest me since my high school chemistry, interested me since my high school years. years. In a few months, I will be studying neurosciencesIn a few I will beat studying neurosciences for my undergrad at formonths, my undergrad McGill University. McGill University. This internship was a once in a life time experience. ThisI learned internship so much was a about once in the a life human timebody, opportunity. I but learned mainlysoI much learned about things theabout human myself body,I wouldn’t but mainly I learned have things imagine aboutbefore. myselfIIsaw wouldn’t duringhave thatimagine trip before. I saw unforgettable during that trip things unforgettable and I met different things and people I metwith different different people with backgrounds differentwhich backgrounds opened which my eyes opened a littlemy biteyes a more littleon bitthe more world on the around world us.around us. 4 A DAY AT THE CTC As it is known, HIV/AIDS is one of the leading viruses in Africa. During the placement in Iringa, I have come to notice the importance of the presence of this virus. Iringa ranks on the list with the highest infection rate of HIV/AIDS within the country. It has become clear to everyone that immediate attention should be given to this continuously growing epidemic. Next to the Iringa Regional Hospital, there is the CTC clinic. This department has a main focus on HIV/AIDS patients. In this clinic, the patients must always sign in and out, see a counselor, have a periodic visit with the doctor and finally pass by the pharmacist whom is also present at the clinic. This CTC clinic is open for children, women and men. All HIV patients are referred to the CTC clinic. Nevertheless, it is common for patients not to show up to the clinic for many reasons. The different steps of the CTC program will be explained more in depth in the following paragraphs. To start, by signing up on entrance to the clinic, it is possible to keep track of the visit history of each patient. The staff will be able to know if the patient is in fact attending the clinic and if he or she is coming back in time for the suggested date of visit by the doctor. Also, it allows to keep a data of how many infected patients are getting the appropriate care and treatment. This data can be used for research and statistical projects. To continue, we could all agree on the fact that education is key in life. Through education, awareness is built amongst the population. In the case of HIV/AIDS, without the presence of an education of the virus, the transmission will inevitably grow. In Iringa, the individuals have access to complementary counseling sessions with professionals at the CTC. During these sessions, information about ways to prevent the transmission of the disease is offered. Some prevention methods will be explained below. 5 In addition, during each visit, the patient must consult a doctor whom will undergo a general evaluation of the patient and the progress of the virus. Also, the doctor will prescribe and renew the appropriate medications for HIV infected patient and will suggest steps to follow in order to keep the patient in the best possible shape. Following the consult with the doctor, the patient passes by the pharmacy that will give him the medication earlier prescribed by the doctor. The treatments consist of ARV prophylaxis and ART, which are explained in the following sections: MOTHERTO-CHILD TRANSMISSION OF HIV/AIDS. 6 MOTHER-TO-CHILD TRANSMISSION OF HIV/AIDS HIV during pregnancy is one of the indirect causes of maternal mortality. It can affect the mother by lowering her QuICK SWAHILI QuICK LESSONSWAHILI LESSON immunity, which increases the risks of infection and may also be the cause of a stillbirth. During our placement, we have heard several times doctors speaking about MTCT: Mother-to-Child Transmission of HIV/Aids. It was drawn to our attention that many infants each year are indeed infected with this virus before, during or after giving birth. Without the PMTCT services, 5-10% of infants are Welcome- Karibou Hello- Mambo How are you- Habari infected during pregnancy, 10-15% while delivery and 5-20% after delivery, while breastfeeding. Luckily, there is the presence of PMTCT services in many facilities, which stands for Prevention of Mother-to-Child Transmission of HIV/AIDS. In fact, UNICEF recorded in 2010 that 90.4% of ANC (Antenatal Care) facilities offer PMTCT services. The issue rises from the fact that not all pregnant women attend the ARC facilities. According to the data collected Good- Nzuri Thank you- Asante Please- Tafadhali Sorry- Samahani Goodbye- Kwaheri by UNICEF in 2010, around 92% of pregnant woman had at least one visit to the ANC. However, only 43% of these women had at Consectetuer: least four visits to an ANC facility. The presence of PMTCT services reduces the risk of MTCT by offering counseling, testing and medical services. Below are some examples of services offered in order to reduce the risk of transmission. To begin, the PMTCT services include testing for HIV in pregnant woman. UNICEF recorded in 2010 that 86% of of pregnant women were tested for HIV. Therefore, the remaining 14% of women whom have not tested might transmit this virus by simply not knowing if they are indeed carrier of the virus Sed venenatis, augue non varius tempus, metus nibh mollis erat, a tempus neque ipsum sit amet nisi. Donec elementum, justo eu pulvinar tincidunt, 7 (Continuation) and therefore not taking the measures necessary to protect the infant. Hence, the importance of frequent visits to the ANC is undeniable as it offers guidance and help necessary for a pregnant woman to protect her infant, as much as possible, from the risk of transmission of HIV/AIDS.2 PMTCT- Drugs and treatment To continue, pregnant woman are offered antiretroviral therapy (ART) and antiretroviral (ARV) prophylaxis as treatment. These medications are free of charge for all pregnant women in Tanzania. The role of ARV drugs are mainly to slow as much as possible or block the replication of the HIV virus, to boost the immune system by increasing the body’s ability to fight the HIV infection and finally to minimize the viral load (amount of HIV in the blood) in the body. In fact, HIV attacks healthy cells in the body such as T-cells and CD4 cells, which are essential in the human body to overcome diseases and infections. Therefore, the immune system of an HIV patient is compromised. Hence, it is important for the ARV drug to also play a role in insuring a boost in the immune system. The ARV drugs interfere with either proteins or enzymes. The target proteins and enzymes are the ones that are used to make copied of HIV inside the body’s cell by HIV itself. Drugs must be used in order to minimize the replication of HIV itself, which will allow saving healthy cells in the body from being attacked. To insure the best treatment options, ART is offered to patients living with HIV. The ART therapy signifies that the patient must take a combination of at least three ARV drugs. This method has been shown to be very effective. It offers a long-term effectiveness in comparison to the ARV drugs taken alone. Hence it is also know as HAART: Highly Active Antiretroviral Therapy. The combinations are also key in prevention of a situation of drug resistance in the body. It is the doctor that decides on the treatments, as there are many options of drug combinations. Over the last few years, many treatments have been used. Thankfully, progress has not stopped and ART is now a highly recommended treatment due to its effectiveness in suppressing the HIV viral replication and to slow down the progress of this disease. The different treatments offered allow to expand the life of the patient and to reduce risks of transmission to a partner or to an infant. Also, infants whom are HIV exposed also receive these treatments in order to minimize the risks of transmission of the virus. There are four main groups of ARV drugs that attack the virus in a different and specific ways. Here is a list of the four groups with a small description of each one: 4. NRTIs Stands for: Nucleoside Reverse Transcriptase Inhibitors Reverse transcriptase is an enzyme that is essential for If HIV to reproduce itself and to infect healthy cells in the body. Therefore, NRTIs inhibits these reverse transcriptase enzymes that work in favor of HIV. Furthermore, the NRTIs stop the completion of the HIV DNA chain, hence not allowing the HIV to replicate in a cell. 3. NNRTIs Stands for: Non- Nucleoside Reverse Transcriptase Inhibitors a woman has not previously been tested for HIV and is tested positive during labor, she must take a combination of two drugs: Nevirapine (NVP) and Zidovudine (ART). 1. PI Stands for: Protease Inhibitors To begin, protease is an enzyme used to cut down NNRTIs mainly play a role proteins. However, HIV also uses it for the purpose in inhibiting the conversion of self-reproduction. These protease used by HIV of HIV RNA into HIV DNA. have a specific role of breaking down proteins and NNRTIs differ from NRTIs by the way they bind to the cell’s Reverse Transcriptase. By blocking the conversion, NNRTIs allow to slow or stop the spread and duplication of HIV. 2. Fusion/Entry Inhibitors enzymes in smaller pieces. These smaller pieces become the cause of infection of other cells. As the name indicates, PI inhibits the HIV protease. This is done prior to the protease break the protein and enzyme, stopping the their fragmentation. What is interesting about PI is that they have the ability of working on cells that are already infected. Fusion/Entry Inhibitors block HIV from entering healthy cells. This fourth group differs from the three groups listed above as it interferes before the entry and infection of HIV in a cell. These inhibitors attach themselves onto a protein found on the surface of HIV. This protein is called gp41. Thanks to these inhibitors, gr41 proteins are blocked; hence the HIV looses its ability to fuse with the cellular membrane. Therefore, HIV cannot entre the cell and reproduce. 3 9 PMTCT- Labor and birth Despite the presence of PMTCT services in most ANC, some pregnant women still entre the maternity ward with an unknown HIV status. This was the case of a few women at the OBS and GYNAE ward while we were shadowing a doctor at the Iringa Regional Hospital. Luckily, the hospital offers the blood count necessary to find out the serostatus of the patient. This is essential to help the health care professionals determine the right obstetric procedure to reduce all risk of transmission of the virus. Therefore, PMTCT services are also offered in maternity wards. This will minimize the chances of transmission of the virus to the infant. A mother that is HIV positive must stay strong during her pregnancy in order to protect the baby. Therefore, she receives complementary medications for prevention of malaria and to raise her hemoglobin levels. To continue, the placenta plays a big role in transfusion of the virus from a mother to her child. Micro transfusion of blood from the mother to her infant is indeed done via the placenta. Therefore, an infection or the parasites of can weaken the placenta, allowing the blood to be transfused to the infant. Hence, the HIV virus can be transfused to the fetus. It is also the case in which strong uterus contraction can rupture a part of the placenta and allow blood flow. Also, a prolonged rupture of membrane can increase the chances of transmission through the infant’s exposure to the mother’s blood or cervicovaginal secretions to the infant. Therefore, the health care professionals must be ready to deliver the baby at any given moment where the risk of transmission is important. 4 After delivery, it was explained by a midwife at the Iringa Regional Hospital that a baby born from an HIV positive mother must immediately take prophylaxis. After a few weeks, if the baby is tested positive for the HIV virus, he or she will need to start treatment instead: ART. 10 PMTCT- Breastfeeding It is know breastfeeding in circumstances beneficial that normal is to very an infant’s development. However, in the case of a mother that is HIV positive, breastfeeding could be of a great challenge and can be the cause transmission child of of the mother-to- transmission of HIV/AIDS. After giving birth, the mother has two options when it comes to feeding her child: exclusive breastfeeding for six months or only giving her child formula. To begin, it is obvious that a child fed with formula eliminated the risks of transmission of HIV through breastfeeding. However, not all families in underdeveloped countries can afford to buy formula. Also, some individuals living in rural areas do not have access to sanitary food or drinks, causing a baby’s health to be at risk because of infections and malnutrition. Therefore, breastfeeding might be the only option certain mothers. However, if the mother and the infant are on ART, the risk of MTCT while breastfeeding is decreased. As mentioned earlier, the breastfeeding must be exclusive for 6 months. In fact, mixing breast milk with other food might injure the infant’s gut. Once the gut is injured, the body of the baby is more susceptible of invasion of the HIV virus. All in all, the mother must consciously choose between formula or breastfeeding while taking into consideration her ability to provide adequate nutrition and the 11 Summary- Strategies to avoid MTCT To sum up, there are a few strategies that are in favor or reducing the risk of Mother-To-Child Transmission. To name a few, prevention education is essential for the mother and family members to know the measures that must be taken to insure a good health of their infant. Also, it is important for the mother and the child to receive the appropriate treatment decided by the doctor. Finally, the mother must receive professional care at a medical institute during delivery to reduce MTCT during labor and birth. 12 PREVENTION OF TRANSMISSION OF HIV In Iringa, we have learned that many services are offered to the population in order to reduce the transmission of HIV, especially after being named as the top prevalence of HIV. To begin, family planning consults are available, free of charge, at local Health Care centers. This service offers counseling on protective measures, reducing the amount of partners and abstinence as well as free contraceptive pills and condoms. Also, mothers and the families receive the counseling necessary with PMTCT services to reduce the risk of transmission of HIV from a mother to her child. To continue, in the past years, it was shown that circumcision help reduce the risk of infection of HIV. Therefore, voluntary medical male circumcision has become of great importance in the region of Iringa. Being covered by the government in addition to international aid, the amount of males in the region to get circumcised had greatly increased, moving one step forward in the urge to minimize HIV transmission. Problems and reality Although there is an important presence in Iringa of services offered to reduce the risk of HIV transmission, many problems are still present and slow down the progress of these facilities. To start, stigma is one important factor that does not contribute to reduce the spread of the infection. The caregivers at the hospital explained to us that many men and women do not like to enter facilities such as CTC for the reason that they do not want to be pointed by the finger from society. They do not want to be judged, treated or looked at differently because they are carriers of the virus. Entering these facilities might include the risk of being rejected by society and even by family members. In fact, many women are scared to get tested in fear of their husbands leaving them or asking for a divorce if the results of HIV come back positive. As a result, these individuals will not receive the appropriate medical treatment and counseling they need. Also, a pregnant woman who does not know her serostatus will not be able to take the measures necessary to reduce MTCT. Furthermore, a lack of medical attention increases the amount of children who will need to be sent to orphanages as a result of untreated HIV virus taking the life of many parents. Here we see the importance of the services offered to HIV patients, but an even bigger importance should be given to changing the mentality of the society since this is not a small issue. References 13 OBSTETRICS AND GYNECOLOGY DEPARTMENT While our placement in the OBS and GYNAE department, we have noticed that an important number of women had cesarean sections rather than natural deliveries. Many were for obvious reasons such as a wrong positioning of the fetus, making a natural delivery impossible to take place. However, one of the doctors who were our mentors pointed out a very interesting fact of why many women fail to have a natural birth. One of the essential P’s is missing in many cases. During our placement in this department, we have learned about these four P’s of a natural delivery. They must all be present in order to have an effective delivery. The four P’s are: Power, Passage, Passenger and Psyche. 14 Power is the first P that stands for the mother’s contractions and ability to push when necessary. The contractions will be responsible of dilating the cervix. In many of the cases at Iringa Regional Hospital, although not all medications are always accessible, oxytocin was available and given to increase the contractions. Passage is the second P. The pelvis must be sized properly for the baby to make his or her way out of the mother’s body. 15 Passenger is the third P. It is representative of the fetus that must be placed in a position where natural delivery is possible. A position where the baby cannot fit through the passageway securely calls for a cesarean section. 16 Psyche is the fourth P. It stands for the emotional state of the mother during labor and birth. Stress, anger and fear are examples of factors that influence a woman’s ability to give birth naturally. Also, support from family members and the caregivers play a huge role in this situation. In a week, we were able to observe that most women arriving to the hospital were mentally and emotionally unprepared to deliver naturally their baby. Many different factors played a role in the mother’s psychological state. Below is a brief presentation of these factors that were mentioned by the caregivers at the hospital. To begin, an involuntary pregnancy can have an effect on the mother’s emotional state. While family planning and contraceptive pills are offered free of charge at the health care centers, some girls at a young age do not take advantage of these services because they are too shy to ask for them. Also, it was explained that some of these young girls are afraid to ask their parents for permission or for their help to go to one of these facilities, ending up having unprotected sex. Therefore, unwanted pregnancies become a reality in their lives. Hence, when it is time to give birth, many might be scared and feel unprepared for what is to come. To continue, our mentor explained to us the importance of the role parents plays while raising their child by informing them about reproduction. Most importantly, he pointed out the need for a mother to explain to her daughter the process of pregnancy, labor and delivery. Unfortunately, not all the girls have this opportunity. This could be due to the fact that they do not live close to home in order to go to school. Therefore, while in labor, some women do not understand what they are going through and have a strong fear when they start to feel pain. This fear arises from knowing why they feel this pain and not being told what normal labor pain would be like. In addition, during our placement in this department, the midwives discussed about 17 In addition, during our placement in this department, the midwives discussed about the lack of staff. On many rotations, there were only two midwives that had to take care of about to 10-15 patients. Therefore, it is impossible for them to give too much of their time to one patient. Hence, the patients might feel a lack of support, attention and affection, which often caused them to be nervous and feel unprepared to deliver a baby. Also, any family members could not accompany the pregnant women in the delivery ward. This is due to the fact that the sections in the ward that women stayed in were not isolated. Therefore, they were exposed and it is not appropriate for others to see them while giving birth. Also, these compartments were far too small to fit more than the patient and the caregivers. Finally, it is important to be aware that the emotional state of the mother can have an affect on the cervical dilation, the descend of the baby and even on the ability of the mother to push when needed often with the lack of self-confidence and the great amount of fear. All in all, one missing P out of the four is enough to schedule a C-section. 18 Un manque de ressources influençant la pratique La première chose qui saute aux yeux lorsque l’on met les pieds dans un hôpital tanzanien est le manque de technologies nécessaires au dépistage et au maintien de la santé des patients. En effet, à Iringa Regional Hospital, il est possible de retrouver deux sortes d’appareils c’est-à-dire un appareil d’imagerie utilisant les rayons X pour faire des radiographies et un appareil d’ultrason. Puisque les ressources sont limitées, les diagnostics réservés aux patients sont basés en grande partie sur l’expérience des médecins comparés aux diagnostics posés au Canada. 19 Que ce soit en Tanzanie ou au Canada, il existe plusieurs étapes entre l’arrivée d’un patient et le moment où il reçoit son traitement. Bien que le cheminement puisse différer légèrement, le but ultime est de remédier aux problèmes de santé du patient. En Tanzanie, ce cheminement comporte 10 étapes bien distinctes les unes des autres : 1- Noter les informations de base du patient c’est-à-dire son nom, son sexe, des noms de relatifs, la religion, etc. Ces détails sont importants puisqu’ils peuvent influencer le traitement général du patient. 2- Prendre en note la complainte principale du patient, autrement dit, quelle est la majeure raison de sa visite à l’hôpital et depuis combien de temps persiste le mal. 3- Demander des précisions sur les autres symptômes ressentis par le patient, pour pouvoir donner un diagnostic précis à la fin de la prise des informations. 4- S’assurer du bon fonctionnement des onze systèmes composants le corps humain : le système urinaire, le système cardiovasculaire, le système digestif, le système endocrinien, le système reproducteur, le système nerveux, le système respiratoire, le système musculaire, le système osseux, le système tégumentaire et le système lymphatique. Tous les systèmes sont complémentaires, donc un débalancement d’un système peut en influencer d’autres. 5- Prendre l’historique de la famille pour s’assurer qu’il n’y ait pas de maladies génétiques. 20 6- Prendre l’historique social, c’est-à-dire les habitudes de vie qui peuvent influencer la santé en général comme l’absorption d’alcool ou de drogues, les habitudes concernant la cigarette et les habitudes sexuelles. 7- Faire un examen général pour vérifier l’état du corps. L’examen se fait de la tête aux orteils par le médecin. 8- Porter une attention particulière à la cage thoracique et à l’abdomen après l’examen général. Lors de cet examen, l’abdomen est séparé en 9 parties plutôt semblables en superficie et chaque partie va être plus ou moins spécifique à un organe, ce qui va permettre un diagnostic plus précis. 9- Continuer l’investigation en prenant les signes vitaux, le niveau d’hémoglobine ou même une radiographie si nécessaire. 10- Diagnostiquer et traiter le patient avec les ressources disponibles. 21 Le manque de technologies entraîne un diagnostic plutôt basé sur l’expérience que sur les résultats des différents examens comme c’est le cas au Canada. Les patients qui arrivent avec des signes et des symptômes typiques d’une maladie comme la malaria par exemple, peuvent être traités sur le champ, même s’ils n’ont pas été testés auparavant. Ce fut le cas d’une patiente de 14 ans qui arriva avec différents signes et symptômes de la malaria. Automatiquement, elle reçut par intraveineuse le médicament contre la malaria c’est-à-dire la quinine, un anti-paludisme provenant d’un arbuste. Après avoir absorbée la médication, ses prises de sang sont revenues du laboratoire et ont été testées négatives au paludisme. Dans ce cas, malgré le résultat, la médication a fait effet et la jeune adolescente se sentait mieux par la suite, mais dans d’autres cas, la médication aurait pu empirer les symptômes puisque son utilisation n’était pas vraiment valider ou même venir interagir avec les prochains médicaments. Ceci est un exemple qui démontre que l’expérience prédomine en Tanzanie dû au manque de ressources et de temps. Au contraire au Canada, les médecins vont se baser sur leurs connaissances et sur les résultats des différents tests pour porter un diagnostic et agir en conséquence. L’erreur commise au Canada par un médecin va avoir des grandes répercussions sur sa carrière, donc il doit s’assurer d’avoir des preuves à l’appui de son résonnement, tandis qu’en Tanzanie, l’erreur commise par un médecin va plutôt servir d’exemple à ne pas reproduire, mais il n’y aura pas de conséquences direct sur le médecin. Ce facteur influence le cheminement pris par les médecins dans les deux différents pays. 22 Comme il a été dit précédemment, il y a seulement deux appareils en place à Iringa Regional Hospital qui permettent une plus grande investigation des divers symptômes des patients. Pour commencer, l’appareil d’ultrason est peu utilisé dans l’hôpital puisque le personnel ne sait pas comment s’en servir, à l’exception d’un médecin spécialisé en obstétrique. Cet appareil fut donné par un hôpital italien qui a un partenariat avec l’hôpital tanzanien. Pour continuer, l’établissement a en sa possession un appareil de radiographie utilisant les rayons X comme outils d’imagerie. Malheureusement, l’appareil représente une source de radioactivité qui peut être dommageable puisque l’appareil n’est pas nouveau. Nous sommes exposés à chaque jour à une petite quantité de radioactivité provenant de notre environnement. La quantité de radiation absorbée par le corps humain est calculée en sievert qui représente des joules par des kilogrammes 5. Nous recevons environ 3 mSv par année 6. Pour donner un exemple, une radiographie d’un poumon faite par un appareil de rayon x au Canada représente 0,02 mSv, soit environ 2,4 jours de radiations dites naturelles 6. Cela n’est pas énorme, mais si une radiographie nécessite une plus grande quantité de radioactivité pour être efficace, comme c’est le cas des technologies moins récentes utilisées en Tanzanie, et que le patient en prend plusieurs durant une année, l’accumulation de toute cette radioactivité peut représenter un risque potentiel pour le patient 7. 23 En effet, il a été prouvé que la radiation peut causer le cancer. Cela se produit puisque les rayons X sont des ondes ayant une très grande quantité d’énergie et qui se promènent sous la forme de photons. Lorsque les photons sont absorbés par les différentes molécules composant les tissus du corps humain, il arrive que des électrons excités s’échappent de l’attraction de leur noyau, ce qui modifie la nature des molécules et entraîne des mutations pouvant causer le cancer 7. Ces mutations sont dues à la modification de l’ADN de la cellule, ce qui peut entraîner une reproduction incontrôlable et non désirée des cellules non viables, ce qui représente le développement du cancer. Le cheminement utilisé pour l’attribution d’un diagnostic peut différencier selon les pays, mais le but ultime dans chacun des cas reste de remédier au problème qui gêne la santé de la personne demandant de l’aide. Ce processus est grandement influencé par les ressources disponibles pour obtenir des réponses. Que ce soit une simple machine pouvant prendre la pression sanguine ou un CT scan, il est important d’utiliser tous les outils à notre disposition pour s’assurer du meilleur traitement possible. 24 Les principales maladies et les ressources mises en place pour les patients Le Canada et la Tanzanie sont deux pays qui ne se retrouvent pas dans les mêmes régions du globe ce qui entraîne inévitablement des différences dans les micro-organismes possibles pouvant causés des maladies. Ainsi, avant de partir dans un pays plus exotique, la prise de vaccin est fortement recommandée pour prévenir différentes maladies. Dans les vaccins et les médicaments pris avant et pendant le voyage, il est possible de retrouver un vaccin contre la fièvre typhoïde et des médicaments prévenant la malaria, deux maladies grandement répandues en Tanzanie. Premièrement, une bonne partie des patients traités en médecine générale sont causés par un manque de salubrité et d’éducation général. C’est le cas de ceux atteints de la fièvre typhoïde, d’une des multiples sortes de gastro-entérite, d’un empoisonnement alimentaire, de l’hépatite A et même de la malaria. Les micro-organismes qui causent ces différentes maladies peuvent se propager de différentes façons et ces moyens de propagation sont intimement liés à l’hygiène. Que ce soit par voie oro-fécale, comme c’est le cas d’un empoissonnement alimentaire, de l’hépatite A et de la fièvre typhoïde, ou par l’absorption d’eau contaminée, les moyens de propagations pourraient être réduits par de simples actions. Par exemple, le simple fait de laver ses mains après urination ou défécation réduit grandement les risques d’infecter une autre personne si nous sommes porteurs de la maladie. De plus, une bonne gestion des déchets réduit le contact avec les mouches et les moustiques porteurs de différentes maladies comme la malaria. 25 Deuxièmement, il est important de souligner la présence en Tanzanie des deux maladies les plus meurtrières des dernières décennies, c’est-à-dire le VIH et la tuberculose. Le VIH, ainsi que les mesures de santé destinées à la prévention et au traitement, vont être discutées amplement dans une autre capsule. En ce qui a trait à la tuberculose, le majeur moyen de prévention est le vaccin BCG administré intradermique, autrement dit sous la peau, après la naissance de l’enfant. Ce vaccin va permettre la création d’anticorps qui vont être capable de reconnaître la bactérie Mycobacterium tuberculosis, celle qui est responsable du développement de la maladie 8. Le vaccin contient des bactéries vivantes, mais peu actives, ce qui va permettre la création d’anticorps spécifiques. Il existe trois majeures caractéristiques qui sont propres aux anticorps 9. Pour débuter, ils vont détruire les antigènes, c’est-à-dire des molécules qui ne sont pas propre à notre organisme. En d’autres mots, ils sont capables de faire la différence entre les composantes du soi, c’est-à-dire toutes les molécules et les cellules nous composant, et les composantes extérieures. De plus, les anticorps sont spécifiques et se souviennent. Ils sont créés après l’infiltration d’une sorte précise de micro-organismes dans notre organisme et ils vont avoir une réponse dans le cas où il y a la présence de cet antigène dans notre organisme 9. Si un nouvel agent pathogène se retrouve dans notre organisme, il va y avoir la formation d’anticorps et cela est le but ultime du vaccin. En introduisant des bactéries vivantes, mais non dommageables, la réponse de l’organisme va être la création d’anticorps spécifiques pour la sorte de bactérie causant la tuberculose et à l’avenir l’individu pourra éradiquer la bactérie avant qu’elle se propage et crée des dommages permanents 9. L’efficacité du vaccin est d’environ 50 % puisqu’il existe plusieurs variantes de la bactérie causant la tuberculose 8. Heureusement, le vaccin dure entre 50 et 60 ans. 26 Troisièmement, il ne faut pas oublier les maladies causées par les défaillances de notre propre corps. Les maladies reliées au système cardiovasculaire, le cancer et le diabète sont présents à travers le globe. Malheureusement, en Tanzanie, le manque de ressources fait en sorte qu’il est difficile de traiter les patients atteints de ces maladies, à l’exception du diabète. Puisqu’il n’y a pas de dialyse, peu de transplantation d’organes, sauf les reins, et de traitements contre le cancer comme la chimiothérapie, les patients souffrant des maladies dites précédemment ont souvent un avenir peu optimiste. Cela contraste avec le Canada où un diagnostic comme celui-ci n’est pas synonyme de décès. Malgré les nombreuses ressources disponibles pour traiter les différentes maladies ici, les maladies cardiovasculaires et le cancer sont les deux principales causes de décès et représentent la moitié des décès. Par exemple, en 2009, 29,8 % des décès sont causés par le cancer et 20,7 % sont causés par des maladies du cœur 10. La pression sanguine; un des principal signe avant-coureur des maladies cardiovasculaires D’un bout à l’autre du globe, certaines maladies changent et évoluent tandis que d’autres pathologies restent inchangées, mais toutes aussi meurtrières. Que l’on parle du VIH ou des maladies cardiovasculaires, il est important de cibler les maladies les plus ravageuses pour pouvoir y remédier. Cette éradication passe par la prévention, l’éducation et la recherche. 27 En conclusion … Il est certain que les principales maladies traités dans les centres de santé à travers le globe se rapportent au mode de vie et au milieu dans lequel chacun vie. La récurrence de certaines maladies va entraîner la recherche et le développement des ressources pour remédier à ces problèmes de santé, ce qui entraîne une spécification des différents milieux de santé dépendamment de la situation géographique et économique. Ainsi, les différentes parties du monde sont spécialistes dans les domaines qui les affectent, mais il est important d’assurer une équité, car tous les êtres humains ont droit à l’accès aux services hospitaliers. De plus, il est important de mettre l’accent sur la prévention qui se fait majoritairement par l’éducation, puisque c’est la première étape pour améliorer la santé de chacun. 28 References **ALL INFORMATIONS PRESENT IN THE TEXT THAT DOES NOT CONTAIN SOURCES ARE TAKEN FROM THE NOTES WE HAVE WRITTEN DURING OUR PLACEMENT AT THE IRINGA REGIONAL HOSPITAL** "PMTCT in Tanzania." PMTCT Tanzania — National Resource Center for Prevention of Mother-toChild HIV Transmission. N.p., n.d. Web. 21 May 2013. <http://pmtct.or.tz/pmtcttanzania/pmtct-in-tanzania/>. 2 "United Republic of Tanzania: PMTCT." UNITE FOR CHILDREN UNITE AGAINST AIDS. N.p., n.d. Web. 18 May 2013. <www.unicef.org/aids/files/Tanzania_PMTCTFactsheet_2010.pdf>. 3What is HIV antiretroviral treatment? | FoundCare." Home | FoundCare. N.p., n.d. Web. 21 May 2013. <http://www.foundcare.org/HIV-Antiretroviral-Treatment>. 4"Countdown To Zero." Unite For Children Unite Against AIDS. N.p., n.d. Web. 18 May 2013. <http://www.emtct-iatt.org/wp-content/uploads/2012/10/PMTCT-FactsheetTanzania.pdf>. 29 5"La mesure du rayonnement et l'évaluation de ses effets." Sievert. N.p., n.d. Web. 20 May 2013. http://www.sievert-system.org/WebMasters/fr/contenu_mesure.html. 6Deschênes, Sylvain. "Effets de la radiation en imagerie diagnostique."Réseau mère-enfant CHU Sainte-Justine. N.p., n.d. Web. 20 May 2013. <www.chu-sainte- justine.org/documents/Pro/radiation%20dr%20Desch%C3%AAnes.pdf>. 7"Radiation Exposure and Cancer."American Cancer Society | Information and Resources for Cancer: Breast, Colon, Lung, Prostate, Skin. N.p., n.d. Web. 20 May 2013. <http://www.cancer.org/cancer/cancercauses/othercarcinogens/medicaltreatments/radiatio n-exposure-and-cancer>. 8"MYCOBACTERIUM TUBERCULOSIS - Agent de la Tuberculose." INRS - Page d'accueil. N.p., n.d. Web. 21 May 2013. http://www.inrs.fr/eficatt/eficatt.nsf/(allDocParRef)/FCTUBERCULOSE.html. 9"IMMUNOLOGIE - CHAPITRE HUIT FORMATION DES ANTICORPS."Microbiologie et immunology On-line. N.p., n.d. Web. 21 May 2013. <http://www.microbiologybook.org/French-immuno/immchapter8.htm>. 10"Principales causes de décès, selon le sexe (Les deux sexes)." Statistics Canada: Canada's national statistical agency / Statistique Canada : Organisme statistique national du Canada. N.p., n.d. Web. 23 May 2013. <http://www.statcan.gc.ca/tables-tableaux/sum-som/l02/cst01/hlth36afra.htm>.