INSTRUCTIONS This booklet contains self-study questions of different types. Be sure you understand the directions accompanying the questions before attempting to answer them. All of your answers should be recorded on the separate answer sheet, which is enclosed. The six-digit Identification Number printed in the box above the column labeled ACE ID# will be the only means of identifying your scores. Fill in one number in each box and the corresponding circle under each digit as shown in the SAMPLE below. Only one digit should be marked in each column. Be sure all pencil marks are heavy and black. Marks should completely fill the circles. You need not enter your Social Security Number. Please note that this answer sheet has spaces for filling in more answers than are actually included in this booklet. Ignore the part of the answer sheet after number 122. It is requested that you answer the demographic questions (items 101-122) at the back of this booklet and mark these answers on the answer sheet. Cumulative information gained will be used to describe the total group of participants in the program and will help guide the development of future educational programs. After you have submitted your answer sheet for scoring, an individualized Performance Report, which provides a record of your answers, an evaluation of your performance, and the correct answers, will be returned to you. It is suggested that you keep a record of your answers in this booklet as well as a record of the Identification Number printed on your answer sheet in case you have any questions concerning the scoring of your materials. The completed answer sheet should be submitted for scoring in the pre-addressed postpaid envelope provided. Scoring on this exercise will end on September 30, 2008. DIRECTIONS FOR ITEMS 1-100. Each of the questions or incomplete statements below is followed by four suggested answers or completions. Select the one that is best in each case and fill in the circle containing the corresponding letter on the answer sheet. 1. Which of the following is MOST likely to minimize pain with fewest side effects for patients undergoing laparoscopic cholecystectomy? (A) (B) (C) (D) 2. A 63-year-old female developed worsening metabolic acidemia on postoperative day one following uneventful coronary artery bypass surgery. With FIO2 = 0.5, arterial blood gas analysis reveals pH 7.24, PaCO2 30 mm Hg, PaO2 257 mm Hg, and base deficit 14. Serum electrolyte determinations include Na+ 138 mEq/L, K+ 3.4 mEq/L, Cl- 112 mEq/L, HCO3- 8mEq/L. Based on these results, the patient is MOST likely to have which of the following? (A) (B) (C) (D) 3. NaCl administration Acute renal failure Mesenteric ischemia Severe magnesium deficiency Which of the following is MOST likely to be associated with the use of ketamine? (A) (B) (C) (D) 5. A metabolic acidosis with an increased anion gap A metabolic acidosis with a normal anion gap A metabolic acidosis with a decreased anion gap A mixed metabolic and respiratory acidosis Which of the following is MOST likely to result in a metabolic acidosis with an increased anion gap? (A) (B) (C) (D) 4. Regular (scheduled) dosing of nonsteroidal antiinflammatory drugs Regular (scheduled) dosing of intravenous opioids Epidural local anesthetic Epidural opioids Maintenance of spontaneous respiration Profound depression of airway reflexes Decreased intracranial pressure Absence of analgesia Which of the following is MOST likely to increase the concentration of carbon monoxide (CO) during the administration of a volatile anesthetic? (A) (B) (C) (D) Recent use of the absorber Use of lower anesthetic concentrations Use of high fresh gas flows during administration of anesthesia Excessive drying of the absorbent 1 6. An otherwise healthy patient indicates that 10 years ago her brother required mechanical ventilation due to a prolonged response to succinylcholine. At the time of her sibling’s problem she was tested and found to have a dibucaine number of 18. Based on this information, which of the following is MOST likely true? (A) (B) (C) (D) 7. An infant has undergone an extensive surgical procedure and the surgeon intends to infiltrate the incision with local anesthetic. Which of the following is associated with the HIGHEST allowable dose of local anesthetic expressed as mg/kg? (A) (B) (C) (D) 8. Administration of 1 mg/kg of succinylcholine will likely result in a normal duration of apnea (5-10 minutes). Administration of 1 mg/kg of succinylcholine will likely result in a slightly prolonged duration of apnea (15-20 minutes). Administration of 1 mg/kg of succinylcholine will likely result in a very prolonged duration of apnea (> 60 minutes). The patient’s dibucaine number should be rechecked prior to administration of succinylcholine. Bupivacaine Levobupivacaine with 1:200,000 epinephrine Ropivacaine Lidocaine with 1:200,000 epinephrine In the United States, the MOST common etiology of mortality related to transfusion of blood products is (A) (B) (C) (D) bacterial contamination. hemolytic transfusion reaction. hepatitis C infection transfusion-related acute lung injury. 2 9. During a major surgical resection, the surgeon says that the field is “oozy” and a thromboelastogram (TEG) is performed. The graphical representation of the TEG is shown in comparison to a normal TEG. Which of the following is the MOST likely cause of the derangement of coagulation? (A) (B) (C) (D) 10. In the preoperative evaluation clinic a 74-year-old man complains of dyspnea on exertion. On auscultation of his precordium, he has a systolic ejection murmur that is heard best at the second right intercostal space and radiates to the carotid arteries. This patient MOST likely has which of the following valvular lesions? (A) (B) (C) (D) 11. Mitral stenosis Mitral regurgitation Aortic stenosis Aortic regurgitation Which of the following represents the MOST important hemodynamic goal in a patient with a severe valvular aortic stenosis? (A) (B) (C) (D) 12. Thrombocytopenia Heparin administration Fibrinolysis Hemophilia B Heart rate over 100 beats/min Decreased preload Decreased contractility Maintenance of afterload Which statement about dopamine is MOST likely true? (A) (B) (C) (D) At high doses it decreases systemic vascular resistance. The drug has central nervous system effects. An infusion at mcg · kg-1 · min-1 will decrease the chance of developing acute renal failure after major vascular surgery. It causes bradycardia. 3 13. During the preoperative assessment, a patient indicates he takes garlic to prevent heart disease. His prothrombin time, partial thromboplastin time, activated thromboplastin time, and platelet count are normal. The surgeon proceeds with the suprapubic prostatectomy. The patient’s coagulation studies remain unchanged; however the surgeon cannot achieve hemostasis. The BEST treatment would be to administer (A) (B) (C) (D) 14. An otherwise healthy 26-year-old man is scheduled to undergo the final stage of a two-stage spinal surgery for scoliosis. He is a devout Jehovah’s Witness. During the first stage of his surgery two months ago, he received aprotinin to minimize surgical blood loss. Which of the following is the single MOST appropriate step to improve his surgical outcome without violating his religious beliefs? (A) (B) (C) (D) 15. aminocaproic acid. 1-deamino-8-D-arginine vasopressin (DDAVP) alone. DDAVP and platelet transfusion. aprotinin. Autologous blood donation Administration of erythropoietin four weeks prior to surgery Administration of aprotinin Prophylactic administration of recombinant activated factor VII Shortly after uneventful tracheal intubation of a healthy 21-year-old athlete the following waveform is noted on the capnogram. The MOST likely cause of this waveform is (A) (B) (C) (D) 16. bronchial intubation. incompetent expiratory valve. incompetent inspiratory valve leak in the sampling line Which of the following values for arterial oxygen tension (PaO2) is MOST likely outside the normal range for the indicated age for a patient breathing air at sea level? (A) (B) (C) (D) 25-year-old male; PaO2 = 95 mm Hg 42-year-old female; PaO2 = 85 mm Hg 57-year-old male; PaO2 = 75 mm Hg 77-year-old female; PaO2 = 60 mm Hg 4 17. Which of the following parameters is MOST likely to be part of the orders for pressure support ventilation (PSV)? (A) (B) (C) (D) 18. In a severely asthmatic parturient, which of the following drugs would be the MOST appropriate treatment for postpartum uterine atony? (A) (B) (C) (D) 19. The closing volume increases with age. The response to beta-adrenergic agonists increases with age. There is progressive atrophy of the left ventricle with age. There is a steady increase in the chest wall compliance with age. You are asked to assist with a neonatal resuscitation. The amniotic fluid was noted to be meconium stained at delivery. The infant is crying, vigorous, and has a heart rate over 100 beats per minute. Which statement about the role of tracheal intubation in this situation is MOST likely true? (A) (B) (C) (D) 21. Ergometrine Oxytocin Methylergonovine 15-Methyl prostaglandin F2-alpha (Hemabate) Which statement about age-related physiologic changes in geriatric patients (age ≥ 65) is MOST likely true? (A) (B) (C) (D) 20. Tidal volume Rate Inspiratory pressure Inspiratory flow rate Tracheal intubation should be initiated with suctioning of the tracheal tube as it is withdrawn. Tracheal intubation is only necessary if oropharyngeal suctioning was not performed by the obstetrician prior to delivery of the shoulders (intrapartum suctioning). Tracheal intubation should not be performed. Tracheal intubation with saline lavage should be performed. You are caring for a postpartum patient with a retained placenta. The obstetrician is having difficulty with manual removal of the placenta and requests uterine relaxation. Assuming this patient is hemodynamically stable, administration of which of the following agents is the MOST appropriate initial therapy to facilitate uterine relaxation? (A) (B) (C) (D) Fentanyl Halothane Nitroglycerine Ketamine 5 22. In which of the following situations is work of breathing MOST efficient with slow, deep breaths? (A) (B) (C) (D) 23. Arterial and venous blood gases are drawn from a healthy patient breathing room air. In the process, a bubble fills one third of the volume of each syringe. Which statement MOST accurately reflects the change in the blood gases that will occur as the result of the bubble? (A) (B) (C) (D) 24. The PO2 of the arterial sample will be decreased. The PO2 of the venous sample will be decreased. The PCO2 of the arterial sample will be increased. The PCO2 of the venous sample will be decreased. Which of the following is MOST likely to be associated with a P50 (the partial pressure of oxygen at which hemoglobin is 50% saturated) of 22 mm Hg? (A) (B) (C) (D) 25. Pulmonary fibrosis Aspiration pneumonia Pulmonary edema Chronic obstructive lung disease Fetal hemoglobin Normal hemoglobin in the presence of nitrous oxide Carboxyhemoglobin Normal hemoglobin in a healthy parturient Which of the following pulmonary artery occlusion pressure waveform findings would MOST likely be present during left ventricular ischemia? (A) (B) (C) (D) Increase in the width of the a wave Increase in the height of the a wave Decrease in the width of the v wave Decrease in the height of the v wave 6 26. A recently published article that compares four commercially available tests contains the following figure. Which receiver operating characteristic (ROC) curve (A, B, C, or D) represents the test BEST able to discriminate patients with the disease from those without the disease? 27. Which statement about the differences between the respiratory system in healthy infants and adults is MOST likely true? (A) (B) (C) (D) 28. An 85-year-old nursing home resident with a history of diabetes mellitus requires emergent laparotomy for presumed bowel perforation. Which of the following laboratory analyses would be MOST consistent with a concomitant diagnosis of hyperglycemic hyperosmolar nonketotic syndrome (HHNS)? (A) (B) (C) (D) 29. Infant dead space as a fraction of body weight is substantially larger than that of adults. Infant work of breathing is greater than that of adults. Closing capacity is a similar fraction of total lung capacity in infants and adults. Functional residual capacity as a fraction of body weight is smaller in infants than in adults. Arterial pH 7.15 Serum osmolality 280 mOsm/kg Serum bicarbonate concentration 20 mEq/L Plasma glucose concentration 340 mg/dL Which statement about the use of epidural 2-chloroprocaine for cesarean delivery is MOST likely true? (A) (B) (C) (D) It enhances the efficacy of epidural morphine. It is contraindicated when late fetal heart rate decelerations are present. The risk of systemic toxicity is increased in a woman homozygous for atypical plasma cholinesterase. The ethylenediaminetetraacetic acid (EDTA) present in some formulations of 2chloroprocaine causes neurotoxicity. 7 30. Which statement about potential anesthetic concerns in a patient with ankylosing spondylitis is MOST likely true? (A) (B) (C) (D) 31. Which of the following opioids is “naturally” long acting such that it does not need to be provided in a sustained-release formulation? (A) (B) (C) (D) 32. Regional anesthesia is contraindicated. Fresh frozen plasma should be administered before surgery. Vitamin K should be administered before surgery. Low molecular weight heparin should be initiated in the postoperative period. Which statement about the oculocardiac reflex (OCR) is MOST likely true? (A) (B) (C) (D) 34. Morphine Hydromorphone Fentanyl Methadone A patient previously diagnosed with antiphospholipid syndrome presents for cesarean delivery for breech presentation. An activated partial thromboplastin time (aPTT) obtained earlier in the day was prolonged at 50 seconds. All other laboratory values, including prothrombin time, fibrinogen, and platelet count, were normal and she has not received recent anticoagulation therapy. Which statement about her perioperative management is MOST likely true? (A) (B) (C) (D) 33. There is an increased risk of neurologic injury with minimal neck extension. The tempromandibular joints are rarely affected. Aortic stenosis is the most common cardiac lesion. Pulmonary function studies are most likely to reveal an obstructive flow pattern. Pressure on the eye may cause a decrease in blood pressure. Retrobulbar block reliably prevents this reflex. The most common manifestation is aystole. Glycopyrrolate is ineffective in blunting the effects of the reflex. A 56-year-old man has suffered a massive subarachnoid hemorrhage and is intubated and mechanically ventilated in the intensive care unit. He is comatose, and unresponsive to painful stimuli. His Glasgow coma score is 5. He breathes above the rate set on the ventilator and has a cough when suctioned. The medical staff involved in his care feel that his prognosis for meaningful neurologic recovery is dismal. Based on a previously signed advanced directive, his family feels that the patient would desire withdrawal of life-sustaining therapies under these circumstances. He had previously expressed a strong desire to donate his organs for transplantation and his driver’s license indicates that he would wish to be an organ donor. Which statement about this patient’s situation is MOST likely true? (A) (B) (C) (D) The patient meets the criteria for brain death. The patient is too old to be a candidate for organ donation. “Donation after cardiac death” can occur without a formal declaration of brain death. Discussion with the family regarding organ donation should occur before the decision to withdraw life-sustaining therapies has been made. 8 35. Which statement about calcium antagonists is MOST likely true? (A) (B) (C) (D) 36. An anesthesiologist develops a new technique (technique X) to perform an ankle block for distal foot surgery. She believes that technique X will allow earlier patient dismissal from the ambulatory surgical center. Her colleagues are skeptical. She wishes to compare the new technique against the conventional approach to obtain definitive evidence of a decrease in time to discharge. The MOST common study design for this purpose is (A) (B) (C) (D) 37. It requires that the patient be in the prone position. It maximizes the patient’s tidal volume. It requires an intact respiratory drive. It delivers breaths at a frequency between 3 and 15 Hertz (breaths/sec). Which statement about methemoglobinemia is MOST likely true? (A) (B) (C) (D) 39. case control study. observational cohort study. randomized control trial. cross-sectional study. A patient with the acute respiratory syndrome (ARDS) is receiving high-frequency oscillatory ventilation (HFOV). Which statement about this method of ventilation is MOST likely true? (A) (B) (C) (D) 38. Verapamil has minimal effects on the atrioventricular node. Diltiazem is not available as an intravenous formulation. Nifedipine is the calcium antagonist of choice for the treatment of atrial fibrillation with rapid ventricular response. Nicardipine may be used as an anthihyperintensive. The treatment is with amyl nitrate. Neonates are at higher risk for development of methemoglobinemia. Methemoglobin levels of greater than 10% are commonly seen in smokers. The saturation reported on a conventional arterial blood gas will be less than that reported on a pulse oximeter. A healthy 42-year-old patient has undergone wrist surgery as an outpatient. He received general anesthesia using propofol for induction and sevoflurane via a laryngeal mask airway for maintenance of anesthesia. He also received an axillary block with 0.5% ropivacaine for postoperative analgesia. Based on the American Society of Anesthesiologists (ASA) guidelines for postanesthetic care, which of the following is MOST likely to be required before he is released home? (A) (B) (C) (D) Ability to drink clear liquids without vomiting Ability to urinate Presence of a responsible adult to accompany him home Resolution of the axillary block 9 40. Which statement about postoperative ulnar neuropathy is MOST likely true? (A) (B) (C) (D) 41. Which of the following is MOST likely to be increased as a result of administration of 100% oxygen to a normal, healthy patient for six hours? (A) (B) (C) (D) 42. more efficient removal of viral particle. less resistance to breathing. an increased risk of tracheal tube occlusion when used in a critical care setting. greater humidification. A patient has a pacemaker that detects an atrial stimulus and responds by stimulating the atrium only when the atrial rate is less than the lower rate limit. The three-letter designation of this pacemaker is MOST likely to be (A) (B) (C) (D) 45. Age less than 12 months Use of a cuffed tracheal tube Absence of an air leak around the tracheal tube at 40 cm H2O airway pressure Use of a lubricant on the tracheal tube Compared to a hydrophobic heat and moisture exchanger (HME), a hygroscopic HME is MOST likely to be associated with (A) (B) (C) (D) 44. Pulmonary compliance Vital capacity Shunt fraction PaCO2 Which of the following factors MOST likely increases the risk that a child will develop postextubation croup following a surgical procedure? (A) (B) (C) (D) 43. It is more common in women than men. It is more common after regional anesthesia than general anesthesia. Pronation of the forearm decreases the risk of developing this injury. It is the most common postoperative peripheral nerve therapy. AOO. DOO. VVI. AAI. Which statement about perioperative wound infections is MOST likely true? (A) (B) (C) (D) Maintenance of normoglycemia may be associated with a lower risk of wound infection. They account for 50% of nosocomial (hospital-acquired) infections. Perioperative oxygen supplementation may increase the incidence. Mild systemic hypothermia protects against wound infection. 10 46. Which statement about a practice advisory developed by the American Society of Anesthesiologists (ASA) is MOST likely true? (A) (B) (C) (D) 47. In which of the following situations is mannitol MOST likely to provide beneficial renal effects? (A) (B) (C) (D) 48. (D) Drowning in sea water is commonly associated with hypervolemia. Drowning in fresh water is commonly associated with profound hyponatremia. Surfactant deficiency is more likely to be present when a drowning occurs in fresh water than in sea water. In approximately 50% of drowning victims, laryngospasm prevents inhalation of significant quantities of water. Ten mL of blood from a healthy adult is divided into two equal aliquots. One is exposed to an oxygen-enriched environment and achieves an oxygen saturation (SO2) of 100%. All oxygen is removed from the environment of the second sample and its SO2 approaches 0%. Which of the following is MOST likely the PO2 of the sample after these aliquots are mixed together? (A) (B) (C) (D) 51. High doses are associated with systemic vasoconstriction. It has a half-life of four hours. Dosing should be adjusted for patients with advanced liver disease. Administration is associated with an increase in creatinine clearance. Which statement about drowning is MOST likely true? (A) (B) (C) 50. Renal transplantation Abdominal aortic surgery Contrast nephropathy Cardiac surgery with cardiopulmonary bypass Which statement about fenoldopam is MOST likely true? (A) (B) (C) (D) 49. It results from a meta-analysis of relevant published material. It does not include input from the members of the ASA. It is intended to be a guideline for practice. It includes opinions from experts. 100 mm Hg 50 mm Hg 26 mm Hg 10 mm Hg Which of the following conditions is MOST likely to increase the cardiac toxicity of bupivacaine? (A) (B) (C) (D) Bradycardia Hyopkalemia Hyperthermia Acidosis 11 52. Which of the following diuretics would be MOST effective in lowering serum potassium in a patient with life-threatening hyperkalemia? (A) (B) (C) (D) 53. Which of the following statements about transient neurologic symptoms (TNS) is MOST likely true? (A) (B) (C) (D) 54. It does not occur after combined spinal/general anesthesia. Use of lidocaine increases the risk by more than fourfold compared to bupivacaine. TNS has never been reported after a mepivacaine spinal anesthetic. The relative risk of TNS after a spinal anesthetic is 1/1,000. Which of the following would MOST likely decrease the mixed venous oxygen saturation (SVO2) of a mechanically ventilated patient? (A) (B) (C) (D) 55. Hydochlorothiazide Ethacrynic acid Triamterene Mannitol Status epilepticus Transfusion of packed red blood cells Initiation of dobutamine infusion Increasing inspired oxygen concentration Lung compliance (change in volume over change in pressure) is MOST likely to be greatest at which of the points (A, B, C, or D) on the static pressure volume curve below? 12 56. Compared with a full-term infant of the same postnatal age, a 2-month-old infant who was born at 32 weeks gestational age is at increased risk of developing which of the following in the perioperative period? (A) (B) (C) (D) 57. Which statement about the risk of developing retinopathy of prematurity is MOST likely true? (A) (B) (C) (D) 58. (D) Often tends to be worse at night Asymmetric proximal distribution of pain Evidence of neuropathy confirmed by nerve conduction velocity testing A prevalence of 2%-5% in patients with diabetes mellitus Which of the following medications is approved by the Food and Drug Administration for the treatment of diabetic peripheral neuropathic pain (DPNP)? (A) (B) (C) (D) 61. Children benefit from parental presence equally regardless of age. Most parents prefer not to be present during induction. Presence of a parent during induction is more effective than oral midazolam in relieving a child’s anxiety. Parental presence is associated with increased satisfaction of the parent for the perioperative experience. Which of the following is MOST characteristic of diabetic peripheral neuropathic pain (DPNP)? (A) (B) (C) (D) 60. Only patients exposed to high oxygen concentrations are at risk. Risk is proportional to birth weight. Risk is increased by alkalosis. Risk is minimal after 44 weeks postconceptional age. Which statement about parental presence during the induction of anesthesia for pediatric patients is MOST likely true? (A) (B) (C) 59. Hyperglycemia Hypercalcemia Malignant hyperthermia Apnea Carbamazepine Gabapentin Amitriptyline Duloxetine Which statement about anesthesia in a patient with Guillain-Barré syndrome is MOST likely ` true? (A) (B) (C) (D) Regional anesthesia is contraindicated. Autonomic dysfunction may result in profound hypotension. The response to nondepolarizing muscle relaxants is likely to be decreased. The response to indirect-acting vasoconstrictors is likely to be decreased. 13 62. A 45-year-old female weighs 100 kg and is 66 inches tall. Based on calculation of body mass index, she is MOST accurately classified as (A) (B) (C) (D) 63. Which statement about diffusion hypoxia is MOST likely true? (A) (B) (C) (D) 64. (C) (D) Preexisting obstructive sleep apnea will be exacerbated by pregnancy. The morbidly obese parturient will experience a greater percentage decrease of functional residual capacity (FRC) from prepregnant values compared to a nonobese parturient. The supine hypotensive syndrome is more severe compared to a nonobese parturient. Gastric volume is similar to that in a nonobese parturient. A 2-week-old neonate born at term has a three-day history of projectile vomiting and an oliveshaped mass palpable in the epigastrium. Which of the following is MOST likely to be present in this patient? (A) (B) (C) (D) 67. Glomerular filtration rate Ability to concentrate the urine Sodium losses Renal threshold for bicarbonate Which statement about a morbidly obese parturient is MOST likely true? (A) (B) 66. It may be a consequence of the administration of any volatile anesthetic agent. It occurs due to the high solubility of nitrous oxide in blood. It is most likely to occur in the postanesthesia care unit. It is more likely to occur if the patient has some degree of airway obstruction on emergence from anesthesia. Compared to normal values in adults, which of the following renal parameters is MOST likely to be increased in a neonate? (A) (B) (C) (D) 65. normal weight for height. overweight. obese. morbidly obese. Hypernatremia Hyperkalemia Hyperchloremia Metabolic alkalosis Which of the following surgical procedures is associated with the LOWEST risk of complications related to sickle cell disease in a susceptible patient? (A) (B) (C) (D) Dilatation and curettage Cesarean delivery Cholecystectomy Tonsillectomy and adenoidectomy 14 68. Compared to adults receiving an equivalent dose of fentanyl (expressed as mcg/kg), which of the following is MOST likely to be decreased in a 21-day-old neonate born at term? (A) (B) (C) (D) Serum blood level Volume of distribution Clearance Elimination half-life 69. Electrocardiographic guidance is used to insert a multi-orificed central venous pressure (CVP) catheter into the right atrium in a patient undergoing a craniotomy in the sitting position. The ECG is set to monitor lead II and the leg lead is connected to a specialized CVP catheter designed for this purpose, which is filled with sodium bicarbonate. Which of the following ECG traces MOST likely indicates that the tip of the catheter is located in the middle of the right atrium? 70. Which of the following is MOST likely required to establish the diagnosis of fibromyalgia? (A) (B) (C) (D) Widespread pain above and below the waist Elevated erythrocyte sedimentation rate Lymphadenopathy Abnormal deep tendon reflexes 15 71. Which of the following is MOST likely to produce resolution of pain symptoms in a patient with fibromyalgia? (A) (B) (C) (D) 72. Which statement about the diffusing capacity for carbon monoxide (DLCO) is MOST likely true? (A) (B) (C) (D) 73. esmolol. hydralazine. nitroglycerin. metoprolol. Which statement about neonatal abdominal wall defects (ie, gastroschisis and omphalocele) is MOST likely true? (A) (B) (C) (D) 76. Emphysema Atelectasis Exercise Bleomycin-induced pulmonary toxicity A 27-year-old male presents for open reduction and internal fixation of an open tibia fracture sustained in a fall several hours ago. His urine drug screen in the emergency room is positive for cocaine. In the preoperative holding area his blood pressure is 190/110 mm Hg and his heart rate is 120 beats/min. He is agitated. The BEST medication to treat his hypertension is (A) (B) (C) (D) 75. Carbon monoxide diffuses across the alveolar/capillary membrane more rapidly than oxygen. Decreased DLCO is a highly specific indicator of decreased diffusing capacity of the alveolar/capillary membrane (“alveolar/capillary block”). The value of DLCO is uninfluenced by inspired oxygen concentration. DLCO is a useful indicator of progression of lung disease. Which of the following conditions is MOST likely to be associated with an increase in the diffusing capacity for carbon monoxide (DLCO)? (A) (B) (C) (D) 74. Glucocorticoids Nonsteroidal antiinflammatory drugs Prolonged rest Tricyclic antidepressants Omphaloceles are commonly associated with other congenital anomalies. Ventilation usually improves after primary repair of a large defect. Intraoperative fluid management typically includes the administration of isotonic crystalloid at the standard maintenance rate. Gastroschisis is more common than omphalocele. Which statement about emergence agitation in pediatric patients is MOST likely true? (A) (B) (C) (D) Using sevoflurane for induction then switching to isoflurane prevents emergence agitation. Midazolam premedication reliably prevents emergence agitation. It is frequently confused with postoperative pain. It is more likely to occur in older rather than preschool-aged children. 16 77. Which statement about intussusception is MOST likely true? (A) (B) (C) (D) 78. A healthy 23-year-old parturient is having uterine contractions every three minutes and is requesting pain relief. Her cervix is dilated 2 cm. According to the American Society of Anesthesiologists Practice Guidelines for Obstetric Anesthesia, which statement about performing epidural labor analgesia in this patient is MOST likely true? (A) (B) (C) (D) 79. 81. Epidural analgesia should not be performed until she reaches a cervical dilation of 4 cm. A platelet count should be obtained before proceeding with epidural placement. She may continue to ingest clear liquids after initiation of epidural analgesia. Continuous fetal heart rate monitoring must be maintained during epidural placement. Which statement about the toxicity of amiodarone is MOST likely true? (A) (B) (C) (D) 80. Ultrasonography is ineffective in establishing the diagnosis. Patients are at increased risk for aspiration of gastric contents. Reduction by enema is associated with recurrence in approximately 50% of patients. The classic triad (abdominal pain, currant jelly stools, and a palpable abdominal mass) is present in approximately 90% of children with intussusception. Toxicity does not occur if the drug is administered intravenously rather than orally. Amiodarone-induced corneal microdeposits commonly reduce visual acuity. Refractory bradycardia necessitating pacemaker placement may occur. Hyperthyroidism is not a manifestation. In which of the following is hyponatremia consistent with the syndrome of inappropriate antidiuretic hormone (SIADH)? Serum osmolality Volume status (A) High Euvolemic (B) Low Euvolemic (C) High Hypovolemic (D) Low Hypovolemic Which statement about the psoas compartment (lumbar plexus) block is MOST likely true? (A) (B) (C) (D) Only 5-10 mL of local anesthetic is required. The psoas compartment lies between the psoas major and the quadratus lumborum muscles. The entire lower extremity can be anesthetized using this technique alone. The needle should be aimed to contact the transverse process of L1. 17 82. Which statement about the anatomy for cannulation of the subclavian vein is MOST likely true? (A) (B) (C) (D) 83. A 23-year-old woman with myasthenia gravis and receiving pyridostigmine presents for thymectomy. Which statement about her anesthetic management is MOST likely true? (A) (B) (C) (D) 84. Transesophageal echocardiography Pulmonary artery pressure monitoring End-tidal carbon dioxide monitoring Precordial Doppler ultrasound A patient with a history of obstructive sleep apnea (OSA) is scheduled for an outpatient procedure at your facility. According to the American Society of Anesthesiologists practice guidelines on the management of patients with OSA, which of the following statements is MOST likely true? (A) (B) (C) (D) 87. Her platelet aggregation will be abnormal. Her platelet count will be low. Administration of desmopressin will increase von Willebrand factor levels for 48 hours. Her factor IX level will be low. Which of the following is the MOST sensitive technique for detecting vascular air embolism (VAE)? (A) (B) (C) (D) 86. An increased dose of nondepolarizing muscle relaxants will be required. Pyridostigmine will prevent the muscle relaxant effects of volatile anesthetics. A decreased dose of opioid analgesics should be administered. The duration of action of succinylcholine will be decreased. A 32-year-old woman with von Willebrand disease presents for an elective surgical procedure. Which statement about her hematologic status is MOST likely true? (A) (B) (C) (D) 85. The subclavian vein lies posterior to the medial third of the clavicle. The subclavian vein lies posterior to the apical portion of the pleura. The subclavian vein does not remain patent in a hypovolemic patient. Cannulation of the subclavian vein is usually performed by the supraclavicular approach. Clinical signs and symptoms reliably predict the severity of OSA. Choice of anesthetic technique appears to be the most important determinant of postoperative complications. During moderate sedation ventilation should be monitored with capnography. If general anesthesia is utilized, awake intubation is recommended. Performance of a regional anesthesia technique using ultrasound guidance is MOST difficult with which of the following blocks? (A) (B) (C) (D) Axillary block Interscalene block Sciatic nerve block at the popliteal fossa Epidural block 18 INSTRUCTIONS FOR ITEMS 88 AND 89: This series of items refers to the diagnosis, treatment, or management of a single patient. 88. After monitored anesthesia care with deep sedation using a propofol infusion for a carpal tunnel release under local anesthesia, a 56-year-old woman is alert and oriented on arrival in Phase 2 Recovery but develops increasing disorientation, lethargy, and then becomes difficult to arouse. Her past medical history includes endovascular coil embolization of a left middle cerebral artery aneurysm nine weeks ago as well as insulin-dependent diabetes. Vital signs include blood pressure 160/90 mm Hg, heart rate 54 beats/min, temperature 36.0°C. Her SPO2 is 96% on room air. Her change in mental status is MOST likely due to (A) (B) (C) (D) 89. hyperglycemia. opioid overdose. cerebral aneurysm rebleed. postictal state following a seizure. Imaging confirms the patient has a new subarachnoid hemorrhage (SAH). She is brought immediately to the operating room for a clip ligation of the aneurysm. Which of the following perioperative anesthetic management strategies is MOST likely to improve her neurological outcome? (A) (B) (C) (D) Maintaining her blood glucose below 140 mg/dL Decreasing her core body temperature to 33.5°C Administering magnesium rather than nimodipine Decreasing mean arterial pressure to 50 mm Hg 19 INSTRUCTIONS FOR ITEMS 90 THROUGH 92: This series of items refers to the diagnosis, treatment, or management of a single patient. 90. A 148 kg, 65 inch tall, 54-year-old woman has necrotizing fasciitis of the perineum and requires immediate surgery. Prior to this illness she had an exercise tolerance of two flights of stairs and poorly controlled hypertension. Vital signs include blood pressure 98/62 mm Hg, heart rate 115 beats/min, SPO2 94% on room air, temperature 38.2°C. She has received morphine and 5 liters of crystalloid in the emergency room. Which of the following statements about this patient is MOST likely true? (A) (B) (C) (D) 91. Which statement about drug administration in this patient is MOST likely true? (A) (B) (C) (D) 92. Her gastric volume is likely decreased. Her risk of fluid overload is low. Trendelenburg position would improve her ventilation mechanics. She is at increased risk of a fatal thromboembolic event. Drugs should be administered based on actual body weight (ABW). Renal clearance of drugs is not affected by obesity. Drugs should be administered based on ideal body weight (IBW). Some antibiotic doses should be adjusted for body weight. After an eight-hour surgical procedure, the patient is mechanically ventilated for 12 hours in the intensive care unit. During the second postoperative day, the patient complains of numbness and muscular pain in both legs and is noted to have brown urine and purpura on both legs. Which of the following statements is MOST likely true? (A) (B) (C) (D) Rhabdomyolysis occurs in obese patients who undergo long surgical procedures. Acidifying the urine will reduce renal injury. Her symptoms are the results of acute renal failure. The rash is caused by a drug reaction. 20 INSTRUCTIONS FOR ITEMS 93 AND 94: This series of items refers to the diagnosis, treatment, or management of a single patient. 93. A 53-year-old woman in the intensive care unit develops the following electrocardiographic changes. This ECG demonstrates which of the following? (A) (B) (C) (D) 94. Acute myocardial infarction Junctional tachycardia Prolonged QT interval Left bundle branch block Which of the following electrolyte abnormalities is MOST likely to be seen on analysis of this patient’s blood? (A) (B) (C) (D) Hyperkalemia Hypophosphatemia Hypomagnesemia Hypernatremia 21 INSTRUCTIONS FOR ITEMS 95 AND 96: This series of items refers to the diagnosis, treatment, or management of a single patient. 95. On the fifth postoperative day following coronary artery bypass surgery a 69-year-old male who had preexisting renal failure treated with hemodialysis is noted to have a decreasing platelet count. Type II heparin-induced thrombocytopenia (HIT) is suspected. Which statement about type II HIT is MOST likely true? (A) (B) (C) (D) 96. HIT is secondary to the destruction of platelets by IgM antibodies in the majority of patients. The risk of developing HIT is increased in cardiac surgical patients. The majority of morbidity from HIT results from complications related to bleeding. Arterial thrombosis occurs with a higher frequency than venous thrombosis. Heparin therapy is discontinued and laboratory findings confirm the diagnosis of type II heparininduced thrombocytopenia (HIT). Which of the following would be the MOST appropriate anticoagulant therapy for treatment? (A) (B) (C) (D) Low molecular weight heparin (LMWH) Warfarin Clopidogrel Argatroban INSTRUCTIONS FOR ITEMS 97 AND 98: This series of items refers to the diagnosis, treatment, or management of a single patient. 97. A 32-year-old woman presents at 10 weeks gestation for prenatal care. She has systemic lupus erythematosus (SLE). She takes prednisone daily. Which statement about her situation is MOST likely true? (A) (B) (C) (D) 98. She is at increased risk for preterm delivery. Renal function will improve during pregnancy. Prednisone should be discontinued. Her risk of intrauterine fetal demise is less than 5%. At 26 weeks gestation, fetal bradycardia of 60 beats/min is detected during ultrasound examination. A normal biophysical profile of the fetus is obtained. The MOST appropriate management at this time is (A) (B) (C) (D) emergency cesarean delivery. maternal intravenous administration of atropine. fetal scalp pH testing. initiation of long-term maternal dexamethasone therapy. 22 INSTRUCTIONS FOR ITEMS 99 AND 100: This series of items refers to the diagnosis, treatment, or management of a single patient. 99. Following brainstem herniation an organ donor is brought to the operating room for harvest of solid organs, including heart, lungs, liver, and kidneys. Which statement about brain-dead, beating-heart donors is MOST likely true? (A) (B) (C) (D) 100. Brain death produces a generalized inflammatory response. Catecholamine storm follows reperfusion injury of the brainstem. Posterior pituitary failure is uncommon. Long-term graft survival is greater in recipients receiving organs from brain-dead, beating-heart donors than from living related donors. On surgical incision, the donor’s systemic arterial blood pressure increases and his left leg twitches. Activation of which of the following would MOST likely explain these events? (A) (B) (C) (D) Spinal cord reflex Central pain pathways Intact brainstem Parasympathetic pathways 23