ウサギの麻酔・鎮痛剤
薬剤


用量(mg/kg) &投与方法


注記
Anticholinergics – Prevents bradycardia and cardiac arrhythmias
0.02-0.05
Some rabbits have atropinase and atropine is quickly
Atropine
Once at induction. May need to administer booster dose.
IM or SC
metabolized
0.1 IM or SC
Once at induction. May need to administer booster dose.
Recommended: Glycopyrrolate
0.01 IV
Inhalation anesthetics – Must use precision vaporizer. Survival surgery requires concurrent pre-emptive analgesia. Mask or chamber induction without injected pre-medication may result in breath-holding
and injury.
Recommended:
Sevoflurane
Isoflurane
or 1-3% inhalant to effect (up to 5% for induction). Whenever general anesthesia is required
Up to 8% for Sevoflurane
Survival surgery requires concurrent pre-emptive analgesia.
Not acceptable for surgery as sole agent – usually used with
inhalant anesthetic to potentiate effect and lower required dose
Ketamine combinations – May sting on IM injection. May be used for pre-anesthesia prior to intubation and induction of isoflurane anesthesia or as general anesthesia.
May not produce surgical-plane anesthesia for major
35 – 50
As needed. If redosing use ¼ dose of each.
procedures. May be partially reversed with Atipamezole or
Recommended: Ketamine-Xylazine + 5 -10 IM or SC (in same syringe)
Yohimbine.
35-50
May not produce surgical-plane anesthesia for major
As needed. If redosing use ¼ dose each of ketamine and
Recommended:
+ 5 -10
procedures. May be partially reversed with Atipamezole or
xylazine only.
Ketamine-Xylazine-Acepromazine + 0.75 – 1.0 IM or SC (in same syringe)
Yohimbine.
35 – 50
+ 0.25 -0.5 IM or SC (in same syringe, or with
May not produce surgical-plane anesthesia for major
Ketamine-Medetomidine
As needed. If redosing use ¼ dose of each.
medetomidine adm. 10-20 minutes in advance)
procedures. May be partially reversed with Atipamezole.
only if pre-medicated with an anticholinergic
35 – 50
May be useful for restraint for performing short, not painful
Ketamine-Midazolam
+2 – 5 IM or SC
As needed
procedures.
(in same syringe)
Reversal agents for alpha 2 agents – Atipamezole is more specific for medetomidine than for xylazine (as a general rule, Atipamezole is dosed at the same volume as Medetomidine, though they are manufactured
at different concentrations)
Atipamezole
0.1 – 1.0 SC, IM, IV
Once. Repeat as needed.
To reverse medetomidine or xylazine
Yohimbine
0.2 – 2.0 IV or SC
Once. Repeat as needed.
For reversal of xylazine effects
Other injectable anesthetics
20 – 50 IV to effect and maintained with
intermittent bolus as needed
Consider supplemental analgesia (opioid or NSAID) for
Recommended for terminal/acute procedures only, with
Sodium pentobarbital (Nembutal)
or
invasive procedures. Rabbits have a very narrow window of
booster doses as needed
2-20 mg/kg/hr IV continuous infusion after
safety for pentobarbital. Apnea is common at anesthetic doses.
induction
As needed. Very short acting unless administered as a an Only useful IV, so therefore limited usefulness. Respiratory
Propofol
12-26 IV
IV drip.
depression upon induction is possible.
Opioid analgesia
Used pre-operatively for preemptive analgesia and For major procedures, require more frequent dosing than 12
0.01 – 0.1 SC or IP
Recommended: Buprenorphine
post-operatively every 6-12 hour
hour intervals. Consider multi-modal analgesia with a NSAID
Nitrous oxide (N2O)

投与回数
Up to 60% with oxygen
Whenever deep sedation or general anesthesia is required
Butorphanol
Morphine
0.1 – 0.5 IM, IV, SC
0.5 -5 IV or IM
Fentanyl patch
Patch /B.Wt.
25 µg/hr
Every 4-6 hours
Every 2-4 hours for 8 hours
Place patch 24 hours in advance of surgery and maintain
for up to 3 days. Alternatively, place at induction,
premedicate with morphine, adm. morphine at 4 and 8 hrs.
Useful for minor, short procedures
When fentanyl patch is placed at induction
When severe post-surgical pain is anticipated. Best placed on
the back at induction and covered by a bandage after surgery
Reversal agents for opioids
Naloxone
0.01 -0.02 IV, IM
Once as needed to reverse respiratory depression
Note that reversal will also remove the analgesic effect of the
opioid
Non-steroidal anti-inflammatory drugs for analgesia (NSAID) — Note that prolonged use may cause renal, gastrointestinal, or other problems. Used pre-operatively for preemptive analgesia and
post-operatively for postoperative analgesia. Depending on the procedure, may be used as sole analgesic, or as multi-modal analgesia with buprenorphine.
DRUG NAME
DOSE (mg/kg) & ROUTE
FREQUENCY
NOTES

Recommended:
Carprofen
Meloxicam
Flunixin meglubin
Banamine®
1.0 – 2.2 PO
0.1 – 0.3 PO, IM or SC
Every 12 hours
Adm. pre-op, then every 24 hours
For supplemental postop analgesia
1.0 IM only
Every 24 hours for no more than 3 days
Adm. pre-op, then
Ketorolac
0.3 – 0.5 IM, SC
every 12-24 hour
Ketoprofen
2 – 5 SC, IM
Adm. pre-op, then every 12-24 hour
Local anesthetic/analgesics (lidocaine and bupivacaine may be combined in one syringe for rapid onset and long duration analgesia)
DRUG NAME
DOSE (mg/kg) & ROUTE
FREQUENCY
Dilute to 0.5%, do not exceed 7 mg/kg total dose, SC or
Use locally before making surgical
Lidocaine hydrochloride
intra-incisional
incision
Dilute to 0.25%, do not exceed 8 mg/kg total dose, SC or
Use locally before making surgical
Bupivacaine
intra-incisional
incision
Useful for treating hyperthermia
NOTES
Faster onset than bupivacaine but short (<1 hour) duration of
action
Slower onset than lidocaine but longer (~ 4-8 hour) duration of
action