C. V. Harumi Jyonouchi, M. D.
CURRICULUM VITAE
NAME:
Harumi Jyonouchi, M. D.
ADDRESS:
Division of Pulmonary, Allergy/Immunology, and Infectious Diseases
Department of Pediatrics, New Jersey Medical School - UMDNJ
F570A MSB, 185 South Orange Ave.
Newark, NJ 07101-1709
EDUCATION:
Yokohama City University - Premedical
School of Medicine, Yokohama, Japan
1972
Yokohama City University - M. D.
School of Medicine, Yokohama, Japan
1976
POSTDOCTORAL TRAINING:
Showa University - Jr. Resident/Pediatrics
Fujigaoka Hospital, 2-30 Fujigaoka, Midori-Ku
Yokohama, Japan
1976-1977
"
-
Sr. Resident/Pediatrics
1977-1978
"
-
Jr. Pediatrician and
Teaching Assistant
1978-1980
POSITIONS HELD:
Sloan-Kettering Institute for Cancer Research
Visiting Research Fellow
New York, New York
1980-1981
Sloan-Kettering Institute for Cancer Research
Research Fellow
New York, New York
1981-1982
Oklahoma Medical Research Foundation
Sr. Research Scientist
Oklahoma City, Oklahoma
1982-1985
Oklahoma Children's Memorial Hospital
Fellow in Pediatric Immunology
Oklahoma City, Oklahoma
1983-1985
1
1
C. V. Harumi Jyonouchi, M. D.
All Children's Hospital
Immunology Fellow
St. Petersburg, Florida
1985
All Children's Hospital
Special Fellow (rotation in general
Pediatrics to fulfill the requirements
for the Board of Pediatrics)
St. Petersburg, Florida
1986
University of South Florida
All Children's Hospital
Allergy/Immunology Fellow
St. Petersburg, Florida
1987-1988
All Children's Hospital/University of South Florida
Bone Marrow Transplant Physician
Clinical Assistant Professor
St. Petersburg, Florida
1988-1989
University of South Florida
All Children's Hospital
Department of Pediatrics/St. Petersburg
Assistant Professor of Pediatrics
St. Petersburg, Florida
1989-1991
All Children's Hospital
Assistant Director
Immunoparameter Laboratory
St. Petersburg, Florida
1989-1991
University of Minnesota
Department of Pediatrics
Assistant Professor
Minneapolis, Minnesota
1991-1999
University of Minnesota
Department of Pediatrics
Associate Professor
Minneapolis, Minnesota
1999-2002
University of Minnesota
Combined Medicine/Pediatrics Allergy/Immunology Fellowship
Co-director
Minneapolis, Minnesota
2
1995-2002
2
C. V. Harumi Jyonouchi, M. D.
3
New Jersey Medical School, University of Medicine and Dentistry of New Jersey (UMDNJ)
Division of Pulmonary, Allergy/Immunology, and Infectious Diseases
Department of Pediatrics
Associate Professor
Newark, NJ
2002-present
LICENSES:
ECFMG Certificate
1982
FLEX
1984
State of Oklahoma
1984
State of Florida
1987
Board of Pediatrics
Recertified in Pediatrics
1989
1991, 1995, and 2001
State of Minnesota
1991
Board of Allergy and Immunology
1993, 2003
State of New Jersey
2002
HONORS:
Graduation of Yokohama City University, School of Medicine
Top of the class
1976
Fellowship, Leukemia Society of America, Inc.
1982-1984
Sr. Fellowship, Leukemia Society of America, Inc.
1984-1986
University of Minnesota
University Children's Foundation Scholar Award
1993
The second place award for The Nestlé Clinical Nutrition Award
for Enternal Nutrition
1997
The Award for appreciation of contributions in making a difference in the lives of the family and children
affected by autism from MN State Representative of ‘Unlocking Autism”
2002
COSAC – Health Care Provider of the Year Award
2006
PROFESSIONAL SOCIETIES/Committee:
Member, American Medical Association
1984-Present
3
C. V. Harumi Jyonouchi, M. D.
Member, American Association of Immunologists
1985-Present
Member, New York Academy of Science
1986-Present
Member, Society of Experimental Biology
and Medicine
1989-Present
Fellow, American Academy of Pediatrics
1990-Present
Member, Clinical Immunology Society
1991-Present
Member, Society of American Cancer Research
4
1991-2009
Member, Society of Mucosal Immunity
1993-Present
Member, Society of Pediatric Research
1993-Present
Member, American Academy of Allergy and
Immunology
1994-present
Review committee, Center for Scientific Review (NIH)
ZRG1 BNP
ZAT 1C
NCCAM study section
ZAT 1C (Dietary supplements)
July 29-30, 1999
July 11-12, 2000
Nov. 2000, Feb. 2001, Oct. 2001
May, 2001
Review committee, Congressional Directed Medical Research Program (CDMRP)
Autism Research Program
2009
October, 2009
Autism Research Program
2010
August, 2010
Editorial Board
Chief Editor - eMedicine (Pediatrics Section)
J Clin Med Res
2007 - present
2009-2011
PUBLICATIONS:
Peer-reviewed articles:
1.
Jyonouchi H and Yamaguchi M: A case of neonatal hyperbilirubinemia secondary due to Rh
incompatibility. (in Japanese) J Pediatr Practice 40:2008-2011, 1977.
2.
Jyonouchi H, Yanagisawa N, and Yamaguchi M: Hereditary spherocytosis requiring exchange
transfusion during the neonatal period with special reference to the morphological studies of HS
erythrocytes. (in Japanese) Acta Paediatr JPN 20:654-658, 1978.
3.
Jyonouchi H, Yanagisawa N, and Soneda Y: A case of neonatal gastric rupture complicating with
congenital diaphragm eventration. (in Japanese) Jap J Pediatr 31:395-398, 1978.
4.
Yamaguchi M, Shioda S, Jyonouchi H, Yamada K, and Ishikawa A: Infectious mononucleosis in
4
C. V. Harumi Jyonouchi, M. D.
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siblings. (in Japanese) Jap J Pediatr 31:2431-2435, 1978.
5.
Jyonouchi H, Shioda S, Yamaguchi M, Yamada K, Ishikawa A, and Ito M: Clinical studies of
infectious mononucleosis. (in Japanese) Jap J Pediatr 31:2436-2442, 1978.
6.
Yamaguchi M, Jyonouchi H, Sata T, Yokoi K, Yanagisawa N, Yamada K, and Ishikawa A:
Clinical and laboratory studies on mycoplasma pneumonia. (in Japanese) Pediatrics of Japan
19:313-319, 1978.
7.
Jyonouchi H, Yanagisawa N, Ishikawa A, and Ishihara K: One pedigree of hereditary spherocytosis
(HS): Scanning electron microscopic studies of HS erythrocytes in vitro. (in Japanese) J Clin
Electron Microsc 12:91-105, 1979.
8.
Jyonouchi H, Kurokawa Y, and Ishidawa A: Studies of RBC 2, 3-DPG in MCLS. (in Japanese)
Igaku No Ayumi 109:86-88, 1979.
9.
Jyonouchi H: Studies of RBC 2, 3-DPG levels in Childhood. 1. Studies on healthy children and
low birth weight babies. (in Japanese) J Showa Med Assoc 39:373-379, 1979.
10.
Jyonouchi H, Yanagisawa N, Ishikawa A, and Ishihara K: Scanning electromicroscopic studies on
the erythrocytes of hereditary spherocytosis III. Effect of propranolol-a beta blocking agent on the
erythrocyte of hereditary spherocytosis. J Clin Electron Microsc 12:5-6, 1979.
11.
Yamaguchi J, Isoyama K, Fujita Y, Jyonouchi H, Hanawa H, Yanagisawa N, Yamada K, and
Ishikawa A: Clinical studies on the complication of mycoplasma pneumonia. (in Japanese) Jap J
Infect Dis 54:173-179, 1980.
12.
Jyonouchi H, Yokoi K, and Ishikawa A: A congenital bronchobiliary fistula. Acta Paediatr JPN
(in Japanese) 84:1270-1277, 1980.
13.
Yamaguchi M and Jyonouchi H: Two cases of male Turner Syndrome. J Showa Med Assoc
40:76-82, 1980.
14.
Jyonouchi H and Yoshio T: A case of vascular purpura complicating with remarkable facial edema.
(in Japanese) Pediatrics of Japan 21:1981.
15.
Jyonouchi H, Kincade PW, Good RA, and Fernandes G: Reciprocal transfer of abnormalities in
clonable B lymphocytes and myeloid progenitors between NZB and DBA/2 mice. J Immunol
127:1232-1235, 1981.
16.
Jyonouchi H, Kincade PW, and Good RA: Immunosuppression of marrow B lymphocytes by
administration of Corynebacterium parvum in mice. J Immunol 127:2502-2507, 1981.
17.
Jyonouchi H, Cyong JC, Fernandes G, Day NK, and Good RA: Alteration of murine serum lipase
activity after allogeneic bone marrow transplantation. J Clin Immunol Immunopathol 22:94-104,
1982.
18.
Jyonouchi H, Kincade PW, Landreth KS, Lee G, Good RA, and Gershwin ME: Age-dependent
deficiency of B lymphocyte lineage precursors in NZB mice. J Exp Med 155:1665-1678, 1982.
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C. V. Harumi Jyonouchi, M. D.
6
19.
Jyonouchi H and Kincade PW: Changes in B lineage cell populations in liver and spleen of
neonatal mice. J Immunol 130:1616-1621, 1983.
20.
Jyonouchi H, Kincade PW, Good RA, and Gershwin ME: B lymphocyte lineage cells in newborn
and very young NZB mice. Evidence for regulatory disorders affecting B cell formation. J Immunol
131:2219-2225, 1983.
21.
Jyonouchi H, Kincade PW, and Misra HP: Analysis of the effects of erythrocytes on mitogendependent clonal proliferation of murine B lymphocytes. Cell Immunol 83:189-198, 1984.
22.
Jyonouchi H and Kincade PW: Precocious and enhanced functional maturation of B lineage cells in
New Zealand Black mice during embryonic development. J Exp Med 159:1277-1282, 1984.
23.
Jyonouchi H, Kincade PW, and Good RA: Age-dependent changes in B lymphocyte lineage cell
populations of autoimmune prone BXSB mice. J Immunol 134:858-864, 1985.
24.
Jyonouchi H, Kimmel MD, Lee G, Kincade PW, and Good RA: Humoral factors in very young
NZB mice that enhance the maturation of normal B cell precursors. Partial Purification and
characterization. J Immunol 135:1891-1899, 1985.
25.
Jyonouchi H, Voss RM, and Good RA: IL-1 like activities present in murine amniotic fluid. A
significantly larger amount of IL-1 like activity is present in the amniotic fluid of autoimmune NZB
mice. J Immunol 138:3300-3307, 1987.
26.
Jyonouchi H, Voss RM, and Good RA: The presence of autoantibodies specific for NZB serum
factors in adult NZB mice and the establishment of monoclonal antibodies against these humoral
factors. Cell Immunol 113:158-174, 1988.
27.
Jyonouchi H, Voss RM, and Good RA: Up-regulation and down-regulation of cell surface and
mRNA expression of CD5 antigen by various humoral factors on murine 70Z/3 pre-B cell leukemia
cell line. IL-4 down-regulates CD5 antigen expression. Cell Immunol 130, 66-78, 1990.
28.
Jyonouchi H, Voss RM, and Good RA: NZB serum factor (NZB-SF): B precursor cell maturation
factor identified in murine lupus. I. Identification of 60-kDa glycoprotein as the major component
from both spleen cell supernatant and serum. Cell Immunol 132:223-235, 1991.
29.
Jyonouchi H, Voss RM, and Good RA: NZB serum factor (NZB-SF) - B precursor cell maturation
factor: II, In vivo effects of NZB-SF or mAb against NZB SF on B lineage cell population. J Clin
Immunol Immunopathol 59:388-397, 1991.
30.
Jyonouchi H, Voss RM, Krishna S, Urval K, Sjahli H, Welty PB, and Good RA: Soluble Fce R II
levels in normal children and patients with immunodeficiency diseases. J Allergy Clin Immunol
87:965-970, 1991.
31.
Jyonouchi H, Hill RJ, Tomita Y, and Good RA: Studies of immunomodulating actions of
carotenoids. I. Effects of b-carotene and astaxanthin on murine lymphocyte functions and cell surface
marker expression in in vitro culture system. Nutr Cancer 16:93-105, 1991.
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C. V. Harumi Jyonouchi, M. D.
7
32.
Jyonouchi H, Voss RM, and Good RA: Zn depletion modifies CD5 expression by 7OZ/3 murine
pre-B leukemia cell line. Proc Soci Exp Biol Med 198:818-825, 1991.
33.
Jyonouchi H, Hill RJ, and Good RA: RNA/nucleotides enhances antibody production in vitro and is
moderately mitogenic to murine spleen lymphocytes. Proc Soci Exp Biol Med 200:101-108, 1992.
34.
Jyonouchi H, Zhang L, and Tomita Y: Studies of Immunomodulating Actions of Carotenoids. II.
Astaxanthin enhances in vitro antibody production to T-dependent antigens without facilitating
polyclonal B cell activation. Nutr Cancer 19:269-280, 1993.
35.
Jyonouchi H, Zhang L, and Tomita Y: Studies of immunomodulating actions of RNA/nucleotides.
RNA/nucleotides enhance in vitro Ig production by human peripheral blood mononuclear cells in
response to T dependent stimuli. Ped Res 33:458-465, 1993.
36.
Jyonouchi H, Zhang L, Georgieff M, and Tomita Y: Immunomodulating actions of nucleotides.
Enhancement of Ig production by human cord blood lymphocytes. Ped Res 34:565-571, 1993
37.
Jyonouchi H, Hill RJ, Voss RM, and Ishii E: Immunomodulating actions of RNA and nucleotides
on murine lymphocytes in vitro. Augmentation of antibody production to T dependent antigens and
expansion of T helper cells. J Nutr Immunol 2(2):5-24, 1993.
38.
Tomita Y, Jyonouchi H, Engelman R, Day NK, and Good RA: Preventive action of carotenoids on
the development of autoimmunity in MRL-lpr/lpr mice. J Autoimmunity 16:95-102, 1993.
39.
Jyonouchi H, Zhang L, and Tomita Y: RNA/nucleotides enhance in vitro antibody and
immunoglobulin production to T-dependent antigen but do not facilitate polyclonal B cell activation
in both normal and autoimmune-prone NZB strains of mice. J Nutr Immunol 2 (3): 5-22, 1993.
40.
Jyonouchi H, Zhang L, Gross M, and Tomita Y.: Immunomodulating actions of carotenoid:
Enhancement of in vivo and in vitro antibody (Ab) production to T-dependent antigens (TD-Ag).
Nutr Cancer 21:47-58, 1994.
41.
Jyonouchi H: Nucleotide actions on humoral immune responses. J Nutr 124:138S-143S, 1994.
42.
Loechelt BJ, Egeler M, Filipovich AH, Jyonouchi H, and Shapiro RS: Immunosuppression: an
alternative maintenance therapy for familial hemophagocytic lymphohistiocytosis (FEL). Med Ped
Oncol 22:325-328, 1994.
43.
Jyonouchi H, Zhang L, Tomita Y, and Yokoyama H: Nucleotide-free diet impairs T-helper cell
functions for antibody production in normal C57Bl/6 mice. J Nutr 124: 475-484, 1994.
44.
Jyonouchi H, Sun S, and Gross MD: Biological actions of carotenoids: astaxanthin, a carotenoid
without vitamin A activity, enhances in vitro Ig production by human peripheral blood mononuclear
cells. Nutr Cancer 23:171-183, 1995
45.
Jyonouchi H, Zhang L, Sun S, and Yokoyama H: Polynucleotides can compensate for impaired Tdependent antibody production induced by a nucleotide-free diet both in vivo and in vitro in C57Bl/6
mice, but mononucleotide/nucleoside mixture (OGVI) is effective only in vivo. J. Nutr. 125:15781586, 1995
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C. V. Harumi Jyonouchi, M. D.
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46.
Jyonouchi H, Sun S, Tomita Y, and Gross MD: Astaxanthin, a carotenoid without vitamin A
activity, augments antibody responses with T-helper clones in response to suboptimal Ag challenges.
J. Nutr. 125:2483-2492, 1995.
47.
Jyonouchi H, Sun S, Goodman D, Yokoyama H, and Sato S: Dietary fatty acid modulates actions of
nucleotides on humoral immune responses. Nutrition 11:437-443, 1995.
48.
Jyonouchi H, Sun S, and Tomita Y: Actions of ß-carotene on T-helper cell functions for antibody
production. J. Nutr. Immunol. 3 (4): 21-34, 1995.
49.
Jyonouchi H and Sun S.: Effects of Orally supplemented mononucleotide mixture on T-dependent
humoral immunity in C57BL/6 mice fed a nucleotide-free diet. J. Nutr. 126:1586-1593, 1996.
50.
Jyonouchi H, Sun S, and Sato S: A nucleotide-free diet suppresses antigen-driven cytokine
production by primed T cells: effects of supplemental nucleotides and dietary fatty acids. Nutrition
12: 608-615, 1996.
51.
Jyonouchi H, Sun S, Mizokami M, and Gross MD: Effects of Various Carotenoids on Cloned,
Effector-stage T-helper Cell Activity. Nutr. Cancer 26:313-324, 1996
52.
Jyonouchi H and Sun S: The actions of polynucleotides on effector stage cloned T-helper cells
differ in each T-helper cell subset and depend on antigen concentration. J. Nutr. 127:411-417, 1997.
53.
Jyonouchi H, Sun S, Mizokami M, and Ingbar DH: Cell density and antioxidant vitamins
determine the effects of hyperoxia on proliferation and death of MDCK epithelial cells. Nutr
Cancer 28:115-124, 1997.
54.
Jyonouchi H, Sun S, Kennedy CA, Kajander, KC, and Rimell FL: IgG antibody levels in the
sinus, ear, and airway in a rabbit model of sinusitis with Bacteroides Archives of
Otolaryngology-Head and Neck Surgery. 124:767-772, 1998
55.
Jyonouchi H, Sun S, Chareancholvanich S, and Ingbar DH: The effects of hyperoxic injury and
antioxidant vitamins on death and proliferation of human small airway epithelial cells. Am. J.
Resp. Cell Mol. Biol. 19:426-436, 1998.
56.
Jyonouchi H, Sun S, Iijima K., Wong M., and Hecht, SS.: Effects of anti-7,8-dihydroxy-9,10epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on human small airway epithelial cells and the
protective effects of myo-inositol. Carcinogenesis. 20: 139-145, 1999.
57.
Kennedy CA, Jyonouchi H, Kajander KC, Sun S, and Rimell FL: Middle ear changes associated
with chronic anaerobic sinusitis in rabbits. Laryngoscope 109: 498-503, 1999.
58.
Jyonouchi H, Sun S, Kennedy CA, Roche A, Kajander KC, Miller J, Germaine G, , and Rimell FL:
The localized sinus inflammation in a rabbit sinusitis model induced by Bacteroides fragilis is
accompanied by rigorous immune responses. Otolaryngology-Head and Neck Surgery. 120: 869875, 1999.
59.
Iijima K, Sun S, Cyong JC, and Jyonouchi H: Juzen-Taiho-To, a Japanese herbal medicine,
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C. V. Harumi Jyonouchi, M. D.
9
modulates type 1 and type 2 T cell responses in old BALB/c mice. Am J Chinese Med 17:191203, 1999.
60.
Jyonouchi H. Airway Epithelium and apoptosis. Apoptosis 4:407-417, 1999.
61.
Jyonouchi H, Sun S, Iijima K, and Gross MD: Anti-tumor activity of astaxanthin and its mode of
action. Nutr. Cancer 36: 59-65, 2000.
62.
Jyonouchi H, Sun S, and Rimell FL: Cytokine production by sinus lavage, bronchial lavage, and
blood mononuclear cells in chronic sinusitis with or without atopy. Archives of OtolaryngologyHead and Neck Surgery 126: 522-528, 2000
63.
Jyonouchi H, Sun S, Kennedy CA, and Rimell FL: Interferon- levels in the sinus, ear, and
airway in a rabbit sinusitis model induced by Bacteroides inoculation. Archives of
Otolaryngology-Head and Neck Surgery 126: 529-532, 2000
64.
Jyonouchi H, Sun S, Abiru T, Whinship, T, and Kuchan, MJ: Dietary nucleotides modulate
antigen-specific type 1 and type 2 T cell responses in young C57BL/6 mice. Nutrition 16: 442446, 2000.
65.
Gollob JA, Veenstra KG, Jyonouchi, H, Kelly AM, Ferrieri P, Panka DJ, Altare F, Casanova JL,
Fieschi C, Frank DA, and Mier JW. Impairment of STAT Activation by IL-12 in a Patient with
Atypical Mycobacterial and Staphylococcal Infections. J. Immunol. 163: 4120-4126. 2000.
66.
Jyonouchi H, Sun S, Winship T, and Kuchan MJ: Dietary nucleotides modulate type 1 vs. type 2
T cell responses against ovalbumin in young BALB/c mice. J. Nutr. 131: 1165-1170, 2001
67.
Jyonouchi H: Immunomodulating actions of dietary nucleotides – any clinical implication?
(Review). Recent Res. Develo. Allergy & Clin. Immunol. 1: 121-128, 2001.
68.
Jyonouchi H, Sun S, K. Porter VA, and Cornfield DN: Polycyclic aromatic hydrocarbon (PAH)
diol epoxides increase cytosolic Ca2+ concentrations of human small airway epithelial cells. Am J
Res Cell Mol Biol. 25: 78-83. 2001
69.
Jyonouchi H, Sun S, Le H.: Proinflammatory and regulatory cytokine production associated with
innate and adaptive immune responses in children with autism spectrum disorders and
developmental regression. J Neuroimmunol. 120: 170-179, 2001
70.
Jyonouchi H, Sun S, Le H, and Rimell, FD: Evidence of dysregulated cytokine production by
sinus lavage and peripheral blood mononuclear cells in patients with treatment-resistant chronic
rhinosinusitis. Arch Otolaryngol Head Neck Surg. 127: 1488-1494. 2001
71.
72.
Jyonouchi H, Sun S, and Itokazu N: Innate immunity associated with inflammatory
responses and cytokine production against common dietary proteins in patients with
autism spectrum disorders. Neuropsychobiology 46: 76-84, 2002.
Jyonouchi H, Sun S, Whiship T, and Kuchan MJ: Dietary ribonucleotides increase antigenspecific type 1 T-helper cells in the regional draining lymph nodes in young BALB/cJ mice.
Nutrition. 19: 41-46, 2003
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C. V. Harumi Jyonouchi, M. D. 10
73.
Jyonouchi H, Sun S, Kelly A, and Rimell FL: The effects of exogenous interferon-γ (IFN-γ) on
patients with treatment-resistant chronic rhinosinusitis and dysregulated IFN-γ production – A
pilot study. Arch Otolaryngol Head Neck Surg 129: 563-569, 2003.
74.
Jyonouchi H, Geng L, Ruby A, and Zimmerman-Bier, B: Dysregulated Innate Immune
Responses in Young Children with Autism Spectrum Disorders (ASD): Their Relationship to
Gastrointestinal (GI) Symptoms and Dietary Intervention. Neuropsychobiology 2005;51:7785 (DOI: 10.1159/000084164)
75.
Jyonouchi H, Geng L, Ruby A, Reddy C, and Zimmerman-Bier, B: Evaluation of possible
association between gastrointestinal (GI) symptoms and cytokine production against common
dietary proteins (DPs) in children with autism spectrum disorders (ASD). J. Pediatrics 146: 605610, 2005.
76.
Zimmerman AW, Jyonouchi H, Comi AM, Connors SL, Milstien S, Varsou A, and Heyes MP.
CSF AND SERUM MARKERS OF INFLAMMATION IN AUTISM Ped Neurology 33: 195201, 2005.
77.
Jyonouchi H, Lien KW, Aguila H, Spinnato, GG, Sabharwal S, and Pletcher BA: Garre’s
osteomyelitis and sarcoid dermatitis in a patient with DiGeorge syndrome. Eur. J. Pediatrics
2006; 165:370-374.
78.
Ward CM, Jyonouchi H, Kotenko S, Patel R, Aguila H, McSherry G, Dashefsky B, and Holland
SM: Adjunctive treatment of disseminated MAC infection with interferon alpha-2b in a patient
with complete interferon-gamma receptor R1 defect. Eur. J. Pediatr 166:981-985, 2007.
79.
Ward CM, Geng L, and Jyonouchi H: Fetal sensitization to milk protein and wheat: milk protein
and wheat-specific TNF-α production by umbilical cord blood cells and subsequent decline of
TNF-α but not IL-10 production by peripheral blood mononuclear cells following dietary
intervention. J. Pediatr Allergy Immunol 18: 276-280, 2007.
80.
Jyonouchi H, Geng L, Toruner GA, Vinekar K, Feng D, Fitzgerald-Bocarsly P: Monozygous twins
with microdeletion syndrome involving BTK, DDPA, and two other genes; evidence of intact
dendritic cell development and TLR responses. Eur J Pediatr 67:317-321, 2008.
81.
Jyonouchi H. Non-IgE mediated food allergy. Inflammation and Allergy Drug Discovery. Inflamm
Allergy Drug Targets. 2008 3:173-80.
82.
Jyonouchi H, Geng L, Cushing-Ruby A, Quraishi H: Impact of innate immunity in a subset of
children with autism spectrum disorders: a case control study.
83.
Jyonouchi H Food Allergy and Autism Spectrum Disorders: Is There a Link? Curr Allergy Asthma
Reports 9:194-201, 2009.
84. Jyonouchi H, Geng L, Cushing-Ruby A, Monteiro I. Aberrant responses to TLR agonists in pediatric
IBD patients: possible association with increased production of Th1/Th17 cytokines in response to
candida, a luminal antigen. J. Ped J Allergy Immunol on line publication first 2009.
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C. V. Harumi Jyonouchi, M. D. 11
85. Timothy Buie, MD; Daniel B. Campbell, PhD; George J. Fuchs III, MD; Glenn T. Furuta, MD;
Joseph Levy, MD; Judy Van de Water, PhD; Agnes H. Whitaker, MD; Dan Atkins, MD; Margaret L.
Bauman, MD; Arthur L. Beaudet, MD; Edward G. Carr, PhD; Michael D. Gershon, MD; Susan L.
Hyman, MD; Pipop Jirapinyo, MD; Harumi Jyonouchi, MD; Koorosh Kooros, MD; Rafail Kushak,
MD, PhD; Pat Levitt, PhD; Susan E. Levy, MD; Jeffery D. Lewis, MD; Katherine F. Murray, BSN,
RN; Marvin R. Natowicz, MD, PhD; Aderbal Sabra, MD, PhD; Barry K. Wershil, MD; Sharon C.
Weston, MS, RD, LDN; Lonnie Zeltzer, MD; and Harland Winter, MD. Evaluation, Diagnosis, and
Treatment of Gastrointestinal Disorders in Individuals With Autism Spectrum Disorder: A Consensus
Report. Pediatrics 125:S1-18, 2010.
86. Jyonouchi, H. Autism spectrum disorders and allergy: Observation from a pediatric
allergy/Immunology Clinic. Expert Review in Immunology. 6:397-411, 2010.
87. Jyonouchi H, Cui C, Geng L, Yin Z, Fitzgerald-Bocarsly P. Age-dependent changes in peripheral
blood dendritic cell subsets in normal children and children with antibody deficiency syndrome. Eur J
Pediatrics. 169:1233-1239, 2010.
88. Jyonouchi H, Geng L, Streck, D, Toruner, GA. Children with autism spectrum disorders
(ASD) who exhibit chronic gastrointestinal (GI) symptoms and markedly fluctuation of
behavioral symptoms exhibit distinct innate immune abnormalities and transcrioptional
profiles of peripheral blood (PB) monocytes. J Neuroimmunol 15: 73-80, 2011.
89. Jyonouchi H. Geng L, Streck D, Toruner GA. Immunological characterization and transcription
profiling of peripheral blood monocytes in children with autism spectrum disorders (ASD) and
specific polysaccharide deficiency (SPAD); case study. J Neuroinflammation 2012 Jan 7;9:4.
90. Pedroza LA, Kumar V, Sanborn KB, Mace EM, Niinikoski H, Nadeau K, Vasconcelos Dde M, Perez
E, Jyonouchi S, Jyonouchi H, Banerjee PP, Buuskanen O, Condino-Neto A, and Orange JS.
Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-α production and complexes
with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and
Dectin-1. J Clin Allergy Immunol 129: 464-472, 2012.
91. Jyonouchi H. Non-IgE mediated food allergy – update of Recent Progress in Mucosal Immunity.
Allergy and Inflammation – Drug Targets. In press. 2012. (published online)
Review articles
1. Kincade PW, Jyonouchi H, Landreth KS, and Lee G: B-lymphocyte precursors in
immunodeficient, autoimmune, and anemic mice. Immunol Rev 64:628-645, 1982.
2. Kincade PW, Jyonouchi H, Landreth KS, Engelhart D, Beare NH, Lee G, and Good RA: Factors
affecting normal and malignant B lymphocyte precursors. Curr Top Microbial Immunol 113:104108, 1984.
3. Jyonouchi H and O’Neill Shigeoka A: Delayed-type Hypersensitivity. eMedicine March 9,
2011 (Review) www.emedicine.com/PED/topic558.htm
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C. V. Harumi Jyonouchi, M. D. 12
4. Jyonouchi H and O’Neill Shigeoka A: Hyperimmunoglobulinemia E (Job) Syndrome.
eMedicine April 1, 2011 (Review) www.emedicine.com/PED/topic1075.htm
5. Agrawal R and Jyonouchi H : Complement Deficiency eMedicine November 9, 2007
www.emedicine.com/ped/topic447.htm
Chapters
1.
Kincade PW, Jyonouchi H, Landreth KS, and Lee G: Microenvironmental and age influences on
development of B lymphocyte lineage cells. In "Progress of Immunology", T Tada and Y
Yamamura (eds), Academic Press Japan, Inc. pp 645-655, 1984.
2.
Kincade PW and Jyonouchi H: B cell differentiation. In "Iwanami Immunology Series 4".
"Evolution and differentiation of the immune system." RA Good (ed), Iwanami Shoten, pp 189-214,
1986.
3.
Filipovich AH, Gross T, Jyonouchi H, and Shapiro RS: Immune-mediated hematologic and
oncologic disorders, including Epstein-Bar virus infection. In “Immunologic Disorders in infants
and children”, ER Stiehm (ed), W. B. Saunders., Philadelpha. pp855-888, 1996.
4.
Jyonouchi H: Immunological issues in patients with autism spectrum disorders. (Review) To be
included in “Neuropsychiatric Disorders and Infection” (Ed: SH Fatemi), Martin Dunitz &
Parthenon Publishing, Taylor & Francis Medical Books. Jan. 2005 pp 187-197.
5.
Jyonouchi H, Geng L, Ruby A, and Reddy C: Suboptimal responses to dietary intervention in
children with autism spectrum disorders and Non-IgE mediated food allergy. In: ‘Autism
Research Advances’ (Editor: L. B. Zhao), pp. 169-184, Nova Science Publishers, Inc. 2007.
6.
Jyonouch H Possible impact of innate immunity on autism (Editor: A. Chauhan), Taylor & Francis
Group LLC. pp 248-265, 2009
7.
Jyonouchi H, Geng L, Kattouf P, Streck D, and Toruner G. Possible impaired oral
tolerance in ASD children with food protein induced enterocolitis syndrome (FPIES):
Difference in innate and adaptive immune responses in ASD children recovered from
FPIES in comparison with non-ASD/FPIES and ASD/non-FPIES children InTech –
Book Chapter - published online in August 2011.
8.
Jyonouchi H. Food Allergy and Autism Spectrum Disorders. – Book Chapter –
“Guidelines in Autism Spectrum Disorders”, in press.
Abstracts: (since 1985)
1.
Jyonouchi H, Kimmel MD, Good RA: Regulatory dysfunction accounts for hyperactive B
lymphocyte formation and later deficiency in NZB mice. Fed Proc. 44(4):978, 1985. [Poster]
2.
Jyonouchi H, Voss R, Good RA: IL-1 like activity in murine amniotic fluid. Fed. Proc. 45(4):1000,
1986. [Poster]
12
C. V. Harumi Jyonouchi, M. D. 13
3.
Jyonouchi H, Voss R, Good RA: Monoclonal antibodies against serum factors of autoimmune NZB
mice. Fed Proc. 46:782, 1987. [Poster]
4.
Jyonouchi H, Voss R, Good RA: Analysis of the effects of NZB Serum Factor on murine pre-B cell
leukemic cell line. FASEB J. 2:A892, 1988. [Poster]
5.
Jyonouchi H, Voss R, Good RA: Analysis of effects of humoral factors on CD5 expression by
murine 70Z leukemic cell line. FASEB J. 3(4):A1368, 1989. [Poster]
6.
Shetty RM, Good RA, Jyonouchi H: Autoimmune neutropenia and erythroid hypoplasia in an infant
with anti-HIV antibody who was not infected with HIV virus. Pediatric Res. 25:169A, 1989.
7.
Jyonouchi H, Urval K, Nelson R, Klemperer M, Good RA: A case of severe combined
immunodeficiency syndrome with apparent normal B cells and the deficiency of post-thymic T
lymphocytes. Presented at The American Academy of Allergy and Immunology, 45th Annual
Meeting, San Antonio, TX February 24-March 1, 1989, J Allergy and Clin Immunol. 83:288, 1989.
[Poster]
8.
Jyonouchi H, Voss R, Hill B, Good RA: Common variable immunodeficiency lupus and IL-2
production deficiency. Presented at the annual meeting of the American Academy of Allergy and
Immunology, Baltimore, MD, March 23-28, 1990. [Minisymposium]
9.
Krishna S, Jyonouchi H, Urval K and Good RA: Studies of serum Fce receptor type II levels in
patients with allergy/immunodeficiency disease. Presented at the annual meeting of the American
Academy of Allergy and Immunology, Baltimore, MD, March 23-28, 1990. [Poster Symposium]
10.
Jyonouchi H, Voss RM, Good RA: Modulation of CD5 expression by a 70Z/3 pre-B leukemic cell
line: Role for a labile repressor. Oral presentation at the 1990 Suncoast Biotech Conference, St.
Petersburg, FL, March 30, 1990. [Minisymposium]
11.
McCann M, Hutto J, Good RA, Jyonouchi H: High-dose intravenous gammaglobulin (IVGG) in
treatment of dermatomyositis. Presented before the Ambulatory Pediatric Association, 99th
Annual Meeting of the American Pediatric Society, May 1-5, 1989. [Poster Discussion]
12.
Di Nicolo R, Hutto J., Jyonouchi H, McCann M, Good RA: Intravenous Gammaglobulin (IVGG)
Improves Treatment of Dermatomyositis. 100th Annual Meeting, American Pediatric
Society/Society for Pediatric Research, Research 27(2):155A, 1990.
13.
Urval K, Sher MR, Jyonouchi H, Day NK, Good RA: A Variant of Common Variable
Immunodeficiency (CVI) with Very Low B Cell Numbers and Moderate
Hypogammaglobulinemia. American Pediatric Society/Society for Pediatric Research
27(2):163A, 1990.
14.
Urval K, Jyonouchi H, Day NK, Good RA: Partial DiGeorge Anomaly - A Review of
Immunological Parameters. American Pediatric Society/Society for Pediatric Research
27(2):162A.
15.
Jyonouchi H, Voss RM, Good RA: Regulation of CD5 expression by 70Z/3 pre-B leukemic cell
13
C. V. Harumi Jyonouchi, M. D. 14
line--possible role of a labile repressor. Poster presentation & discussion session, Annual
Meeting of the American Association of Immunologists, New Orleans, June 3-7, 1990. FASEB
J. 4(7):A2028, 1990. [Poster]
16.
Voss RM, Jyonouchi H, Good RA: The presence of 60 kd NZB-serum factor (NZB-SF) in normal
strains of mice and its actions in vivo. Poster presentation at the annual meeting of the American
Association of Immunologists, New Orleans, June 3-7, 1990. FASEB J. 4(7):A1877, 1990.
[Poster]
17.
Jyonouchi H, Voss RM, Good RA: Regulation of CD5 expression by 70Z/3 pre-B leukemia cell
line -- possible role of labile repressor. Poster presentation at the annual meeting of the Japan
Cancer Society, Sapporo, Japan, July 3, 1990. [Poster]
18.
Klemperer MR, Jyonouchi H, Nelson RP, Di Nicolo R, Krishna SS, Good RA: Attempted
Halploidentical Bone Marrow Transplantation (BMT) in 3 Patients with Lysosomal Storage
Diseases (LSD's). 19th Annual ISEH Meeting, Seattle, Washington. Experimental Hematology
18(6):702, 1990. [Poster]
19.
Klemperer MR, Jyonouchi H, Nelson RP, Urval K, Sjahli H, Krishna S, Good RA: T-Cell
Depleted Partially Matched Bone Marrow Transplantation in a Patient with Omenn's Syndrome,
Second Annual Meeting of The American Society of Pediatric Hematology/Oncology, Chicago,
Illinois, September 15 through 17, 1990. [Poster]
20.
Moore C, Urval K, Day NK, Good RA, Jyonouchi H: B Lineage Cell Populations in a Subset of
CVI Patients. 47th Annual Meeting of the American Academy of Allergy Immunology, San
Francisco, California, March 1-6, 1991. [Poster Discussion]
21.
Sjahli H, Urval K, Good RA, Day NK, Jyonouchi H: Analysis of T and B Lymphocyte
Phenotypes in Patients with Partial DiGeorge Syndrome. 47th Annual Meeting of the American
Academy of Allergy Immunology, San Francisco, California, March 1-6, 1991. [Poster]
22.
Krishna S, Sher M, Jyonouchi H, Prebis J, Perlman S, Good RA: High-Dose Intravenous
Gammaglobulin (IVIG) in the Treatment of Systemic Lupus Erythematosus (SLE). 47th Annual
Meeting of the American Academy of Allergy Immunology, San Francisco, California, March 16, 1991. [Poster]
23.
Karlapudi S, Day NK, Good RA, Jyonouchi H: A Case of Primary T Cell Immunodeficiency with
Decreased Expression of TCR/CD3 Molecules Associated with Robert's Syndrome. 47th Annual
Meeting of the American Academy of Allergy Immunology, San Francisco, California, March 16, 1991. [Poster]
Tomita Y, Engelman RW, Jyonouchi H, Day NK, and Good RA: Influences of Carotenoids on the
Development of Autoimmune Disease in MRL/mpj-lpr/lpr Mice Fed High Calorie Diet. Annual
Meeting of AAI, Atlanta, GA, April 21-25, 1991. [Poster]
24.
25.
Lopez M, Jyonouchi H, Voss R, and Hill B: Influences of IL-4 and NZB-SF (B cell maturation
factor) on spleen lymphocytes obtained from normal and autoimmune-NZB mice. Annual
Meeting of AAI, Atlanta, GA, April 21-25, 1991. [Poster]
26.
Voss R, Jyonouchi H, and Hill B: The regulatory mechanisms of CD5 expression on murine 70Z/3
14
C. V. Harumi Jyonouchi, M. D. 15
pre-B leukemia cell line. Annual Meeting of AAI, Atlanta, GA, April 21-25, 1991. [Poster]
27.
Hill B, and Jyonouchi H: Yeast RNA preparations exert immunomodulating actions on murine
spleen lymphocytes in vitro. Annual Meeting of AIN, Atlanta, GA, April 21-25, 1991.
[Minisymposium]
28.
Jyonouchi H, Hill B, and Tomita Y: Influences of immunomodulating nutrients on lymphocyte
functions of B6 and autoimmune-prone NZB mice. Annual Meeting of AIN, Atlanta, GA, April
21-25, 1991. [Minisymposium]
29.
Klemperer MR, Jyonouchi H, Moore CM, Nelson RP, and Good RA: Bone Marrow
Transplantation (BMT) for Lysosomal Storage Diseases (LSDs) Using Partially Matched Donors.
Fourth Annual Meeting of The American Society of Pediatric Hematology and Oncology,
Chicago, IL, September 12-15, 1991. [Poster]
30.
Zhang L and Jyonouchi H: Effects of NZB-serum factors on in vitro Ab and Ig production in NZB
and B6 mice. Annual Meeting of FASEB, Anaheim, CA April 5-9, 1992. [Poster]
31.
Jyonouchi H, Zhang L, and Tomita Y: RNA/nucleotide and astaxanthin enhance in vitro Ab
production to T dependent antigens (TD-Ag) but not to T independent Ag (TI-Ag) or do not
further enhance polyclonal B cell activation in NZB mice. Annual Meeting of FASEB, Anaheim,
CA, April 5-9, 1992. [Poster]
32.
Jyonouchi H and Zhang L: The effects of yeast RNA and nucleotides on in vitro immunoglobulin
(Ig) production by human peripheral blood mononuclear cells. Annual Meeting of Society of
Pediatric Research, Baltimore MD, May 3-7, 1992 [Poster]
33.
Tomita Y, Jyonouchi H, Tanaka K, Himeno, K, and Nomoto K: Augmentation of syngeneic tumor
immunity by oral administration of carotenoids. Annual Meeting of Japan Cancer Society,
Osaka, Japan, September 25-29, 1992. Japanese Journal of Cancer Research, Abstract:I-67
[Poster]
34.
Loechelt BJ, Jyonouchi H, Shapiro RS, Kamat D, and Filipovich AH: Severe immunodeficiency
with normotherombocytopenia: A Wiskott-Aldorich (WAS) variant? Annual Meeting of the
Clinical Immunology Society, Nov. 13-15, 1992. [Poster Discussion]
35.
Filipovich AH, Jyonouchi H, Loechelt B, Kamat D, Dusenberry K, Ramsay N, Kersey J, and
Shapiro RS: Non sibling bone marrow transplantation (BMT) for congenital disorders associated
with lethal hemophagocytic lymphohistiocytosis. The American Society of Hematology 34th
Annual Meeting. Dec. 5-9, 1992. [Poster]
36.
Jyonouchi H, Zhang L, Tomita Y, and Gross M.: Immunomodulating actions of carotenoids.
Enhancement of Ab production against T-dependent Ag (TD-Ag) in vivo and in vitro.
Experimental Biology '93 New Orleans, LO, March 29-April 1, 1993. [Poster]
37.
Zhang L, Jyonouchi H, Yokoyama H, and Tomita Y.: Immunomodulating actions of nucleotides
on Ab/Ig production by murine spleen lymphocytes in vivo and in vitro. Experimental Biology
'93, New Orleans, LO. March 29-April 1, 1993. [Minisymposium]
15
C. V. Harumi Jyonouchi, M. D. 16
38.
Jyonouchi H, Zhang L, Geogieff MK, and Tomita Y: Immunomodulating actions of nucleotides.
Enhancement of Ig production by human cord blood lymphocytes. Annual Meeting of Society of
Pediatric Research, Washington, D.C. May 3-6, 1993. [Poster]
39.
Jyonouchi H, Zhang L, and Tomita Y: Immunomodulating actions of nucleotides on Ab
production by murine lymphocytes: Evidence of modification of Th1 and Th2 responses to TD &
TD-Ag. Annual Meeting of American Academy of Immunology and Clinical Immunology
Society. Denver, CO. May 21 - May 25, 1993. [Poster]
40.
Jyonouchi H, Zhang L, Gross, M, Takenaka H, and Tomita Y: Enhancing actions on specific Ab
responses to T-dependent antigens in vivo and in vitro. 10th International Symposium on
Carotenoids. Trondheim, Norway. June 20 - June 25, 1993 [Poster]
41.
Loechelt BJ, Egeler RM, Filipovich AH, Jyonouchi H, and Shapiro RS: Immunosuppression: An
alternative maintenance therapy for familial hemophagocytic lymphohistiocytosis. Histiocyte
Society, San Francisco, CA Oct. 1993.
42.
Shapiro RS, Loechelt BJ, Jyonouchi H, and Filipovich AH: Unrelated bone marrow
transplantation in familial hemophagocytic lymphohistiocytosis. Histiocyte Society, San
Francisco, CA, Oct. 1993.
43.
Jyonouchi H, Hordinsky M, Bollom, T, Lewis S, Sun S, and Blumenthal M: Alopecia areata and
atopic features in pediatric population. Annual Meeting of American Academy of Allergy and
Immunology. Anaheim, CA March 4 - March 9, 1994. [Poster Symposium]
44.
Hordinsky M, Lewis S, Blumenthal M, and Jyonouchi H: Childhood alopecia areata (AA) and
atopy. Annual Meeting of Society For Investigative Dermatology. Baltimore, MA April 27 April 30, 1994. [Poster]
45.
Jyonouchi H, Sun S, and Gross M: The meditation of carotenoid immunomodulating activities by
cloned T-helper cells and cytokine mRNA expression. Experimental Biology '94. Anaheim, CA.
April 24 - April 27, 1994. [Minisymposium]
46.
Zhang L, Sun S, Tomita Y, Hayashi K, and Jyonouchi H: In vivo and in vitro actions of all-trans
ß-carotene and ß-carotene stereoisomer mixture from alga Dunaliella bardawil on T-dependent
humoral immune responses. Experimental Biology '94. Anaheim, CA. April 24 - April 27,
1994. [Minisymposium].
47.
Sun S, Yokoyama H, and Jyonouchi H: Actions of mononucleotide/nucleoside mixture (OGVI)
and polynucleotides on in vitro T-dependent humoral immune responses in mice fed a nucleotidefree (NF) diet. Experimental Biology '94. Anaheim, CA. April 24 - April 27, 1994.
[Minisymposium]
48.
Lochelt BJ, Filipovich AH, Jyonouchi H, and Shapiro RS: Successful interferon-a (IFNa)
treatment of fulminant FBV-associated B-cell lymphoproliferative disease (BLPD) following Tcell depleted (T-D) halplo-identical bone marrow transplantation (BMT). The Annual meeting of
the Society for Pediatric Research 1994. Seatle, WA. May 1994. [Minisymposium]
49.
Jyonouchi H, Sun S, and Hayashi H: Immunomodulating actions of carotenoids: Astaxanthin, a
16
C. V. Harumi Jyonouchi, M. D. 17
carotenoid without provitamin A activity, can enhance in vitro Ig production by both adult
peripheral blood and umbilical cord blood lymphocytes. The Annual meeting of the Society for
Pediatric Research. May 1994. Seatle WA
50.
Shapiro RS, Loechelt BJ, Jyonouchi H, and Filipovich AH: Unrelated donor bone marrow
transplantation in familial hemaphagocytic lymphohistiocytosis. 9th Annual Conference on
Clinical Immunology 1994. Anaheim, CA. April 22 - 24, 1994. [Poster]
51.
Hordinsky M, Lewis, S, Blumenthal M, and Jyonouchi H: Atopy and childhoodd alopecia areata
(AA). 43rd Symposium on The Biology of Skin. August 6-10, 1994. Snowmass Village,
Colorado. [Poster]
52.
Tristani-Firouzi M, Kamanga-Sollo EIP, Right G, Anderson R, Mathur A, and Jyonouchi, H:
Kawasaki Syndrome: massive expansion of T cells and suppression of humoral immune
responses in the acute stage. The annual meeting of the Northwest Pediatrics Meeting. Sept. 30,
1994. St. Paul, MN. [Oral Presentation]
53.
Tomita Y and Jyonouchi H: In vivo and in vitro effects of ß-carotene and astaxanthin on tumor
immunity and humoral immunity in mice. Second International Conference: Antioxidant
Vitamins and ß-Carotene in Disease Prevention. October 10-12, 1994, Berlin, Germany.
[Poster]
54.
Tristani-Firouzi M, Kamanga-Sollo EIP, Sun S, Mathur A, and Jyonouchi, H: TCR Vß family
repertoire and T-cell functions in Kawasaki syndrome (KS). The annual meeting of the
American Academy of Allergy and Immunology. Feb. 24-28, 1995. [Poster]
55.
Tristani-Firouzi M, Kamanga-Sollo EIP, Sun S, Mathur A, and Jyonouchi, H: TCR Vß family
repertoire and T-cell functions in Kawasaki syndrome (KS). The 5th International Congress of
Kawasaki Synderome. June, 1995 [Minisymposium]
56.
Sun S, Ingbar D, and Jyonouchi H: Effects of antioxidant vitamins on MDCK cells, a canine
epithelial cell line, in hyperoxia. The annual meeting of Experimental Biology '95. April, 1995.
Atlanta, GA [Minisymposium].
57.
Jyonouchi H, Sun S, Tomita Y, and Gross M: Astaxanthin, a carotenoid without vitamin A
activity, augments antibody production with T-helper clones in response to suboptimal doses of
antigen. The annual meeting of Experimental Biology '95. April, 1995. Atlanta, GA
[Minisymposium].
58.
Yokoyama H, Sun S, Goodman D, Sato S, and Jyonouchi H: Dietary fatty acid modulatesactions
of nucleotides on humoral immunity. The annual meeting of Experimental Biology '95. April,
1995. Atlanta, GA [Minisymposium].
59.
Sun S and Jyonouchi H: Oral supplementation of a mononucleotide mixture prepared on the basis
of mononucleotides in human breast milk restores impaired humoral immunity in mice fed
nucleotide-free (NF) diet. The annual meeting of Society of Pediatric Research '95. May, 1995
San Diego, CA [Poster]
60.
Jyonouchi H, Sun S, and Gross M: Carotenoid action on in vitro immunoglobulin (Ig) production
17
C. V. Harumi Jyonouchi, M. D. 18
by human lymhocytes. The annual meeting of Society of Pediatric Research '95. May, 1995 San
Diego, CA [Poster]
61.
Jyonouchi H, Sun S, Tomita Y, and Gross: Astaxanthin, a carotenoid without vitamin A activity,
augments antibody production with Th clones with suboptimal doses of antigen. The Second
Gordon Conference on Carotenoids. Feb. 5-9, 1995. Ventula, CA [Poster]
62.
Jyonouchi H, Sun S, and Ingbar DH: Antioxidant vitamin protection against hyperoxic injury of
MDCK epithelial cells. The annual meeting of Society of Pediatric Research '95. May, 1995.
San Diego, CA [Poster]
63.
Jyonouchi H, Sun S, M. Mizokami, and Ingbar DH: Antioxidant vitamin protection against
hyperoixc injury in MDCK epithelial cells. The annual meeting of the AAAAI March 1996
[Poster]
64.
Jyonouchi H, Sun S, and Gross MD: Carotenoid action on cloned, effector-stage murine T-helper
activities. Exp. Biology ‘96. April 1996 [Poster]
65.
Mizokami M, Sun S, Ingbar DH, and Jyonouchi H: Confluence and antioxidant vitaminprotection
determine the effects of hyperoxia and MDCK epithelial cells. Exp. Biology ‘96. April 1996
[Poster]
66.
Jyonouchi H and Sining Sun: Nucleotide action on cloned type 1 and type 2 T-helper cells.
ASBMB/ASIP/AAI Joint Meeting April ‘96. [Poster]
67.
Jyonouchi H, Sun S, Kajander KC, and Rimell FL: Augmented IFN production by sinus
infiltrating cells in a subset of chronic sinusitis patients. AAAAI/AAI/CIS Joint Meeting. April
‘97 [Poster]
68.
Sun S, Roche A, Germaine G., Kirmani J, Kajander KC, Rimell FL, and Jyonouchi H:
Inflammatory and immune responses by sinus lavage cells and peripheral blood lymphocytes in a
rabbit model of sinusitis. AAAAI/AAI/CIS Joint Meeting. Feb., ‘97 [Poster]
69.
Jyonouchi H, Sun S, and Abiru T: Dietary nucleotides modulate cytokine production by T cells in
reseponse to antigen stimuli. Annual meeting of Exp. Biology April, ‘97 [Minisymposium]
70.
Abiru T, Sun S, Inbgar DH, and Jyonouchi H: Antioxidatn vitamin and nucleotide effects on
homeostasis of human small airway epithelial cells in normoxia and hyperoxia. Annual meeting
of Exp. Biology April, ‘97 [Poster]
71.
Sun S, Abiru T, and Jyonouchi, H: Actions of polynucleotides on effector-stage type 1 T-helper
cell clones: evidence of augmentation of IFN production through costimulatory molecules.
Annual meeting of Exp. Biology April, ‘97 [Poster]
72.
Jyonouhi H, Sun S, Chareancholvanich S, and Ingbar DH: Homeostasis of cell death and
rpoliferation of human small airway epithelial cells: the effects of hyperoxia and antiboxidant
vitamins. Annual meeting of ATS, May, ‘97 [Poster]
73.
Jyonouchi H, Sun S, Kennedy CA, Kajander KC, and Rimell FL: IgG Ab Levels in The Sinus
18
C. V. Harumi Jyonouchi, M. D. 19
Lavage, BAL, and Ear Lavage Solutions in A Rabbit Model of Sinusitis with Bacteroides fragilis.
Annual meeting of AAAAI, March, ‘98 [Poster]
74.
Sun S, Rimell FL, and Jyonouchi H.: Proinlfammatory and Counter-regulatory Cytokine
Production by Sinus Lavage Cells in Patients with Chronic Sinusitis without Nasal Polyposis.
Annual meeting of AAAAI, March, ‘98 [Minisymposium]
75.
Jyonouchi H, Sun S, and Iijima K. Dietary nucleotides modulate T1/T2 immune responses
against ovalbumin in BALB/c mice. Annual meeting of Exp. Biology April, ‘98 [Poster]
76.
Iijima K, Sun S, Hecht SS, Wang M, and Jyonouchi H: The effects of Benzo[]pyrene-7,8-diol9,10-epoxide (BPDE) on human small airway epithelial cells and protective effects of myoinositol. Annual meeting of Exp. Biology April, ‘98 [Poster]
77.
Watanabe Y, Sun S, and Jyonouchi H: The effects of bovine casein degrades on cytokine
production by murine T-helper cells. Annual meeting of Exp. Biology April, ‘98 [Poster]
78.
Sun S, Gross MD, Iijima K and Jyonouchi H: Anti-tumor activity of astaxanthin on Meth-A tumor
cells and its mode of action. Annual meeting of Exp. Biology April, ‘98 [Minisymposium]
79.
Choo SY and Jyonouchi H: Immunologic considerations of transfusion in a patient with common
variable immunodeficiency and anti-IgA antibody. Annual meeting of the American Association
of Blood Banks. Oct. 31 through November 2, 1998. [Oral presentation]
80.
Rimell FL, Sun S, and Jyonouchi H: Immune response in chronic sinusitis vs. allergic rhinitis.
Annual meeting of Pediatric Otolaryngology and Interamerican Associ. of Ped. Otolaryngol.
May, ‘99 [Oral presentation]
81.
Sun S, Abiru T, and Jyonouchi H: Pyrimidine but Not Purine Mononucleotides Protect Human
Small Airway Epithelial Cells against Injurious Effects of Hyperoxia; Possible Mechanisms of
Action. Annual meeting of AAAAI Feb., ‘99 [Poster]
82.
Jyonouchi H, Sun S, and Iijima K: Modulation of T1/T2 Responses Against Ovalbumin By
Dietary Nucleotides in BALB/c Mice. Annual meeting of AAAAI Feb., ‘99 [Minisymposium]
83.
Iijima K, Sun S, Cyong JC, and Jyonouchi H: Juzen-Taiho-To, a Japanese herbal medicine,
modulates type 1 and type 2 T cell responses in old BALB/c mice. Annual meeting of Exp.
Biology, April, ’99 [Poster]
84.
Jyonouchi, H, Sun S., Winship T, and Kuchan MJ: Dietary mononucleotides attenuates skewed
type 2 responses in young BALB/c mice against ovalbumin, a representative dietary antigen.
Annual meeting of Exp. Biol., Apriol, ’99 [Poster]
85.
Jyonouchi H, Kelly AM, Ferrieri P, Rimell RL, and Gollob F A case of necrotizing
granulomatous lymphadenitis with [italic]Mycobacterium avium[/italic]; impaired IL-12 dependent
IFN production with apparent intact expression of IL-12 receptor (1 and 2 chains) Annual
meeting of Society of Pediatric Research, May, ’99 [Poster Discussion]
86.
McDowell K, Sun S, Hecht, SS and Jyonouchi H. The Effects of Anti-7,8-dihydroxy-9,10-epoxy-
19
C. V. Harumi Jyonouchi, M. D. 20
7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE), a Carcinogenic Metabolite of Benzo[a]pyrene (BP) on
Activation of Externally Regulated Kinases 1 and 2 (Erk1/Erk2) in Human Small Airway Epithelial
(SAE) cells. Annual meeting of AAAAI, March, ’00 [Poster]
87.
Jyonouchi H, Sun S, Cornfield, D, and Hecht, SS. The Effects of Anti-7,8-dihydroxy-9,10-epoxy7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE), a Carcinogenic Metabolite of Benzo[a]pyrene (BP) on
Activation of Externally Regulated Kinases 1 and 2 (Erk1/Erk2) in Human Small Airway Epithelial
(SAE) cells. Annual meeting of AAAAI, March, ’00 [Poster]
88.
Jyonouchi H, Sun S, Winship T, and Kuchan MD. The different effects of dietary supplementation
of mononucleotide (MN) and polynucleotide supplementation on antibody (Ab) responses to
ovalubmin (OVA), a representative dietary antigen (Ag), in young BALB/c mice. Annual meeting
of Exp. Biology, April, ’00 [Minisymposium]
89.
S. Sun, D. Cornfield, S. S. Hecht, and Jyonouchi H. Effects of anti-7,8-dihydroxy-9,10-epoxy7,8,9,10-tetrahydrobenzo[a]pyrene and other carcinogenic polycyclic aromatic hydrocarbon diol
epoxides on free cytosolic Ca2+ concentrations of human small airway epithelial cells. Annual
meeting of Exp. Biology, April, ’00 [Poster]
90.
Jyonouchi H, Sun S, and Rimell, FD. Cytokine production by sinus lavage, bronchial lavage, and
peripheral blood mononuclear cells in children with chronic rhinosinusitis. Annual meeting of
American Association of Immunologists, May, ’00 [Poster].
91.
Rimell FD, Sun S., Le H, and Jyonouchi H. Regulatory cytokine (IL-12, IL-10, and IL-18)
production for IFN- by sinus lavage (SL) and peripheral mononuclear (PBMN) cells in children
with treatment-resistant chronic rhinosinusitis. Annual meeting of AAAAI held in New Orleans,
Louisiana, March, ’01 [Poster]
92.
Jyonouchi, H., Sun S, and Le H. Innate and adaptive immune responses in children with
regression autism – Evaluation of the effects of environmental factors including vaccination.
Annual meeting of AAAAI held in New Orleans, Louisiana, March, ’01 [Poster]
93.
Jyonouchi H, Sun S., Winship T, and Kuchan MD. The effects of dietary monoribonucleotides
(MNs) on costimulatory molecule expression and memory/effector T cells in response to
ovalubmin (OVA) in T2-prone BALB/c mice. Annual meeting of Exp. Biology held in Orlando,
FL, April, ’01 [Poster]
94.
Jyonouchi H, Sun S, Le H. Proinflammatory/regulatory cytokine production in children with
autism spectrum disorders (ASD) Annual meeting of Exp. Biol. ’01 held in Orlando, FL (3/31/01
through 4/4/01)]
96.
Jyonouchi H, Sun S., Itokazu, N, and Le HT. Cytokine Production Against Common Dietary
Proteins In Patients With Autism Spectrum Disorder And Developmental Regression In
Comparison With Patients With Dietary Protein Intolerance. Annual meeting of AAAAI held in
New York, NY (3/1/02 through 3/5/02) [Poster]
97.
Sun S, Itokazu N, Le, HT, and Jyonouchi H. Innate Immune Responses And Cytokine Production
Against Dietary Proteins In Children With Autism Spectrum Disorder (ASD) And Those With
Dietary Protein Intolerance (DPI) Annual meeting of AAAAI held in New York, NY (3/1/02
20
C. V. Harumi Jyonouchi, M. D. 21
through 3/5/02) [Poster]
98.
Jyonouchi H, Sun S, Le H, and Rusche J. CTLA4-Ig down-regulates IFNperipheral blood mononuclear cells of autistic and dietary protein intolerant children (DPI). Annual
meeting of Exp. Biol. ’02 in New Orleans, Louisiana, (4/21/02 through 4/24/02) [Poster]
99.
Sun S, Rimell FL, and Jyonouchi, H. The effects of exogenous IFN-γ in patients with treatmentresistant chronic rhinosinusitis (CRS) Annual meeting of Exp. Biol. ’02 in New Orleans, Louisiana,
(4/21/02 through 4/24/02) [Poster]
100. Heimall JR, Jyonouchi H, Oleske J, Bielory L, and Aguila H. Hypersensitivity Pneumonitis
linked to Pigeon Exposures: Case Report. Annual meeting of American College of Allergy,
Asthma, and Immunology. 2003 (11/8/03 – 11/13/03) [Poster]
101. Du J, Jyonouchi H, Rajakamar A, Zahorodny W, Ming S, Biard S, and Oleske J. Intravenous
immunoglobulin treatment in children with immunodeficiency and autism spectrum disorders.
Annual meeting of American Allergy, Asthma, and Immunology. 2003 (11/8/03 – 11/13/03)
[Poster]
102. Jyonouchi H, Geng L, Ruby A, Zimmerman-Bier, B. Mechanisms of Non-IgE Mediated Adverse
Reaction to Common Dietary Proteins (DPs) in Children with Autism Spectrum Disorders (ASD).
Annual meeting of American Academy of Asthma, Allergy, and Immunology. 2004
(3/19/04-3/23/04) [Poster]
103. Jyonouchi H, Geng L, Ruby A, Reddy C, Zimmerman-Bier, B. Cytokine Production Profile against
Common Dietary Proteins (DPs) in Children with Autism Spectrum Disorders (ASD) on a regular
diet: Relationship to Gastrointestinal (GI) Symptoms and Responses to LPS. Annual meeting of
Experimental Biology 2004 (4/18/04-4/21/04). [Poster Symposium]
104. Jyonouchi H, Geng L, Ruby A, Zimmerman-Bier, B. The Effects of the Elimination Diet on
Cytokine Production Profile against Common Dietary Proteins (DPs) in Children with Autism
Spectrum Disorders (ASD). Annual meeting of Experimental Biology 2004 (4/18/04-4/21/04).
[Poster Symposium]
105. Lien K, Jyonouchi H, Pletcher B, Aguila H, and Spinnato G. A Case of DiGeorge Syndrome:
Development of Sarcoid-like Cutaneous Lesions and Garre’s Osteomyelitis Prior to Diagnosis.
Annual meeting of American College of Allergy, Asthma, and Immunology, October, 2004 [Poster]
106. Mosby C, Patel R, Aguila H, McShirly, G, and Jyonouchi, H. Disseminated mycobacterium avium
complex infection in a patient with complete interferon gamma receptor deficiency. Annual
meeting of American Academy of Asthma, Allergy, and Immunology. 2005 (3/18/05-3/22/05)
[Poster]
107. Buddiga P., Pedra-Nobre M., Jyonouchi H., Wolff A., Bielory L. Macrophage activation syndrome
associated with posterior reversible encephalopathy syndrome. Annual meeting of American
Academy of Asthma, Allergy, and Immunology. 2005 (3/18/05-3/22/05) [Poster]
108. Jyonouchi H, Geng Lee, Ruby A, and Zimmerman-Bier B. Changes in cellular immune reactivity
to cow’s milk protein (CMP) following dietary intervention, in children with Autism Spectrum
21
C. V. Harumi Jyonouchi, M. D. 22
Disorders (ASD) and positive gastrointestinal (GI) symptoms. Annual meeting of Experimental
Biology 2005 (4/2/05-4/6/05). [Poster]
109. Jyonouchi H, Geng L, Ruby A, and Zimmerman-Bier B. Aberrant inflammatory responses by
peripheral blood derived macrophages and dendritic cells in children with autism spectrum
disorders (ASD) and features of immune abnormalities. Annual meeting of Experimental Biology
2005 (4/2/05-4/6/05). [Poster]
110. Ward CM, Geng L, Jyonouchi H. Apparent prenatal sensitization to common dietary proteins
(DPs): positive cellular immune reactivity by umbilical cord blood mononuclear cells (UCBCs) to
DPs and corresponding clinical features.
Annual meeting of American College of Allergy, Asthma, and Immunology. October, 2005
[Poster]
111. Odgen N, Geng, L, Jyonouchi H. Evaluation of cellular immune reactivity to candida antigen in
young children with non-allergic food hypersensitivity to cow’s milk. Annual meeting of
American Academy of Asthma, Allergy, and Immunology. 2006 (3/3/06-3/7/06) [Poster]
112. Hersh ALB, Geng L, Ruby A, Jyonouchi H. Resolution of PANDAS like symptoms by IVIG in a
patient with specific antibody deficiency against polysaccharide antigens. Annual meeting of
American Academy of Asthma, Allergy, and Immunology. 2006 (3/3/06-3/7/06) [Poster]
113. Ward C, Geng L, Ruby A, Jyonouchi H. Clinical outcomes and immunoparameters in children
with chronic otitis media and rhinosinusitis in response to Pneumovax® vaccine. Annual meeting
of American Academy of Asthma, Allergy, and Immunology. 2006 (3/3/06-3/7/06) [Poster]
114. Jyonouchi H, Geng L, Ruby A, Aguila H, Quiraishi H. Decreased production of Th1 and
proinflammatory cytokines in children with poor responses to pneumococcal polysaccharide
antigens. Annual meeting of American Association of Immunologist. 2006 (5/12/06-5/16/06)
[Poster]
115. Jyonouchi H, Geng L, Ruby A, Reddy C. Changes in cellular immune reactivity to cow’s milk
protein (CMP) following dietary intervention in young children with non allergic food
hypersensitivity (NFH) with or without autism spectrum disorders (ASD). Annual meeting of
American Association of Immunologist. 2006 (5/12/06-5/16/06) [Poster]
116. Jyonouchi H, Monteiro I, Geng L, Ruby A. Aberrant responses to TLR (toll-like-receptor)
agonists and common luminal antigens (Ags) in patients with inflammatory bowel diseases (IBD);
difference between Crohn’s disease (CD) and ulcerative colitis (UC). DDW 2007 (5/19/075/24/07) [Poster]
117. Peralejo BM, Aguila H, Geng L, Jyonouchi, H. Mycobacterium fortuitum infection in a child with
defective IL-12/23-IFN-γ circuit: dilemmas in diagnosis and treatment. Annual meeting of
American Academy of Asthma, Allergy, and Immunology. 2007 (2/23/07-2/27/07) [Poster]
118. Jyonouchi H, Geng Lee, Cushing-Ruby, A, Oh C, Hester JD. Association between TLR4 SNPs
(Asp299Gly/Thr399Ile) and non-IgE mediated food allergy (NFA) with or without recurrent otitis
media (OM) and chronic rhinosinusitis (CRS). Annual meeting of American Association of
Immunologist. 2007 (5/18/07-5/22/07) [Poster]
119. Jyonouchi H, Geng Lee, Cushing-Ruby, A, Quraishi H. Evaluation of atopy and immune functions
in children with autism spectrum disorders (ASD): Identification of an ASD subset with distinct
clinical and immunological findings. Annual meeting of Experimental Biology 2008 (4/5/07-
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C. V. Harumi Jyonouchi, M. D. 23
4/9/08) [Poster]
120. Jyonouchi H, Geng Lee, Cushing-Ruby, Monteiro I. A Th17 vs. Th1 cytokine production against
candida and responses to zymosan in patients with chronic airway and gut mucosal inflammation.
Annual meeting of Experimental Biology 2008 (4/5/07-4/9/08) [Poster]
121. Kanuga M, Jyonouchi, H, Fitzgerald-Bocarsly P, Cui C, Yin G, Geng L. Atypical Case of
Autoinflammatory Disease. Annual meeting of American College of Allergy, Asthma, and
Immunology November 2008 [Poster]
122. Nootheti S, Jyonouchi H, Geng L, Cui C, Yin G, Fitzgerald-Bocarsly P. A case of CVID
complicated with Stiff Person’s Syndrome – symptomatic relief by rituxmab. Annual meeting of
American College of Allergy, Asthma, and Immunology. November 2008 [Poster]
123. Jyonouchi H, Cui C, Geng L, Yin Z, and Fitzgerald-Bocarsly P. Age-dependent changes in
peripheral blood dendritic cell subsets in normal children and children with antibody deficiency
syndrome. Annual meeting of AAAAI in Washington, DC (3/13/09 – 3/17/09). [Poster]
124. Jyonouchi H, Geng L, Streck D, and Toruner G. Children with autism spectrum disorders (ASD)
characterized by frequent viral infection and subsequent loss of cognitive skills differ in mRNA
expression of peripheral blood monocytes from other ASD children. Annual meeting of American
Academy of Immunologists held in Seattle, WA (5/9-09 – 5-12-09) [Poster]
125. Desai M, Geng L, and Jyonouchi H. A case of severe autoimmune neutropenia: Evidence of Th17
skewed responses. Annual meeting of American College of Allergy, Asthma, and Immunology.
November 5-10, 2010. [Poster].
126. Gendi, S and Jyonouchi H. Food protein induced enterocolitis syndrome complicated with
persistent candida enteritis. Annual meeting of American College of Allergy, Asthma, and
Immunology. November 5-10, 2009. [Poster]
127. Jyonouchi H, Geng L, Streck D, and Toruner G. A distinct pattern of mRNA expression by
monocytes is found in a subset of children with autism spectrum disorders (ASD) who present with
recurrent infection, repeated loss of cognitive skills, and persistent gastrointestinal (GI) symptoms.
Annual meeting of American Academy of Immunologists held in Baltimore, MA. May 7-10, 2010
[Poster].
128. Kapoor S, Geng L, and Jyonouchi H. Altered responses to agonists of tolle like receptors
(TLR) in patients with severe pediatric asthma but not with mild to moderate asthma.
Annual meeting of American College of Allergy, Asthma, and Immunology held in Phenix,
AZ (11/11/10-11/16-10), [Poster]
129. H. Jyonouchi, L. Geng, S. Kapoor, D. Streck, and G. Toruner. Characterization Of
Children With Autism Spectrum Disorders (ASD) Requiring Intravenous Immunoglobulin
(IVIG) For Specific Polysaccharide Antibody Deficiency
(SPAD)/hypogammaglobulinemia - Distinct Patterns Of Cytokine Production And Gene
Expression Profiles. Annual meeting of American Academy of Asthma, Allergy, and
Immunology held in San Francisco, CA (3/17/11-3/22/11). [Poster]
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C. V. Harumi Jyonouchi, M. D. 24
130. Kapoor S, Geng L, Feldman A, and Jyonouchi H. Characterization of severe asthma (SA)
in children of inner-city of Newark: Altered responses to recall antigens and a panel of
agonists of toll like receptors (TLR). Annual meeting of American Academy of Asthma,
Allergy, and Immunology held in San Francisco, CA (3/17/11-3/22/11). [Poster]
131. Jyonouch H, Geng L, Streck D, and Toruner G. Children with autism spectrum disorders
(ASD) experiencing fluctuating neuropsychiatric symptoms, cognitive skills, and
gastrointestinal (GI) symptoms exhibit distinct innate immune abnormalities and
transcriptional profiles in peripheral blood (PB) monocytes. Annual meeting of American
Association of Immunologist held in San Francisco, CA (5/13/11-5/17/11). [Poster]
132. Feldman A, Rivera R, Geng L, Herbst-Grant M, Kreiswirth B, and Jyonouchi, H.
Necrotizing pulmonary infection and rib osteomyelitis in a patient with suboptimal antiinflammatory response. Annual Meeting of Federation of Clinical Immunology Societies
held in Washington, DC (6/23/11-6/26/11) [Poster]
133. Rahimian V, Lee G, and Jyonouchi H. An IL-1 receptor antagonist as a treatment option
for treatment-resistant seizures (TRS). Annual Meeting of American College of Allergy
and Immunology held in Nov. ’11.
134. Khianey R, Lee G, Aronsky A, and Jyonouchi H. Longitudinal Evaluation of Immune
abnormalities in patients with Down syndrome. Annual Meeting of American College of
Allergy and Immunology held in Nov. ’11.
135. Rahimian V, Lee G, and Jyonouchi H. : Innate and adaptive immune responses differ in
patients with food protein induced enterocolitis syndrome (FPIES) who respond well to the
restrictive diet and those who do not. Annual meeting of American Academy of Allergy,
Asthma, and Immunology held in Orlando, FL in March ‘12
136. Khianey R, Lee G, Shapiro R, and Jyonouchi H. Immune abnormalities in patients with
chronic pain syndrome with unknown etiology. Annual meeting of American Academy of
Allergy, Asthma, and Immunology held in Orlando, FL in March ‘12
137. Jyonouchi H, Geng L, Strek D, and Truner AG. Children with autism spectrum disorders
(ASD) experiencing fluctuating neuropsychiatric symptoms, cognitive skills, and
gastrointestinal (GI) symptoms exhibit distinct innate immune abnormalities and
transcriptional profiles in peripheral blood (PB) monocytes . Annual meeting of American
Academy of Allergy, Asthma, and Immunology held in Boston, MA in May, ‘12.
Invited speaker
1.
Jyonouchi H: Interleukins - functions and clinical application.
Pediatric Ground Round, University of South Florida,
Oct. 7, 1988.
24
C. V. Harumi Jyonouchi, M. D. 25
2.
Jyonouchi H: Enhancing actions of carotenoids on specific antibody (Ab) responses to Tdependent antigens in vivo and in vitro
In a session of Immunomodulating Actions of Carotenoids
Pre-FASEB Carotenoid Symposium, New Orleans March 28, 1993.
3.
Jyonouchi H: Effects of nucleotides on humoral immune responses - experience both in vivo and
in vitro.
Pre-FASEB Symposium: "Nucleotides and Nutrition"
March 28, 1993.
4.
Jyonouchi H: Immunomodulating nutrients in breast milk
Pediatric Ground Round, University of Minnesota
April 21, 1993
5.
Jyonouchi H: Nucleotides as immunomodulating nutrients vs anti-inflammatory agents.
Seminars at Otsuka Pharmaceutical Factory, Inc.
December 17, 1993.
6.
Jyonouchi H: Tumor immunity and chemoprevention
CME course: University of Minnesota, School of Density
September 30, 1994.
7.
Jyonouchi H: Dietary fatty acids and nucleotides: their roles in the immune system.
Seminars at Otsuka Pharmaceutical Factory, Inc.
December 4, 1994.
8.
Jyonouchi H: Allergic rhinitis and sinus infection
CME course: Hennepin County Hospital/University of Minnesota
January 12, 1996.
9.
Jyonouchi H: Chronic sinus infection in children
Ground round: Ramsey Medical Center (General Pediatrics)
February 16, 1996
10.
Jyonouchi H: Inflammatory mediators in chronic sinusitis
Ground round: University of Minnestoa (Pediatrics)
October 16, 1996
11.
Jyonouchi H: The effects of dietary nucleotides on the immune system
25
C. V. Harumi Jyonouchi, M. D. 26
Invited lecture: Yamasa Corp. (Choshi, Japan)
December 17, 1996
12.
Jyonouchi H: The effects of dietary nucleotides on primary and secondary immune responses
against protein neoantigen in rodent models.
Invited lecutre: Ross Product Division/Abott Laboratories
April 21, 1997
13.
Jyonouchi H:The effects of dietary nucleotides on T1 vs. T2 responses against ovalbumin in T2prone BALB/c mice.
Invited lecutre: Meiji Nutrition Research Institute (Odawara, Japan)
December 25, 1997
14.
Jyonouchi H: Immunomodulating actions of non-immunogeneic casein degrades.
Invited lecutre: Annual Meeting of Gifu Bioreseach Institute (Gifu-City, Japan)
Feb. 23, 1998
14.
Jyonouchi H: Pathogenesis of Rhinosinusitis
Ground round: University of Minnestoa (Pediatrics)
May 13, 1998
15.
Jyonouchi H: Adverse Reaction to Food Antigen
Resident Seminar: University of Minnesota (Ped/Med program)
September 1, 1999
16.
Jyonouchi H: Proinflammatory and counter-regulatory cytokine production in ASD children
Invited Seminar at KGNI for basic research (Staten Island, New York)
July 16, 2001
17.
Jyonouchi H: Aberrant immune responses against dietary proteins in ASD children
Ground Rounds at Univ. of Med. Dent. NJ, Nework, NJ
July 16, 2001
18.
Jyonouchi H: Aberrant immune responses in ASD children,
Jonty Foundation Research Conference, Minneapolis, MN, Oct. 20, 2001.
19.
Jyonouchi H: Think Tank meeting for Autism – Research projects involving Autism
Spectrum Disorders.
Jonty Foundation Research Conference, Somerset, NJ, March 22-23, 2003
26
C. V. Harumi Jyonouchi, M. D. 27
20.
Jyonouchi H: Innate immune responses and the linkage to CFS
The 12th Annual CFS Conference – Update on Research and Care, New Jersey CFS Association
and Robert Wood Johnson University Hospital April 12, 2003.
21.
Jyonouchi H: Chronic rhinosinusitis in children. Grounds Rounds for Surgery department (ENT).
UMDNJ-NJMS, April 12, 2006.
22. Jyonouchi H: Autism Immunology Workshop (sponsored by ‘Autism Speaks’ and ‘Cure
Autism Now’) held in Pasadena, CA on 1/25/07 – 1/26/07.
23. Jyonouchi H: Autism Kick-off meeting (sponsored by Nutricia North America) held in
Gaithersburg, MD on 2/16/07
24. Jyonouchi H: Autism Workshop (Autism Think Tank) sponsored by ARI April 2-3, ’08 held in
Cherryhill, NJ.
25. Jyonouchi H: Autism Workshop (Autism Think Tank) sponsored by ARI, Jan 17 ’09 held in Dallas,
TX.
26. Jyonouchi H; Autism One 2010 Conference – May 28-30, 2010 (invited speaker for 2 lectures).
27. Jyonouchi H: Food allergy – Oct 20, 2010 (Abotts Nutrition sponsored seminar held in New
Bruinwick, NJ.
Teaching session:
Project Pediatrics – Oct 15, 2003
Resident Lecture – Oct 10, 2003 (Primary Immunodeficiency)
Fellow’s Lecture – July 22, 2003 (Neuroimmunology)
Resident Lecture – Feb 1, 8, 15, and 22, 2005 (Primary Immunodeficiency Lecture series)
Ground Rounds – March 10, 2005, Allergy/Immunology Fellowship “Apoptosis and the immune system.’
Fellow’s Lecture – Sept. and Oct. 2005 (2 X for A/I fellows and 2X for ID fellows regarding primary
immunodeficiency)
Ground Rounds – Jan. 26, 2006, Allergy/Immunology Fellowship: Defects in Innate Immunity
Clinical Immunology - Aug. 8, 2006, Summer workshop for high-school teachers
Ground Rounds Oct. 20, 2006 Pediatrics  Primary Immunodeficiency
Residents Lecture Series – Feb. 2008 (3 topics) as noon conferences – anaphylaxis and food allergy
Resident Lectures Series – June 2009 (3 topics) as noon conferences – allergy/clinical immunology
testing
Ground Rounds, Oct 16, 2009 Pediatrics  Molecular mechanisms of primary immunodeficiency
Ground Rounds, April 14, 2010 Allergy/Immunology Fellowhip: IVIG treatment
MANUSCRIPT/GRANT REVIEW:
J. Nutrition (Ad hoc review board)
Cancer and Nutrition
J. Immunology
J. Applied Chemistry
27
C. V. Harumi Jyonouchi, M. D. 28
Cancer detection and chemoprevention
Otolaryngology - Head and Neck Surgery (a member of Editorial Review Panel)
Life Sciences
Nutrition (Ad hoc review board)
J. Neuroimmunology
Ann Allergy and Immunology
Pharmacy Review
BMC Gastroenterology
Gene and Immunity
J. Clin. Immunol.
J. Ped. Infect. Dis
Acta Pediatrica
Human Immunology
J Pediatr
Archivum Immunologiae et Therapiae Experimentalis
Expert Review of Gastroenterology
Brain, Behavior, Immunity
Pediatric Research
Archives of General Psychiatry
Pros One
A member of the review committee for NIH center grant (ZRG1 BNP) “Center of Botany and
Dietary Supplements.” - July, 1999
A member of the review committee for NIH center grant (ZAT 1C) “Center of Dietary
Supplements.” - July 11-12, 2000, May 23-25, 2001
A member of the review committee for NCCAM/NIH: Nov, 2000, Feb. 2001
A member of Autism Forum “GI autism literature Review” March 2008 – May 2008
A member of CDMRP ‘autism program’ review board – Oct. 2009.
A member of CDMRP ‘autism program’ review board – Aug. 2010.
28