CPT Code changes for CPT 2016
December 1, 2015
Dear Valued Client:
The American Medical Association (AMA) has made Current Procedural Terminology
(CPT) code changes to the 2016 edition of the CPT coding manual.
Quest Diagnostics will be implementing these changes effective January 1, 2016. The
enclosed lists the individual tests affected and the appropriate CPT code changes.
These tests may also be included in panels or profiles. This list may also be found on
the Quest website http://www.questdiagnostics.com/home/physicians/cpt-icd.html.
In September 2015, Centers for Medicare and Medicaid Services (CMS) announced the
possible adoption of new G codes for toxicology and the deletion of G codes that
existed for 2015. We will be updating our systems when their decision is finalized.
CPT 2016 changes involve a new AMA Panel 80081 Obstetric Panel (includes HIV
testing), a few new molecular testing codes, new GSP codes, changes to Tier 2
molecular codes, additional MAAA tests, and deletion of several methodology CPT
codes in the Chemistry section. Additional detailed information will be available on our
website.
We appreciate your support and look forward to continuing to serve all of your
laboratory needs. We at Quest Diagnostics will make every effort to assist you with the
transition to the 2016 AMA CPT coding being used for our test offerings.
Please do not hesitate to call your Quest Diagnostics Sales Representative with any
questions or concerns you may have regarding CPT code changes. Or visit our website
at QuestDiagnostics.com for further CPT coding updates.
Thank you very much for using Quest Diagnostics for your laboratory testing needs.
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the
sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
AMA Changes in CPT Coding
Effective January 1, 2016
Quest Diagnostics Test Name
BRCAvantageTM, Comprehensive
BRCAvantageTM, Ashkenazi
Jewish Screen with Reflex
BRCAvantage, Comprehensive
Quest
Diagnostics
Order Code
91863
2015 CPT Coding
2016 CPT Coding
81211, 81213
81162
BRCAvantageTM with Reflex to
Breast Plus Panel
92573
81212 with reflex to
81211, 81213
81211, 81213, 81321,
81323, 81404, 81405
(x2), 81406 (x2),
81479
81211, 81213 with
reflex to 81321,
81323, 81404, 81405
(x2), 81406 (x2),
81479
ABL Kinase Domain Mutation in
CML, Cell-based
16029
81403
81170
ABL Kinase Domain Mutation in
CML, Plasma-based, LeumetaR
16031
81403
81170
CEBPA Mutation Analysis
90812
81403
81218
CEBPA Mutation Analysis,
Extracted DNA
90813
81403
81218
Acute Myeloid Leukemia
Prognostic Panel (Normal
Karyotype)
90871
81403, 81310, 81245,
81246
81218, 81310, 81245, 81246
Acute Myeloid Leukemia
Prognostic Panel (Normal
Karyotype)(NY)
91867
81403, 81310, 81245,
81246
81218, 81310, 81245, 81246
Calreticulin (CALR) Mutation
Analysis
92074
81479
81219
c-kit Mutation Analysis, Plasmabased, LeumetaR
19960
81404
81273
C-KIT Mutation Analysis, Cellbased
19961
81404
81273
c-KIT Mutations with Reflex to
PDGFRA Mutations for GIST
16237
81404 with reflex to
81404
81273 with reflex to 81314
BRCAvantageTM Plus (BRCA1,
BRCA2, TP53, PTEN, CDH1,
STK11, PALB2)
92140
92587
81212 with reflex to 81162
81162, 81321, 81323, 81404,
81405 (x2), 81406 (x2), 81479
81162 with reflex to 81321,
81323, 81404, 81405 (x2), 81406
(x2), 81479
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the
sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Quest Diagnostics Test Name
Quest
Diagnostics
Order Code
2015 CPT Coding
2016 CPT Coding
NRAS Mutation Analysis
16818
81404
81311
RAS Mutation Analysis, Plasmabased LeumetaR
16127
81275, 81403, 81404
81311, 81275, 81403
RAS Mutation Analysis, CellBased
16128
81275, 81403, 81404
81311, 81275, 81403
Colorectal Cancer Mutation Panel
(KRAS, PIK3CA, BRAF, NRAS)
18902
81275, 81404, 81210,
81404
81275, 81311, 81210, 81404
Thyroid Cancer Mutation Panel
(BRAF, RAS, RET/PTC,
PAX8/PPAR)
90469
81210, 81404, 81275,
81403, 81404, 81401
81210, 81311, 81275, 81403,
81404, 81401
RAS Mutation Analysis, Thyroid
Cancer
90479
81275, 81403, 81404
81275, 81311, 81403
PDGFRA Mutation Analysis
16859
81404
81314
90891
81220, 81200, 81251,
81242, 81209, 81255,
81260, 81330, 81290,
81250, 81205
81412
Ashkenazi Jewish Panel (11
Tests) (NY)
90892
81220, 81200, 81251,
81242, 81209, 81255,
81260, 81330, 81290,
81250, 81205
81412
IgG, IgA, Indirect
Immunofluorescence, Serum
16690
88347 (x2)
88346, 88350
Acylglycines, Quantitative, Urine
10661
82544
82542
Bromide, Serum/Plasma
30540
82491
82542
Cardio IQ® Omega-3 and -6 Fatty
Acids
91734
82541
82542
Chlordane and Metabolites
6076
82492
82542
Coenzyme Q10
19826
82491
82542
Ashkenazi Jewish Panel (11
Tests)
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the
sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Quest Diagnostics Test Name
Quest
Diagnostics
Order Code
2015 CPT Coding
2016 CPT Coding
Dapsone
3303
82492
82542
DDT with DDD and DDE
34537
82492
82542
Dimethylsulfoxide, Blood
6110
82491
82542
Dopamine, Plasma
14762
82491
82542
Dopamine, Random Urine
17101
82491
82542
Dopamine, Urine
14763
82491
82542
Epinephrine, Plasma
37560
82491
82542
Fatty Acid Profile, Comprehensive
17568
82544
82542
Fatty Acid Profile, Essential (C12C22)
11254
82544
82542
Herbicides Panel 1 Screen
38008
82486
82542
Lecithin/Sphingomyelin Ratio with
Qualitatitve Phosphatidyl Glycerol
19971
83661, 82489
83661, 82542
Methylbromide as Metabolite,
Blood
6202
82491
82542
N,N Dimethylformamide (DMF)
Exposure, Urine
33960
82491
82542
Norepinephrine, Plasma
37562
82491
82542
Omega-3 and -6 Fatty Acids
91001
82541
82542
Organochlorine Pesticides
3529
82492
82542
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the
sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Quest Diagnostics Test Name
Quest
Diagnostics
Order Code
Organochlorine Pesticides, Blood
2015 CPT Coding
2016 CPT Coding
7804
82492
82542
PCB Panel, Blood
26503
82491
82542
Pentachlorophenol, Blood
35380
82491
82542
Polychlorinated Biphenyls Panel
34535
82491
82542
Porphyrins, Fractionated, Plasma
5519
82492
82542
Porphyrins, Fractionated, Plasma
(NY)
10289
82492
82542
Porphyrins, Total, Plasma
10290
82491
82542
Porphyrins, Total, Plasma (NY)
10288
82491
82542
Smith-Lemli-Opitz Screen,
Plasma
15992
82541
82542
Methoxychlor
3195
82491
82441
N,N Dimethylformamide (DMF)
Exposure, Urine
33960
82491
82542
Tetrahydrofuran
38024
82491
82542
Sulfide Exposure Biouptake
Marker
30528
82491
82542
Tamoxifen and Metabolites,
LC/MS/MS
91998
83789
80299
Carbamazepine-10,11-Epoxide
36676
83789
80156
617
82491
82441
Lindane
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the
sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Quest Diagnostics Test Name
Quest
Diagnostics
Order Code
2015 CPT Coding
2016 CPT Coding
894
82491
82441
Chloral Hydrate, Blood
24989
82491
82441
Hypoglycemic Panel
19595
83789
80299
Acetaldehyde, Blood
202
82491
80320
Chloral Hydrate
Acetonitrile Exposure Profile,
Blood
35385
82491, 82010, 82600
80320, 82600
Alfentanil Screen, Urine
21106
80354
80304
Diuretics Screen, Urine
91594
83788
80304
Dextrorphan/Levorphanol Screen,
S/P
3245
80362
80304
Glutethimide
422
83789
80368
Ipecac Use Markers
30511
83789
80304
LSD Trace Analysis, Urine
30165
82492
80323
Meclizine Screen
6184
80375
80304
Naltrexone and Metabolite
Confirmation, Free
(Unconjugated)
34532
83789
80362
Strychnine Screen, Blood
1024
83788
80302
Strychnine Screen,
Serum/Plasma
855
83788
80302
Strychnine Screen, Urine
8305
82486
80302
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the
sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.