Laboratory Specific Standard Operating Procedure Environmental Health and Safety Chemical: Cadmium compounds (replace with specific compound Vanadium (III)chloride used for this SOP) Please fill out form completely. Print a copy and insert into your Laboratory Safety Manual and Chemical Hygiene Plan. Instructions are in italics; if you have questions please contact Environmental Health and Safety at 702.9999. Laboratory Information Department: Principal Investigator: Laboratory Safety Contact/Lab Manager: Laboratory Phone: Office Phone: Emergency Contact: (Name and Phone Number) Locations Covered in this SOP: (Building/Room Number) SOP Approval Date: Type of SOP Purpose (State the purpose and the procedure for the specific chemical that is used in the lab, include quantities and concentrations) Physical & Chemical Properties/Definition of Chemical Group CAS #: Emergency Overview: 7718-98-1 Vanadium (III) chloride OSHA Hazards Toxic by Ingestion, Corrosive GHS Classification Acute toxicity, Oral (Category 4) Skin corrosion (Category 1B) Serious eye damage (Category 1) Molecular Formula: Cl3V Cl3V Form (physical state): Solid powder Color: Dark violet Potential Hazards/Toxicity Cadmium absorption is most efficient via the respiratory tract. Inhalation of dust may produce irritation, headache, metallic taste and/or cough. Severe exposures may produce shortness of breath, chest pain, and flu-like symptoms with weakness, fever, headache, chills, sweating, nausea, and muscular pain. Can cause pulmonary edema, liver and kidney damage, and death. Symptoms from inhalation may be delayed for as long as 24 hours. Ingested cadmium salts may cause severe and sometimes fatal poisonings. Symptoms can include severe nausea, vomiting, diarrhea, abdominal pains, choking, dizziness, and salivation. Kidney and liver dysfunction may occur. Although as little as 10-20mg of soluble cadmium produced severe toxic symptoms when ingested; death likely requires several hundred milligrams taken orally. Contact with skin may cause irritation with redness and pain. Eye contact may cause irritation, redness, and pain. Chronic exposure to cadmium compounds, even at low concentrations may result in kidney damage, anemia, pulmonary fibrosis, emphysema, perforation of the nasal septum, loss of smell, male reproductive effects, and an increased risk of cancer of the lung and prostate. Decrease in bone density, renal stones, and other evidence of disturbed calcium metabolism may be observed. Personal Protective Equipment (PPE) Respiratory Protection The recommended exposure limit set by NIOSH is 0.05mg/m 3 (15 minute ceiling value) for calcium chloride. A fume hood will be used when concentrations exceed this value. No employee of the University of Chicago shall be issued or required to wear a respirator until the need for such protection is validated by Environmental Health and Safety and the affected employee has met the criteria set forth by the Occupational Safety and Health Administration (OSHA). Lab personnel intending to use/wear a respirator mask must be trained and fit-tested by EH&S. This is a regulatory requirement. Please see the University's Respiratory Protection Program for more information. Hand Protection Disposal latex or nitrile gloves may be used when handling dry cadmium compounds NOTE: If you will be working with cadmium solutions or mixtures consult with your preferred glove manufacturer to ensure that the gloves you plan on using are compatible with the reagent you are using. Refer to glove selection chart from the links below: • Ansell - ansellpro.com/download/Ansell_8thEditionChemicalResistanceGuide.pdf • All Safety Products - allsafetyproducts.biz/page/74172 • Microflex - microflex.com/Products/~/media/Files/Literature/Domestic%20Reference%20Materials/ • Mapa Glove - mapaglove.com/ Eye Protection The use of safety glasses or chemical splash goggles are required during procedures when working with cadmium compounds. In procedures where splashing is likely, a face shield should be used in combination with safety glasses or goggles. Skin and Body Protection Lab coats, full-length pants, and closed toed shoes are required. During operations where splashing is likely, a chemical resistant apron must also be worn. Hygiene Measures Remove and replace gloves if contamination occurs. Wash hands after working with the substance. Engineering Controls Work with cadmium compounds must be done in a fume hood with an average face velocity of 100 fpm. If a hood is not available, contact Environmental Health and Safety to have the need for alternate engineering controls or the use of a respirator. First Aid Measures If inhaled: Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt, or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious, or corrosive. Seek immediate medical attention. In case of skin contact: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Cold water may be used. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately. Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician In case of eye contact: If swallowed: Special Handling and Storage Requirements Stable under recommended storage conditions. Avoid strong oxidizing agents. Chemical Spill Procedure Spill – Assess the extent of danger. Help contaminated or injured persons. Evacuate the spill area. Avoid breathing vapors. If possible, confine the spill to a small area using a spill kit or absorbent material. Keep others from entering contaminated area (e.g., use caution tape, barriers). Small (<1 L) – If you have training, you may perform clean-up operations accordingly. Use appropriate personal protective equipment and clean-up material for chemical spilled. (Double bag spill waste in plastic bags, label and arrange for chemical waste pick-up) Refer to University Chemical Spill Response Policyfor more information. Large (>1 L) – Dial University Police at 123 or 773.702.8181 for assistance. Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower for at least 15 minutes. Seek medical attention. Notify supervisor and EH&S at 773.702.9999 immediately. Chemical Splash Into Eyes – Immediately rinse eye and inner surface of eyelid with water from the emergency eyewash station for 15 minutes by holding the eye open. Seek medical attention. Notify supervisor and EH&S at 773.702.9999 immediately. Medical Emergency Life Threatening Emergency, After Hours, Weekends and Holidays – Dial 123 (702.8181 from cellular phone) Note: All serious injuries must be reported to EH&S at 702.9999 within eight hours. Non-Life Threatening Emergency – Go to the University of Chicago Occupational Medicine (UCOM) clinic located in the Chicago Lying-In Hospital, 5815 South Maryland Avenue, L156 from 7:15 a.m. – 4:00 p.m. After hours and on weekend go to the Adult Emergency Room located in the Bernard Mitchell Hospital, 901 East 58th Street. Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash the affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the affected area for 15 minutes using an eyewash station. Go to the UCOM clinic during regular business hours. All other times report to Adult Emergency Room located in the Bernard Mitchell Hospital. Note: All needle stick/puncture exposures must be reported to the needlestick hotline by paging 188.9990 within eight hours. Decontamination/Waste Disposal Procedure (Enter text) General hazardous waste disposal guidelines Label Waste: Label container as hazardous waste and date the container with the accumulation start date (the date the material was declared waste) Store Waste: Store hazardous waste in closed containers, in secondary containment and in a designated location. Double-bag dry waste. Waste must be under the control of the person disposing of it. Dispose of Waste: Dispose of regularly generated chemical waste within 90 days. Create pick u request via online EH&S Assistant program or contact EH&S at 702.9999. Consult Hazardous Material Management policy online for additional information. Safety Data Sheet (SDS) Location In accordance with the Occupational Safety and Health Administration (OSHA), employers shall maintain any safety data sheets that are received with incoming shipments of hazardous chemicals, and ensure that they are readily accessible during each work shift to employees when they are in their work areas. Safety Data Sheets are accessible as follows: Searching under Safety Data Sheets on the Safety as listed below; Contacting 3E Company at 1-800-451-8346 anytime of the day or week with the product name and number, manufacturer name and UPC code (if available); or Contacting Environmental Health and Safety at 773.702.9999 between the hours of 8:00 a.m. – 4:30 p.m., Monday through Friday. CCINFO on the Internet The University of Chicago has established an account with the Canadian Centre for Occupational Health and Safety (CCINFO) Academic Support Program. Note: This collection has been set up to only allow access from University of Chicago computers. The CCINFO Academic Support Program provides access to the following collections: SDS CHEMINFO CHEMpendium RTECS OSH References Canadian enviroOSH Legislation plus Standards Additional Resources Accessing CCINFO To access: 1. 2. 3. 4. 5. Go to CCINFO Choose collection from web collections Type chemical name and click search Choose correct product and click blue link to open safety data sheet If you are prompted to enter a user name and password, the computer in use is not in the IP range and/or domain name provided Other MSDS Sites Sigma, Aldrich, Fluka, Supelco, RdH-Lab Acros Chemicals, Fisher Scientific, Curtin Matheson Scientific VWR Scientific Products Vermont Safety Information Resources Inc. Bio-Rad Laboratories Health Canada CDMS Agro-Chemical Database Protocol/Procedure (Add lab specific Protocol/Procedure here) Documentation of Training Prior to conducting any work with methylene chloride (dichloromethane), designated personnel must provide training to his/her laboratory personnel specific to the hazards involved in working with this substance, work area decontamination, and emergency procedures The principal investigator must provide his/her laboratory personnel with a copy of this SOP and a copy of the SDS provided by the manufacturer The principal investigator shall ensure that his/her laboratory personnel have attended appropriate laboratory safety training or refresher training Note: Any deviation from this SOP requires approval from the principal investigator.