Medical Biochemistry (醫技系) Spring 2015 COURSE COORDINATOR: Woei-Jer Chuang, Ph.D. (莊偉哲) Distinguished Professor Department of Biochemistry and Molecular Biology email: wjcnmr@mail.ncku.edu.tw CREDIT HOUR: 6 credit hours TEXTBOOK: Principles of Biochemistry, International Student Version, Donald Voet, Judith G. Voet, Charlotte W. Pratt, 2013, 4th Edition, John Wiley & Sons, Inc.. (歐亞書局) TIME & PLACE: I. Monday 9:10 - 11:00 AM 303D II. Wednesday 8:10 – 10:00 AM 303D II. Friday 8:10 – 10:00 AM 303D GRADES: Lecture-based term-tests/final exam /experiment, and final grade as follows: Examination Date Lecture covered Weight Place Exam 1 4/17 2 – 29 27.5% 3rd Floor Lab Exam 2 5/18 30 –60 30.0% 3rd Floor Lab Exam 3 6/22 61 – 86 27.5% 3rd Floor Lab Experiment 15.0% Teaching Faculties Name Location Phone Woei-Jer Chuang, Ph.D. (莊偉哲) Distinguished Professor Department of Biochemistry and Molecular Biology 82-0902 5515 Yu-Hung Chen Ph.D. (陳毓宏) Assistant Professor Department of Medicine 82-0651 5365 Chan-Shi Chen, Ph.D. (陳昌熙) Associate Professor Department of Biochemistry and Molecular Biology 82-0931 5548 Hung-Chi Cheng, Ph.D(鄭宏祺) Associate Professor Department of Biochemistry and Molecular Biology 82-0912 5544 Yueh-Ren Ho, Ph.D. (何月仁) Instructor Department of Biochemistry and Molecular Biology 82-0932 5547 Hua-Lin Wu, Ph.D. (吳華林) Chair Professor Department of Biochemistry and Molecular Biology 82-0915 5541 Po-Hsien Huang, Ph.D. (黃柏憲) Assistant Professor Department of Biochemistry and Molecular Biology 82-0904 5513 Chao-Liang Wu, Ph.D. (吳昭良) Distinguished Professor Department of Biochemistry and Molecular Biology 82-0920 5536 Wen-Tsan Chang, D.Phil. (張文粲) Associate Professor Department of Biochemistry and Molecular Biology 82-0923 5533 2 Lecture 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 Date 2/25 Wed Mon 3/2 3/4 Wed 3/6 Fri 3/9 Mon 3/11 Wed 3/13 Fri 3/16 Mon 3/18 Wed 3/20 Fri 3/23 Mon 3/25 Wed 3/27 Fri 3/30 Mon 4/8 Wed 4/10 Fri 4/13 Mon 4/15 Wed 4/17 4/20 Fri Mon Topics Introduction Physical and chemical properties of water Physical and chemical properties of water Overview of DNA structure, function, and engineering Overview of DNA structure, function, and engineering Amino acids: the building blocks of proteins Amino acids: the building blocks of proteins Amino acids: the building blocks of proteins Polypeptide sequences, analysis, and evolution Polypeptide sequences, analysis, and evolution Polypeptide sequences, analysis, and evolution Protein structure and folding Protein structure and folding Protein structure and folding Protein structure and folding physiological activities of proteins physiological activities of proteins physiological activities of proteins Saccharide chemistry Saccharide chemistry Saccharide chemistry Lipids Bilayer and membrane Lipids Bilayer and membrane Lipids Bilayer and membrane Passive and active transport Passive and active transport Passive and active transport Mechanisms of enzyme action Mechanisms of enzyme action Mechanisms of enzyme action Properties of enzymes Properties of enzymes Properties of enzymes Hormones and signal transduction Hormones and signal transduction 1st examination 3 樓實驗室 Bioenergetics Bioenergetics 3 Lecturer 莊偉哲 陳毓宏 陳昌熙 莊偉哲 莊偉哲 莊偉哲 鄭宏祺 鄭宏祺 何月仁 何月仁 吳華林 吳華林 鄭宏祺 陳毓宏 Lecture 38 39 40 41 42 43 44 45 46 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 Date 4/22 Wed 4/24 Fri 4/27 Mon 4/29 Wed 5/1 Fri 5/4 Mon 5/6 Wed 5/8 Fri 5/11 Mon 5/13 Wed 5/15 Fri 5/18 5/20 Mon 5/22 Fri 5/25 Mon 5/27 Wed 5/29 Fri 6/1 Mon 6/3 Wed 6/5 Fri Wed Topics Bioenergetics Bioenergetics Glycolysis and the Pentose phosphate pathway Glycolysis and the Pentose phosphate pathway Glycolysis and the Pentose phosphate pathway Additional Pathway in carbohydrate metabolism Additional Pathway in carbohydrate metabolism Additional Pathway in carbohydrate metabolism The Citric acid cycle The Citric acid cycle The Citric acid cycle Mitochondrial ATP synthesis Mitochondrial ATP synthesis Mitochondrial ATP synthesis Synthesis and degradation of lipids Synthesis and degradation of lipids Synthesis and degradation of lipids Synthesis and degradation of lipids Synthesis and degradation of lipids Synthesis and degradation of lipids Synthesis and Degradation of amino acids Synthesis and Degradation of amino acids 2nd Examination 3 樓實驗室 Synthesis and Degradation of amino acids Synthesis and Degradation of amino acids Regulation of Fuel metabolism Regulation of Fuel metabolism Regulation of Fuel metabolism Regulation of Fuel metabolism Nucleotide synthesis and Degradation Nucleotide synthesis and Degradation Nucleotide synthesis and Degradation Nucleotide synthesis and Degradation DNA structure and interactions with proteins DNA structure and interactions with proteins DNA structure and interactions with proteins DNA structure and interactions with proteins DNA synthesis and repair DNA synthesis and repair 4 Lecturer 陳昌熙 陳昌熙 陳昌熙 陳昌熙 何月仁 黃柏憲 黃柏憲 何月仁 吳昭良 張文粲 黃柏憲 Lecture 77 78 79 80 81 82 83 84 85 86 Date Mon 6/8 6/10 Wed 6/12 Fri 6/15 Mon 6/17 Wed 6/22 Mon Topics DNA synthesis and repair DNA synthesis and repair RNA metabolism RNA metabolism RNA metabolism RNA metabolism The genetic code and translation The genetic code and translation The genetic code and translation The genetic code and translation Final examination 3 樓實驗室 5 Lecturer 黃柏憲 張文粲