Table S1: The physicochemical properties of the positive selected amino acids identified in this study.
branc
hes
branc
ha
M35
family
branc
he
branc
hf
branc
hj
M36
family
branc
ha
sit
e
original
amino acid
physicochemical properties of
original amino acid
substituted
amino acid
A
nonpolar, neutral, hydrophobic
R/Q
K
basic polar, positive, alkaline
M
nonpolar, neutral, hydrophobic
R/H
V
nonpolar, neutral, hydrophobic
Q
polar, neutral
Y
polar, neutral
Q
polar, neutral
E
G
acidic, negative
nonpolar, neutral
T
K/Q
85
E
acidic, negative
S/T/L
99
A
nonpolar, neutral, hydrophobic
K/Q
63
84
18
3
26
7
Y
A
polar, neutral
nonpolar, neutral, hydrophobic
V/I
R
G
nonpolar, neutral
Y
polar, neutral
15
0
16
6
20
3
17
7
25
5
57
79
A/R/G
P
V/I
physicochemical properties of substituted amino acid
R: basic polar, positive, alkaline; Q: polar, neutral
A: hydrophobic R:basic polar, positive, alkaline;
G:nonpolar, neutral
R:basic polar, positive, alkaline; H:basic polar,
positive/neutral,alkaline
polar, neutral
K:basic polar, positive, alkaline; Q:polar, neutral
S:polar,neutral; T: polar, neutral ; L: nonpolar,
neutral
K: basic polar, positive, alkaline, positive ; Q: polar,
neutral
V: nonpolar, neutral, hydrophobic
basic polar, positive, alkaline
nonpolar, neutral, hydrophobic
V: nonpolar, neutral, hydrophobic; I:nonpolar, neutral
40
1
K
basic polar, positive, alkaline
H
basic polar, positive/neutral,alkaline
branc
hb
40
T
polar, neutral
E
acidic, negative
A
nonpolar, neutral, hydrophobic
H
basic polar, positive/neutral,alkaline
I
nonpolar, neutral, hydrophobic
A/P
branc
hg
13
9
22
1
23
2
30
0
51
0
Y
polar, neutral
W
nonpolar, neutral
L
nonpolar, neutral
C
nonpolar, neutral
W
nonpolar, neutral, hydrophobic
M
nonpolar, neutral, hydrophobic
A: nonpolar, neutral, hydrophobic; P: nonpolar,
neutral, hydrophobic