Name:_______________________________Aim:________________________Date:_________
Video:Human Genome
http://app.discoveryeducation.com/player/view/assetGuid/8E340425-0B8E-4C6D-B088-18CAF08227BB
Program Description
It’s a project of enormous magnitude: mapping the human genome. Learn how what began with
the discovery of DNA has now led to the understanding of which human genes are responsible
for specific human traits, including growth, development, health, and even personality.
About the Human Genome Project
 The primary goal was to locate the estimated 30,000 or more human genes on all the
chromosomes and determine their sequence along each strand of DNA.
 By June 2000, scientists had completed a rough draft of the human genome. The final
draft was finished in April 2003, two years ahead of schedule.
 Scientists use this information to understand how genes function, how genetic material
varies among people, and how some genetic variations predispose people to disease
Part 1: Questions
Before watching the video:
1. Give a brief description of the Central Dogma of Molecular Biology? (DNA → RNA →
Protein → Trait)
2. Consider how an understanding of the human genetic code may influence the future of
our species?
As you are watching the video:
3. What is the human genome?
4. How long is our genome?
5. How much of DNA carries coded instruction?
6. What percentage of every human is identical at a molecular level?
7. Describe mitochondrial DNA. How is it useful?
After the Video:
8. What are some of the challenges of deciphering the human genome?
9. Debate the moral and social implications of this project.
Name:_______________________________Aim:________________________Date:_________
Video:Human Genome
Part 2 Questions:
Before the Video:
1. Scientists have proved that some types of cancer are related to an individual’s genetic
code. As you watch the program, look for technologies that allow us to alter our genes.
How might these methods help eliminate some diseases or increase human lifespan?
As you are watching the video:
2. What are the long-term effects of the human genome project?
3. What is p53?
4. What happens if you have damaged p53 genes?
5. What is an adenovirus and how could it help? (This idea is known as gene therapy)
6. What is our defense against free radicals?
7. Describe the “ultimate timekeeper” for human beings.
After the video:
8. The protein P-53 plays a critical role in preventing cancer. Discuss what people with
defective P-53 genes or other inheritable genetic diseases should know before having
children. What are the genetic risks to their children?