MCB 7200 Reading List - Fall 2015
Frank Horodyski
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Chromatin Structure
Lodish Ch. 6, pp. 223-225, 256-266
Zhou, V.W., Goren, A. and Bernstein, B.E. (2011). Charting histone modifications and the
functional organization of mammalian genomes. Nature Rev.Genet. 12, 7-18.
Venkatesh,S. and Workman,J.W. (2015). Histone exchange, chromatin structure and the
regulation of transcription. Nature Rev.Mol.Cell Biol. 16, 178-189.
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Heterochromatin
Lodish, Ch. 7, pp. 315-320
Grewal, S.I.S. and Jia, S. (2007). Heterochromatin revisited. Nature Rev.Genet. 8, 35-46.
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Epigenetics
Lodish Ch. 7, pp. 327-335
Johnstone, S.E. and Baylin, S.B. (2010). Stress and the epigenetic landscape: a link to the
pathobiology of human diseases? Nature Rev.Genet. 11, 806-812.
Margueron, R. and Reinberg, D. (2010). Chromatin structure and the inheritance of epigenetic
information. Nature Rev.Genet. 11, 285-296.
Bantignies, F. and Cavalli, G. (2011). Polycomb group proteins: repression in 3D. Trends Genet.
27, 454-464.
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Imprinting and Dosage Compensation
Bartolomei, M.S. (2009). Genomic imprinting: employing and avoiding epigenetic processes.
Genes Dev. 23, 2124-2133.
Lee, J.T. (2012). Epigenetic regulation by long noncoding RNAs. Science 338, 1435-1539.
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DNA Replication
Lodish Ch. 4, pp.115-123, 145-151
Ch. 6, pp. 273-274
Ch. 19, pp. 894-897
Ch. 24, pp.1148-1150
Alabert, C. and Groth, A. (2012). Chromatin replication and epigenome maintenance. Nature
Rev.Mol.Cell Biol. 13, 153-167.
Martinez, P. and Blasco, M.A. (2015). Replicating through telomeres: a means to an end. Trends
Biochem.Sci. 40, 504-515.
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Mutation-DNA Repair
Lodish Ch. 4, pp. 151-159
Ch. 24, pp.1144-1148
Lindahl, T. (1993). Instability and decay of the primary structure of DNA. Nature 362, 709-715.
Marteijn, J.A., Lans, H., Vermeulen, W. and Hoeijmakers, J.H.J. (2014). Understanding
nucleotide excision repair and its roles in cancer and ageing. Nature Rev.Mol.Cell Biol. 15, 465481.
Panier, S. and Boulton, S.J. (2014). Double-strand break repair: 53BP1 comes into focus. Nature
Rev.Mol.Cell Biol. 15, 7-18.
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Posttranscriptional Gene Silencing/Biological Roles of microRNAs
Lodish Ch. 8, pp. 370-374
Ch. 24, pp. 1143-1144
Huntzinger, E. and Izaurralde, E. (2011). Gene silencing by microRNAs: contributions of
translational repression and mRNA decay. Nature Rev.Genet.12, 99-110.
Thornton, J.E. and Gregory, R.I. (2012). How does Lin28 let-7 control development and disease?
Trends Cell Biol. 22, 474-482
Luteijn, M.J. and Ketting, R.F. (2013). PIWI-interacting RNAs: from generation to
transgenerational epigenetics. Nature Rev.Genet. 14, 523-534.
tenOever, B.R. (2013). RNA viruses and the host microRNA machinery. Nature Rev.Microbiol.
11, 169-180.
Barrangou, R. and Marraffini, L.A. (2014). CRISPR-Cas systems: Prokaryotes upgrade to
adaptive immunity. Mol.Cell 54, 234-244.
Gantz, V.M. and Bier, E. (2015). The mutagenic chain reaction: A method for converting
heterozygous to homozygous mutations. Science 348, 442-444. (student presentation) (1)
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Recombination and Transposition (student presentations)
Lodish Ch. 6, pp. 234-245
Ch. 23, pp.1073-1081, 1111-1112
Topics to be covered:
Mechanism of Homologous Recombination (2)
Immunoglobulin Gene Rearrangement (3)
Transposons and Mechanisms of Transposition (4)