STEPHEN J. PANDOL, MD
Cedars-Sinai Medical Center
8730 Alden Drive, Thalians, Suite E222
Los Angeles, CA 90048
Stephen.Pandol@cshs.org
BIOGRAPHICAL DATA:
Date of Birth:
June 1, 1949, Bakersfield, CA
Education:
University of California, Davis, CA
B.S., 1971
St. Louis University School of Medicine, St. Louis, MO
M.D., 1975
PROFESSIONAL EXPERIENCE AND ACADEMIC APPOINTMENTS:
Intern in Medicine, 1975-1976
Wadsworth Veterans Administration Medical Center, Los Angeles, CA
Resident in Medicine, 1976-1978
Wadsworth Veterans Administration Medical Center, Los Angeles, CA
Chief Resident in Medicine, 1978-1979
Wadsworth Veterans Administration Medical Center, Los Angeles, CA
Fellow in Gastroenterology, 1978-1979
University of California, Los Angeles/Wadsworth Veterans Administration
Clinical Associate, 1979-1982
Digestive Diseases, Nat'l Institute of Diabetes, Digestive & Kidney Diseases
National Institutes of Health, Bethesda, MD
Staff Physician, 1982-1995
Department of Veterans Affairs Medical Center, San Diego, CA
Assistant Professor of Medicine, 1982-1987
University of California, San Diego, CA
Research Associate, 1984-1986
Department of Veterans Affairs Medical Center, San Diego, CA
Associate Professor of Medicine, 1987-1992
University of California, San Diego, CA
Clinical Investigator, 1987-1992
Department of Veterans Affairs Medical Center, San Diego, CA
Chief, Gastroenterology, 1992-1995
Department of Veterans Affairs Medical Center, San Diego, CA
Professor of Medicine, 1992-1995
University of California School of Medicine, San Diego, CA
Director, Research and Development, 1996-1998
West Los Angeles Veterans Administration Medical Center, Los Angeles, CA
Stephen J. Pandol, M.D.
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Professor of Medicine, 1996-Present
University of California School of Medicine, Los Angeles, CA
Staff Physician, 1996-Present
Department of Veterans Affairs Medical Center, West Los Angeles, CA
Co-Director of Southern California Research Center for ALPD and Cirrhosis,
1999-Present
Professor of Molecular Toxicology, 2004-Present
University of California School of Medicine, Los Angeles, CA
Guest Professor, Southern Medical University, P.R. China, 2009-Present
Co-Director of UCLA Center for Excellence in Pancreatic Diseases, 2007-Present
Director, Basic and Translational Pancreatic Research, Cedars-Sinai Medical
Center, 2012-Present
HONORS:
Phi Kappa Phi Honor Society
University of California, Davis, CA, 1970
Outstanding Undergraduate Accomplishment in Biochemistry
Department Citation, University of California, Davis, CA, 1971
Bachelor of Science Degree, With Highest Honors
University of California, Davis, CA, 1971
Alpha Omega Alpha Medical Society
St. Louis University School of Medicine, St. Louis, MO, 1975
Doctor of Medicine Degree, Cum Laude
St. Louis University School of Medicine, St. Louis, MO, 1975
Outstanding Medical Intern
Wadsworth Veterans Administration Hospital, Los Angeles, CA, 1978
Outstanding Medical Resident
Wadsworth Veterans Administration Hospital, Los Angeles, CA, 1978
Department of Medicine's 7th Annual Chief Residents' Teaching Award
University of California School of Medicine, San Diego, CA, 1993
Department of Medicine's Eighth Annual Chief Residents' Teaching Award
University of California School of Medicine, San Diego, CA, 1994
The Kaiser Permanente Award for Excellence in Teaching
Honorable Mention
Dept. of Medicine, Univ. of CA School of Medicine, San Diego, CA, 1994.
Accreditation with Commendation
JCAHO Survey
Received by Veterans Affairs Medical Center, San Diego, CA, 1995
Carey Award
Received by Veterans Affairs Medical Center, West Los Angeles, CA, 1997
Accreditation with Commendation
JCAHO Survey
Received by Veterans Affairs Medical Center, West Los Angeles, CA, 1998
BOARD REQUIREMENTS ACCOMPLISHED:
Stephen J. Pandol, M.D.
Page 2
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National Board of Medical Examiners, 1976
The American Board of Internal Medicine, 1978
The American Board of Internal Medicine, Gastroenterology, 1982
CERTIFICATION:
State of California, Board of Medical Quality Assurance
License Number G033954
MEMBERSHIPS:
American Association for the Advancement of Science
American Federation of Clinical Research
American Gastroenterological Association
Committee Member, Gastrointestinal Teaching Project, 1993-present
Committee Member, Gastrointestinal Research Group, 1999-present
Committee Member, Research Committee, 2002-present
American Liver Foundation
President, San Diego Chapter, 1991-1993
Vice-President, San Diego Chapter, 1993-1995
Member, Medical Advisory Committee, Los Angeles Chapter, 1999-present
American Pancreatic Association
Board Member, 2009-present
President, 2013-2014
American Physiological Society
American Society for Clinical Investigation
Counselor, 1994-1997
San Diego Gastroenterology Society
Secretary-Treasurer, 1993-1994
Vice-President, 1994-1995
President, 1995
Western Association of Physicians
Western Society for Clinical Investigation
Counselor, 1990-1993
REVIEWER FOR:
Alcohol
American Journal of Pathology
American Journal of Physiology
Biochemical Pharmacology
Biochemistry
Endocrinology
Gastroenterology
Stephen J. Pandol, M.D.
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Gut
International Journal of Pancreatology
Journal of Biological Chemistry
Journal of Cell Biology
Journal of Cellular Biochemistry
Journal of Clinical Investigation
Journal of Pharmacology and Experimental Therapeutics
Life Sciences
New England Journal of Medicine
Pancreas
Peptides
Proceedings of the National Academy of Sciences, USA
Regulatory Peptides
Prostaglandins
EDITORIAL BOARD:
American Journal of Physiology Gastrointestinal and Liver Physiology
Gastroenterology
Research News
Cellular and Molecular Gastroenterology and Hepatology
CONSULTING EDITOR:
Journal of Clinical Investigation
EDITOR:
Best and Taylor's Physiological Basis of Medical Practice
Section Editor for Gastrointestinal System, 1991
American Journal of Physiology: Gastrointestinal and Liver Physiology
Associate Editor, 1993-1997
Frontiers in Gastrointestinal Sciences
Chief Editor, 2010-present
GRANT SUPPORT:
1983-1994
1983-1987
1987-1992
1991-1994
Stephen J. Pandol, M.D.
NIH/NIDDK – DK33010
"Pancreatic secretion and phosphatidylinositol metabolism"
Veterans Affairs Career Development Award
Research Associate
Veterans Affairs Career Development Award
Clinical Investigator
Veterans Affairs Merit Review
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1994-1998
1994-1998
1995-1998
1998-2002
1999-2002
1999-2003
2000-2002
2001-2005
2002-2007
2002-2007
2002-2005
2002-2007
2003-2007
Stephen J. Pandol, M.D.
"Pancreatic physiology and pathophysiology"
Principal Investigator: Stephen J. Pandol, M.D.
Veterans Affairs Merit Review
"Mechanisms of acinar cell death in experimental models of
pancreatitis"
Principal Investigator: Stephen J. Pandol, M.D.
NIH/NIDDK – DK33010
"Function and subcellular nature of Ca2+ signaling"
Principal Investigator: Stephen J. Pandol, M.D.
NIH/NIDDK – DK51476
"Mechanism of ethanol-induced pancreatitis"
Principal Investigator: Stephen J. Pandol, M.D.
Veterans Affairs Merit Review
“Molecular mechanisms of experimental pancreatitis”
Principal Investigator: Stephen J. Pandol, M.D.
Veterans Affairs Merit Review
“Extracellular Matrix and Apoptosis in Normal & Cancer Pancreatic Cells”
Principal Investigator: Anna S. Gukovskaya, Ph.D.
Co-Principal Investigator: Stephen J. Pandol, M.D.
NIH/NIAAA – 1 P50 AA11999-01
“USC-UCLA Research Center for Alcoholic Liver and Pancreatic
Disease” Director: Hide Tsukamoto, D.V.M., Ph.D.
Co-Director: Stephen J. Pandol, M.D.
Project IV – “Ethanol and Pancreatic Injury”
Principal Investigator: Stephen J. Pandol, M.D.
State of California – Health and Human Services Agency
California Research Program, UC Davis 00-00776V-20071
“Regulation of Pancreatic Cancer Apoptosis by Polyphenols”
Principal Investigator: Stephen J. Pandol, M.D.
NIH/NIAAA – T32 AA07578-01
“Training Program in Alcoholic Liver and Pancreatic Diseases”
Principal Investigator: Hide Tsukamoto, D.V.M., Ph.D.
Co-Investigator: Stephen J. Pandol, M.D.
NIH/NIDDK – DK59508
“The Inflammatory Response of the Pancreatic Acinar Cell”
Principal Investigator: Stephen J. Pandol, M.D.
Veterans Affairs Merit Review
“Phosphatidylinositol 3-kinase and the Exocrine Pancreas”
Principal Investigator: Stephen J. Pandol, M.D.
Veterans Affairs Merit Review
“Reactive Oxygen Species: Survival Factor in Pancreatic Cancer Cells”
Principal Investigator: Anna S. Gukovskaya, Ph.D.
Co-Principal Investigator: Stephen J. Pandol, M.D.
NIH/NIAAA – AA13847
“MAT 1A Null Mouse: Model for Alcoholic Tissue Injury”
Principal Investigator: Shelly Lu, M.D.
Co-Principal Investigator: Stephen J. Pandol, M.D.
NIH/NIDDK – DK59936
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2003-2007
2005-2009
2004-2008
2004-2005
2005-2008
2005-2007
2006-2009
2006-2008
2006-2010
2006-2010
Stephen J. Pandol, M.D.
"Apoptosis and Necrosis in Pancreatitis"
Principal Investigator: Anna S. Gukovskaya, Ph.D.
Co-Investigator: Stephen J. Pandol, M.D.
NIH/NIAAA – 1 U56 AA0114643
“Role of Alcohol In Pancreatic Acinar Cell Death”
Principal Investigator: Duane Smoot, M.D.
Co-Principal Investigator: Stephen J. Pandol, M.D.
NIH/NIAAA – T32 AA07578-02
“Training Program in Alcoholic Liver and Pancreatic Diseases”
Principal Investigator: Hide Tsukamoto, D.V.M., Ph.D.
Co-Investigator: Stephen J. Pandol, M.D.
NIH/NIAAA – 1 P60 AA11999-01
“USC-UCLA Research Center for Alcoholic Liver and Pancreatic InjuryAdministrative Core”
Director: Hide Tsukamoto, D.V.M., Ph.D.
Associate Director: Stephen J. Pandol, M.D.
PHS/NCI – 5 P01 CA42710
Center PI: Heber
UCLA CNRU Pilot Feasibility Grant
“Plant-Derived Polyphenols Reverse Pancreatic Cancer Metabolic
Phenotype”
Project Principal Investigator: Stephen J. Pandol, M.D.
NIH/NIAAA – 1 P60 AA11999-01
Center PI: Tsukamoto
“USC-UCLA Research Center for Alcoholic Liver and Pancreatic
Disease”
Director: Hide Tsukamoto, D.V.M., Ph.D.
Co-Director: Stephen J. Pandol, M.D.
Project IV – “Protein Kinase C and Alcoholic Pancreatitis”
Project Principal Investigator: Stephen J. Pandol, M.D.
Private Donation: Hirshberg Foundation
“Pancreatic Cancer Metabolic Phenotype is Regulated by NADPH
Oxidase”
Principal Investigator: Stephen J. Pandol, M.D.
NIH/NIAAA – 5 R21 AA016010-02
“Alcohol and the Exocrine Pancreas ER Stress”
Principal Investigator: Stephen J. Pandol, M.D.
NIH/NIAAA – 1 R21 AA015781-01
“Plasminogen System and Alcoholic pancreatitis”
Principal Investigator: Aurelia Lugea, Ph.D.
Co-Principal Investigator: Stephen J. Pandol, M.D.
Veterans Affairs Merit Review
“NOX4, Protein Tyrosine Phosphatases, and Pancreatic Cancer Cell
Survival”
Principal Investigator: Anna S. Gukovskaya, Ph.D.
Co-Principal Investigator: Stephen J. Pandol, M.D.
NIH/NCI – 1 R01 CA119025-01
“NADPH Oxidase and pancreatic Cancer Cell Survival”
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2006-2008
2006-2011
2007-2009
2007-2010
2007-2011
2007-2011
2007-2011
2008-2011
2009-2014
2011-2016
2011-2016
Stephen J. Pandol, M.D.
Principal Investigator: Anna S. Gukovskaya, Ph.D.
Co-Principal Investigator: Stephen J. Pandol, M.D.
NIH/NIAAA – 1 R03 AA016008-01A1
“Urokinase-type Plasminogen Activator System and Pancreatic Stellate
Cells”
Principal Investigator: Aurelia Lugea, Ph.D.
Co-Principal Investigator: Stephen J. Pandol, M.D.
NIH T32 DK07180-33
“Gastroenterology”
Director/PI: Dennis M. Jensen, M.D.
Co-Directors: Peter Anton, M.D., Stephen Pandol, M.D.
NIH/NIAAA – R03 AA016336
“The Effect of Alcohol on NADPH Oxidase Structure in Pancreatic
Stellate Cells”
Principal Investigator: Kym F. Faull, Ph.D.
Co-Principal Investigator: Stephen J. Pandol, M.D.
American Gastroenterological Association Foundation
“Bcl-2 Proteins Regulate Death Responses of Acute Pancreatitis”
Principal Investigator: Olga Mareninova, Ph.D.
Sponsor: Stephen J. Pandol, M.D.
Veterans Affairs Merit Review
“Inflammation Mediates Necrosis in Pancreatitis”
Principal Investigator: Stephen J. Pandol, M.D.
NIH – 1 P01 AT0003960-01
“UCLA Center for Excellence in Pancreatic Diseases – Project 1:
Phytonutrients and Metabolism in Pancreatic Diseases”
Project Principal Investigator: Stephen J. Pandol, M.D.
NIH – 1 P01 AT0003960-01
“UCLA Center for Excellence in Pancreatic Diseases”
Director: Vay Liang W. Go, M.D.
Co-Director: Stephen J. Pandol, M.D.
NIH/NIAAA – 1 R21 AA017276-01
“Alcoholic Pancreatitis Results from Dysregulated Immune Response”
Project Principal Investigator: Ilya Gukovsky, Ph.D.
Co-Project Principal Investigator: Stephen J. Pandol, M.D.
NIH – P50 AA011999-11
“Southern California Research Center for Alcoholic Liver & Pancreatic
Diseases and Cirrhosis”
Director: Hide Tsukamoto, D.V.M., Ph.D.
Project Principal Investigators: Stephen J. Pandol, M.D., Anna
Gukovskaya, Ph.D.
NIH – K01 AA019996-01
“Smoking, Alcohol Abuse and Pancreatic Disease”
Principal Investigator: Mouad Edderkaoui, Ph.D.
Mentors: Anna Gukovskaya, Ph.D., Stephen J. Pandol, M.D.
NIH/NIAAA – R01 AA019730-01A1
“Lysosomal Damage, Impaired Autophagy and Alcoholic Pancreatitis”
Principal Investigators: Olga Mareninova, Ph.D., Ilya Gukovsky, Ph.D.
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2011-2016
2011-2016
2012-2016
2012-2017
2014-2015
2014-2019
2014-2019
Co-Principal Investigator: Stephen J. Pandol, M.D.
NIH – R01 AA019954
“Alcohol Abuse and Endoplasmic Reticulum Dysfunction in Exocrine
Pancreas”
Principal Investigator: Aurelia Lugea, Ph.D.
Co-Principal Investigator: Stephen J. Pandol, M.D.
NIH T32 DK07180-33
“Gastroenterology”
Director/PI: Dennis M. Jensen, M.D.
Co-Directors: Peter Anton, M.D., Stephen Pandol, M.D.
Veterans Affairs Merit Review
“Smoking, Alcohol Abuse and Pancreatic Disease”
Principal Investigator: Stephen J. Pandol, M.D.
NIH/NCI – P01 CA163200-01A1
“Targeting Diet-Induced Promotion of Kras-initiated Pancreatic
Adenocarcinoma-Project IV: Alcohol Abuse, Metabolic Syndrome and
Desmoplasia.”
Program Director: Guido Eibl, M.D.
Project IV Principal Investigator: Stephen J. Pandol, M.D.
CalciMedica
“Development of Orai-1 inhibitors for the treatment of acute pancreatitis”
Principal Investigator: Stephen J. Pandol, M.D
NIH/NIAAA – P50 AA011999-16
“Southern California Research Center for ALPD and Cirrhosis – Project
IV: Mitochondrial alcohol metabolism mediates alcoholic pancreatitis”
Director: Hide Tsukamoto, D.V.M., Ph.D.
Project Principal Investigators: Stephen J. Pandol, M.D., Anna
Gukovskaya Ph.D.
NIH/NIDDK – P01 DK098108-01A1
“Organelle Disorders in Pancreatitis”
Director: Anna Gukovskaya, Ph.D.
Project Principal Investigators: Stephen J. Pandol, M.D.
UNIVERSITY AND LOCAL COMMITTEES:
Organ Physiology Course
Taught 1st year physiology to medical students
UCSD School of Medicine, 1986-1995
Standing and Promotions
UCSD School of Medicine, 1987-1992
Chairman, 1990-1992
Core Curriculum
UCSD School of Medicine, 1988-1991
Housestaff Evaluation
Department of Medicine, UCSD School of Medicine, San Diego, 1987-1995
Quality Assurance Council
Veterans Administration Medical Center, San Diego
Stephen J. Pandol, M.D.
Page 8
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Chairman, 1988-1995
Total Quality Improvement Steering Committee
Veterans Administration Medical Center, San Diego, 1991-1995
Research Equipment
Veterans Administration Medical Center, San Diego, 1986-1995
Medical Education and Research Foundation (Board member)
Department of Medicine, UCSD School of Medicine, San Diego, 1989-present
Pharmacy and Therapeutics
Veterans Administration Medical Center, San Diego 1983-1988
Research and Development
Veterans Administration Medical Center, San Diego, CA, 1986-1989
Chairman, 1988-1989
Representative to the Academic Senate
Department of Medicine, UCSD School of Medicine, San Diego, 1994-1995
Annual Postgraduate Course
Topics and Advances in Internal Medicine
Department of Medicine, UCSD School of Medicine
Course Co-Director, 1990-1995
Department of Medicine Committee on Advancement and Promotion
Department of Medicine, UCSD School of Medicine, 1994-1995
Research and Development
Veterans Affairs Medical Center, West Los Angeles, 1995-1998
Quality Council
Veterans Affairs Medical Center, West Los Angeles,
Co-Chairman, 1996-1999.
Strategic Planning Committee
Veterans Affairs Medical Center, West Los Angeles, 1996-1998
Dean’s Committee
Veterans Affairs Medical Center, West Los Angeles, 1996-1998
Medical Advisory Board
Veterans Affairs Medical Center, West Los Angeles, 1996-1998
Executive Committee
Research Center for Alcoholic Liver and Pancreatic Disease, Los Angeles,
1999-present
Outreach Committee
Research Center for Alcoholic Liver and Pancreatic Disease, Los Angeles,
1999-present
Introduction to Pathology Lecture Series
Taught medical, PhD, and MS students in basic pathologic basis of diseases
USC School of Medicine, 2002-present
Pathophysiology
Taught 2nd year medical students on basic pancreatic diseases
UCLA School of Medicine, 2004-present
NATIONAL COMMITTEES:
Stephen J. Pandol, M.D.
Page 9
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Veterans Administration Gastroenterology Merit Review Board, 1989-1992
Chairman 1991-1992
American Society for Clinical Investigation, Council Member, 1993-1996
Undergraduate Teaching Project of the American Gastroenterological
Association, 1995-2002
Gastroenterology and Hepatic Disorders Research Review Group
Department of Veterans Affairs, Chairman, 1996
Research Council for Southern California and Nevada VA Medical Centers
Chairman, 1996-1998
High School Science Teachers Project, American Society for Clinical Investigation,
1994-1997
Publications Committee, American Gastroenterological Association, 1996-1997
Flying Samaritans, 2000-2003
Gastroenterology Teaching Project of the American Gastroenterological
Association, 2002-2005
Research Committee, American Gastroenterological Association, 2002-2005
Legacy Society of the American Gastroenterological Association, 2007-present
Counselor, American Pancreatic Association, 2010-present
PATENTS ISSUED:
1.
2.
3.
Compositions Comprising Plant-Derived Polyphenolic Compounds and Inhibitors of
Reactive Oxygen Species and Methods of Using Thereof. Continuation-in-Part of U.S.
Patent NO.: US 6,953,786, B2 Date of Patent: October 11, 2005
Methods for Treating Pancreatitis with Curcumin Compounds and Inhibitors of
Reactive Oxygen. U.S. Patent NO.: US 7,060,733, Date of Patent: June 13, 2006
Methods and Systems for Modulating hormones and related methods, agents and
compositions. US Patent Application 20120058965 Date Issued: March 8, 2012
Stephen J. Pandol, M.D.
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BIBLIOGRAPHY
PEER-REVIEWED – PUBLISHED:
1.
Pandol SJ, Korman LY, McCarthy DM, Gardner JD. Beneficial effect of oral lithium
carbonate in the treatment of pancreatic cholera syndrome. N Engl J Med 302:14031404, 1980.
2.
Richter JE, Pandol SJ, Castell DO, McCarthy DM. Gastroesophageal reflux disease in
the Zollinger-Ellison syndrome. Ann Internal Med 95:37-43, 1981.
3.
Pandol SJ, Jensen RT, Gardner JD. Mechanism of (Tyr4) bombesin-induced
desensitization in dispersed acini from guinea pig pancreas. J Biol Chem 257:1202412029, 1982.
4.
Jensen RT, Gardner JD, Raufman JP, Pandol SJ, Doppman JL, Collen MJ. ZollingerEllison syndrome-current concepts and management. Ann Internal Med 98:59-75,
1983.
5.
Raufman JP, Collins SM, Pandol SJ, Korman LY, Collen MJ, Cornelius MJ, Feld MK,
McCarthy DM, Gardner JD, Jensen RT. Reliability of symptoms in assessing control of
gastric acid secretion in patients with Zollinger-Ellison syndrome. Gastroenterology
84:108-113, 1983.
6.
Jensen RT, Collen MJ, Pandol SJ, Allende HD, Raufman JP, Bissonnette BM,
Duncan WC, Durgin PL, Gillin JC, Gardner JD. Cimetidine-induced impotence and
breast changes in patients with gastric hypersecretory states. N Engl J Med 308:883887, 1983.
7.
Pandol SJ, Sutliff VE, Jones SW, Charlton CG, O'Donohue TL, Gardner JD, Jensen
RT. Action of natural glucagon on pancreatic acini: Due to contamination by previously
undescribed secretagogues. Gastrointest Liver Physiol 245:G703-G710, 1983.
8.
Jensen RT, Pandol SJ, Collen MJ, Raufman JP, Gardner JD. Diagnosis and
Management of the Zollinger-Ellison syndrome. J Clin Gastro 5 (Suppl. 1): 123-131,
1983.
9.
Pandol SJ, Seifert H, Thomas MW, Rivier J, Vale W. Growth hormone-releasing factor
stimulates pancreatic enzyme secretion. Science 225:326-328, 1984.
Stephen J. Pandol, M.D.
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10.
Pandol SJ, Thomas MW, Schoeffield MS, Sachs G, Muallem S. Role of calcium in
cholecystokinin-stimulated phosphoinositide breakdown in exocrine pancreas.
Gastrointest Liver Physiol 248: G551-G560, 1985.
11.
Seifert H, Sawchenko P, Chesnut J, Rivier J, Vale W, Pandol SJ. Receptor for
calcitonin gene-related peptide: binding to exocrine pancreas mediates biological
actions. Gastrointest Liver Physiol 249:G147-G151, 1985.
12.
Muallem S, Schoeffield M, Pandol SJ, Sachs G. Inositol trisphosphate modification of
ion transport in rough endoplasmic reticulum. Proc Natl Acad Sci USA 82:4433-4437,
1985.
13.
Pandol SJ, Schoeffield MS, Sachs G, Muallem S. Role of free cytosolic calcium in
secretagogue-stimulated amylase release from dispersed acini from guinea pig
pancreas. J Biol Chem 260:10081-10086, 1985.
14.
Dharmsathaphorn K, Pandol SJ. Mechanism of chloride secretion induced by
carbachol in a colonic epithelial cell line. J Clin Invest 77:348-54, 1986.
15.
Pandol SJ, Dharmsathaphorn, K., Schoeffield MS, Vale W, Rivier J. Vasoactive
intestinal peptide receptor antagonist [4Cl D-Phe6, Leu17] VIP. Gastrointest Liver
Physiol 250:G553-G557, 1986.
16.
Pandol SJ, Schoeffield MS. 1,2 diacylglycerol, protein kinase C, and pancreatic
enzyme secretion. J Biol Chem 261:4438-4444, 1986.
17.
Muallem S, Fimmel CJ, Pandol SJ, Sachs G. Regulation of free cytosolic Ca2+ in the
peptic and parietal cells of the rabbit gastric gland. J Biol Chem 261:2660-2667, 1986.
18.
Pandol SJ, Schoeffield MS, Fimmel CJ, Muallem S. The agonist-sensitive calcium
pool in the pancreatic acinar cell. Activation of plasma membrane Ca 2+ influx
mechanism. J Biol Chem 262:16963-16968, 1987.
19.
Krims PE, Pandol SJ. Free cytosolic calcium and secretagogue-stimulated initial
pancreatic exocrine secretion. Pancreas 3:383-390, 1988.
20.
Muallem S, Schoeffield MS, Fimmel CJ. Pandol SJ. Agonist-sensitive calcium pool in
the pancreatic acinar cell. I. Permeability properties. Gastrointest Liver Physiol
255:G221-228, 1988.
21.
Muallem S, Schoeffield MS, Fimmel CJ, Pandol SJ. Agonist sensitive calcium pool in
the pancreatic acinar cell. II. Characterization of reloading. Gastrointest Liver Physiol
255:G229-G235, 1988.
22.
Muallem S, Beeker T, Pandol SJ. Role of Na+/ Ca2+ exchange and the plasma
membrane Ca2+ pump in hormone-mediated Ca2+ efflux from pancreatic acini. J Mem
Biol 102:153-162, 1988.
Stephen J. Pandol, M.D.
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23.
Kelleher D, Pandol SJ, Kagnoff MF. Phorbol myristate acetate induces IL-2 secretion
by HUT 78 cells by a mechanism independent of protein kinase C translocation.
Immunology 65:351-355, 1988.
24.
Muallem S, Pandol SJ, Beeker TG. Calcium mobilizing hormones activate the plasma
membrane Ca2+ pump of pancreatic acinar cells. J Mem Biol 106:57-69, 1988.
25.
Muallem S, Pandol SJ, Beeker TG. Two components of hormone-evoked calcium
release from intracellular stores of pancreatic acinar cells. Biochem J 255:301-307,
1988.
26.
Muallem S, Pandol SJ, Beeker TG. Hormone-evoked calcium release from
intracellular stores is a quantal process. J Biol Chem 264:205-212, 1989.
27.
Algazi MC, Chen H-S, Koss MA, Hogan DL, Steinbach J, Pandol SJ, Isenberg JI.
Effect of VIP antagonist on VIP-PGE2-, and acid-stimulated duodenal bicarbonate
secretion. Gastrointest Liver Physiol 256:G833-G836, 1989.
28.
Pandol SJ, Rodriguez G, Muallem S, Mendius K. Characteristics of intracellular
calcium changes required for augmentation of phorbol ester-stimulated pancreatic
enzyme secretion. Cell Calcium 10:255-262, 1989.
29.
Dharmsathaphorn K, Huott PA, Vongkovit P, Beuerlein G, Pandol SJ, Ammon HU.
Cl- secretion induced by bile salts. A study of the mechanism of action based on
cultured colonic epithelial cell line. J Clin Invest 84:945-953, 1989.
30.
Muallem S, Pandol SJ, Beeker TG. Modulation of agonist-activated calcium influx by
extracellular pH in rat pancreatic acini. Gastrointest Liver Physiol 257:G917-G924,
1989.
31.
Schmidt DN, Pandol SJ. Differing effects of ethanol on in vitro stimulated pancreatic
enzyme secretion in ethanol fed and control rats. Pancreas 5:27-36, 1990.
32.
Pandol SJ, Schoeffield-Payne MS. Cyclic GMP mediates the agonist-stimulated
increase in plasma membrane calcium entry into the pancreatic acinar cells. J Biol
Chem 265:12846-12853, 1990.
33.
Pandol SJ, Shoeffield-Payne MS. Cyclic GMP regulates free cytosolic calcium in the
pancreatic acinar cell. Cell Calcium 11:477-486, 1990.
34.
O'Konski MS, Pandol SJ. Effects of caerulein on the apical cytoskeleton of the
pancreatic acinar cell." J Clin Invest 86:1649-1657, 1990.
35.
Pandol SJ, Hsu Y, Kondratenki NF, Shoeffield-Payne MS, Steinbach JH. Dual
pathways for agonist-stimulated arachidonic acid release in pancreatic acini: roles in
secretion. Gastrointest Liver Physiol 260:G423-G433, 1991.
Stephen J. Pandol, M.D.
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36.
Brandt DW, Pandol SJ, Deftos LJ. Calcium-stimulated parathyroid hormone-like
protein secretion: potentation through a protein kinase C pathway. Endocrinology
128:2999-3004, 1991.
37.
Perkins PS, Bahrami LH, Lenhard LW, Pandol SJ. Intracellular mechanisms involved
in short-term regulation of net protein synthesis in pancreatic acini. Biochem Biophys
Acta 1092:145-152, 1991.
38.
Cohen ME, Wesolek J, McGullen J, Rys-Sikora K, Pandol SJ, Rood RP, Sharp GWG,
Donowitz M. Carbachol- and elevated Ca2+ -induced translocation of functionally
active protein kinase C to the brush border of rabbit ileal Na+ absorbing cells. J Clin
Invest 88:855-863, 1991.
39.
Perkins PS, Pandol SJ. Cholecystokinin-induced changes in polysome structure
regulate protein synthesis in pancreas. Biochem Biophys Acta 1136:265-271, 1992.
40.
O'Konski MS, Pandol SJ. Cholecystokinin JMV-180 and caerulein effects on the
pancreatic acinar cell cytoskeleton. Pancreas 8:638-646, 1993.
41.
Bahnson TD, Pandol SJ, Dionne VE. Cyclic GMP modulates depletion-activated Ca2+
entry in pancreatic acinar cells. J Biol Chem 268:10808-10812, 1993.
42.
Gukovskaya AS, Pandol SJ. Nitric oxide production regulates cGMP formation and
calcium influx in pancreatic acinar cells. Gastrointest Liver Physiol 266:G350-G356,
1994.
43.
Rutherford RE, Schoeffield-Payne MS, Pandol SJ. Cellular mechanisms and
physiological implications of quantal Ca2+ release in pancreatic acinar cells.
Gastrointest Liver Physiol 267: G1058-G1066, 1994.
44.
Pandol SJ, Schoeffield-Payne MS, Gukovskaya AS, Rutherford RE. Sphingosine
regulates Ca2+-ATPase and reloading of intracellular Ca2+ stores in the pancreatic
acinar cell. Biochem Biophys Acta 1195:45-50, 1994.
45.
Perkins PS, Rutherford RE, Pandol SJ. Effect of chronic ethanol feeding on digestive
enzyme synthesis and mRNA content in rat pancreas. Pancreas 10: 14-21, 1995.
46.
Gukovskaya AS, Pandol SJ. Dual regulation of cGMP formation by calcium in
pancreatic acinar cells. Gastrointest Liver Physiol 286: G900-G907, 1995.
47.
Pandol SJ, Fitzsimmons TJ, Schoeffield-Payne MS, Carlile GW, Evans WJ. Isolation
of subcellular agonist-sensitive calcium stores from the pancreatic acinar cell. Cell
Calcium 18: 364-376, 1995.
48.
Vajanaphanich M, Schultz C, Tsien R, Traynor-Kaplan AE, Pandol SJ, Barrett KE.
Cross-talk between calcium and cAMP-dependent intracellular signalling pathways:
Stephen J. Pandol, M.D.
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Implications for synergistic secretion in T84 colonic epithelial cells and rat pancreatic
acinar cells. J Clin Invest 96:386-393, 1995.
49.
Abdeen O, Pandol SJ, Burton DW, Deftos LJ. Parathyroid hormone-related protein
expression in human gastric adenocarcinomas not associated with hypercalcemia.
Am J Gastroenterol 90:1864-186, 1995.
50.
Gukovskaya AS, Perkins P, Zaninovic V, Sandoval D, Rutherford R, Fitzsimmons TJ,
Pandol SJ, Poucell-Hatton S. Mechanisms of cell death after pancreatic duct
obstruction in the opossum and the rat. Gastroenterology 110:875-884, 1996.
51.
Sandoval D, Gukovskaya AS, Reavey P, Gukovsky S, Sisk A, Braquet P, Pandol SJ,
Poucell-Hatton S. The role of neutrophils and platelet-activating factor in mediating
experimental pancreatitis. Gastroenterology 111:1081-1091, 1996.
52.
Poucell-Hatton S, Perkins PS, Deerink TK, Ellisman MH, Hardison WGM, Pandol SJ.
Myosin I is associated with zymogen granule membranes in the rat pancreatic acinar
cell. Gastroenterology 113:649-658, 1997.
53.
Perkins PS, Pandol SJ. The role of calcium in the regulation of protein synthesis in
the exocrine pancreas. Pancreas 14:133-141, 1997.
54.
Xu X, Weizhong Z, Diaz J, Gukovskaya AS, Kim L, Brown RJ, Pandol SJ, Muallem S.
nNOS and Ca2+ influx in rat pancreatic acinar and submandibular salivary gland cells.
Cell Calcium 22:217-228, 1997.
55.
Gukovskaya AS, Zaninovic V, Gukovsky I, Song M, Sandoval D, Gukovsky S, Pandol
SJ. Pancreatic acinar cells produce, release and respond to tumor necrosis factor- :
Role in regulating cell death and pancreatitis. J Clin Invest 100:1853-1862, 1997.
56.
Fitzsimmons TJ, McRoberts JA, Tachiki K, Pandol SJ. Acyl-coenzyme A causes Ca2+
release in pancreatic acinar cell. J Biol Chem 272:31435-31440, 1997.
57.
Zhou K, Pandol SJ, Bokoch G, Traynor-Kaplan AE. Disruption of Dictyostelium PI3K
genes reduces (32P) phosphatidylinositol 3,4 bisphosphate and 32Pphosphatidylinositol trisphosphate levels, alters F-actin distribution and impairs
pinocytosis. J Cell Sci 111:283-294, 1998.
58.
Gukovsky I, Gukovskaya AS, Blinman T, Zaninovic V, Pandol SJ. Early NF- B
activation is associated with hormone-induced pancreatitis. Gastrointest Liver Physiol
275:G1402-G1414, 1998.
59.
Song M, Zaninovic V, Kim D, Gukovsky I, Gukovskaya AS, Kang K, Pandol SJ.
Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase
inhibitor. Pancreas 18:231-239, 1999.
60.
Pandol SJ, Periskic S, Gukovsky I, Zaninovic V, Jung Y, Zong Y, Solomon TE,
Gukovskaya AS, Tsukamoto H. Ethanol diet increases the sensitivity of rats to
Stephen J. Pandol, M.D.
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pancreatitis induced by cholecystokinin octapeptide. Gastroenterology 117:706-716,
1999.
61.
Gukovskaya AS, Gukovsky S, Pandol SJ. Endoplasmic reticulum Ca2+ ATPase
inhibitors stimulate membrane guanylate cyclase in pancreatic acinar cells. Cell
Physiol 278:C363-C371, 2000.
62.
Zaninovic V, Gukovskaya AS, Gukovsky I, Pandol SJ. Cerulein upregulates ICAM-1
in pancreatic acinar cells which mediates neutrophil adhesion to these cells.
Gastrointest Liver Physiol 279: G666-G676, 2000.
63.
Fitzsimmons TJ, Gukovsky I, McRoberts JA, Rodriguez E, Lai FA, Pandol SJ.
Multiple isoforms of the ryanodine receptor are expressed in rat pancreatic acinar
cells. Biochem J 351: 265-271, 2000.
64.
Blinman T, Gukovsky I, Mouria M, Zaninovic V, Livingston E, Pandol SJ, Gukovskaya
AS. Activation of pancreatic acinar cells on isolation from tissue: cytokine upregulation
via p38 MAP kinase. Cell Physiol 279: C1993-C2003, 2000.
65.
Vaquero E, Gukovsky I, Zaninovic V, Gukovskaya AS, Pandol SJ. Localized
pancreatic NF-kappaB activation and inflammatory response in taurocholate-induced
pancreatitis. Gastrointest Liver Physiol. 280:G1197-G1208, 2001.
66.
Beil M, Leser J, Lutz MP, Gukovskaya A, Seufferlein T, Lynch G, Pandol SJ, Adler G.
Caspase 8-mediated cleavage of plectin precedes F-actin breakdown in acinar cells
during pancreatitis. Gastrointest Liver Physiol. 282:G450-G460, 2002.
67.
Mouria M, Gukovskaya AS, Jung Y, Buechler P, Hines OJ, Reber HA, Pandol SJ.
Food-Derived Polyphenols Inhibit Pancreatic Cancer Growth Through Mitochondrial
Cytochrome C Release and Apoptosis. International Journal of Cancer. 98:761-769,
2002.
68.
Gukovskaya AS, Vaquero E, Zaninovic V, Gorelick FS, Lusis AJ, Brennan ML, Holland
S, Pandol SJ. Neutrophils and NADPH oxidase mediate intrapancreatic trypsin
activation in murine experimental acute pancreatitis. Gastroenterology. 122:974-984,
2002.
69.
Tang SJ, Tran T, Memmesheimer C, Pandol S, Aranda R, Pisegna JR, Jensen DM.
Paraesophageal hernia repair and deep vein thrombosis. J Clin Gastroenterol 34:187188, 2002.
70.
Gukovskaya AS, Jung Y, Mouria M, Gukovsky I, Pandol SJ. Cholecystokinin induces
caspase activation and mitochondrial dysfunction in pancreatic acinar cells: Roles in
cell injury processes of pancreatitis. J Biol Chem 277: 22595-22604, 2002.
71.
Gukovskaya AS, Mouria M, Gukovsky I, Reyes CN, Kasho VN, Faller LD, Pandol SJ.
Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats.
Gastroenterology. 122:106-118, 2002.
Stephen J. Pandol, M.D.
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72.
Savard CE, Blinman TA, Choi HS, Lee SK, Pandol SJ, Lee SP. Expression of
cytokine and chemokine mRNA and secretion of tumor necrosis factor-alpha by
gallbladder epithelial cells: response to bacterial lipopolysaccharides. BMC
Gastroenterol 2:23. 2002.
73.
Lu S, Gukovsky I, Lugea A, Reyes CN, Huang ZZ, Chen L, Mato JM, Bottiglieri T,
Pandol SJ. Role of S-adenosylmethionine in two experimental models of pancreatitis.
FASEB J 17:56-8, 2002.
74.
Gukovsky I, Reyes CN, Vaquero EC, Gukovskaya AS, Pandol SJ. Curcumin
ameliorates ethanol and non-ethanol experimental pancreatitis. Am J Physiol
Gastrointest Liver Physiol 28:G85-95. 2003
75.
Büechler P, Gukovskaya AS, Mouria M, Buchler MC, Buchler MW, Friess H, Pandol
SJ, Reber HA, Hines OJ. Prevention of metastatic pancreatic cancer growth in vivo by
induction of apoptosis with genistein, a naturally occurring isoflavonoid. Pancreas
26:264-273, 2003.
76.
Vaquero EC, Edderkaoui M, Nam KJ, Gukovsky I, Pandol SJ, Gukovskaya AS.
Extracellular matrix proteins protect pancreatic cancer cells from death via
mitochondrial and nonmitochondrial pathways. Gastroenterology 125:1188-202, 2003.
77.
Lugea A, Gukovsky I, Gukovskaya AS, Pandol SJ. Nonoxidative ethanol metabolites
alter extracellular matrix protein content in rat pancreas. Gastroenterology 125:18451859, 2003.
78.
Gukovskaya AS, Hosseini S, Satoh A, Cheng JH, Nam KJ, Gukovsky I, Pandol SJ.
Ethanol differentially regulates NF- B activation in pancreatic acinar cells through
calcium and protein kinase c pathways. Am J Physiol Gastrointest Liver Physiol,
286:G204-G213, 2004. PMID: 15550766, PMCID: Pending.
79.
Gukovsky I, Cheng JH, Nam KJ, Lee OT, Lugea A, Fischer L, Penninger JM, Pandol
SJ, Gukovskaya AS. Phosphatidylinositide 3-kinase gamma regulates key pathologic
responses to cholecystokinin in pancreatic acinar cells. Gastroenterology, 126:554566, 2004. PMID: 14762792, PMCID: Pending.
80.
Vaquero EC, Edderkaoui M, Pandol SJ, Gukovsky I, Gukovskaya AS. Reactive
oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer
cells. J Biol Chem, 279: 34643-34654, 2004.
81.
Satoh A, Gukovskaya AS, Nieto JM, Cheng JH, Gukovsky I, Reeve JR, Jr.,
Shimosegawa T, Pandol SJ. Protein kinase C delta and epsilon regulate NF-B
activation induced by cholecystokinin and TNF- in pancreatic acinar cells. Am J
Physiol Gastrointest Liver Physiol, 287:G582-G591, 2004. PMID: 15117677, PMCID:
Pending
Stephen J. Pandol, M.D.
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82.
Fischer L, Gukovskaya AS, Young SH, Gukovsky I, Lugea A, Buechler P, Penninger JM,
Friess H, Pandol SJ. Phosphatidylinositol 3-kinase regulates Ca2+ signaling in
pancreatic acinar cells through inhibition of sarco-endoplasmic reticulum Ca2+-ATPase
(SERCA). Am J Physiol Gastrointest Liver Physiol, 287:G1200-12, 2004. PMID:
15271649, PMCID: Pending.
83.
Satoh A, Gukovskaya AS, Edderkaoui M, Daghighian MS, Reeve JR, Jr., Shimosegawa
T, Pandol SJ. TNFα mediates pancreatitis responses in pancreatic acinar cells via
protein kinase C and proline-rich tyrosine kinase 2. Gastroenterology, 129: 639-651,
2005. PMID: 16083718, PMCID: Pending.
84.
Edderkaoui M, Hong P, Vaquero EC, Fischer L, Friess H, Buchler MW, Lerch MM,
Pandol SJ, Gukovskaya AS. Extracellular matrix proteins stimulate reactive oxygen
species production and increase pancreatic cancer cells survival through NADPH
oxidase and 5-lipoxygenase. Am J Physiol Gastrointest Liver Physiol, 289: G1137-47,
2005.
85.
Mareninova OA, Sung KF, Hong P, Lugea A, Pandol SJ, Gukovsky I, Gukovskaya AS.
Cell death in pancreatitis: caspases protect from necrotizing pancreatitis. J Biol Chem,
281:3370-81, 2006. PMID: 16339139, PMCID: Pending.
86.
Wang YL, Hu R, Lugea A, Gukovsky I, Smoot D, Gukovskaya AS, Pandol SJ. Ethanol
feeding alters death signaling in pancreas. Pancreas, 32:351-359, 2006.
87.
Satoh A, Gukovskaya AS, Reeve JR, Jr., Shimosegawa T, Pandol SJ. Ethanol
sensitizes NF-B activation in pancreatic acinar cells through effects on protein kinase C
epsilon. Am J Physiol Gastrointest Liver Physiol, 291: G432-8, 2006. PMID: 16574982,
PMCID: Pending
88.
Kubisch CH, Gukovsky I, Lugea A, Pandol SJ, Kuick R, Misek DE, Hanash SM, Logsdon
CD. Long-term ethanol consumption alters pancreatic gene expression in rats: a possible
connection to pancreatic injury. Pancreas, 33:68-76, 2006.
89.
Lugea A, Nan L, French SW, Bezerra JA, Gukovskaya AS, Pandol SJ. Pancreas tissue
repair after cerulein-induced pancreatitis is impaired in plasminogen-deficient mice.
Gastroenterology, 131:885-99, 2006. PMID: 16958657, PMCID: Pending.
90.
Ito Y, Lugea A, Pandol SJ, McCuskey RS. Substance P mediates cerulean-induced
pancreatic micocirculatory dysfunction in mice. Pancreas, 34:138-43, 2007.
91.
Fischer L, Gukovskaya AS, Penninger JM, Friess H, Gukovsky I, Pandol SJ.
Phosphatidylinositol 3-kinase facilitates bile acid-induced calcium responses in
pancreatic acinar cells. AJP, 292:G875-86, 2007. PMID: 17158252, PMCID: Pending.
92.
Hu R, Wang YL, Edderkaoui M, Lugea A, Apte MV, Pandol SJ. Ethanol augments
PDGF-induced NADPH oxidase activity and proliferation in rat pancreatic stellate cells.
Pancreatology, 7:332-340, 2007.
Stephen J. Pandol, M.D.
Page 18
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93.
Cosen-Binker LI, Lam PP, Binker MG, Reeve J, Pandol S, Gaisano HY. Alcohol
cholecystokinin evoked pancreatic acinar basolateral exocytosis is mediated by
PKCalpha phosphorylation of Munc18c. J Biol Chem, 282:13047-58, 2007. PMID:
17324928, PMCID: Pending.
94.
Lam PP, Cosen Binker LI, Lugea A, Pandol SJ, Gaisano HY. Alcohol redirects CCKmediated apical exocytosis to the acinar basolateral membrane in alcoholic
pancreatitis. Traffic 8:605-17, 2007. PMID: 17451559, PMCID: Pending.
95.
Edderkaoui M, Hong PP, Pandol SJ, Gukovskaya AS. Insulin-like growth factor-I
receptor mediates the pro-survival effect of fibronectin. J Biol Chem 282:26646-55,
2007.
96.
Lee JK, Edderkaoui M, Truong P,Hong PP, Ohno I,Jang KT, Berti A, Pandol SJ,
Gukovskaya AS. NADPH Oxidase Promotes Pancreatic Cancer Cell Survival via
Inhibiting JAK2 Dephosphorylation by Tyrosine Phosphatases. Gastroenterology,
133:1637-48, 2007. PMID: 17983808, PMCID: Pending.
97.
Gukovsky I, Lugea A, Shahsahebi M, Cheng JH, Hong PP, Jung YJ, Deng QG, French
BA, Lungo W, French SW, Tsukamoto H, Pandol SJ. A rat model reproducing key
pathologic responses of alcoholic chronic pancreatitis. Am J Physiol Gastrointest Liver
Physiol, 294: G68-79, 2008. PMID: 17884979, PMCID: Pending.
98.
Edderkaoui M, Odinokova I, Ohno I, Gukovsky I, Go VLW, Pandol SJ, Gukovskaya
AS. Ellagic acid induces apoptosis through inhibition of NF-B in pancreatic cancer
cells. World Journal of Gastroenterology, 2008 Jun 21; 14(23):3672-80.
99.
Rakonczay Z Jr, Hegyi P, Dósa S, Iványi B, Jármay K, Biczó G, Hracskó Z, Varga IS,
Karg E, Kaszaki J, Varró A, Lonovics J, Boros I, Gukovsky I, Gukovskaya AS, Pandol
SJ, Takács T. A new severe acute necrotizing pancreatitis model induced by Lornithine in rats. Crit Care Med, 2008 Jul;36(7):2117-27. PMID: 18594222, PMCID:
Pending.
102.
Thrower EC, Osgood S, Shugrue CA, Kolodecik TR, Chaudhuri AM, Reeve JR Jr,
Pandol SJ, Gorelick FS. The novel protein kinase C isoforms -delta and -epsilon
modulate caerulein-induced zymogen activation in pancreatic acinar cells.
Am J Physiol Gastrointest Liver Physiol. 294: G1344-53. 2008. PMCID: PMC2975015
103.
Yuan J, Lugea A, Zheng L, Gukovsky I, Edderkaoui M, Rozengurt E, Pandol SJ.
Protein kinase D1 mediates NF-kappaB activation induced by cholecystokinin and
cholinergic signaling in pancreatic acinar cells. Am J Physiol Gastrointest Liver
Physiol. 295:G1190-201. 2008. PMCID: PMC2604803
104.
Chung C, Shugrue C, Nagar A, Doll JA, Cornwell M, Gattu A, Kolodecik T, Pandol SJ,
Gorelick F. Ethanol exposure depletes hepatic pigment epithelium-derived factor, a
novel lipid regulator. Gastroenterology. 136:331-340. 2009. PMCID: PMC2833423
Stephen J. Pandol, M.D.
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105.
Boros LG, Deng Q, Pandol SJ, Tsukamoto H, Go VL, Lee WN. Ethanol diversely
alters palmitate, stearate, and oleate metabolism in the liver and pancreas of rats
using the deuterium oxide single tracer. Pancreas. 38(2) 2009. PMID: 19248221,
PMCID: Pending.
106.
Sung KF, Odinokova IV, Mareninova OA, Rakonczay Z, Jr., Hegyi P, Pandol SJ,
Gukovsky I, Gukovskaya AS. Prosurvival Bcl-2 proteins stabilize pancreatic
mitochondria and protect against necrosis in pancreatitis. Exp Cell Res. Jul
1;315(11):1975-89 2009. PMID: 19331832, PMCID: Pending.
107.
Nakamura Y, Do JH, Yuan J, Odinokova I, Mareninova O, Gukovskaya A, Pandol SJ.
Inflammatory cells regulate p53 and caspases in acute pancreatitis. Am J Physiol
Gastrointest Liver Physiol. 2009 Oct 22. PMCID: PMC2806100
108.
Mareninova OA, Hermann K, French SW, O'Konski MS, Pandol SJ, Webster P,
Erickson AH, Katunuma N, Gorelick FS, Gukovsky I, Gukovskaya A. Impaired
autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in
rodent models of acute pancreatitis. J Clin Invest. 2009 Nov; 119(11):3340-55.
PMCID: PMC2769194
109.
Thrower EC, Wang J, Cheriyan S, Lugea A, Kolodecik TR, Yuan J, Reeve JR Jr,
Gorelick FS, Pandol SJ. Protein Kinase C delta-Mediated Processes in
Cholecystokinin-8-Stimulated Pancreatic Acini. Pancreas. 2009 Nov; 38(8):930-5.
PMCID: PMC2767410
110.
Lugea A, Tischler D, Gong J, Nguyen J, French SW, Pandol SJ. Cholinergic
Mediation of Alcohol-Induced Experimental Pancreatitis. Alcohol Clin Exp Res. 2010
Oct; 34(10):1768-81. PMID: 20626730
111.
JV Gerasimenko, P Ferdek, L Fischer, AS Gukovskaya, SJ Pandol. (2010) Inhibitors
of Bcl-2 family proteins deplete ER Ca(2+) stores in pancreatic acinar cells. Pflugers
Arch. 2010 Oct; 460(5):891-900. PMCID: PMC2937140
112.
Ohno I, Eibl G, Odinokova I, Edderkaoui M, Damoiseaux RD, Yazbec M, Abrol R,
Goddard, III WA, Pandol SJ. Rottlerin stimulates apoptosis in pancreatic cancer cells
through interactions between proteins of the Bcl-2 family. Am J Physiol Gastrointest
Liver Physiol. 2010 Jan; 298(1):G63-73. PMCID: PMC2806098
113.
Edderkaoui M, Nitsche C, Zheng L, Pandol SJ, Gukovskaya AS. NADPH oxidase
activation in pancreatic cancer cells is mediated through Akt-dependent upregulation of
p22phox. J.Biol Chem. 2010 Nov 30. PMID: 21118808
114.
Ye R, Mareninova OA, Barron E, Wang M, Hinton DR, Pandol SJ, Lee AS. Grp78
heterozygosity regulates chaperone balance in exocrine pancreas with differential
Stephen J. Pandol, M.D.
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response to cerulein-induced acute pancreatitis.. Am J Pathol. Dec; 177(6):282736.2010.
115.
Lugea A, Tischler, Nguyen J, Gong J, French SW, Gukovsky I, Gorelick FS, Pandol
SJ. XBP1 attenuates alcohol-induced chronic endoplasmic reticulum stress in mouse
pancreas. Gastroenterology. 2011 Mar; 140(3):987-97.
116.
Thrower EC, Yuan J, Usmani A, Liu Y, Jones C, Minervini SN, Alexandre M, Pandol
SJ, Guha S. A novel protein kinase D inhibitor attenuates early events of experimental
pancreatitis in isolated rat acini. Am J Physiol Gastrointest Liver Physiol. 2011 Jan;
300(1):G120-9. PMCID: PMC3025506
117.
Yuan J, Liu Y, Tan T, Guha S, Gukovsky I, Gukovskaya A, Pandol SJ. Protein kinase
d regulates cell death pathways in experimental pancreatitis. Front Physiol. 2012; 3:60.
118.
Pham H, Chen M, Takahashi H, King J, Reber HA, Hines OJ, Pandol S, Eibl G.
Apigenin Inhibits NNK-Induced Focal Adhesion Kinase Activation in Pancreatic Cancer
Cells..Pancreas. 2012 Nov; 41(8):1306-15.
119.
Abrol R, Edderkaoui M, Goddard WA 3rd, Pandol SJ. Molecular basis for the interplay
of apoptosis and proliferation mediated by Bcl-xL:Bim interactions in pancreatic cancer
cells. Biochem Biophys Res Commun. 2012 Jun 15; 422(4):596-601.
120.
Lê KA, Li Y, Xu X, Yang W, Liu T, Zhao X, Tang YG, Cai D, Go VL, Pandol S, Hui H.
Alterations in fecal Lactobacillus and Bifidobacterium species in type 2 diabetic patients
in Southern China population. Front Physiol. 2012; 3:496.
121.
Shalbueva N, Mareninova OA, Gerloff A, Yuan J, Waldron RT, Pandol SJ,
Gukovskaya AS. Effects of oxidative alcohol metabolism on the mitochondrial
permeability transition pore and necrosis in a mouse model of alcoholic pancreatitis.
Gastroenterology 2013; 144:437-446.e436.
122.
Edderkaoui M, Nitsche C, Zheng L, Pandol SJ, Gukovsky I, Gukovskaya AS. NADPH
oxidase activation in pancreatic cancer cells is mediated through Akt-dependent upregulation of p22phox. J Biol Chem 2013; 288:19648.
123.
Mareninova OA, Hermann K, French SW, O'Konski MS, Pandol SJ, Webster P,
Erickson AH, Katunuma N, Gorelick FS, Gukovsky I, Gukovskaya AS. Impaired
autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in
rodent models of acute pancreatitis. J Clin Invest 2013; 123:1844.
124.
Park CH, Lee IS, Grippo P, Pandol SJ, Gukovskaya AS, Edderkaoui M. Akt kinase
mediates the prosurvival effect of smoking compounds in pancreatic ductal cells. Pancreas
2013; 42:655-662.
125.
Dawson DW, Hertzer K, Moro A, Donald G, Chang HH, Go VL, Pandol SJ, Lugea A,
Gukovskaya AS, Li G, Hines OJ, Rozengurt E, Eibl GE. High Fat, High Calorie Diet
Stephen J. Pandol, M.D.
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Promotes Early Pancreatic Neoplasia in the Conditional KrasG12D Mouse Model. Cancer
Prev Res (Phila) Cancer Prev Res (Phila). 2013 Oct;6(10):1064-1073.
126.
Edderkaoui M, Lugea A, Hui H, Eibl G, Lu QY, Moro A, Lu X, Li G, Go VL, Pandol SJ.
Ellagic Acid and embelin affect key cellular components of pancreatic
adenocarcinoma, cancer, and stellate cells. Nutr Cancer. 2013;65(8):1232-44.
127.
Lu QY, Zhang L, Lugea A, Moro A, Edderkaoui M, Eibl G, Pandol SJ, Go VL.
Determination of Rottlerin, a Natural Protein Kinases C Inhibitor, in Pancreatic
Cancer Cells and Mouse Xenografts by RP-HPLC Method. J Chromatogr Sep Tech
2013; 4.
128.
Liu Y, Yuan J, Tan T, Jia W, Lugea A, Mareninova OA, Waldron RT, Pandol SJ.
Genetic inhibition of protein kinase Cε attenuates necrosis in experimental
pancreatitis. Am J Physiol Gastrointest Liver Physiol 2014.
129.
Wu BU, Pandol SJ, Amy Liu IL. Simvastatin is associated with reduced risk of
acute pancreatitis: findings from a regional integrated healthcare system. Gut
2014.
PEER-REVIEWED – SUBMITTED:
1.
Fischer L, Lugea A, Shahsahebi M, Penninger JM, Vanhaesebroeck B, Gukovskaya
AS, Pandol SJ, Gukovsky I. Class I PI3K isoforms gamma and delta regulate key
pathologic responses of cerulein-induced pancreatitis. Submitted.
2.
Lugea A., Wu X, Dasari S, French SW, Pandol SJ. Plasminogen Activator Inhibitor
(PAI)-1 regulates fibrogenesis during experimental pancreatitis. Submitting.
INVITED ARTICLES, BOOK CHAPTERS, ETC.
1.
Jensen RT, Collins SM, Pandol SJ, Gardner JD. "Lessons from studies of
secretagogue receptors on pancreatic acinar cells." In: Gut Hormones. Edited by SR
Bloom and JM Polak. Churchill, Livingston, second edition, 133-136, 1981.
2.
Jensen RT, Gardner JD, Raufman JP, Pandol SJ, Doppman JL, Collen MJ. ZollingerEllison syndrome: current concepts and management. Ann Intern Med. 98:59-75. 1983
3.
Jensen RT, Pandol SJ, Collen MJ, Raufman JP, Gardner JD. "Diagnosis and
Management of the Zollinger-Ellison syndrome." In: Receptors and the Upper GI
Tract. Edited by BI Hirschowitz and JG Spenney Advanced Therapeutics
Communications, Inc., New York, 279-291, 1983.
Stephen J. Pandol, M.D.
Page 22
Updated: 2/9/2016
4.
Muallem S, Beeker TG, Fimmel CJ, Pandol SJ. "Inositol phosphate levels during
Ca2+ reloading of internal Ca2+ stores in the exocrine pancreas." Progress in Clinical
and Biological Research. 252: 183-189, 1988.
5.
Pandol, S.J. "Structural abnormalities of the stomach and duodenum." In: Principles
and Practices of Gastroenterology and Hepatology. Edited by G. Gitnick. Elsevier,
New York, 101-115, 1988 .
6.
Muallem S, Beeker TG, Pandol SJ, Fimmel CJ. "Evidence for activation of the ERCa2+ pump in intact and permeabilized cells by Ca2+ mobilizing hormones. Progress
in Clinical and Biological Research. 273:349-354, 1988.
7.
Pandol SJ, Mendius KE. "Calcium metabolism and bombesin - stimulated pancreatic
enzyme secretion." Annuals of the New York Academy of Sciences. 547:268-276,
1988.
8.
Pandol SJ, Krims PE, Schoeffield-Payne MS, Hsu Y, Muallem S. "Cellular calcium
and phospholipid metabolism mediate pancreatic enzyme secretion." In:
Gastrointestinal Endocrinology: Receptors and Post-Receptor Mechanisms. Edited by
James C. Thompson. Academic Press, 59-72, 1990.
9.
Pandol SJ. "Introduction to the function and control of the gastrointestinal system."
In: Best and Taylor's Physiological Basis of Medical Practice. 12th edition. Edited by
John B. West. Williams and Wilkins, Baltimore, 606-613, 1991.
10.
Pandol SJ, Isenberg JI. "Salivary, gastric, duodenal and pancreatic secretion." In:
Best and Taylor's Physiological Basis of Medical Practice. 12th edition. Edited by
John B. West. Williams and Wilkins, Baltimore, 645-674, 1991.
11.
Pandol SJ, Rutherford RE. "Quantal calcium release and calcium entry in the
pancreatic acinar cell." Yale Journal of Biology and Medicine. 65:399-405, 1992.
12.
Pandol SJ. "Pancreatic Physiology" In: Gastrointestinal Disease. Pathophysiology,
Diagnosis, Management. Fifth Edition. Edited by Marvin Sleisenger, John Fordtran,
Bruce Scharschmidt and Mark Feldman. W.B. Sanders, Philadelphia, 1585-1600,
1993.
13.
Pandol SJ, Gukovskaya AS, Bahnson TD, Dionne VE. "Cellular mechanisms
mediating agonist-stimulated calcium influx in the pancreatic acinar cell." Annals of
the New York Academy of Sciences. 713:41-48, 1994.
14.
Pandol SJ. "Pancreatic acinar cell signaling mechanisms." Current Opinion in
Gastroenterology. 10: 485-490, 1994.
15.
Pandol SJ. "Structural abnormalities of the stomach and duodenum." In: Principals
and Practice of Gastroenterology and Hepatology, Second Edition. Edited by Gary
Stephen J. Pandol, M.D.
Page 23
Updated: 2/9/2016
Gitnick, Daniel Hollander, I. Michael Samloft, Leslie J. Schoenfield, and John M.
Vierling. Appleton and Lange, Norwalk, Connecticut, 87-98,1994.
16.
Pandol SJ, Gukovskaya AS, Bahnson TD. "Nitric oxide and cyclic GMP mediate
agonist-stimulated calcium influx in pancreatic acinar cell." Regulatory Peptide Letter
6: 39-42, 1995.
17.
Pandol SJ, Pandol KA, Raybould H. "Integrated response to a meal".
Undergraduate Teaching Project, American Gastroenterological Association, MilnerFenwick, Timonium, Maryland, 1995 (slides).
18.
Raybould H, Pandol KA, Pandol SJ. "Gastrointestinal movements and their functions."
Undergraduate Teaching Project, American Gastroenterological Association. MilnerFenwick, Timonium, Maryland, 1995 (20 minute video).
19.
Pandol SJ. "Pancreatic Physiology and Secretory Testing." In: Gastrointestinal and
Liver Disease. Pathophysiology, Diagnosis, Management. Sixth Edition. Edited by
Marvin Sleisenger, Bruce Scharschmidt and Mark Feldman, W.B. Sanders,
Philadelphia, 771-782, 1997.
20.
Pandol SJ. “Anoikis: Assisted cellular suicide.” Trendletters: News in Physiological
Sciences. Twelfth Edition, pg 96, 1997.
21.
Raybould HE, Pandol SJ. “The integrated response of the gastrointestinal tract to a
meal.” In: Textbook of Gastroenterology. Third Edition. Edited by Tadataka Yamada.
Lippincott-Raven, Philadelphia, 2-10, 1999.
22.
Pandol SJ. “Congressional testimony before a joint hearing on suspension of medical
research at West Los Angeles and Sepulveda VA Medical Facilities and informed
consent and patient safety in VA medical research.”
http://www.house.gov/va/schedule106/apr99/4-21-99J/pandol.htm
23.
Pandol SJ. “Goals for Research on Mechanisms of Alcohol-related Pancreatic
Disease.” National Institute on Alcohol Abuse and Alcoholism, 2000.
24.
Pandol SJ. “Pancreatic Physiology and Secretory Testing.” In: Gastrointestinal and
Liver Disease. Pathophysiology, Diagnosis, Management. Seventh Edition. Edited by
Marvin Sleisenger, Lawrence S. Friedman and Mark Feldman, W.B. Sanders,
Philadelphia, 871-880, 2002
25.
Tang SJ, Tran T, Memmesheimer C, Pandol S, Aranda R, Pisegna JR, Jensen DM.
Letters to the Editor: Paraesophageal Hernia Repair and Deep Vein Thrombosis. J
Clin Gastroenterol, 34:187-188, 2002.
26.
Pandol SJ. “Pancreatic Physiology and Secretory Testing.” In: Gastrointestinal and
Liver Disease. Pathophysiology, Diagnosis, Management. Seventh Edition. Edited by
Mark Feldman, Lawrence S. Friedman and Marvin Sleisenger, W.B. Sanders,
Philadelphia, 871-880, 2002.
Stephen J. Pandol, M.D.
Page 24
Updated: 2/9/2016
27.
Pandol SJ. “Practical guidelines for diagnosis and treatment of gastrointestinal, liver
and pancreatic disorders.” Greater Los Angeles, Health Care System, Intranet 2000Present.
28.
Raybould HE, Pandol SJ, Yee H. “The integrated responses of the gastrointestinal
tract and liver to a meal.” In: Textbook of Gastroenterology. Fourth Edition. Edited by
Tadataka Yamada. Lippincott-Raven, Philadelphia, 2-10, 2003.
29.
Pandol SJ, Gukovsky I, Satoh A, Lugea A, Gukovskaya AS. “Animal Models of
Alcoholic Pancreatitis: Role of Cholecystokinin.” Pancreas, 27:297-300, 2003.
30.
Pandol SJ, Gukovsky I, Satoh A, Lugea A, Gukovskaya AS. “Emerging concepts for
the mechanism of alcoholic pancreatitis from experimental models.” Journal of
Gastroenterology, 38:623-628, 2003.
31.
Gorelick F, Pandol SJ, Topazian M. “Pancreatic physiology, pathophysiology, acute
and chronic pancreatitis.” Gastrointestinal Teaching Project, American
Gastroenterologic Association 2003.
32.
Pandol SJ. “Neurohumoral control of exocrine pancreatic secretion.” Current Opinion
in Gastroenterology, 19(5):443-446, 2003.
33.
Gukovskaya AS, Vaquero EC, Edderkaoui M, Pandol SJ. “Survival signals in
pancreatic cancer.” 11th International Conference on Ulcer Research-ICUR, p. 345,
2003.
34.
Pandol SJ, Gukovsky I, Satoh A, Fischer L, Lugea A, Gukovskaya AS. “Molecular
mechanisms of pancreatitis.” 11th International Conference on Ulcer Research-ICUR,
p. 349, 2003.
35.
Miller A, Davis M, Pandol SJ. “The Rating Racket.” (Letter)
http://govexec.com/features/1103/1103letters.htm
36.
Pandol SJ, Satoh A, Fischer L, Mareninova O, Lugea A, Gukovsky I, Gukovskaya AS.
“Alcoholic pancreatitis: hijacked pancreatic signals.” The Cell, 36(8):24-29, 2004.
37.
Gukovskaya AS, Pandol SJ. “Cell death pathways in pancreatitis and pancreatic
cancer.” Pancreatology, 4:567-86, 2004.
38.
Pandol SJ. “Neurohumoral control of exocrine pancreatic secretion.” Current Opinion
in Gastroenterology, 20(5):435-438, 2004.
39.
Gorelick F, Pandol SJ, Topazian M, Robles-Diaz G. Pancreatitis (Version in Spanish).
Gastrointestinal Teaching Project, American Gastroenterologic Association 2004.
Stephen J. Pandol, M.D.
Page 25
Updated: 2/9/2016
40.
Sawicki M, Pandol SJ, McGee JB. The Genetic and Molecular Basis of
Gastrointestinal and Liver Disease. Gastrointestinal Teaching Project, American
Gastroenterologic Association 2004.
41.
Pandol SJ. “Are we studying the correct state of the stellate cell to elucidate
mechanisms of chronic pancreatitis?” Gut 54:744-5, 2005.
42.
Go VL, Gukovskaya A, Pandol SJ. “Alcohol and pancreatic cancer.” Alcohol 35:20511, 2005.
43.
Pandol SJ. “Acute Pancreatitis.” Curr Opin Gastroenterol 21:538-43, 2005.
44.
Apte MV, Zima T, Dooley S, Siegmund SV, Pandol SJ. Singer MV. Singal
transduction in alcohol-related diseases. Alcohol Clin Exp Res, 29:1299-1309, 2005.
45.
Pandol SJ, Satoh A, Fischer L, Mareninova O, Sung KF, Lugea A, Gukovsky I,
Gukovskaya AS. Alcoholic Pancreatitis: Insights from Animal Models Alcohol Clin Exp
Res, Vol. 29, Nr. 7, Seite 1299-1309, 2005.
46.
Pandol SJ, Edderkaoui M, Lee JK, Hu R, Lugea A, Sul J, Apte M, Vaquero E, Ohno I,
Gukovsky I, Go VL, Gukovskaya AS. “Alcohol, Reactive Oxygen Species, Pancreatitis
and Pancreatic Cancer.” In: Alcohol, Tobacco and Cancer. Edited by Chi Hin Cho,
Vishnudutt Purohit, Karger, New York, 109-118, 2006.
47.
Pandol SJ. “Pancreatic Secretion.” In: Gastrointestinal and Liver Disease.
Pathophysiology, Diagnosis, Management. Eighth Edition. Edited by Mark Feldman,
Lawrence S. Friedman and Lawrence J. Brandt, W.B. Sanders, Philadelphia, 11891201, 2006.
48.
Pandol, SJ. “Acute Pancreatitis: Diagnosis and Management.” Cybergrounds
Gastroenterology InterNDnet. http://www.cyberounds.com/conf/gastroenterology/
2006.
49.
Gukovskaya AS, Mareninova OA, Odinokova IV, Sung KF, Lugea A, Fischer L, Wang
YL, Gukovsky I, Pandol SJ. Cell death in pancreatitis: Effects of alcohol. J
Gastroenterol Hepatol. Suppl 3:S10-3, 2006.
50.
Pandol SJ, Tsukamoto H. Action plan for enhancing global collaboration on alcoholic
liver and pancreatic diseases: White paper. J Gastroenterol Hepatol. Suppl 3:S109-10,
2006.
51.
Pandol SJ. “Acute Pancreatitis.” Curr Opin Gastroenterol 22:481-486, 2006.
52.
Pandol SJ, Lugea A, Gukovskaya AS, Gukovsky I. Epidemiology and
Pathophysiology of Alcoholic Chronic Pancreatitis. In: The Pancreas: A Integrated
Textbook of Basic Science, Medicine and Surgery. 2nd Edition. Eds.: Beger HG,
Büchler MW, Kozarek RA, Lerch MM, Neoptolemos JP, Shiratori K, Warshaw AL,
Whitcomb DC, Blackwell Publishing, Oxford 2009, Chapter 39.
Stephen J. Pandol, M.D.
Page 26
Updated: 2/9/2016
53.
Pandol SJ, Raraty MG. Mechanisms of alcohol-induced pancreatitis. Pancreatology,
7:105-114, 2006.
54.
Omary MB, Lugea A, Lowe AW, Pandol SJ. The pancreatic stellate cells: a star on the
rise in pancreatic diseases. J Clin Invest 117:50-9, 2007.
55.
Raybould HE, Pandol SJ, Yee H. “The integrated responses of the gastrointestinal
tract and liver to a meal.” In: Textbook of Gastroenterology. Fifth Edition. Edited by
Tadataka Yamada. Lippincott-Raven, Philadelphia, publication in 2007.
56.
Pandol, S. Acute Pancreatitis: Diagnosis and Management. Cyberounds Overview
InterMDnet. http://www.cyberounds.com/conf/gastroenterology/2006-08-07/index.html
57.
Pandol S., Cohen H. Chronic Pancreatitis: Diagnosis and Management. Cyberounds
Overview InterMDnet. http://www.cyberounds.com/conf/gastroenterology/2007-0108/index.html
58.
Pandol SJ, Saluja AK, Imrie CW, Banks PA. Acute pancreatitis: Bench to the bedside.
Gastroenterology, 132:1127-51, 2007. PMID: 17383433
59.
Mukherjee R, Criddle DN, Gukovskaya A, Pandol S, Peterson OH, Sutton R.
Mitochondrial injury in pancreatitis. Cell Calcium, Jul;44(1):14-23 2008
60.
Sutton R, Petersen OH, Pandol SJ. Pancreatitis and calcium signalling: report of an
international workshop. Pancreas. 36:e1-14. 2008. PMID: 18437073
61.
Pandol SJ. Integrated Responses to a Meal. JPEN J Parenter Enteral Nutr. 32:
6. 2008.
62.
Gorelick F, Pandol S, Thrower E. Protein kinase C in the pancreatic acinar cell.
Journal of Gastroenterology and Hepatology, 23: S37-S41, 2008. PMID: 18336661
63.
Sutton R, Petersen OH, Pandol SJ. Pancreatitis and Calcium Signaling: Report of an
International Workshop. Pancreas, 38:e47-52, 2009
64.
Topazian M, Pandol SJ. “Acute Pancreatitis.” In: Textbook of Gastroenterology. Fifth
Edition, Volume 2. Edited by Tadataka Yamada. Wiley-Blackwell Publication in 68:
1761-1810, 2009.
65.
Pandol SJ, Raybould HE, Yee HF. “Integrative responses of the gastrointestinal tract
and liver to a meal.” In: Textbook of Gastroenterology. Fifth Edition, Volume 1. Edited
by Tadataka Yamada. Wiley-Blackwell Publication in 1: 3-14, 2009.
66.
Pandol SJ. Edderkaoui M, Gukovsky I, Lugea A, Gukovskaya A. Desmoplasia of
Pancreatic Ductal Adenocarcinoma. Clin Gastro Hep. 2009.
Stephen J. Pandol, M.D.
564-
Page 27
Updated: 2/9/2016
67.
Pandol SJ. “Pancreatic Secretion”. In: Gastrointestinal and Liver Disease. Ninth
Edition, Volume 1. Edited by Mark Feldman, MD Lawrence Friedman, MD, and
Lawrence Brandt, MD. Saunders Elsevier. 1: 921-930, 2010.
68.
Pandol SJ. “Integrating the gastrointestinal sciences”. Integrating the gastrointestinal
sciences. Front. Physio. 1:19, 2010
69.
Pandol SJ., Gorelick FS., Gerloff A., Lugea A. Alcohol Abuse, Endoplasmic Reticulum
Stress and Pancreatitis. Dig Dis. 2010;28(6):776-82.
70.
Pandol SJ., Gorelick FS., Lugea A. Environmental and Genetic Stressors and the
Unfolded Protein Response (UPR) in Exocrine Pancreatic Function- A Hypothesis.
Front Physiol. 2011 Mar 10;2:8.011
71.
Pandol SJ. “The Exocrine Pancreas”. San Rafael (CA): Morgan & Claypool Life
Sciences; 2010.
72.
Pandol SJ. “The Future of Food”. 2011.
73.
Hegyi P, Pandol S, Venglovecz V, Rakonczay Z Jr. The acinar-ductal tango in the
pathogenesis of acute pancreatitis. Gut. 2011 Apr;60(4):544-52. PMID: 20876773
74.
Alexandre M, Pandol SJ, Gorelick FS, Thrower EC. The emerging role of smoking in
the development of pancreatitis. Pancreatology. 2011;11(5):469-74.
75.
Pandol SJ, Lugea A, Mareninova OA, Smoot D, Gorelick FS, Gukovskaya AS,
Gukovsky I. Investigating the pathobiology of alcoholic pancreatitis. Alcohol Clin Exp
Res. 2011 May;35(5):830-7..
76.
Lugea A, Waldron RT, French SW, Pandol SJ. Drinking and driving pancreatitis: links
between endoplasmic reticulum stress and autophagy. Autophagy. 2011 Jul;7(7):7835.
77.
Gukovsky I, Pandol SJ, Gukovskaya AS. Organellar dysfunction in the pathogenesis
of pancreatitis. Antioxid Redox Signal. 2011 Nov 15;15(10):2699-710.
78.
Pandol S, Gukovskaya A, Edderkaoui M, Dawson D, Eibl G, Lugea A. Epidemiology,
risk factors, and the promotion of pancreatic cancer: role of the stellate cell. J
Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:127-34.
79.
Gukovsky I, Pandol SJ, Mareninova OA, Shalbueva N, Jia W, Gukovskaya AS.
Impaired autophagy and organellar dysfunction in pancreatitis. J Gastroenterol
Hepatol. 2012 Mar;27 Suppl 2:27-32.
80.
Pandol SJ, Apte MV, Wilson JS, Gukovskaya AS, Edderkaoui M. The burning
question: Why is smoking a risk factor for pancreatic cancer? Pancreatology. 2012
Jul;12(4):344-9.
Stephen J. Pandol, M.D.
Page 28
Updated: 2/9/2016
81.
Simeone DM, Pandol SJ. The pancreas: biology, diseases, and therapy.
Gastroenterology 2013;144:1163-1165.
82.
Apte MV, Wilson JS, Lugea A, Pandol SJ. A starring role for stellate cells in the
pancreatic cancer microenvironment. Gastroenterology 2013;144:1210-1219.
83.
Liddle RA, Freeman M, Simeone DM, Saluja AK, Castillo CF, Maitra A, Pandol SJ, Go
VL. Minutes of the business meeting of the American Pancreatic Association, Friday,
November 2, 2012, Miami, Florida. Pancreas. 2013: 42:1333-4.
84.
Liu ST, Pham H, Pandol SJ, Ptasznik A. Src as the link between inflammation
and cancer. Front Physiol 2014.
85.
Tan CR, Yaffee PM, Jamil LH, Lo SK, Nissen N, Pandol SJ, Tuli R, Hendifar AE.
Pancreatic cancer cachexia: a review of mechanisms and therapeutics. Front
Physiol 2014.
86.
Zhou G, Sinnett-Smith J, Liu SH, Yu J, Wu J, Sanchez R, Pandol SJ, Abrol R,
Nemunaitis J, Rozengurt E, Brunicardi FC. Down-regulation of pancreatic and
duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for
inhibition of cellular proliferation and insulin secretion by somatostatin. Front
Physiol 2014.
ABSTRACTS:
1.
Pandol SJ, Korman LY, McCarthy DM, Gardner JD. Beneficial effect of oral lithium
carbonate in the treatment of pancreatic cholera syndrome. Gastroenterology
78:1232, 1980.
2.
Richter JE, Pandol SJ, Castell DO, McCarthy DM. Esophageal abnormalities in the
Zollinger-Ellison syndrome. Gastroenterology 78:1244, 1980.
3.
Pandol SJ, Jensen RT, Gardner JD. Glucagon-stimulated pancreatic enzyme
secretion: a potential functional relation between endocrine and exocrine pancreas.
Gastroenterology 80:1247, 1981.
4.
Collins SM, Kinsella T, Korman LY, Jensen RT, Collen MJ, Pandol SJ, Barlas N,
O'Dorisio T, Gardner JD. Tumor radiosensitivity in the pancreatic cholera syndrome.
Gastroenterology 80:1127, 1981.
5.
Pandol SJ, Jensen RT, Gardner JD. Mechanism of bombesin-induced
desensitization of enzyme secretion in pancreatic acini. Gastroenterology 81:1145,
1982.
Stephen J. Pandol, M.D.
Page 29
Updated: 2/9/2016
6.
Collen MJ, Pandol SJ, Raufman JP, Allende HD, Bissonnette BM, Jensen RT,
Gardner JD. Beneficial effects of pirenzepine, a selective anticholinergic agent, in
patients with Zollinger-Ellison syndrome (ZES). Gastroenterology 82:1035, 1982.
7.
Allende HD, Collen MJ, Pandol SJ, Raufman JP, Gardner JD, Jensen RT. Cimetidine
induced impotence and gynecomastia: reversal with ranitidine. Gastroenterology
82:1007, 1982.
8.
Allende HD, Bissonnette BM, Raufman JP, Pandol SJ, Collen MJ, McCarthy DM,
Gardner JD, Jensen RT. Progressive increase in drug requirement in the long-term
medical management of patients with Zollinger-Ellison syndrome (ZES).
Gastroenterology 82:1007, 1982.
9.
Pandol SJ, O'Donohue TL, Gardner JD, Jensen RT. Natural glucagonstimulated pancreatic enzyme secretion: due to contamination by a previously
undescribed pancreatic secretagogue. Gastroenterology 84:1269, 1983.
10.
Pandol SJ, Thomas MW, Rivier J, Vale W. Growth hormone-releasing factors
stimulate in vitro pancreatic enzyme secretion. Gastroenterology 86:1205, 1984.
11.
Pandol SJ, Thomas MW, Schoeffield MS. Independence of cholecystokinin-induced
phosphatidylinositol breakdown from extracellular calcium and mobilization of
intracellular calcium in dispersed acini from guinea pig pancreas. Gastroenterology
86:1205, 1984.
12.
Seifert H, Pandol SJ, Rivier J, Vale W. GRF binding to pancreatic acinar cells."
Gastroenterology 86:1243, 1984.
13.
Pandol SJ, Sachs G, Muallem S. Transient activation of plasma membrane Ca2+
channel and Ca2+ uptake into endoplasmic reticulum upon termination of cell
stimulation. Federation Proceedings 44:1228, 1985.
14.
Muallem S, Pandol SJ, Sachs, G. Ion pathways and IP3-induced Ca2+ release in
hepatic rough endoplasmic reticulum. Federation Proceedings 44:1228, 1985 (1
page).
15.
Pandol SJ, Schoeffield MS, Sachs G, Muallem S. Role of secretagogue-induced
changes in free cytosolic calcium in pancreatic enzyme secretion. Gastroenterology
88:1528, 1985.
16.
Sachs G, Pandol SJ, Muallem S. The regulation of Ca2+ stores in stimulus-secretion
coupling. Gastroenterology 88:1565, 1985.
17.
Dharsathaphorn K, Pandol SJ. Basis for synergism between cAMP and Ca++mediated Cl2 secretion in a human colonic cell line. Gastroenterology 88:1364, 1985.
Stephen J. Pandol, M.D.
Page 30
Updated: 2/9/2016
18.
Dharsathaphorn K, Pandol SJ, McRoberts JA. Cl- secretion induced by cabachol in a
human colonic epithelial cell line: studies of the mechanism of action.
Gastroenterology 88:1364, 1985.
19.
Pandol SJ, Kondratenko NF, Schoeffield MS. Arachidonate release and sustained
pancreatic exocrine secretion. Gastroenterology 90:1577, 1986.
20.
Krims PE, Pandol SJ. Free cytosolic calcium in initial and sustained pancreatic
exocrine secretion. Gastroenterology 90:1503, 1986.
21.
Muallem S, Schoeffield M, Pandol SJ. Hormones mobilize Ca2+ from two intracellular
pools of the exocrine pancreas. Gastroenterology 90:1558, 1986.
22.
Fimmel CJ, Pandol SJ, Sachs G, Muallem S. Regulation of free cytosolic Ca2+ in
peptic cells. Gastroenterology 90:1415, 1986.
20.
McArthur K, Pandol SJ, Rivier J. A vasoactive intestinal peptide (VIP) analog
distinguishes two subtypes of high affinity VIP receptor on guinea pig pancreatic acinar
cells. Gastroenterology 92:1524, 1987.
24.
Muallem S, Pandol SJ. Reloading of the agonist- sensitive calcium pool in the
pancreatic acinar cell. Gastroenterology 92:1543, 1987.
25.
Pandol SJ, Muallem S. The control of plasma membrane calcium channel activation
in the pancreatic acinar cell. Gastroenterology 92:1565, 1987.
26.
Pandol SJ Rodriguez G, Mendius K. The role of intracellular calcium flux in the
mechanism of secretagogue-induced sustained pancreatic enzyme secretion.
Gastroenterology 92:1565, 1987.
27.
Algazi MC, Pandol SJ, Rivier J, Isenberg JI. Vasoactive intestinal peptide (VIP) is a
mediator of HCl-induced duodenal bicarbonate secretion (B.S.). Gastroenterology
92:1796, 1987.
28.
Beuerlein G, Dharmsathaphorn K, Pandol SJ. A phorbol ester inhibits Cl-secretion
stimulated by carbachol and ionomycin. Clinical Research 35:588A, 1987.
29.
Kelleher D, Pandol SJ, Kagnoff MK. Dissociation of protein kinase C activation from
PMA induced IL2 secretion in HUT-78 cells. Clinical Research 35:3:608A, 1987.
30.
Schmidt DN, Pandol SJ. No evidence of changed receptor properties or altered
stimulus-secretion coupling in dispersed pancreatic acini of ethanol-fed rats. Digestion
38(1):56, 1987.
31.
Schmidt DN, Pandol SJ. Prolonged exposure of isolated rat pancreatic acini to
acetaldehyde does not affect secretagogue-stimulated amylase release. Digestion
38(1):56-57, 1987.
Stephen J. Pandol, M.D.
Page 31
Updated: 2/9/2016
32.
Schmidt DN, Pandol SJ. Effects of ethanol feeding on pancreatic enzyme content
and responses to various secretagogues. Digestive Diseases and Sciences
32:(10):1187, 1987.
33.
Rivier J, Rivier C, Perrin M, Hagler A, Struthers S, Pandol SJ, Brown M, Kupryszewski
G, Chadhuri M, Vale W. Competitive antagonists of peptide hormones. Regulatory
Peptides 19:(1-2):135, 1987.
34.
Pandol SJ. Role of calcium flux in the mechanism of action of exocrine pancreatic
secretagogues. Regulatory Peptides 19(1-2):131, 1987.
35.
Chen HS, Hogan DL, Rivier J, Pandol SJ, Koss MA, Isenberg JI. PGE2 stimulated
duodenal mucosal bicarbonate secretion (DBS) functions independently from VIP.
Clinical Research 36:129A, 1988.
36.
Dharmsathaphorn K, Beuerlein G, Reinlib L, Pandol SJ, Donowitz M, Cohn J.
Activation of M2 acetylcholine receptors in a colonic epithelial cell line and intracellular
mediators involved in the Cl- secretory response. Gastroenterology 94:A98, 1988.
37.
Mendius K, Muallem S, Pandol SJ. Agonist- stimulated calcium influx is regulated by
membrane potential in the pancreatic acinar cell. Gastroenterology 94:A299, 1988.
38.
Pandol SJ. Evidence that arachidonic acid is an intracellular mediator of agoniststimulated sustained enzyme secretion from exocrine pancreas. Gastroenterology
94:A341, 1988.
39.
Beuerlein G, Pandol SJ, Dharmsathaphorn K. Modulation of chloride secretory
response in a colonic cell line by free cytosolic calcium. Clinical Research 36:129A,
1988.
40.
Pandol SJ, Schoeffield-Payne MS. Cyclic GMP regulates plasma membrane calcium
pump activity in pancreatic acinar cells. Gastroenterology 96:A382, 1989.
41.
Cohen ME, Pandol SJ, Donowitz M. Elevated Ca2+ increases ileal villus cell
microvillus membrane diacylglycerol content: involvement in protein kinase C (PKC)
translocation. Gastroenterology 96:A92, 1989.
42.
O'Konski MS, Pandol SJ. Effects of Caerulein on the Apical Cytoskeleton of the
Pancreatic Acinar Cell. Gastroenterology 98:A229, 1990.
43.
Perkins PS, Bahrami LS, Pandol SJ. Aspects of the mechanism of regulation of
pancreatic digestive enzyme synthesis by secretagogues. Gastroenterology 98:A230,
1990.
44.
Rutherford RE, Pandol SJ. Rapid desensitization of calcium release from the agonistsensitive pool in the pancreatic acinar cell. Gastroenterology 98:A520, 1990.
Stephen J. Pandol, M.D.
Page 32
Updated: 2/9/2016
45.
O'Konski MS, Pandol SJ. Apical cytoskeletal changes caused by caerulein are
reversed by CCK-JMV-180. Gastroenterology 100:A293, 1991.
46.
Pandol SJ, Schoeffield-Payne MS, Rutherford RE. Agonist mediated increases in
sphingosine regulate internal calcium stores and free cytosolic calcium.
Gastroenterology 100:A293, 1991.
47.
Perkins PS, Pandol SJ. Regulation of digestive enzyme synthesis by CCK-induced
alterations in polysome formation. Gastroenterology 100:A294, 1991.
48.
Buranawuti T, Vajanaphanich M, Barrett KE, Pandol SJ, Traynor-Kaplan AE. Inositol
tetrakisphosphate may mediate phorbol ester inhibition of carbachol stimulated Clsecretion in T84 cells. Gastroenterology 102:A203, 1992.
49.
Vajanaphanich M, Schultz C, Buranawuti T, Tsien RY, Pandol SJ, Traynor-Kaplan
AE, Barrett KE. Synergistic epithelial chloride secretion via cAMP and calcium
pathways - a re-examination. Gastroenterology 102:A249, 1992.
50.
Pandol SJ, Schoeffield-Payne M. The agonist-sensitive pool of calcium regulates
cellular cyclic GMP in the pancreatic acinar cell. Gastroenterology 102:A284, 1992.
51.
Perkins PS, Rutherford RE, Pandol SJ. The effect of chronic ethanol feeding on
digestive enzyme synthesis in rat pancreas. Gastroenterology 102:A285, 1992.
52.
Poucell-Hatton S, Perkins PS, Deerinck TJ, Ellisman M, Hardison WGM, Pandol SJ.
Immunolocalization of a low molecular weight myosin in the pancreatic acinar cell.
Gastroenterology 102:A286, 1992.
53.
Poucell-Hatton S, Perkins PS, Deerinck TJ, Ellisman M, Hardison WGM, Pandol SJ.
Differential distribution of myosin I and myosin II in pancreatic acinar cells: a possible
role in the transport of exocytosis of zymogen granules. Molecular and Cellular
Biology Suppl. 3, pg.158A 1992.
54.
Pandol SJ, Fitzsimmons T, Schoeffield-Payne M, Carlisle GW, Evans WH. Isolation
of subcellular agonist-sensitive calcium stores in the pancreatic acinar cell.
Gastroenterology 104:A327, 1993.
55.
Perkins PS, Pandol SJ. The role of calcium in translational regulation of protein
synthesis in the exocrine pancreas. Gastroenterology 104:A327, 1993.
56.
Vajanaphanich M, Schultz R, Tsien RY, Traynor-Kaplan AE, Pandol SJ, Barrett KF.
Crosstalk between epithelial calcium and cAMP signaling pathways: implications for
secretion. Gastroenterology 104:A286, 1993.
57.
Gukovskaya AS, Pandol SJ. Nitric oxide regulates neurotransmitter induced cGMP
rise and Ca2+ influx in pancreatic acinar cells. Gastroenterology 104:A306, 1993.
Stephen J. Pandol, M.D.
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58.
Gukovskaya AS, Poucell-Hatton S, Fitzsimmons TJ, Perkins PS, Zaninovic V,
Sandoval SI, Rutherford R, Pandol, S.J. Apoptosis in experimental pancreatitis.
Gastroenterology 106:A295, 1994.
59.
Gukovskaya AS, Pandol SJ. Regulation of nitric oxide synthase and guanylyl cyclase
by Ca2+ and Ca2+-binding proteins in dispersed pancreatic acini. Gastroenterology
106:A812, 1994.
60.
Fitzsimmons TS, Evans WH, Pandol SJ. Both cADP-ribose and IP3 release calcium
from compartments of the intracellular stores isolated from pancreatic acinar cells.
Gastroenterology 106:A1026, 1994.
61.
Gukovskaya AS, Poucell-Hatton S, Perkins PS, Zaninovic V, Sandoval DI Fitzsimmons
TJ, Pandol SJ. Different mechanisms of cell death in rat and opossum after duct
ligation. Gastroenterology 108:A358, 1995.
62.
Sandoval D, Gukovskaya AS, Reavey P, Gukovsky S, Braquet P, Pandol SJ, PoucellHatton S. The role of neutrophils and platelet-activating factor in mediating
experimental pancreatitis. Gastroenterology 108:A388, 1995.
63.
Gukovskaya AS, Pandol SJ. Membrane guanylate cyclase in exocrine pancreas.
Gastroenterology 108:A973, 1995.
64.
Perkins PS, Pandol SJ. Intracellular calcium distribution regulates protein synthesis
at translational initiation or elongation in the exocrine pancreas. Gastroenterology
108:A998, 1995.
65.
Gukovskaya AS, Pandol SJ. Ca2+ -ATPase inhibitors stimulate membrane guanylate
cyclase in pancreatic acini. Gastroenterology 110:A1076, 1996.
66.
Gukovskaya AS, Sandoval D, Zaninovic V, Pandol SJ. Tumor necrosis factor
regulates cell death in caerulein-induced pancreatitis. Gastroenterology 110:A394,
1996.
67.
Fitzsimmons TJ, Pandol SJ. Regulation of cyclic ADP ribose levels by Ca2+ in the
pancreatic acinar cell. Gastroenterology 110:A388, 1996.
68.
Gukovsky IY, Feng L, Gukovskaya AS, Pandol SJ. The calcium-binding protein
neurocalcin is expressed in pancreas. Gastroenterology 110:A1076, 1996.
69.
Blinman TA, Gukovsky IY, Gukovskaya AS, Livingston E, Pandol SJ. Pancreatic
acinar cells express a variety of cytokines that are regulated in experimental
pancreatitis. Gastroenterology 112:A429, 1997.
70.
Song MK, Zaninovic V, Kim DR, Gukovskaya AS, Pandol SJ, Kang KW. Peptide
guamerin-D modulated development of cerulein-induced acute pancreatitis in the rat.
Gastroenterology 112:A483, 1997.
Stephen J. Pandol, M.D.
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Updated: 2/9/2016
71.
Periskic S, Zaninovic V, Gukovsky I, Gukovskaya AS, Solomon T, Tsukamoto H,
Pandol SJ. Ethanol feeding increases the sensitivity of the rats to cholecystokinin
(CCK) induced pancreatitis. Gastroenterology 112:A472, 1997.
72.
Gukovskaya AS, Gukovsky I, Periskic S, Blinman T, Zaninovic V, Pandol SJ. Loss of
extracellular matrix contacts leads to NF-B activation, cytokine expression, and
production and apoptosis in pancreatic acinar cell. Gastroenterology 112:A446, 1997.
73.
Gukovsky I, Gukovskaya AS, Zaninovic V, Periskic S, Tsukamoto H, Pandol SJ. NFB activation is an early marker of pancreatic acinar cell injury in rat cerulein
pancreatitis. Gastroenterology 112:A446, 1997.
74.
Zaninovic V, Gukovskaya AS, Blinman T, Gukovsky I, Pandol SJ. ICAM-1
upregulation in experimental pancreatitis induced by supramaximal doses of cerulein.
Gastroenterology 112:A495, 1997.
75.
Fitzsimmons T, McRoberts J, Tachiki K, Pandol SJ. The role of fatty acid-CoA esters
in Ca2+ signaling in the pancreatic acinar cell. Gastroenterology 112:A439, 1997.
76.
Blinman T, Gukovskaya AS, Gukovsky I, Zaninovic V, Livingston E, Pandol SJ.
Pancreatic acinar cells express IL-6, KC, MCP-1, and MIP-2: Evidence from RT-PCR
analysis of microscopically isolated acinar cells. Gastroenterology 114:A443, 1998.
77.
Blinman T, Gukovsky I, Gukovskaya A, Zaninovic V, Pandol SJ, Livingston E.
Intrapancreatic expression of cytokines IL-6 and KC is increased in cerulein
pancreatitis: regulation by NF-B. Gastroenterology 114:A443, 1998.
78.
McRoberts JA, Gukovsky I, Rodriguez E, Lai FA, Pandol SJ. Ryanodine receptor is
present in rat pancreatic acinar cells. Gastroenterology 114:A457, 1998.
79.
Gukovskaya AS, Gukovsky I, Kira DT, Lam J, Gukovsky S, Pandol SJ. Ethanol and
fatty acid ethyl esters induce activation of transcription factors NF-B and AP-1 in
pancreatic acinar cells. Gastroenterology 114:A464, 1998.
80.
Gukovskaya AS, Gukovsky I, Zaninovic V, Kira DT, Pandol SJ. Metalloproteinases
regulate signal transduction pathways triggered by extracellular matrix proteins.
Gastroenterology 114:A464, 1998.
81.
Gukovsky I, Gukovskaya AS, Pandol SJ. Cerulein activates NF-B and AP-1 in
isolated pancreatic acinar cells. Gastroenterology 114:A465, 1998.
82.
Gukovsky I, Blinman TA, Zaninovic V, Jung Y, Gukovskaya AS, Pandol SJ. Role of
transcription factor NF-B in mediating hormone-induced pancreatitis.
Gastroenterology 114:A465, 1998.
Stephen J. Pandol, M.D.
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Updated: 2/9/2016
83.
Zaninovic V, Gukovskaya AS, Gukovsky I, Kim S, Pandol SJ. Adhesion molecule
ICAM-1 is present and functions in rat pancreatic acinar cells. Gastroenterology
114:A512, 1998.
84.
Savard CE, Blinman TA, Pandol SJ, Lee SP. Lipopolysaccharide stimulates cytokine
production by mouse gallbladder epithelial cells. Gastroenterology 114:A1077, 1998.
85.
Gukovskaya AS, Gukovsky I, Mouria M, Pandol SJ. Regulation of pancreatic cancer
apoptosis by polyphenols. International Conference on Diet and Prevention of Cancer,
Finland, 1999.
86.
Gukovskaya AS, Gukovsky I, Mouria M, Pandol SJ. Cerulein stimulates apoptosis in
pancreatic acinar cells. Gastroenterology 116:A1128, 1999.
87.
Gukovskaya AS, Zaninovic V, Lam H, Mouria M, Neil L, Pandol SJ. Neutrophils
regulate trypsin activation in cerulein pancreatitis. Gastroenterology 116:A1128A1129, 1999.
88.
Gukovsky I, Jung Y, Periskic S, Zaninovic V, Kim S, Gukovskaya AS, Tsukamoto H,
Pandol SJ. Ethanol diet sensitizes pancreas to CCK-8 induced activation of NF-B
and cytokine mRNA expression. Gastroenterology 116:A1129, 1999.
89.
Gukovsky I, Gukovskaya AS, Mouria M, Pandol SJ. Detachment from extracellular
matrix stimulates NF-B activation and apoptosis in pancreatic cancer cells.
Gastroenterology 116:A416, 1999.
90.
Mouria M, Gukovskaya AS, Gukovsky I, Pandol SJ. Effects of polyphenols on
apoptosis and NF-B activation in pancreatic cancer cells. Gastroenterology
116:A470, 1999.
91.
Zaninovic V, Gukovskaya AS, Bostandzhyan E, Eysselein VE, Pandol SJ. Effect of
overexpression of transforming growth factor  on necrotizing cerulein pancreatitis in
mice. Gastroenterology 116:A1179, 1999.
92.
Leser J, Beil M, Gukovskaya AS, Pandol SJ, Adler G, Lutz MP. Caspase-8 mediated
cleavage of plectin regulates CCK-induced F-actin breakdown in pancreatic acinar
cells. Gastroenterology 118:A194, 2000.
93.
Buechler P, Hines OJ, Gukovskaya AS, Mouria M, Pandol SJ, Reber HA. The
isoflavonoid genistein induces apoptosis by activation of caspase-3 and inhibits
metastatitic tumor growth in vivo. Gastroenterology 118:A1143, 2000.
94.
Gukovskaya AS, Mouria M, Gukovsky I, Reyes CN, Kasho VN, Pandol SJ.
Acetaldehyde production from ethanol regulates activation of transcription factors NFB and AP-1 in pancreatic acinar cells. Gastroenterology 118:A1146, 2000.
Stephen J. Pandol, M.D.
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95.
Vaquero E, Gukovsky I, Zaninovic V, Gukovskaya AS, Pandol SJ. Upregulation of
transcription factors and cytokine MRNA expression in taurocholate-induced
pancreatitis. Gastroenterology 118:A653, 2000.
96.
Mouria M, Gukovskaya AS, Pandol SJ. Mechanisms of the effects of food
polyphenolic compounds on apoptosis in pancreatic cancer cells. Gastroenterology
118:A538, 2000.
97.
Vaquero E, Gukovskaya AS, Brennan ML, Lusis AJ, Holland SM, Pandol SJ.
Leukocyte NADPH oxidase but not myeloperoxidase regulates pancreatic trypsin
activation in cerulein induced pancreatitis. Gastroenterology 118:A170, 2000.
98.
Gukovskaya AS, Mouria M, Jung Y, Zaninovic V, Pandol SJ. Intracellular
mechanisms of CCK-induced apoptosis in pancreatic acinar cells. Gastroenterology
118:A156, 2000.
99.
Gukovsky I, Blinman TA, Mouria M, Zaninovic V, Livingston E, Pandol SJ,
Gukovskaya AS. p38 MAP kinase is a key regulator of cytokine and chemokine
expression in pancreatic acinar cells. Gastroenterology 118:A157, 2000.
100.
Gukovsky I, Reyes C, Zaninovic V, Wong F, Gukovskaya AS, Pandol SJ.
Improvement of experimental pancreatitis with pharmacologic inhibitors of NF-κB and
AP-1 activation. Pancreas, 21 vol. 4:446, 2000.
101.
Lugea A, Gukovskaya AS, Zaninovic V, Reyes C, Pandol SJ. Ethanol metabolites,
fatty acid ethyl esters and acetaldehyde, stimulate extracellular matrix protein
production by dispersed pancreatic acini. Pancreas, 21 vol. 4:458, 2000.
102.
Mouria M, Gukovskaya AS, Buechler P, Hines OJ, Reber HA, Pandol SJ.
Polyphenolic compounds in food inhibit metastatic pancreatic cancer growth by
causing mitochondrial cytochrome c release and apoptosis. Pancreas, 21 vol. 4:464,
2000.
103.
Vaquero E, Mouria M, Pandol SJ, Gukovskaya AS. Extracellular matrix proteins
protect pancreatic carcinoma cells from apoptosis. Pancreas, 21 vol. 4:487, 2000.
104.
Mouria M, Gukovskaya AS, Jung Y, Buechler P, Hines OJ, Reber HA, Pandol SJ.
Polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C
release and apoptosis. Pancrease 21:464, 2000.
105.
Gukovskaya AS, Mouria M, Gukovsky I, Reyes CN, Kasho VN, Faller LD, Pandol SJ.
Ethanol metabolism and transcription factor activation in pancreatic acinar cells.
Pancreas 21:458, 2000.
106.
Gukovsky I, Reyes CN, Vaquero EC, Baycher A, Gukovskaya AS, Pandol SJ.
Curcumin, a natural phytochemical, inhibits pancreatic NF-kB and AP-1 activation and
ameliorates pancreatitis in two experimental models. Gastroenterology 120, A537.
Stephen J. Pandol, M.D.
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2001.
107.
Gukovsky I, Reyes CN, Cheng JH, Jung Y, Pandol SJ, Gukovskaya AS. PI 3-kinase
mediates CCK-induced activation of both trypsin and NF-kB in pancreatic acinar cells.
Gastroenterology 120, A132. 2001.
108.
Lu SC, Gukovsky I, Reyes CN, Huang ZZ, Chen L, Mato JM, Pandol SJ. The role of
S-adenosylmethionine in the choline-deficient, ethionine supplemented diet model of
pancreatitis. Gastroenterology 120, A537. 2001.
109.
Lugea A, Gukovskaya AS, Gukovsky I, Cheng JH, Pandol SJ. Fatty acid ethyl esters,
the non-oxidative ethanol metabolites, stimulate extracellular matrix protein production
by dispersed pancreatic acini: role of TGF-beta. Gastroenterology 120, A336. 2001.
110.
Vaquero EC, Jung YJ, Pandol SJ, Gukovskaya AS. Extracellular matrix proteins
protect pancreatic carcinoma cells from apoptosis via inhibition of mitochondrial
cytochrome C release. Gastroenterology 120, A722. 2001.
111.
Gukovskaya AS, Nam KJ, Cheng J, Gukovsky I, Pandol SJ. Phosphatidylinositol 3kinase mediates cholecystokinin induced calcium influx in pancreatic acinar cells.
Gastroenterology 122, A167. 2002.
112.
Gukovskaya AS, Nam KJ, Vaquero E, Pandol SJ. Polyphenols synergistically with
antioxidants stimulate apoptosis in pancreatic carcinoma cells. Gastroenterology 122,
A493. 2002.
113.
Gukovskaya AS, Cheng J, Gukovsky I, Lugea A, Hosseini S, Pandol SJ. Ethanol and
acetaldehyde decrease the activity of peroxisome proliferator-activated receptors
(PPARs) in pancreatic acinar cells. Gastroenterology 122, A283. 2002.
114.
Gukovsky I, Lugea A, Cheng J, French BA, Riley NE, French S, Tsukamoto H, Pandol
SJ. Torrance C. Model of chronic alcoholic pancreatitis. Gastroenterology 122, A93.
2002.
115.
Gukovsky I, Lugea A, Cheng JH, French BA, Riley NE, French S, Tsukamoto H,
Pandol SJ. Model of chronic alcoholic pancreatitis. Alcoholism Clinical and
Experimental Research 26, 140A. 2002.
116.
Hosseini S, Gukovskaya AS, Cheng J, Gukovsky I, Pandol SJ, Los Angeles C.
Ethanol potentiates cholecystokinin-induced but inhibits thapsigargin-induced NF-kB
activation in pancreatic acinar cells. Gastroenterology 122, A282. 2002.
117.
Hosseini S, Gukovskaya AS, Cheng JH, Gukovsky I, Pandol SJ. Ethanol has
differential effects on pathways mediating NF-kB activation in the pancreatic acinar
cell. Alcoholism Clinical and Experimental Research 26[5], 59A. 2002.
Stephen J. Pandol, M.D.
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118.
Lugea A, Gukovskaya AS, Pandol SJ, Los Angeles C. Ethanol metabolites alter
extracellular matrix (ECM) degradation and cell death pathways in rat pancreatic
acinar cells. Gastroenterology 122, A167. 2002.
119.
Peng YL, Joseph RR, Gukovsky I, Pandol SJ, Wu SV, Los Angeles C. Identification
and functions of somatostatin receptors in rat pancreatic acinar cells. Gastroenterology
122, A168. 2002.
120.
Vaquero E, Nam KJ, Pandol SJ, Gukovskaya AS. Reactive oxygen species (ROS) as
survival factor in human pancreatic cancer. Gastroenterology 122, A77. 2002.
121.
Gukovskaya AS, Hosseini S, Cheng JH, Nam KJ, Gukovsky I, Pandol SJ. Ethanol
regulates cholecystokinin-induced NF-B activation in pancreatic acinar cells through
calcium and protein kinase C pathways. Pancreas 25:430.
122.
Lugea A, Gukovskaya AS, Pandol SJ. Inhibitory effect of non-oxidative ethanol
metabolites on the plasminogen system in rat pancreas. Pancreas 25:439, 2002.
123.
Vaquero EC, Nam KJ, Gukovsky I, Pandol SJ, Gukovskaya AS. Intracellular sources
of radical oxygen species (ROS) in human pancreatic cancer cells. Pancreas 25:455,
2002.
124.
Gukovsky I, Nam KJ, Cheng JH, Pandol SJ, Gukovskaya AS. Caspases and
poly(ADP-ribose) polymerase (PARP) regulate the balance between apoptosis and
necrosis in experimental pancreatitis. Gastroenterology 124, DDW-2003.
125.
Yazbeck MF, Nam KJ, Vaquero EC, Gukovskaya AS, Pandol SJ. The protein kinase
C delta inhibitor rottlerin greatly stimulates apoptosis in pancreatic cancer cells.
Gastroenterology 124:777, 2003.
126.
Gukovsky I, Cheng JH, Nam KJ, Lee OT, Lugea A, Penninger JM, Pandol SJ,
Gukovskaya AS. Phosphatidylinositide 3-kinase (PI3K) gamma regula-tes key
pathologic responses to CCK in the pancreatic acinar cell. Gastroenterology 124,
DDW-2003.
127.
Vaquero EC, Nam KJ, Gukovsky I, Pandol SJ, Gukovskaya AS. Non-mitochondrial
NAD(P)H oxidase mediates growth factor-induced ROS production and suppression of
apoptosis in pancreatic cancer cells. Gastroenterology 124, DDW-2003.
128.
Satoh A, Gukovskaya AS, Cheng JH, Nam KJ, Lee OT, Pandol SJ. Activation of
individual protein kinase C isoforms and their role in CCK- and TNF- induced NF-B
activation in pancreatic acinar cells. Gastroenterology 124, DDW-2003.
129.
Satoh A, Gukovskaya AS, Nieto JM, Cheng JH, Reeve Jr. JR, Pandol SJ. Novel PKC
isoforms, delta and epsilon, medicate NF-B activation induced by TNF and CCK-8
in pancreatic acinar cells. Pancreas 27:407, 2003.
Stephen J. Pandol, M.D.
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130.
Fischer L, Gukovskaya AS, Young SH, Buechler P, Beuchler MW, Friess H, Pandol
SJ. Phosphatidylinositide 3-kinase regulates calcium signaling in pancreatic acinar
cells. Pancreas 27: 2003.
131.
Edderkaoui M, Vaquero EC, Pandol SJ, Gukovskaya AS. Extracellular matrix proteins
stimulate reactive oxygen species production in human pancreatic cancer cells
through non-mitochondrial NAD(P)H oxidase. Pancreas 27: 2003.
132.
Lugea A, Nan L, French SW, Bezerra JA, Gukovskaya AS, Pandol SJ. Pancreas
tissue repair after cerulein-induced pancreatitis is impaired in plasminogen-deficient
mice. Gastroenterology 126:A-104, 2004.
133.
Gukovsky I, Kubisch C, Lugea A, Tsukamoto H, Pandol SJ, Logsdon CD. Microarray
Profiling of Pancreatic Gene Expression in Ethanol Fed Rats: Down-Regulation of
Protective Genes May Underlie the Sensitizing Effect of Alcohol to Pancreatitis.
Gastroenterology 126:A-596, 2004.
134.
Fischer L, Gukovskaya AS, Young SH, Buechler P, Buechler MW, Friess H, Pandol
SJ. Phosphatidylinositide 3-kinase regulates hormone-induced calcium signals in
pancreatic acinar cells by inhibition of endoplasmic reticulum Ca2+-ATPase.
Gastroenterology 126:A-592, 2004.
135.
Satoh A, Gukovskaya AS, Daghighian MS, Reeve JR Jr, Pandol SJ. Novel protein
kinase C isoforms  and  mediate cholecystokinin-induced activation of PYK2 and
NF-B in pancreatic acinar cells by diverging pathways. Gastroenterology 126:A-530,
2004.
136.
Satoh A, Daghighian MS, Reeve JR Jr, Pandol SJ, Gukovskaya AS. TNF- activated
proline-rich kinase 2 (PYK2) in pancreatic acinar cells by protein kinase C dependent
mechanism. Gastroenterology 126:A-529, 2004.
137.
Edderkaoui M, Vaquero EC, Hong PP, Daghighian MS, Pandol SJ, Gukovskaya AS.
Reactive oxygen species mediate pro-survival effects of both extracellular matrix
proteins and growth factors in pancreatic cancer cells. Gastroenterology 126:A-548,
2004.
138.
Edderkaoui M, Vaquero EC, Hong P, Gukovsky I, Pandol SJ, Gukovskaya AS.
Growth factors and extracellular matrix proteins protect pancreatic cancer cells from
death through activation of membrane NAD(P)H oxidase. Pancreatology 4:135-136,
2004.
139.
Pandol SJ, Gukovsky I, Satoh A, Lugea A, Gukovskaya AS. Alcoholic pancreatitis:
Insights from animal models. International Society for Biomedical Research on
Alcoholism - Heidelberg 2004.
Stephen J. Pandol, M.D.
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140.
Lugea A, Gorelick F, Gukovskaya AS, Pandol SJ. Ethanol feeding induces a
protective endoplasmic reticulum stress response: regulation by cholecystokinin.
Gastroenterology 128:A-632, 2005.
141.
Lugea A, Pandol SJ. Differential effects of ethanol and fatty acid ethyl esters on the
plasminogen activating system in cultured pancreatic stellate cells. Gastroenterology
128:A-632, 2005.
142.
Wang YL, Lugea A, Hu R, Mareninova O, Smoot D, Gukovskaya AS, Pandol SJ.
Ethanol feeding switches death pathway resulting in inhibition of apoptosis and
promotion of necrosis in pancreas. Gastroenterology 128:A-381, 2005.
143.
Hu R, Wang YL, Hong P, Edderkaoui M, Shahsahebi M, Lugea A, Apte MV,
Gukovskaya AS, Pandol SJ. Pancreatic stellate cell NADPH oxidase system and its
regulation by ethanol and growth factors. Gastroenterology 128:A-631, 2005.
144.
Lee JK, Edderkaoui M, Hong P, Truong P, Berti JA, Pandol SJ, Gukovskaya AS.
NADPH oxidase Nox4 mediates pancreatic cancer cell survival by activating JAK2
kinase. Involvement of LMW-PTP protein tyrosine phosphatase. Pancreas 31:451-452,
2005.
145.
Sung KF, Odinokova IV, Mareninova OA, Hong P, Lugea A, Hoffmann A, Gukovsky I,
Pandol SJ, Gukovskaya AS. Bcl-xL is upregulated in different models of acute
pancreatitis and protects pancreas from cell death. Pancreas 31:472, 2005.
146.
Hu R, Wang YL, Edderkaoui M, Lugea A, Apte M, Pandol SJ. Pancreatic stellate cell
NADPH oxidase system and its role in mediating pancreatic stellate cell proliferation
by platelet derived growth factor (PDGF). Pancreas 31:446, 2005.
147.
Edderkaoui M, Hong P, Pandol SJ, Gukovskaya AS. IGF-R mediates the fibronectininduced protection from apoptosis in pancreatic cancer cells. Pancreas 31:438-439,
2005.
148.
Fischer L, Lugea A, Shahsahebi M, Penninger JM, Vanhaesebroeck B, Friess H,
Gukovskaya AS, Pandol SJ, Gukovsky I. Class I PI3K isoforms δ and γ regulate key
responses of cerulein-induced pancreatitis. PI3K δ is necessary for trypsin activation.
Pancreas 31:441, 2005.
149.
Mareninova OM, Sung KF, Hong P, Lugea A, Pandol SJ, Gukovsky I, Gukovskaya
AS. Caspases protect from necrosis and regulate the severity of cerulein pancreatitis.
Pancreas 31:454, 2005.
150.
Lugea A, Nieto J, Daghighian M, Satoh A, Pandol SJ. Role of the Cholinergic ystem in
Alcohol-induced Pancreatitis. Gastroenterology 130:A260, 2006.
151.
Lee JK, Edderkaoui M, Hong PP, Truong P, Lambeth JD, Berti A, Pandol SJ, and
Gukovskaya AS. Sustained Akt phosphorylation is required for anti-apoptotic effect of
Stephen J. Pandol, M.D.
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insulin-like growth factor-I in pancreatic cancer cells: roles of phosphatases.
Gastroenterology 130:A260, 2006.
152.
Edderkaoui M, Ohno I, Hong P, Pandol SJ, Gukovskaya AS. Trans-activation of IGFR by fibronectin protects from apoptosis in pancreatic cancer cells. Gastroenterology
130:A277, 2006.
153.
Edderkaoui M, Ohno I, Pandol SJ, Gukovskaya AS. Embelin and resveratrol increase
apoptosis and decrease proliferation in pancreatic cancer cells through regulation of
IAPs. Gastroenterology 130:A278, 2006.
154.
Satoh A, Gukovskaya AS, Reeve JR Jr., Gukovsky I, Pandol SJ. Ethanol sensitizes
pancreatic acinar cells to NF-κB activation through activation of protein kinase C
epsilon. Gastroenterology 130:A59, 2006.
155.
Gukovsky I, Shahsahebi M, Hong PP, Lugea A, French SW, Pandol SJ. Suppression
of IFN- and increase in IL-6 is associated with ethanol-induced chronic pancreatitis
responses in the CsA model of alcoholic chronic pancreatitis. Gastroenterology
130:A560, 2006.
156.
Mareninova OM, Lugea A, Odinokova IV, Tsukamoto H, Gukovsky I, Pandol SJ, and
Gukovskaya AS. Ethanol stimulates Akt phosphorylation in the pancreas through
PTEN oxidation: a predisposing factor in alcoholic pancreatitis? Gastroenterology
130:A384, 2006.
157.
Ohno I, Edderkaoui M, Truong PB, Odinocova IV, Lee JK, Saisho H, Gukovskaya AS,
Pandol SJ. Inhibition of Bcl-2/Bcl-xL proteins stimulate apoptosis and inhibit
proliferation of pancreatic cancer cells. Gastroenterology 130:A279, 2006.
158.
Wang JL, Satoh A, Fischer LS, Pandol SJ. Role of Protein Kinase C Delta (PKC ) in
Cholecystokinin-8-Induced Amylase Secretion and Nuclear Factor Kappa-B (NF-B)
Activation in Pancreatic Acini. Gastroenterology 130:A562, 2006.
159.
Fischer L, Lugea A, Shahsahebi M, Vanhaesebroeck B, Penninger JM, Friess H,
Gukovskaya AS, Pandol SJ, Gukovsky I. Diverse roles of class I PI3K isoforms  and
 in cerulein-induced pancreatitis. Gastroenterology 130:A72, 2006.
160.
Fischer L, Gukovskaya AS, Penninger JM, Friess H, Gukovsky I, Pandol SJ.
Phosphatidylinositol 3-kinase facilitates bile acid-induced Ca2+ responses in
pancreatic acinar cells. Gastroenterology 130:A712, 2006.
161.
Lugea A, Nieto J, Gukovsky I, Satoh A, Pandol SJ. Role of the Cholinergic System in
Alcohol-induced Pancreatitis. Pancreas 33:479-480, 2006.
162.
Lugea A, Pandol SJ. Plasminogen activating system in cultured pancreatic stellate
cells: effects of ethanol. Pancreas 33:479, 2006.
Stephen J. Pandol, M.D.
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163.
Ohno I, Eibl G, Odinokova I, Edderkaoui M, Yazbeck M, Pandol SJ, Gukovskaya AS.
Rottlerin stimulates apoptosis in pancreatic cancer throughinhibition of Bcl-xL..
Pancreas 33:487, 2006.
164.
Edderkaoui M, Pandol SJ, Gukovskaya AS. Embelin regulates XIAP and survivin
levels through different mechanisms and induces pancreatic cancer cell death.
Pancreas 33:458, 2006.
165.
Mareninova OA, Lugea A, Odinokova IV, Tsukamoto H, Gukovsky I, Pandol SJ,
Gukovskaya AS. Akt activation in alcoholic pancreatitis: role of PTEN. Pancreas
33:481, 2006.
166.
Gukovsky I, Lugea A, Shahsahebi M, Cheng JH, Award M, French SW, Pandol SJ.
Ethanol feeding impairs recovery from acute pancreatitis. Gastroenterology 132:A722,
2007.
167.
Zhao G, Reyes CN, Hermann K, Mareninova O, Sung KF, Gukovskaya AS, Hoffman
A, Pandol SJ, Gukovsky I. Roles of individual NF-kB proteins in pathologic responses
of experimental acute pancreatitis. Gastroenterology 132:A116, 2007.
168.
Do JH, Mareninova O, Paik A, Reyes C, Lugea A, Fischer L, Gukovsky I, Gukovskaya
A and Pandol SJ. The inflammatory response of acute pancreatitis promotes necrosis
through effects on the PI3 kinase system. Gastroenterology 132:A250, 2007.
169.
Mareninova OA, Hermann K, Pandol SJ, French SW, Gorelick FS, Gukovsky I,
Gukovskaya AS. Interrelationship between autophagy and apoptosis in cerulein
pancreatitis. Gastroenterology 132:A250-A251, 2007.
170.
Mareninova OA, Lugea A, Odinokova IV, Gukovsky I, Pandol SJ, Gukovskaya AS.
Mechanisms of pancreatic Akt activation in cerulein pancreatitis and by ethanol
feeding. Role of PTEN. Gastroenterology 132:A251, 2007.
171.
Osgood SE, Kolodecik TR, Reeve JR, Pandol SJ, Gorelick FS, Thrower EC. The role
of protein kinase C isoforms in pancreatic zymogen activation. Gastroenterology
132:A250-A252, 2007.
172.
Ohno I, Gukovskaya AS, Odinokova I, Pandol SJ. Bcl-2/Bcl-XL mediate the
proapoptotic effects of ROS in pancreatic cancer cells. Gastroenterology 132:A250A437, 2007.
173.
Cosen-Binker L, Lam P, Binker M, Reeve J, Pandol S, Gaisano H. Alcohol
cholecystokinin evoked pancreatic acinar basolateral exocytosis is mediated by PKC
phosphorylation of Munc18c. Gastroenterology 132:A722, 2007.
174.
Lugea A; Tischler DA; French SW; Gorelick FS; Pandol SJ. XBP1 plays a critical role
in protecting pancreas against ethanol-induced Endoplasmic Reticulum Stress.
Gastroenterology 132:723, 2007.
Stephen J. Pandol, M.D.
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175.
Y. Nakamura; J. H. Do; I. V. Odinokova; M. Lee; S. J. Pandol; A. S. Gukovskaya
Neutrophil Depletion Stimulates Apoptosis in Pancreatitis Through Upregulating p53.
Pancreas 37:4;53, 2008
176.
Gerasimenko J, Odinokova IV, Sung KF, Mareinova O, Lee MA, Fischer L,
Pandol SJ, Gukovskaya AS. Pro-Survival BCL-2 Proteins Regulate Ca2+ Transport in
Pancreatic Acinar Cells. Gastroenterolgy, A-127: 893, 2008
177.
Lugea A, Wu X, Srivdya D, Pandol SJ. The Urokinase System Plays a Critical Role in
Pancreatic Stellate Cell Activation. Gastroenterology, A-585: T1891, 2008
178.
Lugea A, Wu X, Srivdya D, Pandol SJ. Plasminogen Activator Inhibitor-1 Mediates
Fibrogenesis After Cerulein-Induced Pancreatitis. Gastroenterology, A-585: T1892,
2008
179.
Yuan J, Lugea A, Zheng L, Gukovsky I, Edderkaoui M, Pandol SJ. Protein Kinase D
Mediates Nf-kB Activation Induced By Cholecystokinin and Cholinergic Signaling in
Pancreatic Acinar Cells. Gastroenterology, A-722: W1821, 2008.
180.
Mareninova O, Odinokova IV, Lee MA, Pandol SJ, Gukovsky I, Gukovskaya AS. Role
of mitochondrial permeability transition pore in pancreatitis. Gastroenterology 2009
181.
Mareninova O, Lee MA, Yakubov I, Pandol SJ, French SW, Gorelick FS, Gukovsky I,
Gukovskaya As. Autophagy impairment as a mechanism for acute pancreatitis: the
role of cathepsins. Gastroenterology 2009
182.
Lugea A, Gukovsky I, French SW, Gorelick FS, Pandol SJ. Role of XBP1 in the
protective unfolded protein response to limit chronic ethanol-induced endoplasmic
reticulum stress and damage in the pancreas. Gastroenterology 2009.
183.
Shalbueva N., Mareninova O, Yuan J, Pandol SJ, Gukovskaya AS. Alcohol
Depolarize Pancreatic Mitochondria through PTP-Dependent Mechanism. Pancreas
2009.
184.
Yuan JZ, Liu Y, Pandol SJ, Gukovskaya AS, Tan T, Thrower E, Guha S. Protein
Kinase D Regulates Cell Death Pathways in Acute Pancreatitis. Pancreas 2009.
185.
Yuan JZ, Liu, Y, Shalbueva N, Tan T, Gukovskaya AS, Pandol SJ. Protein Kinase C
Epsilon Mediates Ethanol and Carbachol-Induced Depolrization in Pancreatic Acinar
Cells. Pancreas 2009.
Stephen J. Pandol, M.D.
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