doi: 10.1111/ina.12176 Online supporting information for the following article published in Indoor Air DOI: TO BE ADDED BY THE PRODUCTION EDITOR The effects of building-related factors on classroom relative humidity among North Carolina schools participating in the “Free to Breathe, Free to Teach” study Running Header: Building factor effects on classroom humidity Authors: K.A. Angelon-Gaetz1; D.B. Richardson1; D.M. Lipton2; S.W. Marshall1; B. Lamb3, T. LoFrese.4 1 Epidemiology Department, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC; 2North Carolina Division of Public Health, Department of Health and Human Services, Raleigh, NC; 3New Hanover County Schools, Maintenance Operations Department, Wilmington, NC; 4Chapel Hill-Carrboro City Schools, Support Services, Chapel Hill, NC. Corresponding Author: Kim Angelon-Gaetz, Currently working as an ORISE Research Fellow at the U.S. Environmental Protection Agency, National Exposure Research Laboratory, 109 TW Alexander Drive, Research Triangle Park, NC 27711. Tel: 919-541-1512 Email: kangelongaetz@gmail.com SUPPLEMENTAL MATERIALS: EQUATIONS Conversion from temperature (oC) to saturation vapor pressure (kPa) (Snyder, 2005) ππ.ππ π» es=0.6108 exp [π»+πππ.π], where es is saturation vapor pressure (kPa) and T is temperature (oC). (Equation S1) Unit conversion of saturation vapor pressure from kPa to inHg (This step is optional because you will be converting back to kPa in Equation 5.) es (inHg)= 0.295300 es (kPa) (Equation S2) (http://www.srh.noaa.gov/images/epz/wxcalc/pressureConversion.pdf) Conversion from saturation vapor pressure values (inHg) to vapor pressure (inHg) (Parish and Putnam, 1977) πΌ ev = πππ es, where es is saturation vapor pressure (inHg), ev is vapor pressure (inHg), and U is relative humidity (%) (Equation S3) Reverse Equation 3 to convert back to kPa. Conversion from vapor pressure (kPa) to absolute humidity (g/m3) (Snyder, 2005) ππππ π π χ =π»+πππ.ππ , where ev is vapor pressure (kPa), T is temperature (oC), and χ is absolute humidity (g/m3) (Equation S4) SUPPLEMENTAL MATERIALS: TABLES TABLE S1. UNIVARIATE ASSOCIATIONS BETWEEN OTHER BUILDING-RELATED FACTORS AND DAILY AVERAGE RELATIVE HUMIDITY (N=9044 CLASSROOM-DAYS) COVARIATE LEVEL * UNADJUSTED OR (95% CI) Low Relative Humidity High Relative Humidity >30% vs. >30% vs. >50% vs. >60% vs. 30-50% (ref.) 30-60% (ref.) 30-50% (ref.) 30-60% (ref.) >40 1.06 (0.55, 2.0) 1.42 (0.72, 2.8) 0.66 (0.44, 0.98) 2.6 (1.4, 4.8) 31-40 4.2 (1.96, 8.8) 7.2 (3.2, 16.3) 0.23 (0.11, 0.51) 1.05 (0.34, 3.3) 11-20 3.5 (1.98, 6.1) 5.9 (3.2, 10.8) 0.23 (0.14, 0.38) 0.70 (0.38, 1.30) 0-10 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) Outdoor relative humidity 10 unit increase 0.62 (0.55, 0.71) 0.56 (0.49, 0.65) 1.49 (1.43, 1.55) 1.73 (1.54, 1.94) Heating/ cooling season Cooling 0.52 (0.16, 1.69) 0.41 (0.13, 1.30) 1.82 (1.30, 2.6) 2.4 (1.74, 3.2) Heating 12.4 (9.3, 16.6) 22.3 (16.5, 30.2) 0.04 (0.03, 0.05) 0.02 (0.01, 0.05) Transition 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) Yes 0.02 (0.01, 0.04) 0.01 (0.01, 0.02) 3.4 (2.2, 5.1) 0.58 (0.29, 1.16) No 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) Yes 0.93 (0.40, 2.2) 0.74 (0.30, 1.84) 2.8 (1.77, 4.4) 3.6 (1.4, 9.2) No 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) Building Age (years)** Enthalpy wheels for dehumidification Thermostat setback * Generalized logits estimating the bivariate association between other building-related factors used only as confounders in the models presented in Tables 2 and 3. For each factor, two models were run using different relative humidity (RH) cut points as described above and clustered by classroom. Missing n=22 classroom-days. OR=odds ratio, CI=confidence intervals, ref.= referent. ** No schools participating in this study had buildings between the ages of 21-30. TABLE S2. FULL MODEL FOR ASSOCIATION BETWEEN WATER DAMAGE AND DAILY AVERAGE RELATIVE HUMIDITY LEVEL (N=9044 CLASSROOM-DAYS) COVARIATE * ADJUSTED OR (95% CI) LEVEL Low Relative Humidity High Relative Humidity >30% vs. >30% vs. >50% vs. >60% vs. 30-50% (ref.) 30-60% (ref.) 30-50% (ref.) 30-60% (ref.) Yes 0.86 (0.57, 1.30) 0.91 (0.59, 1.42) 0.72 (0.47, 1.09) 0.52 (0.28, 0.96) No 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) Direct-expansion (Dx) split system Heat pump/ refrigerant 2.1 (1.37, 3.1) 2.9 (1.84, 4.5) 0.06 (0.02, 0.16) 0.06 (0.02, 0.19) 1.35 (0.73, 2.5) 1.10 (0.56, 2.2) 1.56 (0.94, 2.6) 0.82 (0.36, 1.84) Chilled water 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) Outdoor relative humidity 10 unit increase 0.59 (0.53, 0.67) 0.54 (0.48, 0.62) 1.67 (1.59, 1.75) 1.82 (1.62, 2.0) Building Age (years)** >40 0.88 (0.45, 1.71) 1.14 (0.57, 2.3) 0.72 (0.46, 1.13) 3.4 (1.75, 6.5) 31-40 3.2 (1.40, 7.5) 5.8 (2.2, 15.3) 0.19 (0.07, 0.55) 1.44 (0.42, 4.9) 11-20 2.8 (1.42, 5.4) 3.7 (1.76, 7.6) 0.53 (0.35, 0.78) 1.43 (0.81, 2.6) 0-10 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) Visible water damage Heating/ cooling mechanism * *Estimated generalized logits clustered by classroom, using different relative humidity (RH) cut points. Missing n=22 classroom-days. Adjusted OR give the association between the building-related factor and high RH, using a multivariate model that includes the confounders listed below for each factor. Missing n=289 classroom-days of observations for water damage. Water damage includes leaks, history of flooding, or visible signs of moisture/ water damage in the classroom. OR=odds ratio, CI=confidence intervals, ref. = referent. ** No schools participating in this study had buildings between the ages of 21-30. TABLE S3. FULL MODEL FOR ASSOCIATION BETWEEN HVAC MAINTENANCE AND DAILY AVERAGE RELATIVE HUMIDITY LEVEL (N=9044 CLASSROOM-DAYS) COVARIATE * ADJUSTED OR (95% CI) LEVEL Low Relative Humidity Frequency of HVAC maintenance Building Age (years)** High Relative Humidity >30% vs. >30% vs. >50% vs. >60% vs. 30-50% (ref.) 30-60% (ref.) 30-50% (ref.) 30-60% (ref.) Annually 0.47 (0.28, 0.78) 0.32 (0.19, 0.54) 6.6 (4.0, 10.8) 5.8 (2.9, 11.3) As Needed 1.06 (0.73, 1.53) 0.84 (0.57, 1.25) 4.7 (3.0, 7.4) 4.8 (2.5, 9.2) Quarterly 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) >40 1.39 (0.67, 2.9) 2.3 (1.07, 5.1) 0.19 (0.11, 0.34) 0.69 (0.32, 1.52) 31-40 4.8 (2.4, 9.6) 9. 6 (4.5, 20.3) 0.07 (0.04, 0.14) 0.31 (0.10, 0.91) 11-20 3.6 (1.97, 6.5) 6.8 (3.6, 12.9) 0.08 (0.05, 0.13) 0.23 (0.11, 0.47) 0-10 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) * *Estimated generalized logits clustered by classroom, using different relative humidity (RH) cut points. Missing n=22 classroom-days. Adjusted OR give the association between the building-related factor and high RH, using a multivariate model that includes the confounders listed below for each factor. OR=odds ratio, CI=confidence intervals, ref. = referent. ** No schools participating in this study had buildings between the ages of 21-30. TABLE S4. FULL MODEL FOR ASSOCIATION BETWEEN PRESENCE OF AN ECONOMIZER AND DAILY AVERAGE RELATIVE HUMIDITY LEVEL (N=9044 CLASSROOM-DAYS) COVARIATE * ADJUSTED OR (95% CI) LEVEL Low Relative Humidity Economizer Enthalpy wheels for dehumidification High Relative Humidity >30% vs. >30% vs. >50% vs. >60% vs. 30-50% (ref.) 30-60% (ref.) 30-50% (ref.) 30-60% (ref.) Yes 0.84 (0.60, 1.17) 0.65 (0.45, 0.94) 3.1 (2.0, 4.6) 2.6 (1.49, 4.5) No 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) Yes 0.02 (0.01, 0.03) 0.008 (0.004, 0.018) 6.42 (3.9, 10.6) 1.04 (0.49, 2.2) No 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) * *Estimated generalized logits clustered by classroom, using different relative humidity (RH) cut points. Missing n=22 classroom-days. Adjusted OR give the association between the building-related factor and high RH, using a multivariate model that includes the confounders listed below for each factor. OR=odds ratio, CI=confidence intervals, ref.= referent. TABLE S5. FULL MODEL FOR ASSOCIATION BETWEEN HEATING/ COOLING MECHANISM AND DAILY AVERAGE RELATIVE HUMIDITY LEVEL (N=9044 CLASSROOM-DAYS) COVARIATE * ADJUSTED OR (95% CI) LEVEL Low Relative Humidity Heating/ cooling mechanism HVAC Season Building Age (years)** High Relative Humidity >30% vs. >30% vs. >50% vs. >60% vs. 30-50% (ref.) 30-60% (ref.) 30-50% (ref.) 30-60% (ref.) Direct-expansion (Dx) split system 2.5 (1.58, 3.8) 2.7 (1.71, 4.4) 0.03 (0.01, 0.12) 0.06 (0.01, 0.23) Heat pump/ refrigerant 0.97 (0.49, 1.94) 0.93 (0.47, 1.82) 1.35 (0.89, 2.0) 0.85 (0.46, 1.55) Chilled water 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) Cooling 0.25 (0.08, 0.82) 0.26 (0.08, 0.81) 4.4 (2.9, 6.7) 3.3 (2.4, 4.7) Heating 14.4 (11.3, 18.3) 20.6 (15.7, 26.9) 0.04 (0.03, 0.05) 0.02 (0.01, 0.05) Transition 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) >40 0.91 (0.46, 1.79) 0.96 (0.49, 1.86) 0.70 (0.46, 1.08) 3.4 (1.79, 6.4) 31-40 3.3 (1.35, 8.2) 3.8 (1.55, 9.2) 0.33 (0.16, 0.69) 2.1 (0.82, 5.6) 11-20 3.3 (1.98, 5.4) 3.5 (2.1, 5.8) 0.47 (0.30, 0.75) 1.48 (0.82, 2.7) 0-10 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) * *Estimated generalized logits clustered by classroom, using different relative humidity (RH) cut points. Missing n=22 classroom-days. Adjusted OR give the association between the building-related factor and high RH, using a multivariate model that includes the confounders listed below for each factor. OR=odds ratio, CI=confidence intervals, ref. = referent. ** No schools participating in this study had buildings between the ages of 21-30. TABLE S6: JOINT EFFECTS OF VISIBLE CLASSROOM WATER DAMAGE AND DEHUMIDIFIER USE ON DAILY AVERAGE RELATIVE HUMIDITY (N= 9044 CLASSROOM OBSERVATIONS) * ** Adjusted OR (95% CI) Water Damage Dehumidifier Use Low Relative Humidity High Relative Humidity >30% vs. >30% vs. >50% vs. >60% vs. 30-50% (ref.) 30-60% (ref.) 30-50% (ref.) 30-60% (ref.) Yes Yes 0.95 (0.49, 1.86) 1.10 (0.54, 2.3) 0.46 (0.21, 1.0) 0.53 (0.19, 1.49) Yes No 0.76 (0.48, 1.20) 0.79 (0.50, 1.26) 0.70 (0.44, 1.10) 0.44 (0.25, 0.79) No Yes 0.22 (0.04, 1.25) 0.14 (0.02, 1.05) 3.9 (0.73, 20.4) 1.44 (0.15, 13.4) No No 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) 1.0 (ref.) * *Estimated generalized logits clustered by classroom, using different RH cut points. Missing n=22 classroom-days. Adjusted OR give the association between the building-related factor and high RH, using a multivariate model that includes heating/ cooling mechanism, outdoor RH, and building age. Missing n=289 classroom-days of observations for water damage. Water damage includes leaks, history of flooding, or visible signs of moisture/ water damage in the classroom. OR=odds ratio, CI=confidence intervals, ref. = referent.