INNATE Lymphoid Cells (ILCs)
CL:xxxxxxx ID2+ ILC precursor
[Term]
id: CL:xxxxxxx
name: ID2+ ILC precursor
namespace: cell
def: "ID2+ ILC precursors develop from the common lymphoid progenitor (CLP)
and express the transcription factor ID2, which predisposes them to the ILC
lineage." [GOC:dsd, PMID:23348417, PMID:23292121]
synonym: "ID2+ innate lymphoid cell precursor" EXACT []
synonym: "NK/ILC cell precursor" BROAD []
synonym: " ILC/NK cell precursor" BROAD []
is_a: CL:0000542 ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: has_part PR:000000040 ! DNA-binding protein inhibitor ID-2
relationship: develops_from CL:0000051! common lymphoid progenitor
CL:xxxxxxx Innate Lymphoid Cells
[Term]
id: CL:xxxxxxx
name: innate lymphoid cell
namespace: cell
def: "These cells display a lymphoid morphology and lack any characteristic
myeloid or dendritic cell markers. Additionally, they lack any RAG-dependent
antigen receptors, such as BCR and TCR. ILCs are an important part of the
innate immune system." [GOC:dsd, PMID:23348417, PMID:23292121]
synonym: "ILC" EXACT []
is_a: CL:0000542 ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: capable_of GO:0045087 ! innate immune response
intersection_of: capable_of GO:0001816 ! cytokine production
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part GO:0032998 ! Fc-epsilon receptor
I complex
intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X
relationship: develops_from CL:xxxxxxx ! ID2+ ILC precursor
CL:xxxxxxx Group 1 innate lymphoid Cells
[Term]
id: CL:xxxxxxx
name: group 1 innate lymphoid cell
namespace: cell
def: "Group 1 ILCs are ILCs that are capable of producing the type 1 cytokine
IFN-gamma, but not TH2 or TH17 cell-associated cytokines." [GOC:dsd,
PMID:23348417, PMID:23292121]
synonym: "Group 1 ILCs" EXACT [PMID:23348417]
1
is_a: CL:xxxxxxx ! innate lymphoid cell
intersection_of: CL:xxxxxxx! innate lymphoid cell
intersection_of: capable_of GO:0072643 ! interferon-gamma secretion
relationship: develops_from CL:xxxxxxx ! ID2+ ILC precursor
CL:xxxxxxx ILC1
[Term]
id: CL:xxxxxxx
name: ILC1
namespace: cell
def: "In humans, ILC1 are lineage-negative non-cytotoxic ILCs that are
capable of producing the type 1 cytokine IFN-gamma upon stimulation with IL12
and IL18. Their development requires IL12, IL18, and the transcription
factor TBET." [GOC:dsd, PMID:23292121, PMID:23348417]
comment: Human ILC2 cells are reportedly CD1a-negative, CD3-negative, CD4negative, CD11b-negative, CD14-negative, CD16 negative, CD25-low, CD34negative, CD56-positive, CD117-negative, CD123-negative, CD127-positive,
CD335-negative, IL1R-positive, IL23R-negative, IL12RB2-positive, ST2negative, IL17RB-negative, TCRgd-negative, BDCA2-negative,. They may develop
from ILC3 cells.
is_a: CL:xxxxxxx ! group 1 innate lymphoid cell
intersection_of: CL:xxxxxxx ! group 1 innate lymphoid cell
intersection_of: has_part PR:000001835 ! T-box transcription factor TBX21
CL:0000623 NK cell
[Term]
id: CL:0000623
name: natural killer cell
namespace: cell
def: "A lymphocyte that can spontaneously kill a variety of target
without prior antigenic activation via germline encoded activation
and also regulate immune responses via cytokine release and direct
with other cells." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "large granular lymphocyte" BROAD []
synonym: "NK cell" EXACT []
synonym: "null cell" BROAD []
xref: BTO:0000914
xref: BTO:0004716
xref: CALOHA:TS-0664
xref: FMA:63147
xref: FMA:83601
xref: VHOG:0001697
is_a: CL:xxxxxxx ! group 1 innate lymphoid cell
intersection_of: CL:xxxxxxx ! group 1 innate lymphoid cell
intersection_of: lacks_plasma_membrane_part PRO:000001020 ! CD3
epsilon[REMOVE – INHERITED FROM NEW PARENT INNATE LYMPHOID CELL]
intersection_of: RO:0002215 GO:0002228 ! capable_of natural killer
mediated immunity
cells
receptors
contact
cell
2
intersection_of: RO:0002215 GO:0050776 ! capable_of regulation of immune
response
relationship: develops_from CL:0000825 ! pro-NK cell
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: RO:0002215 GO:0002228 ! capable_of natural killer cell mediated
immunity
relationship: RO:0002215 GO:0050776 ! capable_of regulation of immune
response
CL:xxxxxxx ILC2
[Term]
id: CL:xxxxxxx
name: ILC2
namespace: cell
def: "ILC2 cells are ILCs that are capable of producing TH2-cell associated
cytokines upon stimulation with IL25, IL33, and TSLP. Their development
requires the cytokine IL7 and the transcription factors ROR-alpha and GATA3."
[GOC:dsd, PMID:23292121, PMID:23562755]
comment: Human ILC2 cells are reportedly CD1a-negative, CD11b-negative, CD14negative, CD16-negative, CD25-positive, CD34-negative, CD45-positive, CD90positive, CD117-positive, CD123-negative, CD127-positive, CD161-positive,
CD185-positive, CD186-positive, CDw199-positive, CD278-positive, CD294positive, CD303-negative, CD335-negative, SCA1-positive, IL12Rb2-negative,
ST2-positive, IL17rb-positive, TCRab-negative, TCRgd-negative. Upon
activation, they can reportedly produce IL4, IL5, IL6, IL9, IL13, and
amphiregulin.
synonym: "Group 2 ILCs" EXACT []
synonym: "type 2 innate lymphoid cell" EXACT []
synonym: "innate type 2 cytokine-producing lymphoid cell" EXACT
[PMID:22865043]
synonym: "type 2 ILCs" EXACT []
synonym: "group 2 innate lymphoid cell" EXACT []
synonym: "natural helper cells" BROAD [PMID:23292121]
synonym: "NHC" BROAD [PMID:23292121]
synonym: "innate helper 2 cell" EXACT [PMID:23292121]
synonym: "IH2 cell" EXACT [PMID:23292121]
synonym: "nuocyte" EXACT [PMID:23292121]
is_a: CL:xxxxxxx ! innate lymphoid cell
intersection_of: CL:xxxxxxx! innate lymphoid cell
intersection_of: capable_of GO:0035745 ! T-helper 2 cell cytokine production
intersection_of: capable_of GO:0042092 ! type 2 immune response
intersection_of: capable_of GO:0090303 ! positive regulation of wound healing
intersection_of: has_part PR:000014163 ! nuclear receptor ROR-alpha
intersection_of: has_part PR:000001941 ! trans-acting T-cell-specific
transcription factor GATA-3
relationship: develops_from CL:xxxxxxx ! ID2+ ILC precursor
CL:xxxxxxx ILC3
[Term]
3
id: CL:xxxxxxx
name: ILC3
namespace: cell
def: "Group 3 ILCs are capable of producing IL17 and/or IL22 upon
stimulation. Their development is dependent upon IL7 and the transcription
factors RORgammat." [GOC:dsd, PMID:23348417, PMID:23292121]
comment: ILC3 are described as being Lineage-negative. For humans, Lin- is
defined as CD1a-negative, CD11b-negative, CD14-negative, CD16-negative, CD34negative, CD123-negative, CD303-negative, TCRab-negative, TCRgd-negative.
For the mouse, Lin- is defined as CD4-negative, CD8-negative, B220-negative,
CD11b-negative, GR1-negative, and TER119-negative.
synonym: "group 3 innate lymphoid cell" EXACT []
synonym: "group 3 ILC" EXACT []
is_a: CL:xxxxxxx ! innate lymphoid cell
intersection_of: CL:xxxxxxx! innate lymphoid cell
intersection_of: capable_of GO:0072620 ! interleukin-22 secretion
relationship: develops_from CL:xxxxxxx ! ID2+ ILC precursor
CL:xxxxxxx LTi
[Term]
id: CL:xxxxxxx
name: LTi cell
namespace: cell
def: "LTi cells are involved with the development of lymphoid tissues, such
as the lymph nodes and Peyer’s patches. They express the transcription factor
RORgammat. Upon stimulation with IL23 and IL1beta, these cells can produce
IL17 and IL22." [GOC:dsd, PMID:23348417, PMID:23292121]
comment: These cells are also reportedly CD7-positive, CD90-positive, CD94negative, CD117-positive, CD121-positive, CD127-positive, CD161-positive,
CD335-negative, IL223R-positive, IL12RB2-negative, IL17RB-negative, SCA1negative, ST2-negative. Most are CD25-positive (75%). They are also
reportedly capable of producing LT-alpha and LT-beta. They also express the
transcription factors AHR and TOX.
synonym: "lymphoid tissue-inducer cell" EXACT []
synonym: "lymphoid tissue inducer cell" EXACT []
is_a: CL:xxxxxxx ! ILC3
intersection_of: CL:xxxxxxx! ILC3
intersection_of: capable_of GO:0072615 ! interleukin-17 secretion
intersection_of: capable_of GO:0034103 ! regulation of tissue remodeling
relationship: develops_from CL:xxxxxxx ! ID2+ ILC precursor
CL:xxxxxxx NCR-positive ILC3
[Term]
id: CL:xxxxxxx
name: NCR-positive ILC3
namespace: cell
def: "NCR-positive ILC3 cells are Group 3 ILCs that are NKp46/CD335-positive
and whose development is dependent upon RORgt. Upon stimulation with IL13 and
IL1beta, these cells secret IL22." [GOC:dsd, PMID:23348417, PMID:23292121]
4
comment: These cells are reportedly CD56-positive, CD90-positive, CD117positive, CD127-positive, NKp30-positive, NKp46-positive, IL1R-positive,
IL223R-positive, IL12RB2-negative, IL17RB-negative. A small portion of these
cells is CD4-positive (~10%). They also express the transcription factors AHR
and Tbet.
synonym: "NCR+ ILC3" EXACT []
synonym: "NKp46+ ILC" EXACT [PMID:23292121]
synonym: "NK22 cells" EXACT [PMID:23348417]
synonym: "NCR22 cells" EXACT [PMID:23348417, PMID:23292121]
synonym: "NKR-LTi cells" EXACT [PMID:23348417, PMID:23292121]
synonym: "ILC22" EXACT [PMID:23348417, PMID:23292121]
synonym: "LTi-like cells" EXACT [PMID:22224763]
is_a: CL:xxxxxxx ! ILC3
intersection_of: CL:xxxxxxx! ILC3
intersection_of: hsa_plasma_membrane_part PR:000001893 ! natural cytotoxicity
triggering receptor 1
relationship: develops_from CL:xxxxxxx ! ID2+ ILC precursor
CL:xxxxxxx NCR-negative ILC3
[Term]
id: CL:xxxxxxx
name: NCR-negative ILC3
namespace: cell
def: "These ILC3 subtype lacks the expression of NKp46/CD335. Upon
stimulation with IL13 and IL1beta, these cells can produce IL17, IL22 and
IFNgamma. Their development requires IL7 and the transcription factor
RORgammat." [GOC:dsd, PMID:23348417]
comment: These cells are reportedly CD4-negative, CD25-positive, CD90positive, CD117-negative, CD127-positive, IL1R-positive, IL223R-positive,
IL12RB2-negative, IL17RB-negative, SCA1-positive. They are also reportedly
capable of producing IFN-gamma.
synonym: "NCR-ILC3" EXACT []
is_a: CL:xxxxxxx ! ILC3
intersection_of: CL:xxxxxxx! ILC3
intersection_of: capable_of GO:0072615 ! interleukin-17 secretion
intersection_of: capable_of GO:0072643 ! interferon-gamma secretion
intersection_of: lacks_plasma_membrane_part PR:000001893 ! natural
cytotoxicity triggering receptor 1
relationship: develops_from CL:xxxxxxx ! ID2+ ILC precursor
5