4/11/2020 Principal Investigator/Program Director (Last, middle, first): ____________________
NAME
Bridget S. Wilson eRA COMMONS USER NAME (credential, e.g., agency login) bswilson
Provide the following information for the Senior/key personnel and other significant contributors.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
POSITION TITLE
Victor & Ruby Hansen Surface Professor of
Pathology
EDUCATION/TRAINING
INSTITUTION AND LOCATION
Texas Tech University, Lubbock, TX
University of New Mexico, Albuquerque, NM
University of New Mexico, Albuquerque, NM
A. Personal Statement
DEGREE
(if applicable)
B.A.
M.S.
Ph.D.
MM/YY
1974
1987
1989
FIELD OF STUDY
Theater/English
Biology
Medical Sciences
I am a cell biologist with over 20 years experience studying signal transduction, intracellular trafficking and membrane biology. My laboratory specializes in innovative imaging approaches, including live cell, fluorescence-based assays and electron microscopy (EM) approaches. We also use intravital imaging to study progression and dissemination of solid tumors and leukemia blasts. The foundation of my cell biology training was an ACS fellow at UC San Diego, where I was jointly mentored by Nobel Laureate George Palade and
National Academy member Marilyn Farquhar. My laboratory has been continuously supported by NIH since
1995; foundation funding (ACS, LLS) has also been important to our success. Our publications have been recognized by Immunology Today , Trends in Cell Biology and Faculty of 1000 as research breakthroughs and led to invited talks at Gordon, Keystone and FASEB conferences as well as platform presentations at ASBMB,
ACSB and Biophysical Society national meetings. In the field of Systems Biology, my goal is to build interdisciplinary teams that integrate cell geometry and quantitative data sets through computational approaches. I am also a member of the Multi-Scale Modeling/IMAG consortium and lead the Hematologic
Malignancies Program at UNM’s NCI-designated Cancer Center.
B. Positions and Honors
Positions and Employment:
1985 - 1986 Teaching Assistant, Biology Department, University of New Mexico
1986 - 1989 Graduate Student, Biomedical Sciences, Univ. of New Mexico School of Medicine
1990 - 1993 Postdoctoral Fellow, Division of Cellular and Molecular Medicine, Univ. of California, San Diego
1993 - 1996 Research Assistant Professor, Dept. of Pathology, Univ.of New Mexico Health Sciences Center
1996 - 2002 Assistant Professor, Dept. of Pathology, Univ. of New Mexico Health Sciences Center
2002 - 2007 Associate Professor, Dept. of Pathology, Univ. of New Mexico Health Sciences Center
2005 - 2007 co-Director, Hematologic Malignancies Program, UNM Cancer Center
July 2007- Professor, Dept. of Pathology, Univ. of New Mexico Health Sciences Center
2008-present Director, Hematologic Malignancies Program, UNM Cancer Center
Other Experience and Professional Memberships: Member: ASCB, AAAS, ASIP, Biophysical Society,
AAAI, Collegium Internationale Allergologicum (elected); ASH, Society for Mathematical Biology; Member, NIH
SBIR/STTR Study Section 2, 1996-1997, NIH SIG Study Section, 2001; American Cancer Society Leukemia,
Immunology & Blood Study Section, 2001; NIAID Special Emphasis Panel for Asthma & Allergic Diseases
Reseach Center, 2003; NIH NIDCR ad hoc reviewer, Oral Infection & Immunity Branch, 2003 & 2007; NIH ALY
Study Section, ad hoc reviewer, June 2003; Member, NIH CMI-A Study Section, 2005-2008; NCI Eureka
Panel, 2009; NCRR site visit, Imaging Ctrs, 2009; NCI-F Reviews 2009, 2011; MIST, 2011; Asthma & Allergic
Diseases Cooperative Research Ctrs, 2012
;
New Innovators Panel, Jan 2013 Associate Editor, J. of
Immunology, 2006-2009; ad hoc reviewer for Blood, J. Biological Chemistry, J. Cell Physiology, J. Histochem
Cytochem, Biophysical J., J. Cell Biology, Biochemical J., J. Cell Science, BMC Systems Biology
PHS 398/2590 (Rev. 05/01) Page
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4/11/2020 Principal Investigator/Program Director (Last, middle, first): ____________________
Honors: Josiah Macy, Jr., Foundation Graduate Fellowship, 1986-1989; Postdoctoral Research Fellowship,
University of California Cancer Research Coordinating Committee, 1990-1991; American Cancer Society
Postdoctoral Research Fellowship (California Division) 1991-1993; ACS-IRG development award, 1994; UNM
School of Medicine/ HHMI career development award, 1996-1998; named Surface Endowed Professor, 2012;
Elected AAAS Fellow, 2012.
C. Selected Publications (from >90)
1. D. J. Frankel, J. Pfeiffer, J. M. Oliver, BS Wilson and A. R. Burns. (2006) Revealing the topography of cellular membrane domains by combined atomic force microscopy/fluorescence imaging.
Biophysical J.
90: 2404-2413 ( Cover ).
2. BF Lillemeier, JR. Pfeiffer, Z Surviladze, BS Wilson and MM Davis. (2006) Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton . Proc. Natl. Acad. Sci. USA 103: 18992-
18997. (Faculty of 1000 noted paper)
3. S Yang, MA Raymond-Stintz, W Ying, J Zhang, DS Lidke, SL Steinberg, L Williams, JM Oliver , BS Wilson .
(2007) Mapping ErbB receptors on breast cancer cell membranes during signal transduction. J. Cell
Science 120:2763-2773.
4. Hsieh, W Shu, S Yang, M Raymond-Stintz, D Vlahos, S Steinberg, BS Wilson* and J Edwards. (2008)
Stochastic simulations of ErbB homo and hetero-dimerization: potential impacts of receptor conformational state and spatial segregation. IET Systems Biology 2(5): 256-272. PMC2877007 * corresponding author
5. NL Andrews, K Lidke, AR Burns, JM Oliver, BS Wilson and D Lidke. (2008) Actin restricts Fc

RI diffusion and facilitates antigen-induced receptor immobilization. Nature Cell Biology 10:955-963. PMC2828771
6. NL Andrews, JR Pfeiffer, AM Martinez, DM Haaland, RW Davis, T Kawakami, JM Oliver, BS Wilson , D S
Lidke. (2009) Small, mobile Fc

RI aggregates are signaling competent. Immunity, 31: 469-479.
PMC2828771
7. M Hsieh, S Yang, M Raymond-Stinz, JS Edwards and BS Wilson. (2010) Spatio-temporal modeling of signaling protein recruitment to EGFR. BMC Systems Biology 4:57.
PMC2877007
8. A Carroll-Portillo, K Spendier, J Pfeiffer, G Griffiths, H Li, J M Oliver, D Lidke, K Lidke, J Thomas, BS
Wilson* and J Timlin. (2010) Fc

RI membrane dynamics upon binding mobile or immobile ligands on surfaces: formation of a mast cell synapse. J. Immunology 184:1328-1338 *corresponding author.
PMC3087819
9. X Meng, K Matlawska-Wasowska, F Girodon, T Mazel, C Willman, S Atlas, I-M Chen, RC Harvey, SP
Hunger, SS Winter and BS Wilson. (2011) GSII inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia. Leukemia, 25: 1135-1146. PMC3170956
10. F Girodon, M Steinkamp, C Cleyrat, S Hermouet, BS Wilson . (2011) Confocal imaging studies cast doubt on nuclear localization of JAK2 V617F. Blood, 118:2633-2634. PMID:21885612
11. ST Low-Nam, KA Lidke, PJ Cutler, RC Roovers, P van Bergen en Henegouwen, BS Wilson and DS Lidke.
(2011) ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand. Nature
Structural and Molecular Biology, 18:1244-1249. PMC3210321.
12. Pullen NA, BO Barstein, YT Flanga, Z Want, R Suzuki, TDL Tamang, MC Khurant, EA Harry, P Draber, KD
Bunging, K Mizuno, BS Wilson and JJ Ryan. (2012) A novel mechanism for Fc

RI-mediated Stat5 tyrosine phosphorylation and the selective influence of Stat5B over mast cell cytokine production. J. of Biological
Chemistry, 287:2045-2054. PMC3265884.
13. T-L Stephen, BS Wilson and TM Laufer. (2012) Subcellular distribution of Lck during CD4 T cell maturation in the thymic medulla regulates the T cell activation threshold. Proceedings of the National
Academy of Sciences USA, 109:7415-7420.
PMC3358885.
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4/11/2020 Principal Investigator/Program Director (Last, middle, first): ____________________
14. K. Radhakrishnan, A Halász, MM McCabe, JS Edwards and BS Wilson (2012) Mathematical simulation of membrane protein clustering for efficient signal transduction. Annals of Biomed Eng. 40(11)2307-18 PMC pending.
15. K Matlawska-Wasowska, E Ward, S Stevens, Y Wang, R Herbst, SS Winter and BS Wilson . (2013)
Macrophage and NK-mediated killing of precursor-B acute lymphoblastic leukemia cells targeted with afucosylated anti-CD19 humanized antibodies. Leukemia. In press.
16. M Steinkamp, Kimberly Kanigal, S Davies, C Muller, M Moses, Y Jiang and BS Wilson . (2013) Ovarian tumor attachment, invasion and vascularization reflect unique microenvironments in the peritoneum:
Insights from xenograft and mathematical models. Frontiers in Molecular and Cellular Oncology. In press
D. Research Support
Ongoing Research Support
1. NIH R01 AI051575 ( PI: Wilson ) 02/01/2003-01/31/2014 $250,000 annual direct costs.
“Domains for FcεRI Signaling and Internalization.” This project focuses on composition of membrane microdomains associated with immunoreceptor signaling. 20% effort
2. NIH R01 CA119232 ( PI: Wilson ) 7/1/05-6/31/13 $192,000 annual direct costs.
“MSM Mapping and Modeling ErbB Receptor Membrane Topography.” This project is aligned with the
IMAG/MSM program; it involves quantitative measurements and mathematical modeling of membrane signaling proteins, then extends to tumor modeling based upon data from xenografts. 20% effort
3. NIH P50 GM065794 ( Wilson, PI ) 8/1/09-7/31/14 $2,258,134 annual direct costs
“Center for the Spatiotemporal Modeling of Cell Signaling Networks (STMC)” This grant supports a crosscampus, inter-institutional National Systems Biology Center, with participants from UNM, Los Alamos and
Sandia National Laboratories. 30% effort
4. NIH P30 CA118100 (Willman; Wilson , Director of Hematologic Malignancies Program) 10/1/10-9/30/15
$927,507 annual direct costs. UNM Cancer Center Support Grant 10% effort
5. NIH R01AI097154 (Werner, PI with $75,000/yr subaward to Wilson ) 8/1/12-7/31/16
“Three-Dimensional Molecular Tracking of IgE-Fc 
RI in Live Cells.
” 2% effort
6. MedImmune, LCC. Sponsored Research Agreement (PI: Wilson ) ($50,000 total) 2012-2013
“Mechanistic profiling of anti-CD22 immunotoxin for treatment of pre-B ALL” 2% effort
7. NIH R01GM100114 (Lidke, PI; Wilson , co-investigator ) 05/01/201202/28/2017 “Single molecule imaging to quantify Fc
 RI signaling dynamics” 5% effort
Completed Research Support (partial list)
1. Wilson, PI. MedImmune, Sponsored Research Agreement 8/2010-7/2011
“Preclinical studies of anti-CD19 therapeutic antibodies in a pre-B ALL model system”
2. Wilson, Project PI. Specialized Center of Research in Acute Leukemia (PI: Willman) 10/1/05-9/31/10
3. Wilson, PI.
NIH 1S10RR22493-01 High Resolution Digital Camera for TEM 3/1/2006
4. Wilson, Project Co-PI & Lab Core Director.
P50 HL56384 (PI: Lipscomb) 10/1/1996-10/30/2006
NIH NHLBI Asthma SCOR
5. Wilson, PI . American Cancer Society 7/1/99-6/31/02
“Distinct Mechanisms of Activation for PLC 
1 and PLC
 2 in Mast Cells.”
6. Wilson, PI. NIH R29-GM50562 5/1/95-4/30/2000
“Molecular Mechanisms of Mast Cell Secretion”
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4/11/2020 Principal Investigator/Program Director (Last, middle, first): ____________________
7. Wilson, PI.
UNM-SOM, HHMI Career Development Award 7/1/96-6/30/98
“Regulation of PLC  Isoforms in Mast Cells”
8. Wilson, PI.
UNM Cancer Center, ASC-IRG, Career Development Award. 1994
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