Title: Analysis of isopropyl p-toluenesulfonate in cosmetic products using a
high-performance liquid-chromatography diode-array detector method.
Name: Bonnie Tay-Jones Yen Ping
Malaysian Palm Oil Board, Bangi, Selangor , Malaysia
A high-performance liquid-chromatographic (HPLC) method using a diode array detector
(DAD) for the determination of low levels of IPTS in cosmetic products has been developed. The
optimal conditions for IPTS analysis using this method were found to be as follows: monitoring
wavelength of 230 nm; an isocratic mode with a mobile phase of acetonitrile: tetrabutylammonium
phosphate monobasic buffer (5 mM); a flow rate of 0.8 ml/min and the use of a reverse phase C8
column. Recoveries of IPTS from cosmetic matrices such as lotions, cleansing milks and creams
ranged from 94.0 – 101.1 % with relative standard deviation (RSD) of less than 5 %. A six-point
calibration curve (determined over the range 0.5 μg/ml to 50 μg/ml of IPTS) of good linearity with
a correlation coefficient of 0.999 was obtained. The limit of detection of the method was found to
be 0.5 μg/ml and the limit of quantification was 1.6 μg/ml. The identity of the IPTS recovered
from the cosmetic samples was confirmed using a Gas Chromatography-mass spectrometer
detector (GC-MSD). This method is thus applicable for analyses of trace levels of IPTS in cosmetic
products and has the advantage of using only simple sample preparation steps.
Biography
Bonnie Yen Ping Tay-Jones received her Master of Science degree (organic chemistry) from
University Putra Malaysia., Serdang, Malaysia. She is currently a principal research scientist
attached to Quality and Environment Assessment Unit, Advanced Oleochemical Technology
Division , Malaysian Palm Oil Board. Presently, she is actively involved in research (method
development work to detect toxic contaminants/by-products) for the local oleochemical producers.
She was the main author of several publications in reputed journals on topics relating to gel
permeation chromatography analyses for palm-based polyols, chemometrics, basic oleochemical
compositional analyses and method development for detection of contaminants/by-products in
palm-oil derived oleochemicals.