BEST PRACTICES FOR ENSURING
QUALITY CARE OF RESEARCH ANIMALS
& MAINTAINING COMPLIANCE
Perform only those procedures described in
the protocol


There can be NO deviation from a
protocol without prior approval from the
IACUC
Ensure that everyone on the protocol has
read it & is familiar with all its procedures
Document any observations, analgesics, or
therapeutic administrations in Medical
Record and/or Monitoring Form

Remember- if it’s not written down, it
didn’t happen!
Communicate with veterinary staff regarding
the health status of post-procedural animals

If an animal develops any complications
during or after procedures, you must
communicate with the veterinary staff and
document this in the medical record or
Monitoring Form
Observe post-procedural animals according
to the schedule outlined in the approved
protocol



Follow the protocol exactly as written.
Any reduction in the schedule must be
approved by the IACUC.
Pay close attention to any weight loss and
if an animal’s weight loss approaches the
maximum allowed in your protocol, notify
the veterinary staff.
Record observations on daily log (all
species)
Label syringes and containers


Always label secondary containers with
the name of the substance stored and the
expiration date (if mixed compound, the
expiration date to use is the earliest). If
there is no expiration date, then record
date made. Initials of person making
solution/compound should be on label.
Label syringes with contents to be used on
live animals. Dispose of properly after use.
Allow only people listed on the protocol to
perform procedures on animals


Assure that all staff are added to the
protocols and have been thoroughly
trained to perform all procedures they are
listed to do.
Document the training in their training
log.
Follow aseptic technique for all survival
surgeries- including those with rodents



Follow IACUC policies for rodent & large
animal surgeries.
Use sterile instruments & supplies and
good aseptic technique.
All staff performing surgeries should be
competent in anesthesia & surgical
procedures prior to beginning
experiments. (Training available by
Training Coordinator)
Ensure all administered substances can be
used




Any use of non-pharmaceutical grade
compounds must follow IACUC SOP.
Expired anesthetics & analgesics must
never be used.
Label any item that is not for animal use
“not for use in live animals”
Label any item that has expired and will be
used in terminal procedures “for terminal
procedures only”
Store controlled substances in secured
locations


Always lock up controlled substances
Record all usage on appropriate log sheet.
Expiration Dates

Make it a habit to check the expiration
dates on all substances and supplies on a
regular basis.