The long list of the key products/services, technologies and topics of research and developments in “Biotechnology” for the period until 2030 year Product/Service 1. High-production animals are resistant to diseases and unfavourable factors of environmental. 2. High-production plants are resistant to abiotic and biotic factors. Technologies Agrobiotechnologies 1. Technologies of genetic and cell engineering to improve an animal productivity, the resistance to diseases and unfavourable factors of environmental. 2. Technologies of genomic breeding of animals. 1. Technologies of genetic and cell engineering to improve the properties of commercially valuable plants. 2. Technologies of genomic breeding of plants and structural and functional genome editing. 3. New strains producing the biological products. 4. Modern vaccines for the prevention of animal diseases. 1. Technologies of a design of producer strains to create the biological products to control diseases and agricultural pests. 1. Technologies for the screening, selection and modification of strains of microorganisms and viruses. 2. Technologies for producing the recombinant vaccines and tools for managing to the animal immunity. 3. Technologies for producing the subunit, epitope, peptide, antiidiotypic, aptomernyh vaccines, vaccines based on nanoparticles, DNA/RNA vaccines and other vaccines produced by using the bioengineering. Topics of research and development 1. Development of methods for editing the genomes of commercially valuable animals to give them a sign of increased productivity, resistance to diseases and unfavourable factors of environmental. 1. Development of methods for genomic breeding of animals. 1. The development of methods for editing the genomes of commercially valuable species to increase productivity, resistance to diseases and unfavourable factors of environmental. 2. Development and improvement of methods of cell breeding of plants. 1. Genotyping of cultivated plant species to identify the useful traits using next generation technologies and bioinformatics. 2. Development and improvement of methods of induced mutagenesis of plants based on a combination of methods genomic technology and bioinformatics. 1. Creation of strains of microorganisms to control agricultural pests. 1. Genome sequencing of microorganisms and viruses for the development of vaccines against the animal diseases. 2. Screening and selection of strains of microorganisms and viruses for use in live vaccines. 3. Preparation of recombinant microorganisms and viruses for vaccine development. 1. Creating the genetically modified microorganisms for use in designing of the vaccines. 2. Creating the new adjuvants, based on the immunostimulants of vegetablebased and lipids for inclusion in vaccines. 1. Creating the nanoparticles, VLPs, peptides, synthetic antigens for use in designing of the vaccines. 2. Development of technologies isolating DNA/RNA for use in designing of the vaccines. 3. Preparation of monoclonal antibodies, aptomers, ligands and conjugates for their usage in designing of the vaccines. 5. Modern test-systems for the diagnosis of animal diseases and plant diseases. 1. Biomedical cell preparations. 1. Technologies for producing the molecular and genetic, cellular and protein diagnostic systems. Biomedicine 1. Technologies for producing the biomedical cell preparations on the basis of stem cells for regenerative medicine and pharmacology. 1. Development of technologies for the producing of reagents for immunodiagnostic test-systems. 2. Development of systems for molecular and genetic diagnosis. 3. Development of systems for diagnostics using the cellular technology. 4. Development of systems for diagnostics using the immunological and immunochemical methods. 1. Development of methods for induced pluripotent stem cells. 2. Development of methods for obtaining differentiated cells specific for a given cell therapy and drug testing. 3. Development of methods for cell preparations for the treatment of diseases of vital organs and systems of the human body. 4. Development of methods for the preparation of cell preparations for the treatment of cancer. 5. Development of a technological platform for producing the blood components (red cells, platelets) from induced pluripotent stem cells. 2. Artificial organs and tissues that are based on cell and tissue engineering. 1. Technologies of the cell and tissue engineering for regenerative medicine and transplantation. 1. Development of technologies for creating the bioengineered organs and tissues for transplantation. 2. Creation of the bioreactors to grow the autologous tissues and organs. 3. Development of technologies for the creation of vascularized tissueengineered constructs for regenerative medicine. 4. Development of technologies for the creation of artificial tissue based on the 3-D bioprinting. 5. Development of technologies for creation of biocompatible dressing and wound-healing nanocomposite materials. 1. Technologies for producing of drugs based on recombinant DNA. 3. The biopharmaceuticals of new generation. 1. Creation of technological platforms for preparation and testing of new pharmaceutical products based on the genetic engineering and cell bioengineering. 2. Development of technologies for the producing of the recombinant proteins with therapeutic properties in prokaryotic and eukaryotic cells. 3. Development of technologies for the producing of recombinant proteins with therapeutic properties in the body of transgenic animals and plants. 4. Creation of the recombinant microorganisms and viruses for therapeutic purposes. 5. Development of the recombinant DNA techniques for gene therapy. 2. Technologies for producing of the anticancer drugs. 1. Development of technologies for the creation of targeted anticancer drugs based on the products of genetic engineering and cell bioengineering. 2. Development of technologies for producing humanized monoclonal antibodies with anti-tumor specificity. 3. Technologies for producing of the medicinal drugs based on the natural compounds of vegetable-based and microbial-based. 4. Modern vaccines for the prevention and treatment of human diseases. 1. Technologies of screening, selection and modification of strains of microorganisms and viruses. 2. Technologies for producing of the recombinant and natural subunit vaccines and tools to control the immune response. 3. Technologies for producing of subunit, epitope, peptide, antiidiotypic, aptomernyh vaccines, vaccines based on the nanoparticle, DNA/RNA vaccines and other vaccines produced by using the bioengineering. 5. Modern test-systems for rapid diagnosis of human diseases. 6. Means and methods of the personalized medicine. 1. Technologies for producing the molecular and genetic, cellular and protein diagnostic systems. 1. Technologies for producing the genetic passports. 1. Technologies of creation of the antiviral drugs based on biologically active vegetable-based compounds. 2. Technologies for immunostimulatory agents to increase the effectiveness of the vaccines. 3. Biotechnologies of the creation of new antibiotics against drug-resistant strains of microorganisms. 1. Genome sequencing of microorganisms and viruses to generate the vaccines for the prevention and treatment of human diseases. 2. Screening and selection of strains of microorganisms and viruses for use in live vaccines. 3. Preparation of recombinant microorganisms and viruses for vaccine development. 1. Creating the genetically modified microorganisms for use in constructing therapeutic and prophylactic vaccines. 2. Development of delivery systems for microbial and viral antigens and control by the immune response after vaccination. 1. Creating the genetically modified microorganisms for use in constructing therapeutic and prophylactic vaccines. 2. Development of delivery systems for microbial and viral antigens and control the immune response after vaccination. 3. Preparation of the monoclonal antibodies, aptomers, ligands and conjugates for use in designing of the vaccines. 1. Development of technologies for the production of reagents for immunodiagnostic test-systems. 2. Development of systems for molecular and genetic diagnosis. 3. Development of systems for diagnostics with using the cellular technologies. 4. Development of systems for diagnostics with using the immunological and immunochemical methods. 1. Assessment of the role of genetic and environmental factors in the formation of multifactorial diseases. 2. Development of high-performance and high-density technologies of sequencing and genome typing. 3. Development of technologies for cytogenetic testing based on high-density typing. 1. Microbial and enzymatic preparations. Industrial biotechnology 1. Technologies for obtaining of producer strains of biologics. 1. Isolation, screening and high-density typing of microorganisms for the selection of strains producing biologics. 2. Development of technologies for the construction of strains/varieties producing biologics. 3. Development of technologies for the production of biological products in genetically modified organisms. 4. Development of technologies for the production of biological products in cultures in vitro or in isolated conditions. 5. Development of technologies for the production of biological products based on producers of enzymes for the food industry. 6. Development of technologies for the production of biological products based on producers of biologically active substances for the oil and chemical industry, agriculture and environmental protection. 2. Technologies for obtaining of producer strains of enzymes. 3. Technologies of biocatalysis. 2. New functional foods with high nutritional value and probiotic activity. 1. Technologies for producing the probiotics and starter cultures. 2. Technologies for producing of functionally active dietary food supplements. 1. Isolation and screening of promising strains producing enzymes. 2. Development of technologies for production of new recombinant enzymes with desired properties. 3. Development of biotechnologies of producing the enzyme preparations for the processing industry, agriculture and environmental protection. 1. High-density typing of microorganisms for the selection of microbial strains for biocatalysis. 2. Development of technologies of the biocatalysis aimed to the pharmaceutical, food processing industry and agriculture. 1. Creation and selection of new probiotic s eukaryotic and prokaryotic microorganisms. 2. Development of new microbial consortia to create starter cultures for the food processing industry and agriculture, taking into account ethnic, cultural and regional characteristics. 1. Development of production’s biotechnologies of biologically active substances (nutraceuticals and parapharmaceutics) for the prevention of disease. 2. Isolation of biologically active substances from native and introduced species of plants based on the use of biotechnology techniques. 3. Food and feed supplements 1. Technologies for obtaining the strains producing the protein, amino acids and feed additives 2. Biotechnologies of selection of food and feed protein 3. Biotechnologies of releasing of amino acids 4. Bio- and fitoremidiation 1. Technologies for producing the strains of microorganisms for bioremidiatation of the environment and restoration of soil fertility 2. Biotechnological methods of remediation and fitoremidiation for purification of the environment, restoration of soil fertility 3. Biotechnologies for preservation and reproduction of grass and forest genetic resources 1. Isolation and screening of promising strains producing the protein, amino acids and food/feed additives 1. Isolation and screening of promising strains producing protein, amino acids and food feed additives 1. Development of technology of microbiological synthesis, extraction separation of food and feed protein from industrial environments, followed by purification of the final product 1. Development of microbiological synthesis technology, extraction separation of amino acids from industrial environments and purification followed by crystallization 1. Preparation of promising strains of microorganisms for soil bioremidiation and restore its fertility 2. Isolation of promising strains of microorganisms, yeasts and fungi for industrial wastewater treatment and disposal of waste 1. Development of technology for bioremediation of groundwater, surface natural waters and bottom sediments from oil and oil products. 2. Development of technology for bioremediation of surface water, domestic water and sewage companies of surfactants 3. Development of biotechnologies to improve the soil fertility on the principles of biological biodynamic farming 4. Modification of the genome to obtain the transgenic plants having enhanced stability, the ability to accumulate and pollutant degradation. 5. Development of biotechnology cleaning technogenic pollution of soils and wastewater through the use of fitoremidiation methods 6. Development of biological products and technologies for bioremediation of soils, grounds and sludge from the oil and oil products 7. Development of technologies for bioremediation of soils and groundsl from ions of heavy metals and radionuclides 8. Development of technologies for bioremediation of soils from persistent organic pollutants (dioxins, pesticides, biphenyls) 9. Development of methods for the bioconversion of waste in agriculture and organic wastes of food industry 10. Development of technologies for biological waste and complex processing of domestic and industrial wastes 11. Development of technology for comprehensive and targeted biologics to improve soil fertility 1. Development and improvement of clonal micropropagation methods of commercially valuable species of herbaceous and forest plants to create the reserves 5. New biomaterials 1. Technologies for producing of the biodegradable materials 6. Biofuel 1. Technologies for energy production from renewable sources by bioengineering methods 7. The strains of microorganisms to improve the efficiency of the extraction of commercial minerals 1. Technologies bioleaching of metals from refractory and poor ores 2. Biotechnologies of enhanced the oil production 1. Development of technologies for creating biodegradable implants of polymerbased organic acids 2. Development of technologies for creating packaging biodegradable materials and coatings based on synthetic and natural polymers 1. Development of technologies for the use of methanogenic bacteria and their associations in the production of biogas for different regions of the Kazakhstan. 2. Development of biotechnologies for producing hydrogen 3. Improving the processing technologies of cellulose waste into biofuel 4. Development of technologies for the production of biogas by processing nonfood biomass using enzymes 1. Isolation of promising strains of microorganisms and the creation of consortia for bioleaching precious metals. 2. Creation of a consortium of microorganisms for the removal of arsenic and cyanide from mining waste. 3. Development of industrial technology of bioleaching of precious metals. 1. Development of technologies for stimulation of native microflora reservoir for enhanced oil recovery. 2. Development of technologies for enhanced oil recovery using oil-oxidizing microorganisms. 3. Development of biotechnologies to combat asphalt-resinous and paraffin deposits in the wells and pipelines 4. Development of biotechnologies to reduce the oil viscosity