“..reishi was listed as the most respected herb out of
120 superior herbs….Superior herbs were classified as
the highest category of medicines since they were
considered to prolong life, prevent aging, boost energy
(qi), and make the body light and limber.” 106
www.UltimateElixir.com
(Panacea) Treatment/Therapies for several
diseases – 52, 53, 55, 60, 63, 73, 75, 93, 98, 102, 117,
125, 127, 128
orders@UltimateElixir.com
“The list of effects is huge ranging from anti-cancer to
relieving blockages of the bladder.” 93
Studies & Articles -Ganoderma Reishi:
“Ganoderma lucidum (Reishi), a medical mushroom,
has been used as a home remedy for numerous types
of chronic diseases.” 127
Immune-Enhancing/Stimulating – 1, 3, 5, 6, 8, 17,
18, 19, 41, 43, 44, 49, 53, 54, 55, 57, 59, 60, 61, 62,
63, 64, 65, 68, 72, 75, 76, 79, 80, 81, 82, 84, 86, 89,
92, 94, 95, 97, 102, 104, 106, 107, 114, 117, 118, 120,
125, 131
“It is generally accepted that the antitumor activity of
Ganoderma polysaccharides is due to their positive
effect on the consumer’s immune system, rather than
direct cytotoxicity against cancer cells (Lin and
Zhang, 2004).” 63
“There is no doubt that mushroom-based products can
serve as superior dietary supplements, particularly, the
Ganoderma products, which have been used as a
dietary supplement or medicine food in China for
more than 2000 years.” 64
“Of great interest has been the recent reports from the
United States indicating a possible central role for
inflammation in the development of such diverse
diseases as Alzheimer’s Disease and Cardiovascular
disease. This research has the possibility of linking
some of the historical uses of Ganoderma in promoting
longevity with contemporary Western scientific
theory. The provocative connections are: (1)
Ganoderma was used to prevent memory loss in old
age (2) Ganoderma is anti-inflammatory, (3)
inflammation is involved in the development of
Alzheimer’s disease (4) Alzheimer’s disease appears
to be ameliorated by chronic anti-inflammatory use.”
77
“Furthermore, this application is in accord with the
practice of herbal medicine, in which the use of the
whole product could reduce the toxicity of its purified
components, and the interaction between different
biologically active components can increase the
therapeutic activity of the whole product.” 127
“..thus it is considered as a very safe mushroom.” 130
“It [Ganoderma lucidum] has been known to have
numerous pharmacological effects including immunemodulating, anti-inflammatory, anti-cancer, antidiabetic, anti-oxidative and radical-scavenging and
anti-aging effects” 131
Cardiovascular Disorders/Heart Disease – 1, 3, 10,
49, 53, 57, 59, 63, 64, 68, 70, 77, 90, 97, 106
“The results also were suggestive of an improved
biomarker profile in terms of CHD [Coronary Heart
Disease] risk after 10 d of Lingzhi supplementation.”
Heart Contraction Frequency & Amplitude Preventing Thrombosis & Heart Attack by
suppress platelet aggregation – 1, 3, 53, 57, 63, 68,
70, 94, 103, 104, 114, 126, 130
Arrhythmia – 53, 68
Anti-Angiogenic (Engiogenic) (formation of new
blood vessels) – 1, 94
Alleviate Hypertension / High Blood Pressure – 1,
3, 4, 52, 53, 55, 56, 57, 63, 68, 94, 97, 104, 120, 127,
130
Chronic Fatigue Syndrome – 1, 63, 104
“…G. lucidum was shown to be highly effective in a
very large number of treated cases. In the more
successful cases, blood pressure was back to normal
within 2 mo, and in some cases, within 2 weeks.” 57
Hypoxia / Oxygen Shortage to the Brain causing
Migraines (Improves) – 1, 3
Cholesterol/Hypercholesterolemia – 1, 3, 5, 49, 50,
53, 57, 63, 68, 94, 97, 104, 126
Hyper/Hypo -Lipidemia – 1, 52, 53, 56, 57, 61, 64,
70, 71, 90, 104, 114, 120
Headache/Migraine – 57, 68
Toothache – 68
Cataracts –68
Dizziness – 53, 57, 63
Anaphylaxis Inhibitor - 3
Amino Acids – Contains 8 Essential Amino Acids -
Blocked Coronary Arteries by Atheromas, Spasms,
Clots, Palpitation, dyspnea, precordial pain, edema
– 3, 53, 70
Atherosclerosis – 52, 61, 63, 68, 103, 120
Blood Vessel
Circulation – 1
Dilator
/
Accelerates
Blood
Insomnia – 3, 52, 53, 67, 61, 63, 68, 120, 130
Leukopenia/Lack of White Blood Cells – 3, 53, 63,
120
Anemia –
Asthma – 3, 52, 53, 56, 57, 63, 68, 120
Epilepsy - 3
Allergic Asthma (Children) - 55
Stroke – 68
Bronchitis (& Chronic) – 3, 52, 53, 57, 63, 68, 106,
120, 130
Allergies – 53, 68, 106
Several Allergic Disease & Type I, II, III and IV
allergic Sensitivity reactions – 53
Tuberculosis – 68
Psoriasis - 57
Endocrine System (Menopause, Menstruation,
Cramps) – 3, 68
Food Sensitivities - 53
Histamine (Anti-Histamine) release – 1, 5, 57, 63,
68, 94, 106, 130
Skin Allergies & Diseases of the Skin (Dermatitis)
– 3, 55, 57, 68
“The currently used topical and systemic antiinflammatory drugs have serious drawbacks; for
example corticosteroids can suppress pituitary-adrenal
function, dangerously unbalance fluids/electrolytes
and cause undesirable changes in skin texture, whilst
the salicylic acid-derived prostaglandin inhibitors can
result in severe gastric irritation. Consequently, the
potential use of Ganoderma lucidum (reishi)
supplementation could offer a safe and effective
alternative for the reduction of histamine-mediated
immune responses.” 106
Anti-Inflammatory (and/or Pain from) – 1, 5, 52,
53, 55, 59, 61, 63, 68, 73, 77, 104, 106, 115, 123, 131
Neurasthenia – 3, 53, 63, 68, 120, 130
Rheumatism – 3, 57, 68
Gout - 3
Arthritis – 52, 53, 56, 57, 68, 120, 130, 131
Osteo-arthritis - 3
Dengue Fever – 3
Diabetes (& Anti-) – 3, 4, 52, 53, 56, 57, 61, 63, 68,
69, 97, 104, 116, 120, 130, 131
Diabetes Type II - 71
Diabetic Wound Healing Type I – 1, 4, 21
Diabetic –Renal Complications - 22
Diuretic, Laxative, Sedative, & Tonic - 53
Constipation – 3, 68
Diarrhea – 68
Gall Stones - 68
Hemorrhoids – “Reducing & Also Curing” –3, 63, 68
Lupus Erythematosis – 3, 68
Ulcers (and Anti) - 3, 52, 53, 57, 61, 68, 120, 130
Duodenal Ulcers – 53
Canker Sores - 68
Anti-Stress /Calming/Anxiety – 1, 53, 68, 69
Parkinson’s Disease – 5
“In conclusion, our results support that GL
[Ganoderma Lucidum] may be a promising agent for
the treatment of PD [Parkinson’s Disease] through
anti-inflammation.” 5
“Thus, Ganoderma lucidum exerts its effect on cancer
cells by multiple mechanisms and may have potential
therapeutic use for the prevention and treatment of
cancer.” 46
“Our results found that patients with G. lucidum
extract in their anticancer regimen were 1.27 times
more likely to respond to chemotherapy or
radiotherapy than those without.” 54
“…lowers the risk of cancer and heart disease and
boosts the immune system.” 59
“Ganoderma lucidum has now become recognized as
an alternative adjuvant in the treatment of leukemia,
carcinoma, hepatitis, and diabetes.” 61
“Inhibition of cancer cell proliferation” 63
“Because of its non-toxic and selective anti-cancer
activity, medicinal mushroom extracts have received
attention for their use in cancer therapy.” 105
“Thus, triterpenes in G. lucidum directly suppress
growth and invasive behavior of cancer cells, whereas
G. lucidum polysaccharides stimulate immune system
resulting in the production of cytokines and activation
of anti-cancer activities of immune cells.” 117
Anti-Cancer – 1, 7, 33, 34, 35, 38, 39, 45, 49, 51, 54,
59, 61, 62, 65, 73, 76, 79, 90, 117, 118, 121, 125, 126,
127, 130, 131
“Since Ganoderma lucidum is currently available in
the form of dietary supplements, the clarification of its
potential ant-cancer activity would scientifically
justify its use by cancer patients.” 127
“….has been utilized for centuries in East Asia to
prevent or treat various diseases and to reduce the
likelihood of cancer invasion and metastasis.” 7
“In addition, the observed anti-cancer activities of
Ganoderma have prompted its usage by cancer
patients alongside chemotherapy.” 131
“Our finding suggest that the triterpenes contained in
G. lucidum are potential anticancer agents.” 33
“Taken together [two studies], these results
demonstrate that GA-T [ganoderic acid T] effectively
inhibits cancer cell invasion in vitro and metastasis in
vivo, and thus may act as a potential drug for treating
cancer.” 38
CANCER (Anti-Tumor)–used as a treatment (with
and/or without Chemo/Rad) – 1, 3, 5, 7, 8, 9, 12, 13,
15, 17, 18, 19, 23, 28, 29, 30, 31, 32, 34, 36, 37, 38,
40, 41, 43, 45, 46, 47, 48, 51, 52, 53, 54, 55, 56, 57,
60, 62, 63, 64, 65, 68, 69, 72, 75, 76, 78, 79, 80, 82,
84, 85, 86, 87, 89, 92, 93, 94, 95, 96, 98, 99, 101, 104,
105, 106, 112, 117, 119, 120, 122, 123, 124, 127, 128,
131
“G. lucidum may be an effective nutraceutical used in
the prevention of cancer metastasis.” 45
Advanced-Stage and/or Invasive Cancer – 17, 29,
36, 63, 89, 104
Inducing Apoptosis (Cell Death) of Cancer Cells –
8, 9, 13, 28, 30, 34, 39, 40, 46, 51, 63, 91, 95, 99, 117,
122, 123, 131
and has possible therapeutic potential as a dietary
supplement for an alternative therapy for breast and
prostate cancer.” 48
Used in Japan as adjunct herb for Cancer
“..alcohol extract of Ganoderma lucidum inhibited the
proliferation of MCF-7 [breast cancer cells] in a doseand time-dependent manner. After 48 hr of treatment,
at 500ug/ml, this alcohol extract caused nearly a 70%
inhibition of cell growth compared to the control.” 84
Used in Moscow for treating Cancer patients – 53
Organ Damage due to Chemotherapy Medication
(Cisplatin, Doxorubicin) – 51, 52, 64, 98, 102, 104,
106
Pain Relief (Antinociceptive/Analgesic) & Reduced
Morphine (terminal cancer patients) – 1, 64, 76
Used during Remission to prevent relapses
Reduce Side Effects of Cancer Treatment – 41, 54,
61, 64, 76, 102, 104
Improved Survival and/or Quality of Life (Cancer)
– 16, 54, 57, 64, 76, 85
Leukemia – 4, 13, 40, 57, 61, 63, 73, 82, 86, 99, 117,
124, 127, 131
Acute Myeloid Leukemia (AML) - 53
Lymphoma – 13, 117, 124
Myeloma (Multiple) – 13, 117, 124, 131
Sarcoma 180 Tumors (Inhibiting) – 53, 57, 63, 76,
78 101, 131
Sarcoma – 63, 80, 127
Breast Cancer (and Invasive) – 29, 36, 46, 47, 48,
52, 63, 84, 98, 105, 112, 117, 127, 128
“These findings provide evidence for a novel role of
GA-Me [ganoderic acid Me] in the prevention and
treatment of breast cancer by its ability to modulate the
NF-kB signaling pathway.” 36
“Our results suggest that Ganoderma lucidum inhibits
the growth of MDA-MD-231 breast cancer cells by
modulating Akt/NF-kappaB signaling and could have
potential therapeutic use for the treatment of breast
cancer.” 47
Thus, Ganoderma lucidum clearly demonstrates
anticancer activity in experiments with cancer cells
“…suggesting that Reishi is a potential natural
therapeutic for breast and other cancers.” 105
“Here we show that Ganoderma lucidum inhibits cell
migration, cell adhesion, and cell invasion, as well as
colony formation of human breast cancer cells.” 127
“In summary, Ganoderma lucidum demonstrated a
strong inhibitory effect against the invasive behavior
of highly metastatic breast cancer cells in vitro.” 127
Head Cancer – (associated) – 34, 76
Brain Cancer (Astrocytoma) – 34, 76
Neck Cancer - (associated) - 76
Prostate Cancer – 9, 31, 46, 48, 57, 63, 101, 117, 122,
127, 128, 131
Thus, Ganoderma lucidum clearly demonstrates
anticancer activity in experiments with cancer cells
and has possible therapeutic potential as a dietary
supplement for an alternative therapy for breast and
prostate cancer.” 48
“We have previously demonstrated that G. lucidum
induces apoptosis, inhibits cell proliferation, and
suppresses cell migration of highly invasive human
prostate cancer cells PC-3.” 122
Nasopharyngeal Carcinoma – 4, 53
Carcinoma (Generalized) – 57, 61, 87, 119, 123,
127, 131
Ovarian Cancer – 51
“Taken together [both studies], these findings suggest
that Ganoderma lucidum exerts multiple anti-tumor
effects on ovarian cancer cells and can enhance the
sensitivity of EOC cells to cisplatin.” 51
Cervical Cancer – 30, 39, 63, 84
Bladder Cancer – 1, 41, 63, 131
Colon Cancer – 32, 37, 38, 98, 117, 123
“Ganoderma Lucidum extract inhibits proliferation of
human colorectal cancer cells and possesses
antioxidant properties.” 32
“These studies show that G. lucidum aids in the
reduction of toxicities resulting from various popular
modes of cancer treatment and could therefore play a
major role in combination therapy for cancer
treatments.” 131
Improves Appetite Complementary & Alternative Medicine – 16, 54
Liver Cancer – 15, 33, 52, 53, 57, 63, 104, 117, 130,
131
Red Blood Cells – 19
Anti-Lewis-Lung Carcinoma – 1, 38, 63, 131
White Blood Cells (Lymphocytes, Neutrophil) – 53,
55, 57, 62, 65, 72, 76, 79, 91, 106, 107, 130, 131
Lung Cancer – 35, 38, 63, 76, 78, 85, 87, 112, 118,
127, 131
Bone Marrow Cells – 19, 53, 76, 79
Melanoma Cancer & Immune (and/or Skin
Cancer) – 23, 65, 72, 95, 104
Natural T Killer Cells – 19, 53, 54, 55, 57, 62, 63, 76,
80, 83, 84, 96, 106, 131
AutoImmune Disorders – 55
Fibrosarcoma - 34
Spleen/Liver Cancer – 15, 57
Gastric Cancer – 28
Chemotherapy – 1, 19, 43, 51, 52, 57, 64, 76, 101,
102, 131
Radiation – 1, 19, 43, 53, 57, 64, 76, 99, 101, 131
Radiation Protection (protecting normal cells from
Radiation damage) – 1, 25, 53, 57, 63, 68, 75, 131
“However, G. lucidum has been proven to exhibit
radio-protective effects in normal cells and enhance
the recovery of cellular immune-competence from
gamma-irradiation.” 131
Methotrexate Protection (Brand name: Trexall)
synthetic chemical (causes small intestinal damage)
used to treat Leukemia, bone cancer, blood cancers,
lung cancer, breast cancer, head and neck cancer,
arthritis, and psoriasis. – 24
“Since G. lucidum has been proven to possess in-vitro
and anti-oxidant properties, a study was conducted to
examine the prevention of nephrotoxicity induced by
the anti-cancer drug cisplatin. … Renal anti-oxidant
defense system levels following treatment with
cisplatin were restored to normal and the therapeutic
effects of cisplatin were retained.” 131
Circulatory System – 1, 3, 68, 114
Metabolism – provides more oxygen – 1, 3
Dysmenorrhea – “Reducing or Eliminating” Physiological Disorder Prevention HIV / AIDS (& Anti-) – 1, 53, 57, 61, 63, 64, 69, 104,
130, 131
“At the end of 1999, the number of children orphaned
by AIDS in Sub-Saharan Africa, stood at 12.1 million,
compared to 1.1 million children orphaned by AIDS in
the rest of the world…..with a well-established fact
that Ganoderma and other medicinal mushrooms can
be farmed on available natural substrates and are
known to be very effective in promoting the body’s
immune systems, including them as a dietary
supplement to HIV-positive individuals and AIDS
victims is a reasonable approach.” 64
Epstein Barr Virus (EBV) – 1, 53, 57
Crohn’s Disease - 131
Mono (Mononucleosis) - 53
Baldness/Hair Loss – 63, 68, 76, 130
Acne – 63, 68
Intestinal Disorders (Wound Healing, Injury &
Repair) – 20, 98
“These results suggest the potential usefulness of GIPS [Polysaccharides from Ganoderma Lucidum] to
cure intestinal disorders characterized by injury and
ineffective repair of the intestinal mucosa.” 20
Enlarged Prostrate / Lower Urinary Tract
(LUTS)–BPH (benign prostatic hyperplasia) – 14,
88, 93, 100, 104, 129
“..with 2.1 points decreasing at the end of treatment..”
88
Sexual Vigor – 53, 68
Flu (Influenza) – 1, 27, 49, 68
Ganoderma lucidum has the highest Selenium element
when studied among other mushrooms for its AntiInfluenza role. - 49
Colds/Cough – 1, 53, 68
Expectorant – 53
Rhinitis – 53
Altitude/Elevation Stress Symptoms – 53, 57, 68
Oxygenating Blood - 53
Anorexia (Symptoms assoc. with) – 53, 120
Hypo/Hyper -Glycemic Actions – 1, 3, 49, 53, 55,
56, 57, 61, 64, 67, 68, 71
Liver Disorders – 53, 56, 58, 68, 120, 130
Liver Fibrosis – 26
Liver Function Stimulant – 3, 4, 50, 53, 109
Liver Failure - 53
Hepatitis Protectant – 1, 3, 5, 52, 53, 55, 56, 57, 58,
61, 94, 106, 113, 130
Hepatitis A, B, C –– 1, 3, 4, 52, 53, 57, 58, 61, 63, 68,
69, 120, 130
Kidney (Renal) Problems – 3, 53, 104, 113, 115, 120
Pancreas – 66, 68, 116
Wound Healing (General) - 68
Obesity – 68
General Health & Wellness (Nutraceutical)– 1, 3, 5,
53, 55, 57, 102, 131
Herpes Virus - 63
Natural Defense System – 1, 64
Infections (General) – 53, 68, 76
Life Threatening Diseases (Chronic & Acute) – 1
Anti-Bacterial – 1, 2, 42, 52, 53, 57, 61, 106, 129
Greatly increased the life-span – 1, 59
E-coli Infection –Escherichia coli – 2
Youthful Vigor, Vitality, Longevity – 18, 49, 53, 55,
57, 59, 69, 77, 82, 90, 96, 115, 122, 127, 131
Enterococcus faecalis - 129
“It is widely consumed throughout the world as a
health food, being commonly and regularly used by
many Asian individuals for the promotion of health
and longevity, and as a remedy for illness” 59
Improving Memory – 5, 77
Increasing Thinking Faculty – 77
Preventing Forgetfulness - 77
Endurance Enhancing – 53, 57, 64, 104
Salmonella typhi – 2, 129
Listeria monocytogenes – 129
Bacillus subtilis – 129
Klebsiella pneumonia - 129
Pseudomonas aeruginosa – 2, 129
Staphylococcus aureus (MRSA-superbug)– 2, 42
Streptococcus mutans – 2, 129
Proteus vulgaris – 129
H. Pylori Bacteria (Helicobacter) – 57
“The extracts of many mushrooms inhibited the
growth of this bacterium.” 57
“The methanolic extract of Ganoderma lucidum
showed effective antibacterial activity even at very
low concentrations…” 42
Anti-biotic- “Ganoderma samples were highly active
against the gram positive as well as negative bacteria
and hence are a broad spectrum antibiotic, while these
also showed strong activities against candida
albicans.” 2, 42
Anti-Viral – 53, 57, 61, 63, 104, 106, 130
Encephalitis - 1
Anti-Fungal - 2
Penicillium sp. - 2
Aspergillus Fumigatous - 2
Aspergillus niger - 2
Aspergillus flavus - 2
Mucor indicus - 2
Anti-Microbial – 2, 57, 63, 129
Anti-Parasitic - 106
Anti-Oxidant “Natural” (free radical scavenging)–
5, 32, 49, 52, 53, 56, 57, 58, 59, 61, 62, 63, 64, 66, 68,
73, 74, 75, 90, 94, 97, 104, 106, 109, 110, 111, 113,
115, 116, 127, 129, 131
“….that showed that antioxidant power in plasma
increased after Lingzhi ingestion…..within 3 h of a
single dose of Lingzhi..” 59
“However, numerous studies have shown that regular
consumption of certain mushroom species as either a
regular food or as extracted compounds
(nutriceuticals) is effective in both preventing and
treating
specific
diseases,
mainly through
immunopotentiation
and
antioxidant
activity….Another important factor is the certainty
that mushroom extracts, compared with other drugs,
show a very low toxicity when regularly consumed,
even at high dosages." 64
Anti-Aging – 5, 53, 57, 61, 63, 106, 131
Energy – 53, 68, 77, 106
Maldeveloped brain – 53
Retinal Pigmentary degeneration – 53
Progressive Muscular Dystrophy – 53, 68
Atrophic Nyotonus – 53
Osteogenic Hyperplasia – 53
Muscular Atrophy - 53
Mental Disease (caused by Environmental Stress,
stabilizes) – 53, 68, 69, 77
Nervous Disability - 53
Alzheimer’s Disease /Dementia – 53, 77
Myotonia Dystrophica (alleviate symptoms) – 53
Antidote for Poisonous Mushrooms - 53
“The polysaccharides extracted from g. lucidum have
shown higher anticomplementary activity than Krestin
(PSK), an immunostimulant.” 131
Taking a low quality Ganoderma product wastes your
money and your time. Poor cultivation may play a
contamination problem. Worse, you may lose
confidence in it and never experience its true valuable
qualities.
“Unfortunately, less reputable manufacturing
companies have exploited the fact that quality control
regulations are virtually nonexistent in order to market
poorly defined products of questionable efficacy.
However it is generally recognized that the situation is
changing and that companies, in particular those
marketing their products in the major growth areas of
North America and Western Europe..” 64
Japan uses Ganoderma Lucidum as a treatment for
Cancer. With over 2000 years of use, it’s considered
one of the most revered and sought after supplement
for those who know about its benefits.
Of meaningful significance is the realization that many
bioactive nutriceutical components in G. lucidum are
biological response modifiers (BRM’s). These
physiologically active BRM’s (polysaccharides, LZ-8,
triterpenes/sterols and related compounds, and RNA)
activate the immune systems of the hosts against some
of the most devastating health problems, such as,
cancer, AIDS and CFS (chronic fatigue syndrome). 1
In the “Compendium of Material Medica” a book
which contains hundreds of natural Chinese medicines
that have been used over thousands of years, the
following statement attributed to Li Shi Zhen,
celebrated physician of the 16th century, can be found:
“It benefits the life energy, or ‘qi” of the heart,
repairing the chest area and benefiting those with a
knotted and tight chest. Taken over a long period of
time, agility of the body will not cease, and the years
are lengthened to those of the Immortal Fairies.”
“Ganoderma lucidum has been used for a broad
spectrum of health benefits from preventative
measures and maintenance of health to the regulation
or treatment of chronic as well as acute life threatening
illness (Chang 1995)…..The use of Ganoderma in
Russian cosmonaut training is a dramatic example of
its use to improve working capacity, particularly under
stress, and for rapid restoration to normal physiology.
The fungus is best known for its immune-stimulatory
effects in managing certain types of cancer in
combination with conventional therapy and for its
anti-HIV effect. ” 1
“Is there anything that nature has made for us to keep
us healthy & hygienic? Answer comes yes. So today I
am going to unveil a very good mystery which all of
us are not aware of. So this is nothing but a fungus or
being more particular a mushroom named Lingzhi.”
68
“It is a highly potent medicine, which is free from side
effects. Ancient emperors used to take it for
longevity.” 68
The majority of Reishi products that claim to be using
"wild" Reishi generally use black Reishi. While it
still possesses some value as a moderate herbal tonic,
black Reishi is considered to be inferior to red Reishi
because of its lower polysaccharide content.
“King of Adaptogens’ which means that it is nontoxic, non-specific & has a normalizing effect on the
body.” 68
Suggestive Dosing:
.5 mL -1mL daily for health maintenance and 5mL –
10mL for serious illness such as cancer or AIDS.
1.5mL – 9mL for general use and 3mL – 15mL
depending on the severity of illness. -3
10mL 3x/day. 53
Reishi was ranked in highest in this superior category
of the Herbal Pharmacopoeia.
“Precautions should be taken to stop temporarily the
usage during surgery or with severe cuts to avoid
excessive bleeding since G. lucidum is a blood vessel
dilator and accelerates blood circulation (Andreacchi
1995).” 1
“The macrofungus is very rare in nature…” 61
“..but numerous trials (both laboratory and human)
have shown, again and again, that they [Ganoderma
products] are effective in complementing conventional
medicines in fighting diseases.” 64
DISCLAIMER: Despite all the possible health
benefits that can be obtained from Ganoderma Extract,
it is not intended to replace the recommendations of
health practitioner. Patients with specific problems
should always consult their physician. These studies
have been conducted in various ways, always refer to
the complete study for the entire research.
REFERENCE:
___________________________________________
1.
2.
3.
4.
5.
6.
Alice W. Chen & Philip G. Miles.
Biomedical Research and the Application of
Mushroom Nutriceuticals from Ganoderma
Lucidum. Mushroom Biology & Mushroom
Products, Royse (ed.) 1996 Penn State Univ.,
Rochester Area Mycological Association,
Penfield, NY, USA and the Department of
Biological Sciences, State University of New
York at Buffalo, Buffalo, NY.
Evaluation of Antibacterial & Antifungal
Activities of Ganoderma Lucidum (Curtis) P.
Karst Fruit Bodies Extracts - World Journal
of Science and Technology 2011, 1(6): 08-11
ISSN:2231-2587
Teow Sun Soo. Effective Dosage of Extract
of Ganoderma lucidum in the Treatment of
Various Ailments. Mushroom Biology &
Mushroom Products. Royse (ed.) 1996 Penn
State Univ.; Department of Microbiology &
Biochemistry, School of Applied Sciences,
MARA Institute of Technology, 40450 Sha
Alam, Selangor, Malaysia
Teow Sun Soo. Cultivation, Utilization, and
Medicinal Effects of Ganoderma Lucidum in
Malaysia. Department of Microbiology &
Biochemistry, School of Applied Sciences
MARA
Institute
of
Technology
http://www.canited.com/reishi97d-9.htm
Ruiping Zhang, Shengli Xu, Yanning Cai,
Ming Zhou, Xiaohong Zuo, and Piu Chan.
Ganoderma lucidum Protects Dopaminergic
Neuron Degeneration through Inhibition of
Microglial
Activation.
Evid
Based
Complement Alternat Med. 2011; 2011:
156810 June 18. Doi: 10.1093/ecam/nep075
www.ncbi.nlm.nih.gov/pmc/articles/PMC31
36196/
Lin ZB. Cellular and molecular mechanisms
of immune-modulation by Ganoderma
lucidum. J Pharmacol Sci. 2005 Oct, 99(2):
144-53 Department of Pharmacology, School
of Basic Medical Sciences, Peking
University
Health
Science
Center.
www.ncbi.nlm.nih.gov/pubmed/16230843
7. Weng CJ, Yen GC. The in vitro and in vivo
experimental evidences disclose the
chemopreventative effects of Ganoderma
lucidum on cancer invasion and metastasis.
Clin Exp Metastasis. 2010 May;27(5);361-9.
Dol:10.1007/s10585-010-9334-z. Epub 2010
May
12.
www.ncbi.nlm.nih.gov/pubmed/20461449
8. Radwan FF, Perez JM, Haque A. Apoptotic
and Immune Restoration Effects of
Ganoderic Acids Define a New Prospective
for Complementary Treatment of Cancer. J
Clin Cell Immunol. 2011 Dec 11;S3:4.
Department
of
Microbiology
and
Immunology, Hollings Cancer Center, and
Children’s Research Institute, Medical
University of South Carolina, Charleston,
SC.
www.ncbi.nlm.nih.gov/pubmed/23336088
9. Jiang J, Sivova V, Valachovicova T, Harvey
K, Sliva D. Ganoderma lucidum inhibits
proliferation and induces apoptosis in human
prostate cancer cells PC-3. Int J. Oncol. 2004
May;24(5);1093-9.
Cancer
Research
Laboratory, Methodist Research Institue,
E504, Indianapolis, IN 46202, USA.
www.ncbi.nlm.nih.gov/pubmed/15067330
10. Lasukova TV, Arbuzov AG, Maslov LN,
Burkova VN. Ganoderma lucidum extract in
cardiac diastolic dysfunction and irreversible
cardiomyocytic damage in ischemia and
reperfusion of the isolated heart. Patol Fiziol
Eksp
Ter.
2008
Jan-Mar;(1):22-5.
www.ncbi.nlm.nih.gov/pubmed/18411655
11. Sliva D. Ganoderma lucidum (Reishi) in
cancer treatment. Integr Cancer Ther. 2003
Dec;2(4);358-64.
Cancer Research Laboratory, Methodist
Research Institute, Indianapolis, IN USA
www.ncbi.nlm.nih.gov/pubmed/14713328
12. Charles B. Simone II, MD; Nicole L. Simone,
MD; Victoria Simone, RN; Charles B.
Simone, MD. Antioxidants and other
Nutrients
Do
Not
Interfere
with
Chemotherapy or Radiation Therapy and can
Increase Kill and Increase Survival, Part 2.
13.
14.
15.
16.
17.
18.
Alternative Therapies, Mar/Apr 2007, Vol
13, No. 2
Claudia I. Muller, Takashi Kumagai, James
O’Kelly, Navindra P. Serram, David Herber,
H. Phillip Koeffler. Ganoderma lucidum
causes apoptosis in leukemia, lymphoma and
multiple myeloma cells. Cedars-Sinai
Medical Center, David Geffen School of
Medicine at UCLA, Los Angeles, CA.
Division
of
Haematology/Oncology,
University Hospital, Freiburg, Germany.
Center for Human Nutrition, David Geffen
School of Medicine at UCLA, Los Angeles,
CA.
Rumi Fujita, Jie Liu, Kuniyoshi Shimizu,
Fumiko Konishi, Kiyoshi Noda, Shoichiro
Kumamoto, Chie Ueda, Hisatoshi Tajiri,
Shuhei Kaneko, Yoshitaro Suimi, Ryuichiro
Kondo.Anti-androgenic
activities
of
Ganoderma
lucidum.
Journal
of
Ethnopharmacology 102 (2005) 107-112.
www.sciencedirect.com
Kimura Y, Taniguchi M, Baba K.AntiTumor
and AntiMetastatic effects on liver of
triterpenoid fractions of Ganoderma
lucidum: mechanism of action and isolation
of an active substance. Anticancer Res. 2002
Nov-Dec;22(6a);3309-18.
Second
Department of Medical Biochemostry,
School of Medicine, Ehime University,
Shigenobu-cho, Onsen-gun, Ehime Japan.
www.ncbi.nl.nih.gov/pubmed/12530080
. Nahleh Z, Tabbara IA. Complementary and
alternative medicine in breast cancer patients.
Palliat Support Care. 2003 Sep;1(3):267-73
George Washington University Medical
Center,
Washington,
DC.
www.ncbi.nlm.nih.gov/pubmed/16594427
Gao Y, Zhou S, Jian W, Huan M, Dai X.
Effects of ganopoly (a Ganoderma lucidum
polysaccharide extract) on the immune
functions in advanced-stage cancer patients.
Immunol Invest. 2003 Aug;32(3):201-15.
Institute of Food, Nutrition and Human
Health, Massey University, New Zealand.
www.ncbi.nlm.nih.gov/pubmed/12916709
Lin ZB, Zhang HN.Anti-tumor and
immunoregulatory activities of Ganoderma
lucidum and its possible mechanisms. Acta
19.
20.
21.
22.
23.
Pharmacol Sinc. 2004 Nov;25(11):1387-95.
Department of Pharmacology, School of
Basic Medical Sciences, Peking University
Health Science Center, Beijing, China.
www.ncbi.nlm.nih.gov/pubmed/15525457
Zhu XL, Chen AF, Lin ZB. Ganoderma
lucidum polysaccharides enhance the
function of immunological effector cells in
immunosuppressed mice. J Ethnopharmacol.
2007 May4;111(2);219-26. Epub 2006 Nov
21. Department of Pharmacology, School of
Basic Medical Science, Peking University
Health Science Center, Beijing China.
www.ncbi.nlm.nih.gov/pubmed/17182202
Sun LX, Chen LH, Lin ZB, Qin Y, Zhang JQ,
Yang J, Ma J, Ye T, Li WD. Effects of
Ganoderma lucidum polysaccharides on
IEC-6 cell proliferation, migration and
morphology of differentiation benefiting
intestinal epithelium healing in vitro. J Pharm
Pharmacol. 2011 Dec;63(12):1595-603. doi:
10.111/j.204258.2011.01367.x Epub 2011
Oct
13.
www.ncbi.nlm.nih.gov/pubmed/22060291
Tie, L, Yang HQ, An Y, Liu SQ, Han J, Xu
Y, Hu M, Li WD, Chen AF, Lin ZB, Li XJ.
Ganoderma
lucidum
polysaccharide
accelerates refractory wound healing by
inhibition of mitochondrial oxidative stress in
type 1 diabetes. Cell Physiol Biochem.
2012;29(3-4):583-94.
Doi:
10.1159/000338512. Epub 2012 Apr 3.
www.ncbi.nlm.nih.gov/pubmed/22508065
He CY, Li WD, Guo SX, Lin SQ, Lin
ZB.Effect
of
polysaccharides
from
Ganoderma lucidum on streptozotocininduced diabetic nephropathy in mice. J
Asian Nat Prod Res. 2006 Dec;8(8):705-11.
Department of Pharmacology School of
Basic Medical Sciences, Peking University
Health Science Centre, Beijing, China.
www.ncbi.nlm.nih.gov/pubmed/17145658
Sun LX, Lin ZB, Duan XS, Lu J, Ge ZH, Li
XJ, Li M, Xing EH, Jia J, Lan TF, Li WD.
Ganoderma
lucidum
polysaccharides
antagonize the suppression on lymphocytes
induced by culture supernatants of B16F10
melanoma cells. J Pharm Pharmacol. 2011
May;63(5):725-35. doi: 10.111/j.20427158.2011.01266.x.
Department
of
Pharmacology, Peking University Health
Science Center, School of Basic Medical
Sciences,
Beijing,
China.
www.ncbi.nlm.nih.gov/pubmed/21492175
24. Chen LH, Lin ZB, Li WD. Ganoderma
lucidum
polysaccharides
reduce
methotrexate-induced
small
intestinal
damage in mice via induction of epithelial
cell proliferation and migration.
Acta
Pharmacol Sin. 2011 Dec;32(12):1505-12.
Doi: 10.1038/aps.2011.126. Epub 2011 Oct
24. Department of Pharmacology, School of
Basic Medical Sciences, Peking University
Health Science Center, Beijing, China.
www.ncbi.nlm.nih.gov/pubmed/22019957
25. Smina TP, De S, Devasagayam TP, Adhikari
S, Janardhanan KK. Ganoderma lucidum
total triterpenes prevent radiation-induced
DNA damage and apoptosis in splenic
lymphocytes in vitro. Mutat Res. 2011 Dec
24;726(2):188-94.
doi:
10.1016/j.mrgentox.2011.09.005. Epub 2011
Sept 16. Amala Cancer Research Centre,
Amala Nagar, Thrissur, Kerala, India.
www.ncbi.nlm.nih.gov/pubmed/21944902
26. Kwon Sc, Kim YB. Antifibrotic activity a
fermentation filtrate of Ganoderma lucidum.
Lab Anim Res. 2011 Dec;27(4):369-71.
Doi:10.5625/lar.2011.27.4.369.Epub 2011
Dec 19. Food Safety Support Organization,
Korea Food Industry Association, Seoul,
Korea.
www.ncbi.nlm.nih.gov/pubmed/22232650
27. Wang L, Hou Y. Determination of tract
elements in anti-influenza virus mushrooms.
Dio Trace Elem Res. 2011 Dec 143(3):1799807. Doi:10.1007/s12011-011-8986-0. Epub
2011 Feb 8. Department of Pharmacy, The
2nd Affiliated Hospital of Shangdong
University of Traditional Chinese Medicine,
Jinan Peoples Republic of China.
www.ncbi.nlm.nih.gov/pubmed/21301988
28. Jang KJ, Han MH, Lee BH, Kim BW, Kim
CH, Yoon HM, Choi YH. Induction of
apoptosis by ethanol extracts of Ganoderma
lucidum in human gastric carcinoma cells. J
Acupunct Meridian Stud. 2010 Mar;3(1):2431. Doi: 10.1016/S2005-2901(10)60004-0.
Department of Acupunture and Moxibustion,
College of Oriental Medicine, Dongeui
University,
Busan,
Korea.
www.ncbi.nlm.nih.gov/pubmed/20633512
29. Jiang J, Grieb B, Thyagarajan A, Sliva
D.Ganoderic acids suppress growth and
invasive behavior of breast cancer cells by
modulating AP-1 and NF-kappaB signaling.
Int J Mol Med. 2008 May;21(5):57-84.
Cancer Research Laboratory, Methodist
Research Institute, Indianapolis, IN.
www.ncbi.nlm.nih.gov/pubmed/18425349
30. Yue QX, Song XY, Ma C, Feng LX, Guan
SH, Wu WY, Yang, M, Jiang BH, Liu X, Cui
YJ, Guo DA. Effects of Triterpenes from
Ganoderma lucidum on protein expression
profile of HeLa cells. Phytomedicine. 2010
Jul;17(8-9):606-13.
Doi:
10.1016/j.phymed.2009.12.013. Epub 2010
Jan25. Shanghai Research Center for
Modernization of Traditional Chinese
Medicine, Shanghai Institute of Materia
Medica, Chinese Academy of Sciences, PR
China.
www.ncbi.nlm.nih.gov/pubmed/20092987
31. Zaidman BZ, Wasser SP, Nevo E, Mahajna J.
Androgen receptor-dependent and –
independent
mechanisms
mediate
Ganoderma lucidum activities in LNCaP
prostate cancer cells. Int J. Oncol. 2007
Oct;31(4):959-67.
Migal,
Galilee
Technology Center, Cancer Drug Discovery
Program,
Kiryat
Shmona,
Israel.
www.ncbi.nlm.nih.gov/pubmed/17786330
32. Xie JT, Wang CZ, Wicks S, Yin JJ, Kong J,
Li J, Li YC, Yuan CS. Ganoderma lucidum
extract inhibits proliferation of SW 480
human colorectal cancer cells. Exp. Oncol.
2006 Mar;28(1):25-9. Tang Center for
Herbal Medicine Research, the Pritzker
School of Medicine, University of Chicago,
USA.
www.ncbi.nlm.nih.gov/pubmed/16614703
33. Lin SB, Li CH, Lee SS, Kan LS. Triterpeneenriched extracts from Ganoderma lucidum
inhibit growth of hepatoma cells via
suppressing protein kinase C, activating
mitogen-activated protein kinases and G2phase cell cycle arrest. Life Sci
2003;72:2381-90.
www.ncbi.nlm.nih.gov/pubmed/12639703
34. Harhaji Trajkovic LM, Mijatovic SA,
Maksimovic-Ivanic DD, Stojanovic ID,
Momcilovic MB, Tufegdzic SJ, Maksimovic
VM, Marjanovic ZS, Stosic-Grujicic SD.
Anticancer properties of Ganoderma lucidum
methanol extracts in vitro and in vivo. Nutr
Cancer.
2009,
61(5)696-707.
Doi10.1080/0163558002898743. Institute of
Biological Research Sinisa Stankovic,
Belgrade University, Belgrade, Serbia.
www.ncbi.nlm.nih.gov/pubmed/19838944
35. Yuen JW, Gohel MD. Anticancer effects of
Ganoderma lucidum: a review of scientific
evidence. Nutr Cancer. 2005,53(1). 11-7.
Department of Health Technology and
Informatics, The Hong Kong Polytechnic
36.
37.
38.
39.
40.
41.
University,
Kowloon,
SAR,
China.
www.ncbi.nlm.nih.gov/pubmed/16351502
Li F, Wang Y, Wang X, Li J, Cui H, Niu M.
Ganoderic acids suppress growth and
angiogenesis by modulating the NF-kB
signaling pathway in breast cancer cells. Int J
Clin Pharmacol Ther. 2012 Oct:50(10):71221. doi:10.5414/CP201663 Department of
Center of Breast Disease, Affiliated Hospital
of Medical College, QingDoa University,
QingDao,
China.
www.ncbi.nlm.nih.gov/pubmed/22762853
Hsu SC, Ou CC, Li JW, Chuang TX, Kuo HP,
Liu JY, Chen CS Lin SC, Su CH, Kao MC.
Ganoderma tsugae extracts inhibit colorectal
cancer cell growth via G(2)/M cell cycle
arrest. J Ethnopharmacol. 2008 Dec
8;120(3);394-401.
doi:
10.1016/j.jep.2008.09.025. Epub 2008 Oct 2.
Graduate Institute of Medical Sciences,
Taipei Medical University, Taipei, Taiwan;
Kang-Ning Junior College of Medical Care
and
Management,
Taipei,
Taiwan.
www.ncbi.nlm.nih.gov/pubmed/18951965
Chen NH, Liu JW, Zhong JJ. Ganoderic acid
T inhibits tumor invasion in vitro and in vivo
through inhibition of MMP expression.
Pharmacol Rep. 2010 Jan-Feb;62(1):150-63.
Key Laboratory of Microbial Metabolism,
Ministry of Education, School of Life
Sciences and Biotechnology, Shanghai Jiao
Ton
University,
Shanghai,
China.
www.ncbi.nlm.nih.gov/pubmed/20360625
Liu RM, Li YB, Zhong JJ. Cytotoxic and proapoptotic effects of novel ganoderic acid
derivatives on human cervical cancer cells in
vitro. Eur J. Pharmacol. 2012 Apr 15(66)(13).23-33. doi: 10.1016/j.ejphal.2012.02.007.
Epub 2012 Feb 17. State Key Laboratory of
Bioreactor
Engineering,
School
of
Biotechnology, East China University of
Science and Technology, Shanghai, China.
www.ncbi.nlm.nih.gov/pubmed/22366428
Wang SY, Hsu ML, Hsu HC, Tzeng CH, Lee
SS, Shiao MS, Ho CK. The anti-tumor effect
of Ganoderma lucidum is mediated by
cytokines
released
from
activated
macrophages and T lymphocytes. Int J
Cancer. 1997 Mar 17;70(6):699-705.
Department of Medical Research, Veterans
General Hospital-Taipei, Taiwan, Republic
of
China.
www.ncbi.nlm.nih.gov/pubmed/9096652
Yuen JW, Gohel MD, Ng CF. Synergistic
Cytotoxic Effects of Ganoderma lucidum and
Bacillus Calmette Guerin on Premalignant
42.
43.
44.
45.
46.
Urothelial HUC-PC Cells and Its Regulation
on Proinflammatory Cytokine Secretion.
Evid Based Complement Alternate Med.
2012;2012:147896.
Doi:
10.1155/2012/147896. Epub 2012 Aug 28.
School of Nursing, The Hong Kong
Polytechnic University, Hung Hom, Hong
Kong.
www.ncbi.nlm.nih.gov/pubmed/22969822
Prasad Y. Wesely. Antibacterial activity of
The bio-Multidrug (Ganoderma lucidum) on
Multidrug resistant Staphlococcus aureus
(MRSA). Advanced BioTech, volume:6
Issue 09: March 10, 2008. Department of
Biotech,
MCAS,
Rasipuram,
India.
www.advancedbiotech.in/archieves_...
Yue GG, Chan B, Han XQ, Cheng L, Wong
EC, Leung PC, Fung KP, Ng MC, Fan K, Sze
DM, Lau CB. Immunomodulatory activities
of Ganoderma sinense polysaccharides in
human immune cells. Nutr Cancer.
2013;65(5):765-74.
doi:
10.1080/01635581.2013.788725. Institute of
Chinese Medicine, State Key Laboratory of
Phytochemistry and Plant Resources in West
China, The Chinese University of Hong
King, Shatin, New Territories, Hong Kong
SAR.
www.ncbi.nlm.nih.gov/pubmed/23859044
Lin ZB. Cellular and molecular mechanisms
of immune-modulation by Ganoderma
lucidum.
J
Pharmacol
Sci.
2005
Oct;99(2):144-53.
Department
of
Pharmacology, School of Basic Medical
Sciences, Peking University Health Science
Center.
www.ncbi.nlm.nih.gov/pubmed/16230843
Weng CJ, Yen GC. The in vitro and in vivo
experimental evidences disclose the
chemopreventive effects of Ganoderma
lucidum on cancer invasion and metastasis.
Clin Exp Metastasis. 2010 May;27(5):361-9.
Doi: 10.1007/s10585-010-9334-z. Epub
2010 May 12. Graduate Institute of Applied
Science of Living, Tainan University of
Technology, Yongkang, Tainan, Taiwan.
www.ncbi.nlm.nih.gov/pubmed/20461449
Jiang J, Slivova V, Valachovicova T, Harvey
K, Sliva D. Ganoderma lucidum inhibits
proliferation and induces apoptosis in human
prostate cancer cells PC-3. Int J. Oncol. 2004
May;24(5):1093-9.
Cancer
Research
Laboratory, Methodist Research Institute,
Indianapolis,
IN.
www.ncbi.nlm.nih.gov/pubmed/15067330
47. Jian J, Slivova V, Harvey K, Valachovicova
T, Sliva D. Ganoderma lucidum suppresses
growth of breast cancer cells through the
inhibition of Akt/NF-kappaB signaling. Nutr
Cancer. 2004;49(2):209-16. Cancer Research
Laboratory, Methodist Research Institute,
Indianapolis,
IN.
www.ncbi.nlm.nih.gov/pubmed/15489214
48. Sliva D. Ganoderma lucidum (Reishi) in
cancer treatment. Integr Cancer Ther. 2003
Dec;2(4):358-64
Cancer
Research
Laboratory, Methodist Research Institute,
Indianapolis,
IN.
www.ncbi.nlm.nih.gov/pubmed/14713328
49. Richard Walden and Brian Tomlinson.
Herbal Medicine: Biomolecular and Clincal
Aspects.
2nd
edition.
www.ncbi.nlm.nih.gov/books/nbk92767
50. Hajjaj H, Mace C, Roberts M, Niederberger
P, Fay LB. Effect of 26-oxygenosterols from
Ganoderma lucidum and their activity as
cholesterol synthesis inhibitors. Appl
Environ Microbiol. 2005 Jul;71(7):3653-8.
Nestle Research Centre, Nestec Ltd. Verschez-les-Blanc, Lausanne Switzerland.
www.ncbi.nlm.nih.gov/pubmed/16000773
51. Zhao S, Ye G, Fu G, Chen Jx, Yang BB, Peng
C. Ganoderma lucidum exerts anti-tumor
effects on ovarian cancer cells and enhances
their sensitivity to cisplatin. Int J. Oncol.
2011
May;38(5):1319-27.
Doi:
10.3892/ijo.2011.965. Epub 2011 Mar 8.
Department of Biology, York University,
Toronto,
Canada.
www.ncbi.nlm.nih.gov/pubmed/21399867
52. N Sheena, B Lakshmi and KK
Janardhana.Therapeutic
potential
of
Ganoderma lucidum (Fr.) P. Karst. Amala
Cancer Research Centre, Amala Nagar,
Thrissur, Kerala, Indian. November 2004:
Revised 20 April 2005.
53. Christopher
Hobbs,
L.
Medicinal
Mushrooms – An Exploration of Tradition,
Healing, & Culture. Ac. 96-107.
54. Xingzhong Jin, Julieta Ruiz Beguerie, Daniel
Man-yeun Sze, Godfrey CF Chan.
Ganoderma lucidum (Reishi mushroom) for
cancer treatment. Cochran Gynaecological
Cancer Group, 13 JUN 2012 DOI:
10.1002/14651858.CD007731.pub2.
55. Rong-Hwa Jan, Teng-Yi Lin, Ya-Chun Hsu,
Shuh-Shen Lee, Shih-Yen Lo, Mingi Chang,
Li-Kuang Chen, Yu-Li Lin. Immunomodulatory activity of Ganoderma lucidumderived
polysaccharide
on
human
monocytoid dendritic cells pulsed with Der p
56.
57.
58.
59.
60.
61.
62.
63.
1 allergen. BMC Immunol. 2011; 12: 31.
2011 May 25, doi: 10.1186/147-2172-12-31.
www.ncbi.nlm.nih.gov/pmc/articles/PMC31
27845/
Rosalia Rubel, Herta S. Dalla Santa, Luiz
Claudio Fernandes, Sandro J. R. Bonatto,
Sergio Bello, Bonald C. Figueiredo, Jose
Hermenio C. Lima Filho, Cid Aimbire M.
Santos,
Carlos
Ricardo
Soccol.
Hypolipidemic and antioxidant properties of
Ganoderma lucidum (Leyss:Fr) Karst used as
a dietary supplement. World J Microbiol
Biotechnol (2011) 27:1083-1089 DOI:
10.1007/s11274-010-0554-9
Solomon P. Wasser. Book: Encyclopedia of
Dietary Supplements, Second Edition,
Chapter
78,
June
2010.
www.informahealthcare.com/doi/abs/10.310
9/9781439819296.078
Yihuai Gao, Min Huang, Zhi-Bin Lin,
Shufeng Zhou. Hepatopretective Activity and
the Mechanisms of Action of Ganoderma
lucidum (Curt.:Fr.) P. Karst (Ling Zhi, Reishi
Mushroom)
(Aphyllophoromycetidease)
(Review). International Journal of Medicinal
Mushrooms
DOI:
10.1615/InterJMedicMushr.v5.i2.20
Sissi Wachtel-Galor, Brian Tomlinson, Iris
F.F. Benzie. Ganoderma lucidum (Lingzhi),
a Chinese medicinal mushroom: biomarkers
responses
in
a
controlled
human
supplementation study. British Journal of
Nutrition (2004), 91, 263-269.
Sliva, Daniel.Cellular and Physiological
Effects of Ganoderma lucidum (Reishi).
Volume 4, Number 8, October 2004, pp 873879(7),
Sanodiya, Bhagwan S.; Thakur, Gulab S.;
Baghel, Rakesh K.; Prsad, G. B. K. S.; Bisen,
P.S. Ganoderma lucidum: A potent
Pharmacological Macrofungus. Volum 10,
Number 8, December 2009, pp 717-742(26).
Yihuai
Gao,
Shufeng
Zhou.
Chemopreventive
and
Tumoricidal
Properties of Ling Zhi Mushroom
Ganoderma lucidum (W.Curt.:Fr.) Lloyd
(Aphyllophoromycetideae).
Part
II.
Mechanism
Considerations
(Review).
International
Journal
of
Medicinal
Mushrooms.
DOI:
10.1615/IntJMedMushr.v6.i3.20.
Angel Trigos, Jorge Saarez Medillin.
Biologically active metabolites of the genus
Ganoderma: Three decades of mycochemistry research. p.64-83
64. Shu-Ting Change, Philip G. Miles.
Mushroom Cultivation, Nutritional Value,
Medicinal Effect, and Environmental Impact.
Second Edition. p.40-47
65. Sun Lx, Lin ZB, Duan XS, Lu J, Ge ZH, Li
M, Xing EH, Lan TF, Jian MM, Yang N, Li
WD. Ganoderma lucidum polysaccharides
counteract inhibition on CD71 and FasL
expression by culture supernatant of B16F10
cells upon lymphocyte activation. Exp Ther
Med 2013 Apr;5(4):1117-1122 Epub 2013
Jan 29. The Affiliated Hospital of Chengde
Medical College, Chengde, Hebei 067000.
www.ncbi.nlm.nih.gov/pubmed/23596479
66. Zhang HN, He JH, Yuan L, Lin ZB. In vitro
and in vivo protective effects of Ganoderma
lucidum polysaccharides on alloxan-induced
pancreatic islets damage. Lif Sci. 2003 Sep
19;73(18).2307-19.
Department
of
Pharmacology, School of Basic Medical
Sciences, Peking University Health Science
Center, 38 Xueyuan Road, Beijing 100083,
PR
China.
www.nci.nlm.nih.gov/pubmed/12941433
67. Zhang HN, Lin ZB. Hypoglycemic effects of
Ganoderma lucidum polysaccharides. Acta
Pharmacol Sin 2004 Feb, 25(2). 191-5.
Department of Pharmacology, School of
Basic Medical Sciences, Peking University,
Beijing
100083,
China.
www.ncbi.nlm.nih.gov/pubmed/14769208
68. Chandrasekhar Gahan. LingZhi: Mushroom
Herb of Spiritual Potency and Medicinal
Wonder. Seminar on Perspectives in
Microbial Applications 29th March, 2003.
Abstracts and Seminar Articles, P.G.A.I.M.
Course, School of Life Science P.G.
Department of Botany, Utkal University,
Bhubaneswar – 751 004
69. Huie CW, Di X. Chromatographic and
electrophoretic methods for Lingzhi
pharmacologically active components. J
Chromatogr B Anatyt Technol Biomed Life
Sci.
2004
Dec
5;812(1-2):241-57.
Department of Chemistry Hong Kong Baptist
University, Kowloon Tong, Hong Kong,
China.
www.ncbi.nlm.nih.gov/pubmed/15556502
70. Gao, Y. Chen, G. Dai, X. YE, J., Zhou, S. A
phase I/II study of ling zhi mushroom
Ganoderma lucidum (W.Curt.:Fr.) Lloyd
(Aphyllophoromycetideae)
extract
in
patients with coronary heart disease.
International
Journal
of
Medicinal
Mushrooms, vol. 6, no. 4, pp 327-334. 2004.
71.
72.
73.
74.
75.
76.
http://researchbank.rmit.edu.au/view/rmit:19
066
Yihuai Gao, Jin Lan, Xihu Dai, Jingxian Ye,
Shufeng Zhou. A Phase I/II Study of Ling Zhi
Mushroom
Ganoderma
lucidum
(W.Curt.:Fr.)
Lloyd
(Aphyllophoromycetideae)
Extract
in
Patients with Type II Diabetes Mellitus.
International
Journal
of
Medicinal
Mushrooms.
DOI:
10.1615/IntJMedMushr.v6.i1.30
Sun LX, Lin ZB, Li XJ, Li M, Lu J. Duan XS,
Ge ZH, Song YX, Xing EH, Li WD.
Promoting effects of Ganoderma lucidum
polysaccharides on B16F10 cells to activate
lymphocytes. Basic Clin Pharmacol Toxicol.
2011
Mar;108(3):149-54.
Doi:
10.1111/j.1742-7843.2010.00632.x.
Epub
2010 Oct 22. Department of Pharmacology,
Peking University Health Science Center,
School of Basic Medical Sciences, Beijing,
China.
www.ncbi.nlm.nih.gov/pubmed/20964805
Lee JM, Kwon H, Jeong H, Lee JW, Lee SY,
Baek SJ, Surh YJ. Inhibition of lipid
peroxidation and oxidative DNA damage by
Ganoderma lucidum. Phytother Res. 2001
May;15(3):245-9. College of Pharmacy,
Seoul National University, Seoul 151-742,
South
Korea.
www.ncbi.nlm.nih.gov/pubmed/11351361
Lin JM, Lin CC, Chen MF, Ujiie T, Takada
A. Radical scavenger and antihepatotoxic
activity of Ganoderma formosanum,
Ganoderma lucidum and Ganoderma neojaponicum. J Ethnopharmacol. 1995 June
23;47(1):33-41 Graduate Institute of Natural
Products, Kaohsiung Medical College,
Taiwan,
R.O.C.
www.ncbi.nlm.nih.gov/pubmed/7564419
Kim KC, Kim IG. Ganoderma lucidum
extract protects DNA from stand breakage
caused by hydroxyl radical and UV
irradiation. Int J Mol Med. 1999
Sep;4(3):273-7 Department of Radiation
Biology, Environmental Radiation Research
Group, Lorea Atomic Energy Research
Institute, Yusong, Taejon 305-600, Korea.
www.ncbi.nlm.nih.gov/pubmed/10425278
Chang, Raymond Y. Role of Ganoderma
Supplementation in Cancer Management.
Meridian Medical Group at the Institute of
East-West Medicine and Department of
Medicine, Cornell Medical College.
www.canited.come/reishi97d-3.htm
77. Stavinoha, William B. Status of Ganoderma
Lucidum in United States: Ganoderma
Lucidum as an Anti-inflammatory Agent.
University of Texas Health Science Center
San
Antonio,
TX.
www.canited.com/reishi97d-5.htm
78. Cao QZ, Lin ZB. Antitumor and antiangiogenic activity of Ganoderma lucidum
polysaccharides peptide. Acta Pharmacol
Sin. 2004 Jun;25(6):833-8 Department of
Pharmacology, Health Sciences Center,
Peking University, Beijing 100083 China.
www.ncbi.nlm.nih.gov/pubmed/15169641
79. Pang X, Chen Z, Gao X, Liu W, Slavin M,
Yao W. Yu LL. Potential of a novel
polysaccharide preparation (GLPP) from
Anhui-grown Ganoderma lucidum in tumor
treatment and immunostimulation. J Food Sci
2007 Aug;72(6):S435-42. School of Life
Science
and
Technology,
China
Pharmaceuticals University, Nanjing, MD
210009,
PR
China.
www.ncbi.nlm.nih.gov/pubmed/17995702
80. Chien CM, Cheng JL Chang WT, Tien MH,
Tsao CM, Chang YU, Chang HY, Hsieh JF,
Wong CH, Chen ST. Polysaccharides of
Ganoderma
lucidum
alter
cell
immunophenotypic expression and enhance
CD56+ NK-cell cytotoxicity in cord blood.
Bioorg Med Chem. 2004 Nov 1;12(21):56039. Institute of Biological Chemistry and the
Genomic Research Center, Academia Sinica,
Nankang,
Taipei
115,
Taiwan.
www.ncbi.nlm.nih.gov/pubmed/15465338
81. Lin KI, Kao YY, Kuo HK, Yang WB, Chou
A, Lin HH, Yu AL, Wong CH. Reishi
polysaccharides induce immunoglobulin
production through the TLR4/TLR2mediated induction of transcription factor
Blimp-1. J Biol Chem. 2006 Aug
25;281(34):24111-23. Epub 2006 June 23.
Genomics Research Center, Academia
Sinica,
Taipei
115,
Taiwan.
www.ncbi.nlm.nih.gov/pubmed/16798741
82. Chen KC, Huan HC, Chen JH, Hsu JW, Chen
HC, Ou CH, Yan WB, Chen ST. Wong CH,
Juan
HF.
Ganoderma
lucidum
polysaccharides in human monocytic
leukemia cells: from gene expression to
network construction. BMC Genomics 2007
Nov 9;8:411. Department of Life Science,
National Taiwan University, Taipei 106,
Taiwan.
www.ncbi.nlm.nih.gov/pubmed/17996095
83. Chen WY, Yang WB, Wong CH, Shih DT.
Effects of Reishi polysaccharides on human
84.
85.
86.
87.
88.
89.
stem/progenitor cells. Bioorg Med Chem.
2010
Dec
15;18(24):8583-91.
Doi:10.1016/j.bmc.2010.10.016 Epub 2010
Nov 4. Genomics Research Center,
Academia Sinica, No. 128, Academia Road,
Sec 2, Nankang, Taipei 115, Taiwan.
www.ncbi.nlm.nih.gov/pubmed/21055951
Hu, Hongbo, et al. Ganoderma lucidum
extract induces cell cycle arrest and apoptosis
in MCF-7 Human Breast Cancer Cell. Int. J.
Cancer:102, 250-253 (2002)
Yuen JW, Gohel MD. Anticancer effects of
Ganoderma lucidum: a review of scientific
eveidence. Nutr Cancer. 2005;53(1):11-7
Department of Health Technology and
Informatics, The Hong Kong Polytechnic
University,
Kowloon,
SAR,
China.
www.ncbi.nlm.nih.gov/pubmed/16351502
Chan WK, Cheung CC, Law HK, Lau YL,
Chan
GC.
Ganoderma
lucidum
polysaccharides
can
induce
human
monocytic leukemia cells into dendritic cells
with immune-stimulatory function. J
Hematol
Oncol.
2008
Jul
21;1:9.doi:10.1186/1756-8722-1-9.
Department of Paediatrics & Adolescent
Medicine, Li Ka Shing Faculty of Medicine,
The University of Hong Kong, Hong Kong,
PR
China.
www.ncbi.nlm.nih.gov/pubmed/18644156
Chen NH, Liu JW, Zhong JJ. Ganoderic acid
ME inhibits tumor invasion through downregulaton matrix metalloproteinases 2/9 gene
expression. J Pharmacol Sci. 2008
Oct;108(2):212-6 State Key Laboratory of
Bioreactor
Engineering,
East
China
University of Science and Technolog, 130
Meilong
Road,
Shanghai,
China.
www.ncbi.nlm.nih.gov/pubmed/18946196
Noguchi M, Kakuma T, Tomiyasu K,
Yamada A, Itoh K, Konishi F, Kumamoto S,
Shimizu K, Kondo R, Matsuoka K.
Randomized clinical trial of an ethanol
extract of Ganoderma lucidum in men with
lower urinary tract symptoms. Asian J Androl
2008 Sep;10(5):777-85. Epub 2007 Dec 20.
Department of Urology, Kurume University
School of Medicine, 67, Ashahi-machi,
Kurume
830-0011,
Japan.
www.ncbi.nlm.nih.gov/pubmed/18097505
Gao Y, Zhou S, Jiang W, Huang M, Dai X.
Effects of ganopoly (a Ganoderma lucidum
polysaccharide extract) on the immune
functions in advanced-stage cancer patients.
Immunol Invest. 2003 Aug;32(3):201-15
Institute of Food, Nutrition and Human
90.
91.
92.
93.
94.
95.
Health, Massey University, New Zealand.
www.ncbi.nlm.nih.gov/pubmed/12916709
Wachtel-Galor S, Tomlinson B, Benzie IF.
Ganoderma lucidum (“Lingzhi”), a Chinese
medicine mushroom: biomarker responses in
a controlled human supplementation study.
Br J. Nutr. 2004 Feb;91(2):263-9. Ageing &
Health Group, School of Nursing, The Hong
Kong Polytechnic University, Kowloon,
Hong
Kong
SAR,
China.
www.ncbi.nlm.nih.gov/pubmed/14756912
Hsu MJ, Lee SS, Lin WW. Polysaccharide
purified from Ganoderma lucidum inhibits
spontaneous and Fas-mediated apoptosis in
human neutrophils through activation of the
phosphatidylinositol 3 kinase/Akt signaling
pathway. J Leukoc Biol 2002 Jul;72(1):20716 Department of Pharmacology, College of
Medicine, National Taiwan University, No. 1
Sec. 1, Jen-Ai Road, Taipei, Taiwan, ROC.
www.ncbi.nlm.nih.gov/pubmed/12101282
Chen HS, Tsai YF, Lin S, Lin CC, Khoo KH,
Lin CH, Wong CH. Studies on the immunemodulating and anti-tumor activities of
Ganoderma
lucidum
(Reishi)
polysaccharides. Biorg Med Chem. 2004
Nov 1;12(21):5595-601 The Genomic
Research Center, Academia Sinica, No. 128
Academia Road, Section 2, Nan-Kang,
Taipei,
Taiwan.
www.ncbi.nlm.nih.gov/pubmed/15465337
Paterson RR. Ganoderma – a therapeutic
fungal biofactory. Phytochemistry. 2006
Sep;67(18):1985-2001. Epub 2006 Aug 14.
Micoteca da Universidad do Minho, Centro
de Engenharia Biologica, Campus de
Gualtar,
Braga
Portugal.
www.ncbi.nlm.nih.gov/pubmed/16905165
Boh B, Berovic M, Zhang J, Zhi-Bin L.
Ganoderma
lucidum
and
its
pharmaceutically
active
compounds.
Biotechnol Annu Rev. 2007; 13:265-301.
Faculty of Natural Sciences and Engineering,
University of Ljubjana, Vegova 4, Ljubljana,
Slovenia.
www.ncbi.nlm.nih.gov/pubmed/17875480
Sun LX, Lin ZB, Duan XS, Lu J, Ge ZH, Li
XF, Li XJ, Li M, Xing EH, Song YX, Jia J,
Li WD. Enhanced MHC class I and
costimulatory molecles on B16F10 cells by
Ganoderma lucidum polysaccharides. J Drug
Target. 2012 Aug;20(7):582-92. Department
of Pharmacology, Peking University Health
Science Center, School of Basic Medical
Sciences,
Beijing,
China.
www.ncbi.nlm.nih.gov/pubmed/22697491
96. Chang CJ, Chen YY, Lu CC, Lin CS, Martel
J, Tsai SH, Ko YF, Huang TT, Ojcius DM,
Young JD, Lai HC Ganoderma lucidum
stimulates NK cell cytotoxicity by inducing
NKG2D/NCR activation and secretion of
perforin and granulysin. Innate Immun. 2013
Jun 26. Center for Molecular and Clinical
Immunology, Chang Gung University,
Taoyuan, Taiwan, Republic of China.
www.ncbi.nlm.nh.gov/pubmed/23803412
97. Chu TT, Benzie IF, La CW, Fok BS, Lee KK,
Tomlinson
B.
Study
of
potential
cardioprotective effects of Ganoderma
lucidum (Lingzhi): results of a controlled
human interventional trial. Br J Nutr. 2012
Apr;107(7):1017-27.
Department
of
Medicine and Therapeutics, Faculty of
Medicine, Prince of Wales Hospital, The
Chinese University of Hong Kong, Shatin,
Hong
Kong.
www.ncbi.nlm.nih.gov/pubmed/21801467
98. Sliva D, Loganthan J, Jiang J, Jedinak A,
Lamb JG, Terry C, Baldridge LA, Adamec J,
Sandusky GE, Dudhgaonkar S. Mushroom
Ganoderma lucidum prevents colitisassociated carcinogenesis in mice. PLoS One
2012;7(10):e47873.
Cancer
Research
Laboratory, Methodist Research Institute,
Indiana University Health, Indianapolis,
Indiana,
USA.
www.ncbi.nlm.nih.gov/pubmed/23118901
99. Kim KC, Jun HJ, Kim JS, Kim IG.
Enhancement of radiation response with
combined
Ganoderma
lucidum
and
Duchesnea chrysantha extracts in human
leukemia HL-60 cells. Int J Mol Med. 2008
Apr;21(4):489-98. Department of Radiation
Biology, Nuclear Environmental Safety
Research Center, Korea Atomic Energy
Research Institute, Daejeon 305-353, Korea.
www.ncbi.nlm.nih.gov/pubmed/18360695
100. Noguchi M, Kakua T, Tomivasu K, Kurita Y,
Kukihara H, Konishi F, Kumamoto S, Shimiz
K, Kondo R, Matsuoka K. Effects of an
extract of Ganoderma lucidum in men with
lower urinary tract symptoms: a doublebling, placebo-controlled randomized and
dose-ranging study. Asian J Androl. 2008
Jul;10(4):651-8. Department of Urology,
Kurume University School of Medicine,
Kurume,
Japan.
www.ncbi.nlm.nih.gov/pubmed/18097503
101. Li YB, Wang R, Wu HL, Li Yh, Zhong LJ,
Yu HM, Li XJ. Serum amyloid A mediates
the inhibitory effect of Ganoderma lucidum
polysaccharides on tumor cell adhesion to
endothelial cells. Oncol Rep. 2008
Sep;20(3):549-56.
Department
of
Pharmacology, School of Basic Medical
Sciences and State Key Laboratory
Biomimetic
Drugs,
Beijing,
China.
www.ncbi.nlm.nih.gov/pubmed/18695905
102. Wang CZ, Basila D, Aung HH, Mehendale
SR, Chang WT, McEntee E, Guan X, Yuan
CS. Effects of Ganoderma lucidum extract on
chemotherapy-induced nausea and vomiting
in a rat model. Am J Chin Med.
2005;33(5):807-15. Tang Center for Herbal
Medicine
Research,
Department
of
Anesthesia and Critical Care, University of
Chicago,
Chicago,
IL,
USA.
www.ncbi.nlm.nih.gov/pubmed/16265993
103. Tao J, Feng KY. Experimental and clinical
studies on inhibitory effect of Ganoderma
lucidum on platelet aggregation. J Tongji
Med Univ. 1990;10(4):240-3. Department of
Internal Medicine, Tongji Hospital, Tongji
Medical
University,
Wuhan.
www.ncbi.nlm.nih.gov/pubmed/2098581
104. Memorial Sloan-Kettering Cancer Center.
Reishi Mushroom Herbs, Botanicals & Other
Products.
www.mskcc.org/cancercare/herb/reishi-mushroom
105. Suarez-Arroyo IJ, Rosario-Acevedo R,
Aguilar-Perez A, Clemente PL, Cuano LA,
Serrano J, Schneider RJ, MartinezMontemayor MM. Anti-tumor effects of
Ganoderma lucidum (reishi) in inflammatory
breast cancer in in-vivo and in-vitro models.
PLoS One. 2013;8(2);e5731. Department of
Biochemistry, Universidad Central del
Caribe, School of Medicine, Bayamon,
Puerto
Rico,
USA.
www.ncbi.nlm.nih.gov/pubmed/23468988
106. The use of Ganoderma lucidum (Reishi) in
the management of histamine-mediated
allergic
responses.
www.mycologyresearch.com
107. Ye L, Zhang J, Zhou K, Yang Y, Zhou S, Jia
W, Hao R, Pan Y. Purification, NMR study
and immunostimulating property of a
fucogalactan from the fruiting bodies of
Ganoderma lucidum. Planta Med. 2008
Nov;74(14):1730-4. College of Life
Sciences, Nanjing Agricultural University,
Nanjing,
P.R.
China.
www.ncbi.nlm.nih.gov/pubmed/18683124
108. Ye L, Zhang J, Ye X, Tang Q, Liu Y, Gong
C, Du X, Pan Y. Structural elucidation of the
polysaccharide moiety of a glycopeptide
(GLPCW-II) from Ganoderma lucidum
fruiting bodies. Carbohydr Res. 2008 Mar
17;343(4):746-52. College of Life Sciences,
Nanjing Agricultural University, Nanjing,
Jiangsu,
China.
www.ncbi.nlm.nih.gov/pubmed/18179790
109. Sun J, He H, Xie BJ. Novel antioxidant
peptides from fermented mushroom
Ganoderma lucidum. J Agric Food Chem.
2004 Oc 20;52(21):6646-52. College of Food
Science and Technology, Huazhong
Agricultural University, Wuhan, Hubei,
China.
www.ncbi.nlm.nih.gov/pubmed/15479035
110. Liu W, Wang H, Pang X, Yao W, Gao X.
Characterization and antioxidant activity of
two low-molecular-weight polysaccharides
purified from the fruiting bodies of
Ganoderma lucidum. Int J. Bio Macromol.
2010
May
1;46(4):451-7.
China
Pharmaceutical University, Nanjing, PR
China.
www.ncbi.nlm.nih.gov/pubmed/20153767
111. Wu Y, Wang D. A new class of natural
glycopeptides with sugar moiety-dependent
antioxidant
activities
derived
from
Ganoderma lucidum fruiting bodies. J
Proteome Res. 2009 Feb;8(2):436-42.
Department of Ophthalology, Columbia
University, New York, New York USA.
www.ncbi.nlm.nih.gov/pubmed/18989955
112. Jiang J, Thyagarajan-Sahu A, Loganathan J,
Eliaz I, Terry C, Sandusky GE, Sliva D.
BreastDefend™prevents
breast-to-lung
cancer metastases in an orthotopic animal
model of triple-negative human breast
cancer. Oncol Rep. 2012 Oct;28(4):1139-45.
Cancer Research Laboratory, Methanodist
Research Institute, Indiana University
Health,
Indianapolis,
IN
USA.
www.ncbi.nlm.nih.gov/pubmed/22842551
113. Shieh YU, Liu CF, Huang YK, Yang JY, Wu
IL, Lin CH, Li SC. Evaluation of the hepatic
and renal-protective effects of Ganoderma
lucidum in mice.
Am J Chin Med.
2001;29(3-4):501-7.
www.ncbi.nlm.nih.gov/pubmed/11789593
114. Futrakul N, Boonyen M, Patumraj S,
Siriviriyakul P, Tosukhowong P, Futrakul P.
Treatment of glomerular endothelial
dysfunction in steroid-resistant nephrosis
with Ganoderma lucidum, vitamins C, E, and
vasodilators. Clin Hemorheol Microcirc.
2003;29(3-4):205-10.
Departments
of
Physiology
and
Pediatrics,
King
Chulalongkorn Memorial Hospital, Bangkok
Thailand.
www.ncbi.nlm.nih.gov/pubmed/14724343
115. Lai KN, Chan LY, Tang SC, Leung JC.
Ganoderma extract prevents albumininduced oxidative damage and chemokines
synthesis in cultured human proximal
tubular epithelial cells. Nephrol Dial
Transplant.
2006
May;21(5):1188-97.
www.ncbi.nlm.nih.gov/pubmed/16434408
116. Yang Q, Wang S, Xie Y, Sun J, Wang J.
HPLC analysis of Ganoderma lucidum
polysaccharides and its effects on antioxidant
enzymes activity and Bax, Bcl-2 expression.
Int J. Biol Macromol. 2010 Mar 1;46(2):16772. Insitute of Materia Medica, School of
Pharmacy,
Fourth
Military Medical
University
Shaanxi,
China.
www.ncbi.nlm.nih.gov/pubmed/19941892
117. Daniel Sliva. Ganoderma lucidum in cancer
research. Cancer Research Laboratory,
Methodist Research Institute, Indianapolis,
IN.
www.sciencedirect.com
Leukemia
Research
30
(2006)
767-768.
Doi:10.1016/j.leukres.2005.12.015
118. Liao CH, Hsiao YM, Lin CH, Yeh CS, Wang
JC, Ni CH, Hsu CP, Ko JL. Induction of
premature senescence in human lung cancer
by fungal immunomodulatory protein from
Ganoderma tsugae. Food Chem Toxicol.
2008 May;46(5)1851-9. Institute of Medical
and Molecular Toxicology, Chung Shan
Medical University, Taichung, Taiwan.
www.ncbi.nlm.nih.gov/pubmed/18329152
119. Hsu SC, Ou CC, Chuang TX, Li JW, Lee YJ,
Wang V, Liu JY, Chen CS, Lin SC, Kao MC.
Ganoderma
tsugae
extract
inhibits
expression of epidermal growth factor
receptor and angiogenesis in human
epidermoid carcinoma cells: In vitro and in
vivo. Cancer Lett. 2009 Aug 18;281(1):10816. Graduate Institute of Medical Sciences,
Taipei Medical University, Taiwan.
www.ncbi.nlm.nih.gov/pubmed/19332363
120. Batra P, Sharma AK, Khajuria R. Probing
Lingzhi or Reishi medicinal mushroom
Ganoderma lucidum (higher Basidimycetes):
a bitter mushroom with amazing health
benefits.
Int
J
Med
Mushrooms.
2013;15(2):127-43.
Department
of
Biotechnology, Maharishi Markandeshwar
University, Mullana-Ambala, Haryana,
India.
www.ncbi.nlm.nih.gov/pubmed/23557365
121. Yun TK. Update from Asia. Asian studies on
cancer chemoprevention. Ann N Y Acad Sci.
1999;889:157-92.
Laboratory
of
Experimental Pathology, Korea Cancer
Center
Hospital,
Seuol,
Korea.
www.ncbi.nlm.nih.gov/pubmed/10668493
122. Standley G, Harvey K, Slivova V, Jiang J,
Sliva D. Ganoderma lucidum suppresses
angiogenesis through the inhibition secretion
of VEGF and TGF-beta1 from prostate
cancer cells. Cancer Research Laboratory,
Methodist Research Institute, Indianapolis,
IN.
USA.
www.ncbi.nlm.nih.gov/pubmed/15781230
123. Hong KJ, Dunn DM, Shen CL, Pence BC.
Effects of Ganoderma lucidum on apoptotic
and anti-inflammatory function in HT-29
human colonic carcinoma cells. Phytother
Res. 2004;18(9):768-70. Department of
Pathology, Texas Tech University Health
Sciences Center, Lubbock, TX, USA.
www.ncbi.nlm.nih.gov/pubmed/15478180
124. Muller CI, Kumagai T, O’Kelly J, Seeram
NP, Herber D, Koeffler HP. Ganoderma
lucidum causes apoptosis in leukemia,
lymphoma and multiple myeloma cells. Keuk
Res. 2006 Jul;30(7):841-8. Cedars-Sinai
Medical Center, David Geffen School of
Medicine at UCLA, Los Angeles, CA. USA.
www.ncbi.hlm.nih.gov/pubmed/16423392
125. Sliva D. Cellular and physiological effects of
Ganoderma lucidum (Reishi). Mini Rev Med
Chem.
2004
Oct;4(8):873-9.
www.ncbi.nlm.gov/pubmed/15544548
126. Shiao MS. Natural products of the medicinal
fungus Ganoderma lucidum: occurrence,
biological activities, and pharmacological
functions. Chem Rec. 2003;3(3):172-80.
Department of Medical Research and
Education, Taipei Veterans General Hospital,
Taiwan.
www.ncbi.nlm.nih.gov/pubmed/12900937
127. Veronika
Slivova,
BS;
Tatiana
Valachovicova, BS; Jiahua Jian, PhD; Daniel
Sliva, PhD. Ganoderma lucidum inhibits
invasiveness of breast cancer cells. Journal of
Cancer Integrative Medicine™ Winter 2004,
Vol. 2, No. 1.
128. Sliva D, Labarrere C, Slivova V, Sedlak M,
Lloyd FP Jr, Ho NW. Ganoderma lucidum
suppresses motility of highly invasive breast
and prostate cancer cells. Biochem Biophys
Res Commun. 2002 Nov 8;298(4):603-12.
www.ncbi.nlm.nih.gov/pubmed/12408995
129. Anita Kamra, A, B, Bhatt. Evaluation of
Antimicrobial and Antioxidant Activity of
Ganoderma Lucidum Extracts Against
Human Pathogenic Bacteria. Dept of Botany
and Microbiology, HNB Garhwal Central
University, Srinagar, Uttarakhand, India. Sep
2011. International Journal of Pharmacy and
Pharmaceutical Sciences. .
130. Byong Kak Kim, Ha Won Kim and Eung
Chil Choi. Medicinal Efficacies of
Ganoderma lucidum (XV) Anti-HIV
Activities
of
Ganoderma
lucidum.
Mushroom Bilogy and Mushroom Products,
Royse 1996 Penn State University p.187-94
131. Chi H.L. Kao et al. Anti-Cancer activities of
Ganoderma lucidum: active ingredients and
pathways. Functional Foods in Health and
Disease 2013; 3(2):48-65.