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Abstract Introduction: Anemia in children with cancer is a common disorder that has many causes . One of the therapeutic approaches is the use of recombinant human erythropoietin that can remove the anemia and Reduce the need for blood transfusion and its complications. Therefore, this study aimed to investigate the effects of erythropoietin on the anemia associated with acute lymphoblastic leukemia (ALL) in children . Materials and methods: This study is analyticand clinical trial (RCT) On the 60 children with ALL till done. Samples were randomly divided into two groups, control (n = 30 ) and experimental group (n = 30 ) . The experimental group received150u / kg erythropoietin (Eprex) and subcutaneously for 4 weeks. The data using the Chi-square test and t-test were analyzed in software Spss ver.18 . Findings: The mean age in the group treated with erythropoietin 6/46±3/23 and 6/73±3/27 years in the control group . In the present study , a significant association between baseline hemoglobin and hemoglobin at the end of the study ( 4 weeks ) was observed(P.value=0.009). While the frequency of blood transfusion during treatment were not significantly different in the two treatment groups(P.value=0.20). Conclusion: Based on the results of this study and comparison with other similar studies, Erythropoietin can be a useful drug in the treatment of anemia associated with acute lymphoblastic leukemia who were tolerated without any side effects in this study .Further studies are needed to evaluating further complication. Key words : erythropoietin , anemia , leukemia , children . Islamic Azad Univercity Branch Yazd Medical school of Ali ebn abi taleb A Thesis Presented for Medical Degree (MD) Title: Effect of erythropoietin on the anemia associated with acute lymphoblastic leukemia in children(1-15years) Advisor: Dr. Azam Hashemi Supervisor: Dr. Farzad Ferdosian Statistical Supervisor: Prof. Nasrollah Bashardoost By: Azadeh Seifadini Summer 2013