Conference Session C3 Paper 6188 Disclaimer — This paper partially fulfills a writing requirement for first year (freshman) engineering students at the University of Pittsburgh Swanson School of Engineering. This paper is a student, not a professional, paper. This paper is based on publicly available information and may not be provide complete analyses of all relevant data. If this paper is used for any purpose other than these authors’ partial fulfillment of a writing requirement for first year (freshman) engineering students at the University of Pittsburgh Swanson School of Engineering, the user does so at his or her own risk. THE USE OF POLYDIMETHYLSILOXANE (PDMS) MICROSYSTEMS IN ARTIFICIAL SKIN TO SIMULATE A SENSE OF TOUCH Sadhana Tadepalli, slt71@pitt.edu , Mahboobin 4:00pm , Isreal Williams, icw6@pitt.edu, Vidic 2:00pm Revised Proposal — This paper explores the application of polydimethylsiloxane (PDMS) in artificial skin to improve prosthetic limbs. It is proposed that artificial skin using PDMS best restores sense of touch in the skin created to cover a prosthetic limb. Its flexibility and sensitivity, and durability make it an ideal foundational microsystem when creating “electronic skin”. One of the biggest drawbacks of prosthetic limbs is that one cannot feel that body part once it has been lost. Thus, it has been a goal to create artificial skin that better replicates human skin in more biologically practical sense. Recreating this sensation goes beyond trying to make a luxury, as the sense of touch is essential to human safety. It functions as one of the body’s first alarms against physical damage, and helps prevent infection. A study of prosthetic limbs usage reports that approximately 1 in 190 persons in the year 2005 have a prosthetic limb. Within 5 years, that number has risen to approximately 1 in 170. By 2050, the number is expected to increase to 1 in 95[1]. Given this projection, the amount of people who would walk around with an increased chance of sustaining an injury without the human sense is alarmingly large, and the demand for “e-skin” is significant [2]. However, collaborative efforts from universities the world over may be reaching a solution. Getting closer to understanding the processes which occur in the human body has allowed researchers to connect materials, like PDMS, to sensors that allow communication between the artificial skin and brain. Synthetic skin must be capable of performing basic tasks, such as grasping and squeezing, without ruining the integrity of the skin, or overloading the brain. To do this engineers conduct laboratory tests. Comparing the results of these tests, it has been found that PDMS can effectively relay information between circuitry of the sensors and also as the epidermal layer, repeatedly [3]. Additionally, the low cost of production serves as another argument for the implementation of PDMS [1]. In order to properly assess the role of PDMS in the advancement of artificial skin, we will review other materials used for artificial skin and their effectiveness. The development of artificial skin will also be holistically summarized to show how it has evolved, specifically focusing on how the implementation of PDMS and its impact for artificial skin. From this, we will validate the effectiveness of University of Pittsburgh Swanson School of Engineering 1 2016/01/29 PDMS, maintaining the claim that it is the best material to use in order to make artificial skin. It has the potential to be as human as possible, while having the power to work with sensors, communicate with the brain, and perform tasks much like natural skin. REFERENCES [1] K. Ziegler-Graham, E. MacKenzie, P. Ephraim, et al. (2008). "Estimating the Prevalence of Limb Loss in the United States: 2005 to 2050." Science Direct. (online article) [2] G. Schwartz, B. Tee, J. Mei, A. Appleton, et al. (2013). "Flexible Polymer Transistors with High Pressure Sensitivity for Application in Electronic Skin and Health Monitoring." Nature Communications. (online journal). [3] L. Griscom, Y. Chateau, J. Pennec, L. Misery, B. Pioufle, (2005). "Co-culture of cells in PDMS microsystem for sensitized artificial skin," 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology, pp.184-187, 12-15 [4]C. Lucarotti, et al., (2013). “Synthetic and Bio-Artificial Tactile Sensing: A Review.” Sensors, (online review). ANNOTATED BIBLIOGRAPHY C. Arnaud, (2015). "Artificial Skin Sends Touching Signals to Nerve Cells." Scientific American. (online magazine article). This article, posted on an online technology magazine, reports on the newly made “electronic skin” produced at a lab at Stanford university headed by Zhenan Bao. The article focuses on how they used pressure sensors and converted them to electrical pulses so that the brain can understand. It also discusses the potential benefits it has for the future of prosthetics as it is a huge development in this field. D. Cheneler, (2014). "A Bio-Hybrid Tactile Sensor Incorporating Living Artificial Skin and an Impedance Sensing Array." US National Library of Public Medicine. National Institutes of Health, (online article). This article was published on an online, peer edited open access journal, which is dedicated to articles and papers about sensors. It discusses the bio-hybrid tactile sensor, a type of Sadhana Tadepalli Isreal Williams sensor that has been engineered to work in artificial skin. One of its components is polydimethylsiloxane (PDMS), so its role in this specific sensor can be evaluated. It was determined that PDMS did act effectively as an epidermis layer. University of Pittsburgh ULS. (2014). “A Current, Significant Engineering Topic” (Video) This is an online tutorial video regarding the picking and writing of a conference paper. It is made and provided by the writing instructor staff at the University of Pittsburgh. It goes step by step as to how to decide on a topic to write about and finding appropriate research using online sources. This was helpful when deciding what to write the conference paper about. L. Griscom, Y. Chateau, J. Pennec, L. Misery, B. Pioufle, (2005). "Co-culture of cells in PDMS microsystem for sensitized artificial skin," 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology, pp.184-187, 12-15 This publication reports the finding of various researches at a medical and scientific conference from 2005. The most applicable finding is the tests conducted on polydimethylsiloxane (PDMS) polymer, which we will use to assert the argument in favor of using PDMS. PDMS has been tested with the intent to create artificial nerve endings and relay information to the brain after detected by artificial skin. K. Ziegler-Graham, E. MacKenzie, P. Ephraim, et al. (2008). "Estimating the Prevalence of Limb Loss in the United States: 2005 to 2050." Science Direct. (online article). This online article, published on the US National Library of Medicine’s website, reports on a study about limb loss. This information will be used to give statistics about limb loss to show the need for prosthetics and its development. It is said that by 2050, it is expected that 1 in 95 people will have lost limbs, indicating that proper prosthetics will be more in demand for the future. S. Halim, S.Yahud, W. Muhamad, R. Daud, N. Zain, (2015). “The application of finite element analysis on polydimethylsiloxane” AIP Conference Proceedings, 1660, 070004, (conference paper). This conference paper, published in 2014, evaluates the material of polydimethylsiloxane, which is the polymer that our conference paper will be about, with regards to artificial skin. It specifically tests the material’s ability to stretch and sees how it reacts to stress in order to determine if it would be viable material to replicate human skin as close as possible, which is something our paper wants to determine overall. C. Lucarotti, C. Oddo, N. Vitiello, M. Carrozza, (2013). “Synthetic and Bio-Artificial Tactile Sensing: A Review”. Sensors. (online review). This review, published by an online, peer edited journal that focuses on sensors, discusses the need for artificial sensing in regards to synthetic skin and bio-artificial skin. It compares and contrast the different sensors that can be used. The most useful part of this review is the discussion it has about the overall need for artificial skin and how it should be implemented, as our paper will discuss this. G. Schwartz, B. Tee, J. Mei, A. Appleton, et al. (2013). "Flexible Polymer Transistors with High Pressure Sensitivity for Application in Electronic Skin and Health Monitoring." Nature Communications. (online journal). In order to ensure that PDMS would improve the artificial skin’s ability to convey touch, teams of engineers subject the microsystem to various experiments and help produce a measure of sensitivity. Results from these experiments such as one published by Nature Communications, during in which PDMS undergoes tests at various pressures and its sensitivity is recorded, can help support the claim that using polydimethylsiloxane would improve the ability of artificial organ’s ability to restore the sense of touch to an area around a prosthetic limb. 2